Steven A. Middleton

ScholarGPS® ID: 98631120547652

Affiliation

Roche Holding AG, Basel, Switzerland

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmacology and Toxicology

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

3,916

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Clinical pharmacology characterization of RG7112, an MDM2 antagonist, in patients with advanced solid tumors (journal article) Patnaik, Amita \| Tolcher, Anthony \| Beeram, Murali \| Nemunaitis, John \| Weiss, Glen J. \| Bhalla, Kapil \| Agrawal, Manish \| Nichols, Gwen \| Middleton, Steven \| Beryozkina, Anna \| ... \| Zhi, Jianguo Cancer Chemotherapy and Pharmacology, volume 76, issue 3, pages 587-595 (2015). 10.1007/s00280-015-2830-8 Cited by (38) \| Cite \| Source
Inhibition of MDM2 by RG7388 confers hypersensitivity to X‐radiation in xenograft models of childhood sarcoma (journal article) Phelps, Doris \| Bondra, Kathryn \| Seum, Star \| Chronowski, Christopher \| Leasure, Justin \| Kurmasheva, Raushan T. \| Middleton, Steven \| Wang, Dian \| Mo, Xiaokui \| Houghton, Peter J. Pediatric Blood & Cancer, volume 62, issue 8, pages 1345-1352 (2015). 10.1002/pbc.25465 Cited by (24) \| Cite \| Source \| Open Access
Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma (journal article) Chen, Lindi \| Rousseau, Raphaël F. \| Middleton, Steven A. \| Nichols, Gwen L. \| Newell, David R. \| Lunec, John \| Tweddle, Deborah A. Oncotarget, volume 6, issue 12 (2015). 10.18632/oncotarget.3504 Cited by (59) \| Cite \| Source \| Open Access
A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety (journal article) Ross, Tina Morgan \| Battista, Kathleen \| Bignan, Gilles C. \| Brenneman, Doug E. \| Connolly, Peter J. \| Liu, Jingchun \| Middleton, Steven A. \| Orsini, Michael \| Reitz, Allen B. \| Rosenthal, Dan I. \| ... \| Vaidya, Anil H. Bioorganic & Medicinal Chemistry Letters, volume 25, issue 3, pages 602-606 (2015). 10.1016/j.bmcl.2014.12.015 Cited by (14) \| Cite \| Source
Structurally diverse MDM2–p53 antagonists act as modulators of MDR-1 function in neuroblastoma (journal article) Chen, L \| Zhao, Y \| Halliday, G C \| Berry, P \| Rousseau, R F \| Middleton, S A \| Nichols, G L \| Del Bello, F \| Piergentili, A \| Newell, D R \| ... \| Tweddle, D A British Journal of Cancer, volume 111, issue 4, pages 716-725 (2014). 10.1038/bjc.2014.325 Cited by (35) \| Cite \| Source \| Open Access
Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders (patent) Battista, Kathleen \| Bignan, Gilles \| Connolly, Peter J. \| Reitz, Allen B. \| Ross, Tina Morgan \| Scott, Malcolm \| Middleton, Steven A. \| Orsini, Michael Patent Number: 8778956 (2014) Cited by (2) \| Cite \| Source
Phase 1 dose escalation, food effect, and biomarker study of RG7388, a more potent second-generation MDM2 antagonist, in patients (pts) with solid tumors. (journal article) Siu, Lillian L. \| Italiano, Antoine \| Miller, Wilson H. \| Blay, Jean-Yves \| Gietema, Jourik A. \| Bang, Yung-Jue \| Mileshkin, Linda R. \| Hirte, Hal W. \| Reckner, Monica \| Higgins, Brian \| ... \| Chen, Lin Chi Journal of Clinical Oncology, volume 32, issue 15_suppl, pages 2535-2535 (2014). 10.1200/jco.2014.32.15_suppl.2535 Cited by (44) \| Cite \| Source
Phase 1b Study Of The MDM2 Antagonist RG7112 In Combination With 2 Doses/Schedules Of Cytarabine (journal article) Yee, Karen \| Martinelli, Giovanni \| Assouline, Sarit \| Kasner, Margaret \| Vey, Norbert \| Kelly, Kevin R. \| Drummond, Mark W. \| Dennis, Michael \| Seiter, Karen \| Blotner, Steven \| ... \| Nichols, Gwen Blood, volume 122, issue 21, pages 498-498 (2013). 10.1182/blood.V122.21.498.498 Cited by (20) \| Cite \| Source
