Heng-Keang Lim

ScholarGPS® ID: 95126473242416

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Life Sciences

Discipline

Biology and Biological Sciences

Top Specialties

Mass Spectrometry | Chromatography | Medicinal Chemistry | Metabolism | Drug Metabolism

Metrics Summary

Publication Count

Predicted Citations

1,819

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Application of Covalent Binding Body Burden in the HμREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs (journal article) Shang, Jackie \| Coe, Kevin J. \| Lim, Heng Keang \| Chen, Lu \| Khatri, Buddha B. \| Salter, Rhys \| Mitra, Kaushik \| Iyer, Ramaswamy Chemical Research in Toxicology, volume 37, issue 4, pages 540-544 (2024). 10.1021/acs.chemrestox.4c00046 Cite \| Source
Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans (journal article) Lim, Heng-Keang \| Chen, Jie \| Lam, Wing \| Gong, Yong \| Leclercq, Laurent \| Silva, Jose \| Salter, Rhys \| Berwaerts, Joris \| Gelotte, Cathy K. \| Vakil, Amy M. \| ... \| Flores, Christopher M. Regulatory Toxicology and Pharmacology (2023). 10.1016/j.yrtph.2023.105379 Cited by (4) \| Cite \| Source
Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer (journal article) Zhang, Zhuming \| Connolly, Peter J. \| Trabalón Escolar, Luis \| Rocaboy, Christian \| Pande, Vineet \| Meerpoel, Lieven \| Lim, Heng-Keang \| Branch, Jonathan R. \| Ondrus, Janine \| Hickson, Ian \| ... \| Bignan, Gilles ACS Medicinal Chemistry Letters, volume 12, issue 8, pages 1245-1252 (2021). 10.1021/acsmedchemlett.1c00032 Cited by (3) \| Cite \| Source
Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC) (journal article) Zhang, Zhuming \| Connolly, Peter J. \| Lim, Heng Keang \| Pande, Vineet \| Meerpoel, Lieven \| Teleha, Christopher \| Branch, Jonathan R. \| Ondrus, Janine \| Hickson, Ian \| Bush, Tammy \| ... \| Bignan, Gilles Journal of Medicinal Chemistry, volume 64, issue 2, pages 909-924 (2021). 10.1021/acs.jmedchem.0c01563 Cited by (17) \| Cite \| Source
Reductive Desulfuration as an Important Tool in Detection of Small Molecule Modifications to Payload of Antibody Drug Conjugates (journal article) Wang, Jianyao \| Zhang, Wei \| Salter, Rhys \| Lim, Heng-Keang Analytical Chemistry, volume 91, issue 3, pages 2368-2375 (2019). 10.1021/acs.analchem.8b05134 Cited by (5) \| Cite \| Source
Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α-Fluorination (journal article) Huang, Hui \| Meegalla, Sanath K. \| Lanter, James C. \| Winters, Michael P. \| Zhao, Shuyuan \| Littrell, James \| Qi, Jenson \| Rady, Brian \| Lee, Paul S. \| Liu, Jianying \| ... \| Player, Mark R. ACS Medicinal Chemistry Letters, volume 10, issue 1, pages 16-21 (2019). 10.1021/acsmedchemlett.8b00444 Cited by (19) \| Cite \| Source
Preparation of PEGylated Iodine‐Loaded Nanoparticles via Polymer‐Directed Self‐Assembly (journal article) Tang, Christina \| York, Adam W. \| Mikitsh, John L. \| Wright, Alexander C. \| Chacko, Ann‐Marie \| Elias, Drew R. \| Xu, Yaodong \| Lim, Heng‐Keang \| Prud'homme, Robert K. Macromolecular Chemistry and Physics, volume 219, issue 11 (2018). 10.1002/macp.201700592 Cited by (5) \| Cite \| Source
Discovery of novel benzo[b]thiophene tetrazoles as non-carboxylate GPR40 agonists (journal article) Huang, Hui \| Winters, Michael P. \| Meegalla, Sanath K. \| Arnoult, Eric \| Paul Lee, S. \| Zhao, Shuyuan \| Martin, Tonya \| Rady, Brian \| Liu, Jianying \| Towers, Meghan \| ... \| Player, Mark R. Bioorganic & Medicinal Chemistry Letters, volume 28, issue 3, pages 429-436 (2018). 10.1016/j.bmcl.2017.12.022 Cited by (12) \| Cite \| Source
Standard-Free Bioanalytical Approach for Absolute Quantitation of Drug Metabolites Utilizing Biosynthesis of Reciprocal Radio and Stable Isotopologues and Its Application (journal article) Gong, Yong \| Chen, Jie \| Shi, Yifan \| Lim, Heng-Keang \| Weng, Naidong \| Salter, Rhys Analytical Chemistry, volume 89, issue 16, pages 8399-8404 (2017). 10.1021/acs.analchem.7b01830 Cited by (6) \| Cite \| Source
