John Spurlino

ScholarGPS® ID: 98806253415532

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Life Sciences

Discipline

Biology and Biological Sciences

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

4,632

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor (journal article) Xu, Guozhang \| Gaul, Michael D. \| Liu, Zhijie \| DesJarlais, Renee L. \| Qi, Jenson \| Wang, Weixue \| Krosky, Daniel \| Petrounia, Ioanna \| Milligan, Cynthia M. \| Hermans, An \| ... \| Spurlino, John C. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 23, pages 127602- (2020). 10.1016/j.bmcl.2020.127602 Cited by (4) \| Cite \| Source
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt (journal article) Gege, Christian \| Albers, Michael \| Kinzel, Olaf \| Kleymann, Gerald \| Schlüter, Thomas \| Steeneck, Christoph \| Hoffmann, Thomas \| Xue, Xiaohua \| Cummings, Maxwell D. \| Spurlino, John \| ... \| Goldberg, Steven D. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 12, pages 127205- (2020). 10.1016/j.bmcl.2020.127205 Cited by (12) \| Cite \| Source
3-Substituted Quinolines as RORγt Inverse Agonists (journal article) Tanis, Virginia M. \| Venkatesan, Hariharan \| Cummings, Maxwell D. \| Albers, Michael \| Kent Barbay, J. \| Herman, Krystal \| Kummer, David A. \| Milligan, Cynthia \| Nelen, Marina I. \| Nishimura, Rachel \| ... \| Leonard, Kristi Bioorganic & Medicinal Chemistry Letters, volume 29, issue 12, pages 1463-1470 (2019). 10.1016/j.bmcl.2019.04.021 Cited by (10) \| Cite \| Source
Identification and biological evaluation of thiazole-based inverse agonists of RORγt (journal article) Gege, Christian \| Cummings, Maxwell D. \| Albers, Michael \| Kinzel, Olaf \| Kleymann, Gerald \| Schlüter, Thomas \| Steeneck, Christoph \| Nelen, Marina I. \| Milligan, Cindy \| Spurlino, John \| ... \| Hoffmann, Thomas Bioorganic & Medicinal Chemistry Letters, volume 28, issue 9, pages 1446-1455 (2018). 10.1016/j.bmcl.2018.03.093 Cited by (19) \| Cite \| Source
Identification and biological evaluation of thiazole-based inverse agonists of ROR gamma t. (journal article) Gege, Christian \| Cummings, Maxwell D. \| Albers, Michael \| Kinzel, Olaf \| Kleymann, Gerald \| Schlüter, Thomas \| Steeneck, Christoph \| Nelen, Marina I. \| Milligan, Cindy \| Spurlino, John \| ... \| Hoffmann, Thomas Bioorganic & Medicinal Chemistry Letters, volume 28, issue 9, pages 1446-1455 (2018). 10.2210/pdb6cvh/pdb Cite \| Source
6-Substituted quinolines as RORγt inverse agonists (journal article) Barbay, J. Kent \| Cummings, Maxwell D. \| Abad, Marta \| Castro, Glenda \| Kreutter, Kevin D. \| Kummer, David A. \| Maharoof, Umar \| Milligan, Cynthia \| Nishimura, Rachel \| Pierce, Joan \| ... \| Leonard, Kristi Bioorganic & Medicinal Chemistry Letters, volume 27, issue 23, pages 5277-5283 (2017). 10.1016/j.bmcl.2017.10.027 Cited by (23) \| Cite \| Source
Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation (journal article) Scannevin, Robert H. \| Alexander, Richard \| Haarlander, Tara Mezzasalma \| Burke, Sharon L. \| Singer, Monica \| Huo, Cuifen \| Zhang, Yue-Mei \| Maguire, Diane \| Spurlino, John \| Deckman, Ingrid \| ... \| Rhodes, Kenneth J. Journal of Biological Chemistry, volume 292, issue 43, pages 17963-17974 (2017). 10.1074/jbc.M117.806075 Cited by (93) \| Cite \| Source \| Open Access
Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt (journal article) Kummer, David A. \| Cummings, Maxwell D. \| Abad, Marta \| Barbay, Joseph \| Castro, Glenda \| Wolin, Ronald \| Kreutter, Kevin D. \| Maharoof, Umar \| Milligan, Cynthia \| Nishimura, Rachel \| ... \| Leonard, Kristi Bioorganic & Medicinal Chemistry Letters, volume 27, issue 9, pages 2047-2057 (2017). 10.1016/j.bmcl.2017.02.044 Cited by (25) \| Cite \| Source
Methods of treatment using allosteric processing inhibitors for matrix metalloproteinases (patent) Leonard, Kristi A. \| Alexander, Richard Scott \| Barbay, Joseph Kent \| Bone, Roger F. \| Crysler, Carl \| Deckman, Ingrid Christa \| Jackson, Paul F. \| Kuo, Lawrence C. \| Lewandowski, Frank A. \| Maguire, Diane M. \| ... \| Wang, Aihua Patent Number: 8883473 (2014) Cited by (3) \| Cite \| Source
