Rebecca Sitsapesan

ScholarGPS® ID: 94742179745808

Affiliation

University of Oxford, Oxford, United Kingdom

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmacology and Toxicology

Top Specialties

Metrics Summary

Publication Count

105

Predicted Citations

4,242

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

Add Delete
A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice (journal article) Benucci, Sofia \| Ruiz, Alexis \| Franchini, Martina \| Ruggiero, Lucia \| Zoppi, Dario \| Sitsapesan, Rebecca \| Lindsay, Chris \| Pelczar, Pawel \| Pietrangelo, Laura \| Protasi, Feliciano \| ... \| Zorzato, Francesco Journal of General Physiology, volume 156, issue 4 (2024). 10.1085/jgp.202313486 Cite \| Source
Screening of statin analogues for effects on the activity of the cardiac ryanodine receptor (journal article) Lindsay, Chris \| Hu, Jianshu \| Russell, Angela \| Sigalas, Charalampos \| Sitsapesan, Rebecca M. Biophysical Journal, volume 123, issue 3, pages 103a- (2024). 10.1016/j.bpj.2023.11.746 Cite \| Source
The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2 (journal article) Hu, Jianshu \| Venturi, Elisa \| Sigalas, Charalampos \| Murayama, Takashi \| Nishi, Miyuki \| Takeshima, Hiroshi \| Sitsapesan, Rebecca Journal of General Physiology, volume 155, issue 11 (2023). 10.1085/jgp.202113070 Cite \| Source
Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition (journal article) Lindsay, Chris \| Musgaard, Maria \| Russell, Angela J. \| Sitsapesan, Rebecca British Journal of Pharmacology, volume 179, issue 21, pages 4941-4957 (2022). 10.1111/bph.15893 Cited by (2) \| Cite \| Source
The ryanodine receptor mutational characteristics and its indication for cancer prognosis (journal article) Wang, Fenglin \| Yu, Jingbo \| Lin, Ping \| Sigalas, Charalampos \| Zhang, Shibo \| Gong, Yuan \| Sitsapesan, Rebecca \| Song, Lele Scientific Reports, volume 12, issue 1 (2022). 10.1038/s41598-022-19905-y Cited by (5) \| Cite \| Source
Biophysical characteristics of TRIC-A and TRIC-B channels and their regulation of RYR2 (journal article) Hu, Jianshu \| Venturi, Elisa \| Sigalas, Charalampos \| Murayama, Takashi \| Nishi, Miyuki \| Takeshima, Hiroshi \| Sitsapesan, Rebecca Journal of General Physiology, volume 154, issue 9 (2022). 10.1085/jgp.2021ecc13 Cite \| Source
The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca2+ and Mg2+ (journal article) Wilson, Abigail D. \| Hu, Jianshu \| Sigalas, Charalampos \| Venturi, Elisa \| Valdivia, Héctor H. \| Valdivia, Carmen R. \| Lei, Ming \| Musgaard, Maria \| Sitsapesan, Rebecca The Journal of Physiology, volume 599, issue 23, pages 5179-5201 (2021). 10.1113/JP281707 Cited by (2) \| Cite \| Source
A Homology Modelling Study of Potential RyR2 Structural Changes in R2474S and V2475F CPVT1 (journal article) Hu, Jianshu \| Sitsapesan, Rebecca M. \| Musgaard, Maria Biophysical Journal, volume 120, issue 3, pages 150a- (2021). 10.1016/j.bpj.2020.11.1096 Cite \| Source
The Malignant Hyperthermia G2435R Mutation Causes Constitutive RYR1 Openings (journal article) Humberstone, Thomas M. \| Lindsay, Chris \| Wilson, Abigail D. \| Venturi, Elisa \| Alhussni, Ahmed \| Sigalas, Charalampos \| Allen, Paul D. \| Sitsapesan, Rebecca M. Biophysical Journal, volume 120, issue 3, pages 111a- (2021). 10.1016/j.bpj.2020.11.893 Cite \| Source
Quantitative RyR1 reduction and loss of calcium sensitivity of RyR1Q1970fsX16+A4329D cause cores and loss of muscle strength (journal article) Elbaz, Moran \| Ruiz, Alexis \| Bachmann, Christoph \| Eckhardt, Jan \| Pelczar, Pawel \| Venturi, Elisa \| Lindsay, Chris \| Wilson, Abigail D \| Alhussni, Ahmed \| Humberstone, Thomas \| ... \| Zorzato, Francesco Human Molecular Genetics, volume 28, issue 18, pages 2987-2999 (2019). 10.1093/hmg/ddz092 Cited by (17) \| Cite \| Source
