Pamela Chan

ScholarGPS® ID: 99512970522046

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmacology and Toxicology

Top Specialties

Antibody | Antibody-drug Conjugate

Metrics Summary

Publication Count

Predicted Citations

1,533

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry (journal article) Shi, Rachel Liuqing \| Dillon, Michael A. \| Compton, Philip D. \| Sawyer, William S. \| Thorup, John R. \| Kwong, Mandy \| Chan, Pamela \| Chiu, Cecilia P. C. \| Li, Ran \| Yadav, Rajbharan \| ... \| Tran, John C. Analytical Chemistry, volume 95, issue 47, pages 17263-17272 (2023). 10.1021/acs.analchem.3c03158 Cite \| Source
Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys (journal article) Cai, Hao \| Tao, Xun \| Shim, Jeongsup \| Bauer, Rebecca N. \| Bremer, Meire \| Bu, Wei \| LaMar, Jason \| Basile, Rachel \| Dere, Edward \| Nguyen, Tien \| ... \| Stefanich, Eric The AAPS Journal, volume 25, issue 4 (2023). 10.1208/s12248-023-00829-y Cited by (4) \| Cite \| Source
Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma (journal article) Cai, Hao \| Kakiuchi-Kiyota, Satoko \| Hendricks, Robert \| Zhong, Shelly \| Liu, Luna \| Adedeji, Adeyemi O. \| Chan, Pamela \| Schutten, Melissa M. \| Kamath, Amrita V. \| Ovacik, Meric A. The AAPS Journal, volume 24, issue 6 (2022). 10.1208/s12248-022-00744-8 Cited by (4) \| Cite \| Source
Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid (journal article) Sadekar, Shraddha S. \| Bowen, Mayumi \| Cai, Hao \| Jamalian, Samira \| Rafidi, Hanine \| Shatz‐Binder, Whitney \| Lafrance‐Vanasse, Julien \| Chan, Pamela \| Meilandt, William J. \| Oldendorp, Amy \| ... \| Horvath, Joshua Clinical Pharmacology & Therapeutics, volume 111, issue 4, pages 826-834 (2022). 10.1002/cpt.2531 Cited by (16) \| Cite \| Source
High‐throughput identification of conditional MHCI ligands and scaled‐up production of conditional MHCI complexes (journal article) Darwish, Martine \| Wichner, Sara \| Li, Jenny \| Chang, Jiun Chiun \| Tam, Christine \| Franke, Yvonne \| Li, Hong \| Chan, Pamela \| Blanchette, Craig Protein Science, volume 30, issue 6, pages 1169-1183 (2021). 10.1002/pro.4082 Cited by (3) \| Cite \| Source
The Immunoglobulin Superfamily Receptome Defines Cancer-Relevant Networks Associated with Clinical Outcome (journal article) Verschueren, Erik \| Husain, Bushra \| Yuen, Kobe \| Sun, Yi \| Paduchuri, Sairupa \| Senbabaoglu, Yasin \| Lehoux, Isabelle \| Arena, Tia A. \| Wilson, Blair \| Lianoglou, Steve \| ... \| Martinez-Martin, Nadia Cell, volume 182, issue 2, pages 329-344.e19 (2020). 10.1016/j.cell.2020.06.007 Cited by (64) \| Cite \| Source
A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155 (journal article) Husain, Bushra \| Ramani, Sree R. \| Chiang, Eugene \| Lehoux, Isabelle \| Paduchuri, Sairupa \| Arena, Tia A. \| Patel, Ashka \| Wilson, Blair \| Chan, Pamela \| Franke, Yvonne \| ... \| Martinez-Martin, Nadia Molecular & Cellular Proteomics, volume 18, issue 11, pages 2310-2323 (2019). 10.1074/mcp.TIR119.001433 Cited by (52) \| Cite \| Source
High throughput screening identifies novel, cell cycle‐arresting small molecule enhancers of transient protein expression (journal article) Meyer, Hermann‐Josef \| Turincio, Rebecca \| Ng, Shirley \| Li, Juan \| Wilson, Blair \| Chan, Pamela \| Zak, Mark \| Reilly, Dorothea \| Beresini, Maureen H. \| Wong, Athena W. Biotechnology Progress, volume 33, issue 6, pages 1579-1588 (2017). 10.1002/btpr.2517 Cited by (7) \| Cite \| Source
Taming hyperactive h DN ase I: Stable inducible expression of a hyperactive salt‐ and actin‐resistant variant of human deoxyribonuclease I in CHO cells (journal article) Lam, Cynthia \| Santell, Lydia \| Wilson, Blair \| Yim, Mandy \| Louie, Salina \| Tang, Danming \| Shaw, David \| Chan, Pamela \| Lazarus, Robert A. \| Snedecor, Brad \| Misaghi, Shahram Biotechnology Progress, volume 33, issue 2, pages 523-533 (2017). 10.1002/btpr.2439 Cited by (12) \| Cite \| Source
