Phospholipase A2

Phospholipases A2 (PLA2s) 3.1.1.4 are enzymes that cleave fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glycerol molecule. This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond, releasing arachidonic acid and lysophosphatidic acid. Upon downstream modification by cyclooxygenases or lipoxygenases, arachidonic acid is modified into active compounds called eicosanoids. Eicosanoids include prostaglandins and leukotrienes, which are categorized as anti-inflammatory and inflammatory mediators.

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Lifetime

10,956

Prior Five Years

884

Total Citations

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285,202

Prior Five Years

6,327

Total Scholars

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20,976

Prior Five Years

13,670

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Academic Institutions Lifetime		Academic Institutions Prior Five Years		Non-academic Institutions Lifetime
#1	University of Costa Rica Costa Rica	#1	University of California, San Diego United States	#1	Spanish National Research Council Spain
#2	Washington University in St. Louis United States	#2	São Paulo State University Brazil	#2	GlaxoSmithKline plc
#3	University of Washington United States	#3	Sorbonne Université France	#3	Pasteur Institute France
#4	Ohio State University United States	#4	Andong National University South Korea	#4	National Jewish Health United States
#5	Showa University Japan	#5	University of Costa Rica Costa Rica	#5	Brigham and Women's Hospital United States
#6	University of São Paulo Brazil	#6	University of Tokyo Japan	#6	St. Michael's Hospital Canada
#7	University of Pennsylvania United States	#7	University of Arizona United States	#7	AstraZeneca plc United States
#8	University of Groningen Netherlands	#8	University of Michigan United States	#8	National Center for Global Health and Medicine Japan
#9	National University of Singapore Singapore	#9	National and Kapodistrian University of Athens Greece	#9	Bill and Melinda Gates Foundation United States
#10	University of California, San Diego United States	#10	University Côte d'Azur France	#10	Academia Sinica Taiwan
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