Methods for designing, selecting and/or optimizing allosteric processing inhibitors for matrix metalloproteinases (patent) Leonard, Kristi A. \| Alexander, Richard Scott \| Barbay, Joseph Kent \| Bone, Roger F. \| Deckman, Ingrid Christa \| Jackson, Paul F. \| Kuo, Lawrence C. \| Lewandowski, Frank A. \| Maguire, Diane M. \| Milligan, Cynthia M. \| ... \| Wang, Aihua Patent Number: 8798939 (2014) Cite \| Source
Crystal structure of the pro form of a matrix metalloproteinase and an allosteric processing inhibitor (patent) Leonard, Kristi A. \| Alexander, Richard Scott \| Barbay, Joseph Kent \| Bone, Roger F. \| Deckman, Ingrid Christa \| Jackson, Paul F. \| Kuo, Lawrence C. \| Lewandowski, Frank A. \| Maguire, Diane M. \| Milligan, Cynthia M. \| ... \| Wang, Aihua Patent Number: 8753857 (2014) Cited by (2) \| Cite \| Source
Structural Biology in Early Phase Drug Discovery (book chapter) In Frontiers in Drug Design & Discovery (Volume 1) Alexander, Richard \| Spurlino, John BENTHAM SCIENCE PUBLISHERS (2012) 10.2174/978160805199110501010287 Cite \| Source
Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors (journal article) Tresadern, Gary \| Delgado, Francisca \| Delgado, Oscar \| Gijsen, Harrie \| Macdonald, Gregor J. \| Moechars, Dieder \| Rombouts, Frederik \| Alexander, Richard \| Spurlino, John \| Gool, Michiel Van \| ... \| Trabanco, Andrés A. Bioorganic & Medicinal Chemistry Letters, volume 21, issue 24, pages 7255-7260 (2011). 10.1016/j.bmcl.2011.10.050 Cited by (47) \| Cite \| Source
HDM2-inhibitor complexes and uses thereof (patent) Schubert, Carsten \| Grasberger, Bruce \| Maguire, Diane \| Deckman, Ingrid \| Spurlino, John Patent Number: 8058390 (2011) Cite \| Source
Fragment Screening Purely with Protein Crystallography (book chapter) In Fragment-Based Drug Design - Tools, Practical Approaches, and Examples Spurlino, John C. Elsevier (2011) 10.1016/B978-0-12-381274-2.00013-3 Cited by (23) \| Cite \| Source
Potency variation of small-molecule chymase inhibitors across species (journal article) Kervinen, Jukka \| Crysler, Carl \| Bayoumy, Shariff \| Abad, Marta C. \| Spurlino, John \| Deckman, Ingrid \| Greco, Michael N. \| Maryanoff, Bruce E. \| de Garavilla, Lawrence Biochemical Pharmacology, volume 80, issue 7, pages 1033-1041 (2010). 10.1016/j.bcp.2010.06.014 Cited by (24) \| Cite \| Source
Discovery and Clinical Evaluation of 1-{ N -[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif (journal article) Lu, Tianbao \| Markotan, Thomas \| Ballentine, Shelley K. \| Giardino, Edward C. \| Spurlino, John \| Brown, Kathryn \| Maryanoff, Bruce E. \| Tomczuk, Bruce E. \| Damiano, Bruce P. \| Shukla, Umesh \| ... \| Player, Mark R. Journal of Medicinal Chemistry, volume 53, issue 4, pages 1843-1856 (2010). 10.1021/jm901802n Cited by (30) \| Cite \| Source
CRYSTAL STRUCTURE OF THE CARBOXYL TRANSFERASE DOMAIN OF HUMAN ACETYL-COA CARBOXYLASE 2 PROTEIN (ACC2 CT) AND USES THEREOF (patent) Grasberger, Bruce L. \| Milligan, Cynthia M. \| Spurlino, John \| Steele, Ruth A. \| Singleton, Kenneth R. \| Gibbs, Alan C. \| Lewandowski, Francis A. Patent Number: 20090155815 (2008) Cite \| Source
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif (journal article) Kreutter, Kevin D. \| Lu, Tianbao \| Lee, Lily \| Giardino, Edward C. \| Patel, Sharmila \| Huang, Hui \| Xu, Guozhang \| Fitzgerald, Mark \| Haertlein, Barbara J. \| Mohan, Venkatraman \| ... \| Player, Mark R. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 9, pages 2865-2870 (2008). 10.1016/j.bmcl.2008.03.087 Cited by (29) \| Cite \| Source
Device and method for high throughput screening of crystallization conditions in a vapor diffusion environment (patent) Lewandowski, Francis A. \| Kwasnoski, Joseph Daniel \| Spurlino, John Patent Number: 20090111711 (2008) Cite \| Source