Phase Ib study of RG7112 with doxorubicin (D) in advanced soft tissue sarcoma (ASTS). (journal article) Chawla, Sant P. \| Blay, Jean-Yves \| Italiano, Antoine \| Gutierrez, Martin \| Le Cesne, Axel \| Gomez-Roca, Carlos Alberto \| Gouw, Launce G. \| von Mehren, Margaret \| Wagner, Andrew \| Maki, Robert G. \| ... \| Chen, Lin Chi Journal of Clinical Oncology, volume 31, issue 15_suppl, pages 10514-10514 (2013). 10.1200/jco.2013.31.15_suppl.10514 Cited by (19) \| Cite \| Source
Substituted pyrimidinyl oxime kinase inhibitors (patent) Bignan, Gilles C. \| Battista, Kathleen A. \| Lee, Lily \| Abad, Marta C. \| Connolly, Peter J. \| Kamachi, Prabha S. \| Middleton, Steven A. \| Wetter, Steven K. \| Emanuel, Stuart L. \| Hughes, Terry V. \| Guozhang, Xu Patent Number: 8367825 (2013) Cite \| Source
Bicyclic pyrimidine kinase inhibitors (patent) Connolly, Peter J. \| Emanuel, Stuart \| Lin, Ronghui \| Lu, Yanhua \| Middleton, Steven A. Patent Number: 8314234 (2012) Cited by (3) \| Cite \| Source
Results of the Phase 1 Trial of RG7112, a Small-Molecule MDM2 Antagonist, in Acute Leukemia (journal article) Andreeff, Michael \| Kelly, Kevin R. \| Yee, Karen \| Assouline, Sarit \| Strair, Roger \| Popplewell, Leslie \| Bowen, David \| Martinelli, Giovanni \| Drummond, Mark W. \| Vyas, Paresh \| ... \| Nichols, Gwen Blood, volume 120, issue 21, pages 675-675 (2012). 10.1182/blood.V120.21.675.675 Cited by (17) \| Cite \| Source
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study (journal article) Ray-Coquard, Isabelle \| Blay, Jean-Yves \| Italiano, Antoine \| Le Cesne, Axel \| Penel, Nicolas \| Zhi, Jianguo \| Heil, Florian \| Rueger, Ruediger \| Graves, Bradford \| Ding, Meichun \| ... \| Bui, Binh Nguyen The Lancet Oncology, volume 13, issue 11, pages 1133-1140 (2012). 10.1016/S1470-2045(12)70474-6 Cited by (470) \| Cite \| Source
1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives (patent) Huang, Shenlin \| Lin, Ronghui \| Connolly, Peter J. \| Emanuel, Stuart L. \| Middleton, Steven A. \| Gruninger, Robert H. \| Wetter, Steven K. Patent Number: 8299082 (2012) Cite \| Source
Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors (journal article) Tolcher, Anthony W. \| Messersmith, Wells A. \| Mikulski, Stanislaw M. \| Papadopoulos, Kyriakos P. \| Kwak, Eunice L. \| Gibbon, Darlene G. \| Patnaik, Amita \| Falchook, Gerald S. \| Dasari, Arvind \| Shapiro, Geoffrey I. \| ... \| Wheler, Jennifer J. Journal of Clinical Oncology, volume 30, issue 19, pages 2348-2353 (2012). 10.1200/JCO.2011.36.8282 Cited by (212) \| Cite \| Source \| Open Access
Substituted pyrimidinyl oxime kinase inhibitors (patent) Xu, Guozhang \| Lee, Lily \| Hughes, Terry V. \| Wetter, Steven K. \| Connolly, Peter J. \| Abad, Marta C. \| Emanuel, Stuart L. \| Karnachi, Prabha S. \| Middleton, Steven A. \| Battista, Kathleen A. \| Bignan, Gilles C. Patent Number: 8153791 (2012) Cited by (2) \| Cite \| Source
1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives (patent) Huang, Shenlin \| Lin, Ronghui \| Connolly, Peter J. \| Emanuel, Stuart L. \| Middleton, Steven A. \| Gruninger, Robert H. \| Wetter, Steven K. Patent Number: 7888380 (2011) Cited by (2) \| Cite \| Source
Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders (patent) Huang, Shenlin \| Li, Ronghua \| Connolly, Peter J. \| Emanuel, Stuart L. \| Middleton, Steven A. Patent Number: 7855205 (2010) Cited by (12) \| Cite \| Source
Thiazolopyridine kinase inhibitors (patent) Connolly, Peter J. \| Johnson, Sigmond G. \| Pandey, Niranjan B. \| Middleton, Steven A. Patent Number: 7659284 (2010) Cite \| Source
3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators (patent) Battista, Kathleen A. \| Bignan, Gilles C. \| Connolly, Peter J. \| Liu, Jessica J. \| Middleton, Steven A. \| Orsini, Michael J. Patent Number: 7655670 (2010) Cited by (5) \| Cite \| Source