Loading Icon

Amyloid precursor protein

Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicated as a regulator of synapse formation, neural plasticity, antimicrobial activity, and iron export. It is coded for by the gene APP and is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.

Metrics Summary

Total Publications
Lifetime
5,299
Prior Five Years
493
Total Citations
Lifetime
230,400
Prior Five Years
6,666
Total Scholars
Lifetime
11,542
Prior Five Years
8,051

Institutional Rankings

Global (Worldwide)
Show More
National Institutional Rankings

Publications and Citation History

Publications based on Disciplines

Scholars based on Disciplines

Publications based on Fields

Scholars based on Fields

Highly Ranked Scholars™

Lifetime
Prior Five Years

Highly Cited Publications

Lifetime