Xavier Lucas

ScholarGPS® ID: 95266268718987

Affiliation

University of Freiburg, Freiburg im Breisgau, Germany

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmaceutical Sciences

Top Specialties

Cancer | Catalysis

Metrics Summary

Publication Count

Predicted Citations

385

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines (journal article) Hügle, Martin \| Regenass, Pierre \| Warstat, Robin \| Hau, Mirjam \| Schmidtkunz, Karin \| Lucas, Xavier \| Wohlwend, Daniel \| Einsle, Oliver \| Jung, Manfred \| Breit, Bernhard \| Günther, Stefan Journal of Medicinal Chemistry, volume 63, issue 24, pages 15603-15620 (2020). 10.1021/acs.jmedchem.0c00478 Cited by (11) \| Cite \| Source
Inhibitors of proteins specific for the secretome of a chondrocyte for use in the treatment of breast cancer metastasis (patent) Shastri, Prasad \| Christensen, Jon \| Lucas, Xavier \| Günther, Stefan Patent Number: 10495642 (2019) Cite \| Source
Compounds for use as bromodomain inhibitors (patent) Guenther, Stefan \| Lucas, Xavier \| Jung, Manfred \| Einsle, Oliver \| Wohlwend, Daniel \| Gerhardt, Stefan Patent Number: 10435364 (2019) Cite \| Source
Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure‐Selectivity Relationship of a Ketoreductase (journal article) Häckh, Matthias \| Lucas, Xavier \| Marolt, Marija \| Leadlay, Peter F. \| Müller, Michael \| Günther, Stefan \| Lüdeke, Steffen ChemBioChem, volume 20, issue 9, pages 1150-1154 (2019). 10.1002/cbic.201800799 Cited by (6) \| Cite \| Source
Cover Feature: Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure‐Selectivity Relationship of a Ketoreductase (ChemBioChem 9/2019) (journal article) Häckh, Matthias \| Lucas, Xavier \| Marolt, Marija \| Leadlay, Peter F. \| Müller, Michael \| Günther, Stefan \| Lüdeke, Steffen ChemBioChem, volume 20, issue 9, pages 1090-1090 (2019). 10.1002/cbic.201900222 Cite \| Source
A thorough anion–π interaction study in biomolecules: on the importance of cooperativity effects (journal article) Lucas, Xavier \| Bauzá, Antonio \| Frontera, Antonio \| Quiñonero, David Chemical Science, volume 7, issue 2, pages 1038-1050 (2016). 10.1039/C5SC01386K Cited by (178) \| Cite \| Source \| Open Access
Addressing binding site specificities of bromodomains using an in silico drug discovery pipeline (journal article) Pervaiz, Mehrosh \| Lucas, Xavier \| Guenther, Stefan F1000Research, volume 4 (2015). 10.7490/f1000research.1110247.1 Cite \| Source
Target Fishing by Cross‐Docking to Explain Polypharmacological Effects (journal article) Patel, Hitesh \| Lucas, Xavier \| Bendik, Igor \| Günther, Stefan \| Merfort, Irmgard ChemMedChem, volume 10, issue 7, pages 1209-1217 (2015). 10.1002/cmdc.201500123 Cited by (21) \| Cite \| Source
The Purchasable Chemical Space: A Detailed Picture (journal article) Lucas, Xavier \| Grüning, Björn A. \| Bleher, Stefan \| Günther, Stefan Journal of Chemical Information and Modeling, volume 55, issue 5, pages 915-924 (2015). 10.1021/acs.jcim.5b00116 Cited by (36) \| Cite \| Source
Using chiral molecules as an approach to address low‐druggability recognition sites (journal article) Lucas, Xavier \| Günther, Stefan Journal of Computational Chemistry, volume 35, issue 29, pages 2114-2121 (2014). 10.1002/jcc.23726 Cited by (4) \| Cite \| Source
Metabolic pathway monitoring of phenalinolactone biosynthesis from Streptomyces sp. Tü6071 by liquid chromatography/mass spectrometry coupling (journal article) Kiske, Christiane \| Erxleben, Anika \| Lucas, Xavier \| Willmann, Lucas \| Klementz, Dennis \| Günther, Stefan \| Römer, Winfried \| Kammerer, Bernd Rapid Communications in Mass Spectrometry, volume 28, issue 13, pages 1459-1467 (2014). 10.1002/rcm.6920 Cited by (5) \| Cite \| Source
Targeting the Bet Family for the Treatment of Leukemia (journal article) Lucas, Xavier \| Günther, Stefan Epigenomics, volume 6, issue 2, pages 153-155 (2014). 10.2217/epi.14.5 Cited by (8) \| Cite \| Source
ChemicalToolBoX and its application on the study of the drug like and purchasable space (journal article) Lucas, Xavier \| Grüning, Björn A \| Günther, Stefan Journal of Cheminformatics, volume 6, issue S1 (2014). 10.1186/1758-2946-6-S1-P51 Cited by (4) \| Cite \| Source \| Open Access
Dynamic information system for small molecules (journal article) Telukunta, Kiran K \| Lucas, Xavier \| Döring, Kersten \| Grüning, Björn A \| Günther, Stefan Journal of Cheminformatics, volume 6, issue S1 (2014). 10.1186/1758-2946-6-S1-P28 Cite \| Source \| Open Access
Discovery of the Inhibitory Effect of a Phosphatidylinositol Derivative on P-Glycoprotein by Virtual Screening Followed by In Vitro Cellular Studies (journal article) Lucas, Xavier \| Simon, Silke \| Schubert, Rolf \| Günther, Stefan PLoS ONE, volume 8, issue 4, pages e60679- (2013). 10.1371/journal.pone.0060679 Cited by (7) \| Cite \| Source \| Open Access