Brian Biehs

ScholarGPS® ID: 96718948008492

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Drosophila | Stem Cell | Notch Signaling Pathway | Hedgehog Signaling Pathway

Metrics Summary

Publication Count

Predicted Citations

3,744

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Methods of treating hedgehog-related diseases with an anti-LGR5 antibody (patent) De Sauvage, Frederic J. \| Biehs, Brian Patent Number: 10246515 (2019) Cite \| Source
A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition (journal article) Biehs, Brian \| Dijkgraaf, Gerrit J. P. \| Piskol, Robert \| Alicke, Bruno \| Boumahdi, Soufiane \| Peale, Franklin \| Gould, Stephen E. \| de Sauvage, Frederic J. Nature, volume 562, issue 7727, pages 429-433 (2018). 10.1038/s41586-018-0596-y Cited by (100) \| Cite \| Source
Notch pathway inhibition (patent) de Sauvage, Fred \| Siebel, Christian \| Biehs, Brian \| Tian, Hua \| Klein, Ophir Patent Number: 9914774 (2018) Cited by (2) \| Cite \| Source
Stem cell plasticity enables hair regeneration following Lgr5+ cell loss (journal article) Hoeck, Joerg D. \| Biehs, Brian \| Kurtova, Antonina V. \| Kljavin, Noelyn M. \| de Sousa e Melo, Felipe \| Alicke, Bruno \| Koeppen, Hartmut \| Modrusan, Zora \| Piskol, Robert \| de Sauvage, Frederic J. Nature Cell Biology, volume 19, issue 6, pages 666-676 (2017). 10.1038/ncb3535 Cited by (60) \| Cite \| Source
Notch pathway inhibition (patent) De, Sauvage Fred \| Siebel, Christian \| Biehs, Brian \| Tian, Hua Patent Number: 20160068596 (2016) Cite \| Source
Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis (journal article) Tian, Hua \| Biehs, Brian \| Chiu, Cecilia \| Siebel, Christian W. \| Wu, Yan \| Costa, Mike \| de Sauvage, Frederic J. \| Klein, Ophir D. Cell Reports, volume 11, issue 1, pages 33-42 (2015). 10.1016/j.celrep.2015.03.007 Cited by (167) \| Cite \| Source \| Open Access
Microarray Comparison of Anterior and Posterior Drosophila Wing Imaginal Disc Cells Identifies Novel Wing Genes (journal article) Ibrahim, Daniel M \| Biehs, Brian \| Kornberg, Thomas B \| Klebes, Ansgar G3 Genes\|Genomes\|Genetics, volume 3, issue 8, pages 1353-1362 (2013). 10.1534/g3.113.006569 Cited by (14) \| Cite \| Source \| Open Access
BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor (journal article) Biehs, Brian \| Hu, Jimmy Kuang-Hsien \| Strauli, Nicolas B. \| Sangiorgi, Eugenio \| Jung, Heekyung \| Heber, Ralf-Peter \| Ho, Sunita \| Goodwin, Alice F. \| Dasen, Jeremy S. \| Capecchi, Mario R. \| Klein, Ophir D. Nature Cell Biology, volume 15, issue 7, pages 846-852 (2013). 10.1038/ncb2766 Cited by (115) \| Cite \| Source \| Open Access
From molecules to mastication: the development and evolution of teeth (journal article) Jheon, Andrew H. \| Seidel, Kerstin \| Biehs, Brian \| Klein, Ophir D. WIREs Developmental Biology, volume 2, issue 2, pages 165-182 (2013). 10.1002/wdev.63 Cited by (75) \| Cite \| Source \| Open Access
A graphical model method for integrating multiple sources of genome-scale data (journal article) Dvorkin, Daniel \| Biehs, Brian \| Kechris, Katerina Statistical Applications in Genetics and Molecular Biology, volume 12, issue 4 (2013). 10.1515/sagmb-2012-0051 Cited by (5) \| Cite \| Source \| Open Access
