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Aflatoxin B1

Aflatoxin B is an aflatoxin produced by Aspergillus flavus and A. parasiticus. It is a very potent carcinogen with a TD 3.2 μg/kg/day in rats. This carcinogenic potency varies across species with some, such as rats and monkeys, seemingly much more susceptible than others. Aflatoxin B is a common contaminant in a variety of foods including peanuts, cottonseed meal, corn, and other grains; as well as animal feeds. Aflatoxin B is considered the most toxic aflatoxin and it is highly implicated in hepatocellular carcinoma (HCC) in humans.date=October 2020 In animals, aflatoxin B has also been shown to be mutagenic, teratogenic, and to cause immunosuppression. Several sampling and analytical methods including thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), mass spectrometry, and enzyme-linked immunosorbent assay (ELISA), among others, have been used to test for aflatoxin B contamination in foods. According to the Food and Agriculture Organization (FAO), the worldwide maximum tolerated levels of aflatoxin B was reported to be in the range of 1–20 μg/kg in food, and 5–50 μg/kg in dietary cattle feed in 2003.

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