Matthew J. Todd

ScholarGPS® ID: 96783787142485

Affiliation
Johnson & Johnson, New Brunswick, New Jersey, United States
Affiliation History

Field
Life Sciences
Discipline
Biology and Biological Sciences
Top Specialties
Protein Folding | HIV | Carbonic Anhydrase | Enzyme | HIV-1 Protease | Thermodynamics | Active Site
Metrics Summary
Publication Count
63
Predicted Citations
5,197
Predicted h-index
33
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Inhibitor Binding to Carbonic Anhydrases by Isothermal Titration Calorimetry (book chapter)
In Carbonic Anhydrase as Drug Target
Paketurytė, Vaida | Zubrienė, Asta | Chen, Wen-Yih | Keller, Sandro | Bastos, Margarida | Todd, Matthew J. | Ladbury, John E. | Matulis, Daumantas
Springer International Publishing (2019)
10.1007/978-3-030-12780-0_6
Cited by (4) | Cite | Source
Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation (journal article)
Scannevin, Robert H. | Alexander, Richard | Haarlander, Tara Mezzasalma | Burke, Sharon L. | Singer, Monica | Huo, Cuifen | Zhang, Yue-Mei | Maguire, Diane | Spurlino, John | Deckman, Ingrid | ... | Rhodes, Kenneth J.
Journal of Biological Chemistry, volume 292, issue 43, pages 17963-17974 (2017).
10.1074/jbc.M117.806075
Cited by (93) | Cite | Source | Open Access
Intrinsic thermodynamics of sulfonamide inhibitor binding to human carbonic anhydrases I and II (journal article)
Morkūnaitė, Vaida | Gylytė, Joana | Zubrienė, Asta | Baranauskienė, Lina | Kišonaitė, Miglė | Michailovienė, Vilma | Juozapaitienė, Vaida | Todd, Matthew J. | Matulis, Daumantas
Journal of Enzyme Inhibition and Medicinal Chemistry, volume 30, issue 2, pages 204-211 (2015).
10.3109/14756366.2014.908291
Cited by (24) | Cite | Source | Open Access
Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors (patent)
Chevalier, Kristen | Clemente, Jose | Dax, Scott L | Flores, Chris | Liu, Li | Macielag, Mark J | McDonnell, Mark | Nelen, Marina | Nulton, Erica | Prouty, Stephen | ... | Zhu, Bin
Patent Number: 8815839 (2014)
Cited by (4) | Cite | Source
Methods for designing, selecting and/or optimizing allosteric processing inhibitors for matrix metalloproteinases (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | Milligan, Cynthia M. | ... | Wang, Aihua
Patent Number: 8798939 (2014)
Cite | Source
Crystal structure of the pro form of a matrix metalloproteinase and an allosteric processing inhibitor (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | Milligan, Cynthia M. | ... | Wang, Aihua
Patent Number: 8753857 (2014)
Cited by (2) | Cite | Source
Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors (patent)
Flores, Christopher M | Nelen, Marina I | Nulton, Erica L | Prouty, Stephen M | Todd, Matthew J | Zhang, Sui-Po
Patent Number: 8729064 (2014)
Cite | Source
Assay for evaluating affinity and specificity of ligand-albumin binding (patent)
Todd, Gabrielle C. | Kranz, James K. | Todd, Matthew J.
Patent Number: 8476081 (2013)
Cite | Source
Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors (patent)
Flores, Chris | Nulton, Erica | Nelen, Marina | Todd, Matthew | Prouty, Stephen | Zhang, Sui-Po
Patent Number: 8435977 (2013)
Cited by (5) | Cite | Source
Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors (patent)
Zhu, Bin | Flores, Chris | Nulton, Erica | Clemente, Jose | Chevalier, Kristen | Liu, Li | Nelen, Marina | Macielag, Mark | McDonnell, Mark | Todd, Matthew | ... | Zhang, Sui-Po
Patent Number: 8415341 (2013)
Cited by (10) | Cite | Source