Characterization of Dental Epithelial Stem Cells from the Mouse Incisor with Two-Dimensional and Three-Dimensional Platforms (journal article) Chavez, Miquella G. \| Yu, Wenli \| Biehs, Brian \| Harada, Hidemitsu \| Snead, Malcolm L. \| Lee, Janice S. \| Desai, Tejal A. \| Klein, Ophir D. Tissue Engineering Part C: Methods, volume 19, issue 1, pages 15-24 (2013). 10.1089/ten.tec.2012.0232 Cited by (21) \| Cite \| Source \| Open Access
BCL11B Regulates Epithelial Proliferation and Asymmetric Development of the Mouse Mandibular Incisor (journal article) Kyrylkova, Kateryna \| Kyryachenko, Sergiy \| Biehs, Brian \| Klein, Ophir \| Kioussi, Chrissa \| Leid, Mark PLoS ONE, volume 7, issue 5, pages e37670- (2012). 10.1371/journal.pone.0037670 Cited by (27) \| Cite \| Source \| Open Access
Expression and Characterization of Drosophila Signal Peptide Peptidase-Like (sppL), a Gene That Encodes an Intramembrane Protease (journal article) Casso, David J. \| Liu, Songmei \| Biehs, Brian \| Kornberg, Thomas B. PLoS ONE, volume 7, issue 3, pages e33827- (2012). 10.1371/journal.pone.0033827 Cited by (5) \| Cite \| Source \| Open Access
Erratum: A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable (journal article) Tian, Hua \| Biehs, Brian \| Warming, Søren \| Leong, Kevin G. \| Rangell, Linda \| Klein, Ophir D. \| de Sauvage, Frederic J. Nature, volume 482, issue 7383, pages 120-120 (2012). 10.1038/nature10788 Cited by (8) \| Cite \| Source \| Open Access
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable (journal article) Tian, Hua \| Biehs, Brian \| Warming, Søren \| Leong, Kevin G. \| Rangell, Linda \| Klein, Ophir D. \| de Sauvage, Frederic J. Nature, volume 478, issue 7368, pages 255-259 (2011). 10.1038/nature10408 Cited by (951) \| Cite \| Source \| Open Access
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling (journal article) Charles, Cyril \| Hovorakova, Maria \| Ahn, Youngwook \| Lyons, David B. \| Marangoni, Pauline \| Churava, Svatava \| Biehs, Brian \| Jheon, Andrew \| Lesot, Hervé \| Balooch, Guive \| ... \| Klein, Ophir D. Development, volume 138, issue 18, pages 4063-4073 (2011). 10.1242/dev.069195 Cited by (51) \| Cite \| Source \| Open Access
A Novel Interaction Between hedgehog and Notch Promotes Proliferation at the Anterior–Posterior Organizer of the Drosophila Wing (journal article) Casso, David J \| Biehs, Brian \| Kornberg, Thomas B Genetics, volume 187, issue 2, pages 485-499 (2011). 10.1534/genetics.110.125138 Cited by (17) \| Cite \| Source \| Open Access
Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling (journal article) Biehs, Brian \| Kechris, Katerina \| Liu, SongMei \| Kornberg, Thomas B. Development, volume 137, issue 22, pages 3887-3898 (2010). 10.1242/dev.055871 Cited by (29) \| Cite \| Source \| Open Access
Generalizing Moving Averages for Tiling Arrays Using Combined P-Value Statistics (journal article) Kechris, Katerina J \| Biehs, Brian \| Kornberg, Thomas B Statistical Applications in Genetics and Molecular Biology, volume 9, issue 1 (2010). 10.2202/1544-6115.1434 Cited by (36) \| Cite \| Source \| Open Access
Drosophila Signal Peptide Peptidase Is an Essential Protease for Larval Development (journal article) Casso, David J \| Tanda, Soichi \| Biehs, Brian \| Martoglio, Bruno \| Kornberg, Thomas B Genetics, volume 170, issue 1, pages 139-148 (2005). 10.1534/genetics.104.039933 Cited by (43) \| Cite \| Source \| Open Access