Tissue plasminogen activator

Tissue plasminogen activator (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots. It is a serine protease (3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown. Human tPA has a molecular weight of ~70 kDa in the single-chain form.

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5,377

Prior Five Years

664

Total Citations

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149,373

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4,322

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12,996

Prior Five Years

9,134

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Academic Institutions Lifetime		Academic Institutions Prior Five Years		Non-academic Institutions Lifetime
#1	Duke University United States	#1	University of Colorado Anschutz Medical Campus United States	#1	Brigham and Women's Hospital United States
#2	Autonomous University of Barcelona Spain	#2	University of Shizuoka Japan	#2	Scripps Research United States
#3	Umeå University Sweden	#3	University of Colorado Denver United States	#3	Massachusetts General Hospital United States
#4	Erasmus University Rotterdam Netherlands	#4	Chang Gung University Taiwan	#4	Memorial Hermann Health System United States
#5	KU Leuven Belgium	#5	Massachusetts Institute of Technology United States	#5	Hospital Universitario Virgen Macarena Spain
#6	Rockefeller University United States	#6	Wenzhou Medical University China	#6	Genentech, Inc. United States
#7	State University of New York at Stony Brook United States		Show More	#7	Auckland City Hospital
#8	Malmö University Sweden			#8	Henry Ford Health System
#9	University of California, San Diego United States			#9	BioMarin Pharmaceutical Inc. United States
#10	University of Tennessee Health Science Center United States			#10	Shimadzu Corporation Japan
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