In vitro and physiologically‐based pharmacokinetic based assessment of drug–drug interaction potential of canagliflozin (journal article) Mamidi, Rao N. V. S. \| Dallas, Shannon \| Sensenhauser, Carlo \| Lim, Heng Keang \| Scheers, Ellen \| Verboven, Peter \| Cuyckens, Filip \| Leclercq, Laurent \| Evans, David C. \| Kelley, Michael F. \| ... \| Snoeys, Jan British Journal of Clinical Pharmacology, volume 83, issue 5, pages 1082-1096 (2017). 10.1111/bcp.13186 Cited by (24) \| Cite \| Source \| Open Access
Cytochrome P450 induction response in tethered spheroids as a three‐dimensional human hepatocyte in vitro model (journal article) Xia, Lei \| Hong, Xin \| Sakban, Rashidah Binte \| Qu, Yinghua \| Singh, Nisha Hari \| McMillian, Michael \| Dallas, Shannon \| Silva, Jose \| Sensenhauser, Carlo \| Zhao, Sylvia \| ... \| Yu, Hanry Journal of Applied Toxicology, volume 36, issue 2, pages 320-329 (2016). 10.1002/jat.3189 Cited by (14) \| Cite \| Source
In vitro and PBPK based assessment of drug-drug interaction potential of canagliflozin. (journal article) Mamidi, Rao N V S \| Dallas, Shannon \| Sensenhauser, Carlo \| Lim, Heng Keang \| Scheers, Ellen \| Verboven, Peter \| Cuyckens, Filip \| Leclercq, Laurent \| Evans, David C \| Kelley, Michael F \| ... \| Snoeys, Jan British journal of clinical pharmacology (2016). Cite
Method for determining the stability of organic methyleneamines in the presence of semicarbazide-sensitive amine oxidase (patent) Adedoyin, Adedayo \| Angelastro, Michael R. \| Bick, Julie \| Caims, Jennifer \| Huang, Yongqing \| Liang, Guyan \| Lim, Heng-Keang Patent Number: 8883410 (2014) Cite \| Source
Metabolism and Excretion of Canagliflozin in Mice, Rats, Dogs, and Humans (journal article) Mamidi, Rao N. V. S. \| Cuyckens, Filip \| Chen, Jie \| Scheers, Ellen \| Kalamaridis, Dennis \| Lin, Ronghui \| Silva, Jose \| Sha, Sue \| Evans, David C. \| Kelley, Michael F. \| ... \| Lim, Heng Keang Drug Metabolism and Disposition, volume 42, issue 5, pages 903-916 (2014). 10.1124/dmd.113.056440 Cited by (56) \| Cite \| Source \| Open Access
Quantitative Assessment of Reactive Metabolites (book chapter) In Optimization in Drug Discovery Chen, Jie \| Xu, Rongfang Fran \| Lam, Wing W. \| Silva, Jose \| Lim, Heng-Keang Humana Press (2014) 10.1007/978-1-62703-742-6_29 Cited by (1) \| Cite \| Source
In Vitro Assessment of the Reactivity of Acyl Glucuronides (book chapter) In Optimization in Drug Discovery Xu, Rongfang Fran \| Lam, Wing W. \| Chen, Jie \| McMillian, Michael \| Silva, Jose \| Lim, Heng-Keang Humana Press (2014) 10.1007/978-1-62703-742-6_30 Cite \| Source
Metabolite Identification in Drug Discovery (book chapter) In Optimization in Drug Discovery Lam, Wing W. \| Chen, Jie \| Xu, Rongfang Fran \| Silva, Jose \| Lim, Heng-Keang Humana Press (2014) 10.1007/978-1-62703-742-6_26 Cited by (9) \| Cite \| Source
Bio-generation of stable isotope labeled internal standards for absolute and relative quantitation of drug metabolites in plasma samples by LC–MS/MS (journal article) Li, Pei \| Gong, Yong \| Lim, Heng-Keang \| Jian, Wenying \| Edom, Richard W. \| Salter, Rhys \| Silva, Jose \| Weng, Naidong Journal of Chromatography B, volume 926 (2013). 10.1016/j.jchromb.2013.03.006 Cited by (12) \| Cite \| Source
Design and Characterization of Optimized Adenosine A2A /A1 Receptor Antagonists for the Treatment of Parkinson's Disease (journal article) Shook, Brian C. \| Rassnick, Stefanie \| Wallace, Nathaniel \| Crooke, Jeffrey \| Ault, Mark \| Chakravarty, Devraj \| Barbay, J. Kent \| Wang, Aihua \| Powell, Mark T. \| Leonard, Kristi \| ... \| Jackson, Paul F. Journal of Medicinal Chemistry, volume 55, issue 3, pages 1402-1417 (2012). 10.1021/jm201640m Cited by (50) \| Cite \| Source
Overcoming the Genotoxicity of a Pyrrolidine Substituted Arylindenopyrimidine As a Potent Dual Adenosine A2A /A1 Antagonist by Minimizing Bioactivation to an Iminium Ion Reactive Intermediate (journal article) Lim, Heng-Keang \| Chen, Jie \| Sensenhauser, Carlo \| Cook, Kevin \| Preston, Robert \| Thomas, Tynisha \| Shook, Brian \| Jackson, Paul F. \| Rassnick, Stefanie \| Rhodes, Kenneth \| ... \| Evans, David C. Chemical Research in Toxicology, volume 24, issue 7, pages 1012-1030 (2011). 10.1021/tx1004437 Cited by (33) \| Cite \| Source