Christian Kretzer

ScholarGPS® ID: 96328731146641

Affiliation

University of Jena, Jena, Germany

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Lipid | Biosynthesis | Inflammation

Metrics Summary

Publication Count

Predicted Citations

363

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

Add Delete
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms (journal article) Mikutis, Sigitas \| Lawrinowitz, Stefanie \| Kretzer, Christian \| Dunsmore, Lavinia \| Sketeris, Laurynas \| Rodrigues, Tiago \| Werz, Oliver \| Bernardes, Gonçalo J. L. ACS Chemical Biology, volume 19, issue 1, pages 217-229 (2024). 10.1021/acschembio.3c00725 Cite \| Source
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators (journal article) Peltner, Lukas K. \| Gluthmann, Lars \| Börner, Friedemann \| Pace, Simona \| Hoffstetter, Robert K. \| Kretzer, Christian \| Bilancia, Rosella \| Pollastro, Federica \| Koeberle, Andreas \| Appendino, Giovanni \| ... \| Jordan, Paul M. Cell Chemical Biology, volume 30, issue 12, pages 1508-1524.e7 (2023). 10.1016/j.chembiol.2023.08.001 Cited by (6) \| Cite \| Source
Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E2 and Leukotriene Biosynthesis Inhibitors (journal article) Potenza, Marianna \| Giordano, Assunta \| Chini, Maria G. \| Saviano, Anella \| Kretzer, Christian \| Raucci, Federica \| Russo, Marina \| Lauro, Gianluigi \| Terracciano, Stefania \| Bruno, Ines \| ... \| Bifulco, Giuseppe ACS Medicinal Chemistry Letters, volume 14, issue 1, pages 26-34 (2023). 10.1021/acsmedchemlett.2c00343 Cite \| Source
Label-Free Characterization of Macrophage Polarization Using Raman Spectroscopy (journal article) Naumann, Max \| Arend, Natalie \| Guliev, Rustam R. \| Kretzer, Christian \| Rubio, Ignacio \| Werz, Oliver \| Neugebauer, Ute International Journal of Molecular Sciences, volume 24, issue 1, pages 824- (2023). 10.3390/ijms24010824 Cited by (8) \| Cite \| Source
Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages (journal article) Rao, Zhigang \| Caprioglio, Diego \| Gollowitzer, André \| Kretzer, Christian \| Imperio, Daniela \| Collado, Juan A. \| Waltl, Lorenz \| Lackner, Sandra \| Appendino, Giovanni \| Muñoz, Eduardo \| ... \| Koeberle, Andreas Biochemical Pharmacology, volume 203 (2022). 10.1016/j.bcp.2022.115202 Cited by (6) \| Cite \| Source
Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors (journal article) Çapan, İrfan \| Jordan, Paul M. \| Olğaç, Abdurrahman \| Çalışkan, Burcu \| Kretzer, Christian \| Werz, Oliver \| Banoglu, Erden ChemMedChem, volume 17, issue 12 (2022). 10.1002/cmdc.202200137 Cited by (3) \| Cite \| Source
Encapsulation of the Anti-inflammatory Dual FLAP/sEH Inhibitor Diflapolin Improves the Efficiency in Human Whole Blood (journal article) Grune, Christian \| Kretzer, Christian \| Zergiebel, Stephanie \| Kattner, Sven \| Thamm, Jana \| Hoeppener, Stephanie \| Werz, Oliver \| Fischer, Dagmar Journal of Pharmaceutical Sciences, volume 111, issue 6, pages 1843-1850 (2022). 10.1016/j.xphs.2021.10.030 Cited by (1) \| Cite \| Source
Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase (journal article) Ergül, Azize Gizem \| Maz, Tuğçe Gür \| Kretzer, Christian \| Olğaç, Abdurrahman \| Jordan, Paul M. \| Çalışkan, Burcu \| Werz, Oliver \| Banoglu, Erden European Journal of Medicinal Chemistry, volume 231 (2022). 10.1016/j.ejmech.2022.114167 Cited by (9) \| Cite \| Source
Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood (journal article) Kretzer, Christian \| Shkodra, Blerina \| Klemm, Paul \| Jordan, Paul M. \| Schröder, Daniel \| Cinar, Gizem \| Vollrath, Antje \| Schubert, Stephanie \| Nischang, Ivo \| Hoeppener, Stephanie \| ... \| Werz, Oliver Cellular and Molecular Life Sciences, volume 79, issue 1 (2022). 10.1007/s00018-021-04039-7 Cited by (8) \| Cite \| Source
Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201 (journal article) Kretzer, Christian \| Jordan, Paul M \| Bilancia, Rossella \| Rossi, Antonietta \| Gür Maz, Tuğçe \| Banoglu, Erden \| Schubert, Ulrich S \| Werz, Oliver Journal of Inflammation Research, volume Volume 15 (2022). 10.2147/JIR.S345510 Cited by (15) \| Cite \| Source
Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages (journal article) Kretzer, Christian \| Jordan, Paul M. \| Meyer, Katharina P.L. \| Hoff, Daniel \| Werner, Markus \| Hofstetter, Robert Klaus \| Koeberle, Andreas \| Cala Peralta, Antonio \| Viault, Guillaume \| Seraphin, Denis \| ... \| Werz, Oliver Biochemical Pharmacology, volume 195 (2022). 10.1016/j.bcp.2021.114825 Cited by (15) \| Cite \| Source
Benzylated dihydrochalcone MF-15 as a potent multitarget inhibitor of cancer cell growth (conference) Huber-Cantonati, P \| Mähr, T \| Schwitzer, F \| Kretzer, C \| Koeberle, A \| Mayr, F \| Engels, N \| Waltenberger, B \| Stuppner, H \| Werz, O \| ... \| Schuster, D GA – 69th Annual Meeting 2021, Virtual conference (2021) Bonn, Germany 10.1055/s-0041-1736947 Cited by (1) \| Cite \| Source
Switching from inflammation to resolution: what can we learn from medicinal plants? (conference) Tran, V A \| Mostafa, A \| Rao, Z \| Pace, S \| Schwaiger, S \| Kretzer, C \| Jordan, P M \| Rosella, B \| Waltenberger, B \| Tran, H \| ... \| Koeberle, A GA – 69th Annual Meeting 2021, Virtual conference (2021) Bonn, Germany 10.1055/s-0041-1736757 Cite \| Source
Effect of Crystallinity on the Properties of Polycaprolactone Nanoparticles Containing the Dual FLAP/mPEGS-1 Inhibitor BRP-187 (journal article) Vollrath, Antje \| Kretzer, Christian \| Beringer-Siemers, Baerbel \| Shkodra, Blerina \| Czaplewska, Justyna A. \| Bandelli, Damiano \| Stumpf, Steffi \| Hoeppener, Stephanie \| Weber, Christine \| Werz, Oliver \| Schubert, Ulrich S. Polymers, volume 13, issue 15, pages 2557- (2021). 10.3390/polym13152557 Cited by (14) \| Cite \| Source
From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution (journal article) Van Anh, Tran Thi \| Mostafa, Alilou \| Rao, Zhigang \| Pace, Simona \| Schwaiger, Stefan \| Kretzer, Christian \| Temml, Veronika \| Giesel, Carsten \| Jordan, Paul M. \| Bilancia, Rossella \| ... \| Koeberle, Andreas Acta Pharmaceutica Sinica B, volume 11, issue 6, pages 1629-1647 (2021). 10.1016/j.apsb.2021.04.011 Cited by (8) \| Cite \| Source
Biocompatible valproic acid-coupled nanoparticles attenuate lipopolysaccharide-induced inflammation (journal article) Kühne, Marie \| Kretzer, Christian \| Lindemann, Henry \| Godmann, Maren \| Heinze, Thomas \| Werz, Oliver \| Heinzel, Thorsten International Journal of Pharmaceutics, volume 601 (2021). 10.1016/j.ijpharm.2021.120567 Cited by (8) \| Cite \| Source
Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators (journal article) Pace, Simona \| Zhang, Kehong \| Jordan, Paul M. \| Bilancia, Rossella \| Wang, Wenfei \| Börner, Friedemann \| Hofstetter, Robert K. \| Potenza, Marianna \| Kretzer, Christian \| Gerstmeier, Jana \| ... \| Werz, Oliver Pharmacological Research, volume 167 (2021). 10.1016/j.phrs.2021.105556 Cited by (21) \| Cite \| Source
Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity (journal article) Shkodra, Blerina \| Kretzer, Christian \| Jordan, Paul M. \| Klemm, Paul \| Koeberle, Andreas \| Pretzel, David \| Banoglu, Erden \| Lorkowski, Stefan \| Wallert, Maria \| Höppener, Stephanie \| ... \| Schubert, Ulrich S. Journal of Nanobiotechnology, volume 18, issue 1 (2020). 10.1186/s12951-020-00620-7 Cited by (24) \| Cite \| Source
Discovery of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by Exploiting a Multistep Virtual Screening Protocol (journal article) Olgac, Abdurrahman \| Carotti, Andrea \| Kretzer, Christian \| Zergiebel, Stephanie \| Seeling, Andreas \| Garscha, Ulrike \| Werz, Oliver \| Macchiarulo, Antonio \| Banoglu, Erden Journal of Chemical Information and Modeling, volume 60, issue 3, pages 1737-1748 (2020). 10.1021/acs.jcim.9b00941 Cited by (9) \| Cite \| Source
Improved Bioactivity of the Natural Product 5-Lipoxygenase Inhibitor Hyperforin by Encapsulation into Polymeric Nanoparticles (journal article) Traeger, Anja \| Voelker, Susanna \| Shkodra-Pula, Blerina \| Kretzer, Christian \| Schubert, Stephanie \| Gottschaldt, Michael \| Schubert, Ulrich S. \| Werz, Oliver Molecular Pharmaceutics, volume 17, issue 3, pages 810-816 (2020). 10.1021/acs.molpharmaceut.9b01051 Cited by (17) \| Cite \| Source