Uwe Grether

ScholarGPS® ID: 94392196354456

Affiliation

Roche Holding AG, Basel, Switzerland

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

137

Predicted Citations

1,966

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice (journal article) Gonzalo-Consuegra, Claudia \| Santos-García, Irene \| García-Toscano, Laura \| Martín-Baquero, Raquel \| Rodríguez-Cueto, Carmen \| Wittwer, Matthias B. \| Dzygiel, Pawel \| Grether, Uwe \| de Lago, Eva \| Fernández-Ruiz, Javier Biomedicine & Pharmacotherapy, volume 174 (2024). 10.1016/j.biopha.2024.116473 Cite \| Source
Prospective de novo drug design with deep interactome learning (journal article) Atz, Kenneth \| Cotos, Leandro \| Isert, Clemens \| Håkansson, Maria \| Focht, Dorota \| Hilleke, Mattis \| Nippa, David F. \| Iff, Michael \| Ledergerber, Jann \| Schiebroek, Carl C. G. \| ... \| Schneider, Gisbert Nature Communications, volume 15, issue 1 (2024). 10.1038/s41467-024-47613-w Cited by (3) \| Cite \| Source
Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer ( R )‐[11 C]YH132: Application in Drug Development and Neurodegenerative Diseases (journal article) He, Yingfang \| Delparente, Aro \| Jie, Caitlin V. M. L \| Keller, Claudia \| Humm, Roland \| Heer, Dominik \| Collin, Ludovic \| Schibli, Roger \| Gobbi, Luca \| Grether, Uwe \| Mu, Linjing ChemBioChem, volume 25, issue 7 (2024). 10.1002/cbic.202300819 Cite \| Source
Identification of ( R )-[18 F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development (journal article) He, Yingfang \| Krämer, Stefanie D. \| Grether, Uwe \| Wittwer, Matthias B. \| Collin, Ludovic \| Kuhn, Bernd \| Topp, Andreas \| Heer, Dominik \| O’Hara, Fionn \| Honer, Michael \| ... \| Mu, Linjing Journal of Nuclear Medicine, volume 65, issue 2, pages 300-305 (2024). 10.2967/jnumed.123.266426 Cite \| Source
Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning (journal article) Nippa, David F. \| Atz, Kenneth \| Hohler, Remo \| Müller, Alex T. \| Marx, Andreas \| Bartelmus, Christian \| Wuitschik, Georg \| Marzuoli, Irene \| Jost, Vera \| Wolfard, Jens \| ... \| Schneider, Gisbert Nature Chemistry, volume 16, issue 2, pages 239-248 (2024). 10.1038/s41557-023-01360-5 Cited by (8) \| Cite \| Source
Geometric deep learning-guided Suzuki reaction conditions assessment for applications in medicinal chemistry (journal article) Atz, Kenneth \| Nippa, David F. \| Müller, Alex T. \| Jost, Vera \| Anelli, Andrea \| Reutlinger, Michael \| Kramer, Christian \| Martin, Rainer E. \| Grether, Uwe \| Schneider, Gisbert \| Wuitschik, Georg RSC Medicinal Chemistry (2024). 10.1039/D4MD00196F Cite \| Source
Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening (journal article) Nippa, David F. \| Atz, Kenneth \| Müller, Alex T. \| Wolfard, Jens \| Isert, Clemens \| Binder, Martin \| Scheidegger, Oliver \| Konrad, David B. \| Grether, Uwe \| Martin, Rainer E. \| Schneider, Gisbert Communications Chemistry, volume 6, issue 1 (2023). 10.1038/s42004-023-01047-5 Cited by (3) \| Cite \| Source
Identification of (R)-[18F]YH134 as a promising reversible MAGL PET tracer and the impact of peripheral MAGL blockade on its brain uptake (journal article) Mu, Linjing \| He, Yingfang \| Krämer, Stefanie \| Grether, Uwe \| Wittwer, Matthias \| Honer, Michael \| Keller, Claudia \| Schibli, Roger \| Gobbi, Luca Nuclear Medicine and Biology, volume 126-127 (2023). 10.1016/j.nucmedbio.2023.108546 Cite \| Source