High-throughput assay for evaluating dipeptidyl peptidase I activity (patent)
Olson, Matthew | Todd, Matthew
Patent Number: 8313920 (2012)
Cite | Source
Screening and Characterization of Human Monoglyceride Lipase Active Site Inhibitors Using Orthogonal Binding and Functional Assays (journal article)
Clemente, José C. | Nulton, Erica | Nelen, Marina | Todd, Matthew J. | Maguire, Diane | Schalk-Hihi, Céline | Kuo, Lawrence C. | Zhang, Sui-Po | Flores, Christopher M. | Kranz, James K.
SLAS Discovery, volume 17, issue 5, pages 629-640 (2012).
10.1177/1087057112441012
Cited by (8) | Cite | Source | Open Access
METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION (patent)
Jackson, Paul Francis | Manthey, Carl | Rhodes, Kenneth | Scannevin, Robert | Leonard, Kristi Anne | Barbay, Joseph Kent | Todd, Matthew | Springer, Barry A.
Patent Number: 20120302573 (2012)
Cite | Source
Long-Term Response to Galantamine in Relation to Short-Term Efficacy Data: Pooled Analysis in Patients with Mild to Moderate Alzheimers Disease (journal article)
Kavanagh, S. | Howe, I. | R. Brashear, H. | Wang, D. | Van Baelen, B. | Todd, M. | Schwalen, S.
Current Alzheimer Research, volume 8, issue 2, pages 175-186 (2011).
10.2174/156720511795256044
Cited by (12) | Cite | Source | Open Access
A novel fluorogenic substrate for the measurement of endothelial lipase activity (journal article)
Darrow, Andrew L. | Olson, Matthew W. | Xin, Hong | Burke, Sharon L. | Smith, Charles | Schalk-Hihi, Celine | Williams, Robyn | Bayoumy, Shariff S. | Deckman, Ingrid C. | Todd, Matthew J. | ... | Connelly, Margery A.
Journal of Lipid Research, volume 52, issue 2, pages 374-382 (2011).
10.1194/jlr.D007971
Cited by (23) | Cite | Source | Open Access
Assay for evaluating affinity and specificity of ligand-albumin binding (patent)
Kranz, James K. | Todd, Gabrielle C. | Todd, Matthew J.
Patent Number: 20110124120 (2010)
Cite | Source
Combining Label‐free and Flourometric Functional Assays with Biophysical Binding Assays in Drug Discovery: A Comparison of Positives from an HTS Campaign (journal article)
Olson, Matthew Wayne | Kervinen, Jukka | Schubert, Carsten | Kirkpatrick, Jennifer | Kranz, James | Ma, Hongchung | Sun, Wenfeng | Lawson, Ed | DeCorte, Bart | Jordan, Alfonzo | ... | Todd, Matthew
The FASEB Journal, volume 23, issue S1 (2009).
10.1096/fasebj.23.1_supplement.LB303
Cite | Source
Carbonic Anhydrase-II Inhibition. What Are the True Enzyme–Inhibitory Properties of the Sulfamide Cognate of Topiramate? (journal article)
Maryanoff, Bruce E. | McComsey, David F. | Lee, Jung | Smith-Swintosky, Virginia L. | Wang, Yuanping | Minor, Lisa K. | Todd, Matthew J.
Journal of Medicinal Chemistry, volume 51, issue 12, pages 3660-3660 (2008).
10.1021/jm8004916
Cite | Source | Open Access
Carbonic Anhydrase-II Inhibition. What are the True Enzyme–Inhibitory Properties of the Sulfamide Cognate of Topiramate? (journal article)
Maryanoff, Bruce E. | McComsey, David F. | Lee, Jung | Smith-Swintosky, Virginia L. | Wang, Yuanping | Minor, Lisa K. | Todd, Matthew J.
Journal of Medicinal Chemistry, volume 51, issue 8, pages 2518-2521 (2008).
10.1021/jm7015649
Cited by (9) | Cite | Source
Evaluation of No-Wash Calcium Assay Kits: Enabling Tools for Calcium Mobilization (journal article)
Xin, Hong | Wang, Yuanping | Todd, Matthew J. | Qi, Jianshen | Minor, Lisa K.
SLAS Discovery, volume 12, issue 5, pages 705-714 (2007).
10.1177/1087057107301522
Cited by (13) | Cite | Source | Open Access