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K (journal article) Bushell, Simon R. \| Pike, Ashley C. W. \| Falzone, Maria E. \| Rorsman, Nils J. G. \| Ta, Chau M. \| Corey, Robin A. \| Newport, Thomas D. \| Christianson, John C. \| Scofano, Lara F. \| Shintre, Chitra A. \| ... \| Carpenter, Elisabeth P. Nature Communications, volume 10, issue 1 (2019). 10.1038/s41467-019-11753-1 Cited by (96) \| Cite \| Source
Enhanced activity of multiple TRIC‐B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents (journal article) O'Brien, Fiona \| Eberhardt, David \| Witschas, Katja \| El‐Ajouz, Sam \| Iida, Tsunaki \| Nishi, Miyuki \| Takeshima, Hiroshi \| Sitsapesan, Rebecca \| Venturi, Elisa The Journal of Physiology, volume 597, issue 10, pages 2691-2705 (2019). 10.1113/JP277241 Cited by (9) \| Cite \| Source
Cooperative Gating Among Ion-Channel Species in Junctional Sarcoplasmic Reticulum (journal article) Venturi, Elisa \| O'Brien, Fiona \| Eberhardt, David \| Witschas, Katja \| El-Ajouz, Sam \| Iida, Tsunaki \| Takeshima, Miyuki \| Takeshima, Hiroshi \| Sitsapesan, Rebecca Biophysical Journal, volume 116, issue 3, pages 521a- (2019). 10.1016/j.bpj.2018.11.2810 Cite \| Source
Impaired Ligand Regulation of Native RyR2 Channels in the Catecholaminergic Polymorphic Ventricular Tachycardia Mutation, RyR2-V2475F(+/−) (journal article) Wilson, Abigail D. \| Venturi, Elisa \| Sigalas, Charalampos \| Song, Yuanlong \| Valdivia, Carmen R. \| Valdivia, Héctor H. \| Lei, Ming \| Sitsapesan, Rebecca M. Biophysical Journal, volume 116, issue 3, pages 381a- (2019). 10.1016/j.bpj.2018.11.2067 Cite \| Source
Modelling the ATP Binding Site of RyR2 to Rationalise Ligand-Induced Gating Behaviour (journal article) Lindsay, Chris \| Sitsapesan, Mano \| Mun Chan, Wei \| Venturi, Elisa \| Welch, William \| Musgaard, Maria \| Sitsapesan, Rebecca M. Biophysical Journal, volume 116, issue 3, pages 42a- (2019). 10.1016/j.bpj.2018.11.271 Cite \| Source
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K (journal article) Bushell, Simon R \| Pike, A.C.W. \| Falzone, Maria \| Rorsman, Nils J.G. \| Ta, Chau M \| Corey, Robin A \| Newport, Thomas D \| Shintre, C.A. \| Tessitore, Annamaria \| Chu, Amy \| ... \| Carpenter, Elisabeth P. bioRxiv (2018). 10.1101/447417 Cited by (10) \| Cite \| Source
Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour (journal article) Lindsay, Chris \| Sitsapesan, Mano \| Chan, Wei Mun \| Venturi, Elisa \| Welch, William \| Musgaard, Maria \| Sitsapesan, Rebecca Scientific Reports, volume 8, issue 1 (2018). 10.1038/s41598-018-33328-8 Cited by (12) \| Cite \| Source
Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform (journal article) Venturi, Elisa \| Lindsay, Chris \| Lotteau, Sabine \| Yang, Zhaokang \| Steer, Emma \| Witschas, Katja \| Wilson, Abigail D \| Wickens, James R \| Russell, Angela J \| Steele, Derek \| ... \| Sitsapesan, Rebecca British Journal of Pharmacology, volume 175, issue 6, pages 938-952 (2018). 10.1111/bph.14136 Cited by (16) \| Cite \| Source \| Open Access
Atorvastatin Activates Skeletal RyR1 Channels: Towards Reducing Statin Side-Effects (journal article) Lindsay, Chris \| Wilson, Abigail D. \| Venturi, Elisa \| Russell, Angela J. \| Sitsapesan, Rebecca Biophysical Journal, volume 114, issue 3, pages 470a- (2018). 10.1016/j.bpj.2017.11.2589 Cited by (2) \| Cite \| Source
Statins Bind to Cardiac Ryanodine Receptor (RyR2) Channels to Alter Opening Frequency (journal article) Wilson, Abigail D. \| Lindsay, Chris \| Venturi, Elisa \| Russell, Angela J. \| Sitsapesan, Rebecca Biophysical Journal, volume 114, issue 3, pages 621a-622a (2018). 10.1016/j.bpj.2017.11.3361 Cite \| Source