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years (journal article) Maccarrone, Mauro \| Di Marzo, Vincenzo \| Gertsch, Jürg \| Grether, Uwe \| Howlett, Allyn C. \| Hua, Tian \| Makriyannis, Alexandros \| Piomelli, Daniele \| Ueda, Natsuo \| van der Stelt, Mario Pharmacological Reviews, volume 75, issue 5, pages 885-958 (2023). 10.1124/pharmrev.122.000600 Cited by (26) \| Cite \| Source
Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors (journal article) Scott-Dennis, Morgan \| Rafani, Fikri A. \| Yi, Yicheng \| Perera, Themiya \| Harwood, Clare R. \| Guba, Wolfgang \| Rufer, Arne C. \| Grether, Uwe \| Veprintsev, Dmitry B. \| Sykes, David A. Frontiers in Pharmacology, volume 14 (2023). 10.3389/fphar.2023.1158091 Cited by (1) \| Cite \| Source
Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells (journal article) Kosar, Miroslav \| Sykes, David A. \| Viray, Alexander E. G. \| Vitale, Rosa Maria \| Sarott, Roman C. \| Ganzoni, Rudolf L. \| Onion, David \| Tobias, Janelle M. \| Leippe, Philipp \| Ullmer, Christoph \| ... \| Carreira, Erick M. Journal of the American Chemical Society, volume 145, issue 28, pages 15094-15108 (2023). 10.1021/jacs.2c13629 Cited by (10) \| Cite \| Source
Mutually Rewarding Academia‐Industry Collaborations in the Field of Chemical Biology (journal article) Auberson, Yves P. \| Grether, Uwe \| Vauzeilles, Boris \| Vázquez, Olalla ChemBioChem, volume 24, issue 11 (2023). 10.1002/cbic.202300121 Cite \| Source
EFMC: Trends in Medicinal Chemistry and Chemical Biology (journal article) Auberson, Yves P. \| Arimondo, Paola B. \| Duca, Maria \| Essig, Sebastian \| Grether, Uwe \| Rufer, Arne C. \| Sbardella, Gianluca \| Schopfer, Ulrich \| Torrens, Antoni \| van der Stelt, Mario \| ... \| Zhang, Andrew X. ChemBioChem, volume 24, issue 7 (2023). 10.1002/cbic.202200690 Cited by (4) \| Cite \| Source
CB₂R ligands to treat inflammatory diabetes (journal article) Grether, Uwe \| Nazaré, Marc Open Access Government, volume 40, issue 1, pages 224-225 (2023). 10.56367/OAG-040-10485 Cite \| Source
CB2R agonists in the clinics: A treasure chest for treating inflammatory diseases (journal article) Grether, Uwe \| Nazaré, Marc Open Access Government, volume 39, issue 1, pages 218-219 (2023). 10.56367/OAG-039-10485 Cite \| Source
Visualizing the anti-inflammatory cannabinoid Type-2 receptor (journal article) Nazaré, Marc \| Grether, Uwe Open Access Government, volume 38, issue 1, pages 30-31 (2023). 10.56367/OAG-038-10485 Cited by (1) \| Cite \| Source
Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Cofactor Recruitment Assay for PPARα and PPARγ (book chapter) In Endocannabinoid Signaling Roth, Doris \| Benz, Jörg \| Grether, Uwe \| Dietz, Michel Springer US (2023) 10.1007/978-1-0716-2728-0_12 Cited by (1) \| Cite \| Source
Challenges bringing CB₂R medicine to bedside (journal article) Pacher, Pal \| Grether, Uwe Open Access Government, volume 37, issue 1, pages 22-23 (2023). 10.56367/OAG-037-10485 Cite \| Source
Machine Learning and Computational Chemistry for the Endocannabinoid System (book chapter) In Endocannabinoid Signaling Atz, Kenneth \| Guba, Wolfgang \| Grether, Uwe \| Schneider, Gisbert Springer US (2023) 10.1007/978-1-0716-2728-0_39 Cited by (4) \| Cite \| Source
Scintillation Proximity Assay (SPA)-Based Radioligand Binding for PPARα, PPARγ, and PPARδ Receptors (book chapter) In Endocannabinoid Signaling Grether, Uwe \| Benz, Jörg \| Hartung, Thomas \| Roth, Doris Springer US (2023) 10.1007/978-1-0716-2728-0_11 Cite \| Source