High-throughput functional assay to screen anti-BDCA2 candidates for systemic lupus erythematosus therapeutics (THER3P.973) (journal article) Li, Jenny \| Ladi, Ena \| Pappu, Rajita \| Chan, Pamela The Journal of Immunology, volume 194, issue 1_Supplement, pages 68.6-68.6 (2015). 10.4049/jimmunol.194.Supp.68.6 Cite \| Source
A Neutralizing Anti-gH/gL Monoclonal Antibody Is Protective in the Guinea Pig Model of Congenital CMV Infection (journal article) Auerbach, Marcy R. \| Yan, Donghong \| Vij, Rajesh \| Hongo, Jo-Anne \| Nakamura, Gerald \| Vernes, Jean-Michel \| Meng, Y. Gloria \| Lein, Samantha \| Chan, Pamela \| Ross, Jed \| ... \| Feierbach, Becket PLoS Pathogens, volume 10, issue 4, pages e1004060- (2014). 10.1371/journal.ppat.1004060 Cited by (39) \| Cite \| Source \| Open Access
DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody–Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma (journal article) Li, Dongwei \| Poon, Kirsten Achilles \| Yu, Shang-Fan \| Dere, Randall \| Go, MaryAnn \| Lau, Jeffrey \| Zheng, Bing \| Elkins, Kristi \| Danilenko, Dimitry \| Kozak, Katherine R. \| ... \| Polson, Andrew G. Molecular Cancer Therapeutics, volume 12, issue 7, pages 1255-1265 (2013). 10.1158/1535-7163.MCT-12-1173 Cited by (86) \| Cite \| Source \| Open Access
Total Antibody Quantification for MMAE-Conjugated Antibody–Drug Conjugates: Impact of Assay Format and Reagents (journal article) Kozak, Katherine R. \| Tsai, Siao Ping \| Fourie-O’Donohue, Aimee \| dela Cruz Chuh, Josefa \| Roth, Leslie \| Cook, Ryan \| Chan, Elton \| Chan, Pamela \| Darwish, Martine \| Ohri, Rachana \| ... \| Wong, Wai Lee T. Bioconjugate Chemistry, volume 24, issue 5, pages 772-779 (2013). 10.1021/bc300491k Cited by (29) \| Cite \| Source
A strategy for risk mitigation of antibodies with fast clearance (journal article) Hötzel, Isidro \| Theil, Frank-Peter \| Bernstein, Lisa J. \| Prabhu, Saileta \| Deng, Rong \| Quintana, Leah \| Lutman, Jeff \| Sibia, Renuka \| Chan, Pamela \| Bumbaca, Daniela \| ... \| Kelley, Robert F. mAbs, volume 4, issue 6, pages 753-760 (2012). 10.4161/mabs.22189 Cited by (211) \| Cite \| Source \| Open Access
Antibodies against the gH/gL/UL128/UL130/UL131 Complex Comprise the Majority of the Anti-Cytomegalovirus (Anti-CMV) Neutralizing Antibody Response in CMV Hyperimmune Globulin (journal article) Fouts, Ashley E. \| Chan, Pamela \| Stephan, Jean-Philippe \| Vandlen, Richard \| Feierbach, Becket Journal of Virology, volume 86, issue 13, pages 7444-7447 (2012). 10.1128/JVI.00467-12 Cited by (186) \| Cite \| Source \| Open Access
Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice (journal article) Qing, Jing \| Du, Xiangnan \| Chen, Yongmei \| Chan, Pamela \| Li, Hao \| Wu, Ping \| Marsters, Scot \| Stawicki, Scott \| Tien, Janet \| Totpal, Klara \| ... \| Ashkenazi, Avi Journal of Clinical Investigation, volume 119, issue 5, pages 1216-1229 (2009). 10.1172/JCI38017 Cited by (237) \| Cite \| Source \| Open Access
Anti-CD22-MCC-DM1 and MC-MMAF Conjugates: Impact of Assay Format on Pharmacokinetic Parameters Determination (journal article) Stephan, Jean-Philippe \| Chan, Pamela \| Lee, Chien \| Nelson, Christopher \| Elliott, James Michael \| Bechtel, Charity \| Raab, Helga \| Xie, David \| Akutagawa, Jon \| Baudys, Jakub \| ... \| Ebens, Allen Bioconjugate Chemistry, volume 19, issue 8, pages 1673-1683 (2008). 10.1021/bc800059t Cited by (75) \| Cite \| Source
High CD21 expression inhibits internalization of anti‐CD19 antibodies and cytotoxicity of an anti‐CD19‐drug conjugate (journal article) Ingle, Gladys S \| Chan, Pamela \| Elliott, J Michael \| Chang, Wesley S \| Koeppen, Hartmut \| Stephan, Jean‐Philippe \| Scales, Suzie J British Journal of Haematology, volume 140, issue 1, pages 46-58 (2008). 10.1111/j.1365-2141.2007.06883.x Cited by (63) \| Cite \| Source \| Open Access