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MTOR inhibitors

mTOR inhibitors are a class of drugs that inhibit the mechanistic target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases (PIKKs). mTOR regulates cellular metabolism, growth, and proliferation by forming and signaling through two protein complexes, mTORC1 and mTORC2. The most established mTOR inhibitors are so-called rapalogs (rapamycin and its analogs), which have shown tumor responses in clinical trials against various tumor types.

Metrics Summary

Total Publications
Lifetime
2,265
Prior Five Years
590
Total Citations
Lifetime
46,484
Prior Five Years
6,222
Total Scholars
Lifetime
8,585
Prior Five Years
7,724

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Publications and Citation History

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Highly Ranked Scholars™

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Lifetime