Christoph Loenarz

ScholarGPS® ID: 94087991691194

Affiliation

University of Freiburg, Freiburg im Breisgau, Germany

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmaceutical Sciences

Top Specialties

Hypoxia-inducible Factors | Histone | Medicinal Chemistry | Translation | Enzyme

Metrics Summary

Publication Count

Predicted Citations

4,491

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Non‐canonical nucleosides: Biomimetic triphosphorylation, incorporation into mRNA and effects on translation and structure (journal article) Benčić, Patricia \| Keppler, Michael \| Kuge, Marco \| Qiu, Danye \| Schütte, Lena M. \| Häner, Markus \| Strack, Katharina \| Jessen, Henning J. \| Andexer, Jennifer N. \| Loenarz, Christoph The FEBS Journal, volume 290, issue 20, pages 4899-4920 (2023). 10.1111/febs.16889 Cited by (4) \| Cite \| Source
β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner (journal article) Eisenbeis, Verena B. \| Qiu, Danye \| Gorka, Oliver \| Strotmann, Lisa \| Liu, Guizhen \| Prucker, Isabel \| Su, Xue Bessie \| Wilson, Miranda S. C. \| Ritter, Kevin \| Loenarz, Christoph \| ... \| Jessen, Henning J. Proceedings of the National Academy of Sciences, volume 120, issue 34 (2023). 10.1073/pnas.2306868120 Cited by (2) \| Cite \| Source
Biomimetic S ‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes (journal article) Gericke, Lukas \| Mhaindarkar, Dipali \| Karst, Lukas C. \| Jahn, Sören \| Kuge, Marco** \| Mohr, Michael K. F. \| Gagsteiger, Jana \| Cornelissen, Nicolas V. \| Wen, Xiaojin \| Mordhorst, Silja \| ... \| Andexer, Jennifer N. ChemBioChem, volume 24, issue 9 (2023). 10.1002/cbic.202300133 Cited by (11) \| Cite \| Source
A Cobalamin‐Dependent Radical SAM Enzyme Catalyzes the Unique Cα ‐Methylation of Glutamine in Methyl‐Coenzyme M Reductase (journal article) Gagsteiger, Jana \| Jahn, Sören \| Heidinger, Lorenz \| Gericke, Lukas \| Andexer, Jennifer N. \| Friedrich, Thorsten \| Loenarz, Christoph \| Layer, Gunhild Angewandte Chemie, volume 134, issue 32 (2022). 10.1002/ange.202204198 Cite \| Source
A Cobalamin‐Dependent Radical SAM Enzyme Catalyzes the Unique Cα ‐Methylation of Glutamine in Methyl‐Coenzyme M Reductase (journal article) Gagsteiger, Jana \| Jahn, Sören \| Heidinger, Lorenz \| Gericke, Lukas \| Andexer, Jennifer N. \| Friedrich, Thorsten \| Loenarz, Christoph \| Layer, Gunhild Angewandte Chemie International Edition, volume 61, issue 32 (2022). 10.1002/anie.202204198 Cited by (6) \| Cite \| Source
An Oxygen Sensation: Progress in Macromolecule Hydroxylation Triggered by the Elucidation of Cellular Oxygen Sensing (journal article) Loenarz, Christoph Angewandte Chemie International Edition, volume 59, issue 10, pages 3776-3780 (2020). 10.1002/anie.201913263 Cited by (5) \| Cite \| Source
Ein Gespür für Sauerstoff: Entdeckung des molekularen Mechanismus der zellulären Sauerstoffregulation rückt die Hydroxylierung von Makromolekülen in den Blickpunkt (journal article) Loenarz, Christoph Angewandte Chemie, volume 132, issue 10, pages 3804-3809 (2020). 10.1002/ange.201913263 Cite \| Source
Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding (journal article) Thinnes, Cyrille C. \| Lohans, Christopher T. \| Abboud, Martine I. \| Yeh, Tzu‐Lan \| Tumber, Anthony \| Nowak, Radosław P. \| Attwood, Martin \| Cockman, Matthew E. \| Oppermann, Udo \| Loenarz, Christoph \| Schofield, Christopher J. Chemistry – A European Journal, volume 25, issue 8, pages 2019-2024 (2019). 10.1002/chem.201804790 Cited by (6) \| Cite \| Source
Studies on the Substrate Selectivity of the Hypoxia‐Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain (journal article) Abboud, Martine I. \| Chowdhury, Rasheduzzaman \| Leung, Ivanhoe K. H. \| Lippl, Kerstin \| Loenarz, Christoph \| Claridge, Timothy D. W. \| Schofield, Christopher J. ChemBioChem, volume 19, issue 21, pages 2262-2267 (2018). 10.1002/cbic.201800246 Cited by (6) \| Cite \| Source
YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase (journal article) Sekirnik, Rok \| Wilkins, Sarah E. \| Bush, Jacob \| Tarhonskaya, Hanna \| Münzel, Martin \| Hussein, Aayan \| Flashman, Emily \| Mohammed, Shabaz \| McDonough, Michael A. \| Loenarz, Christoph \| Schofield, Christopher J. Extremophiles, volume 22, issue 3, pages 553-562 (2018). 10.1007/s00792-018-1016-9 Cited by (6) \| Cite \| Source \| Open Access
Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal <em>Trichoplax adhaerens</em> (journal article) Lippl, Kerstin \| Boleininger, Anna \| McDonough, Michael \| Abboud, Martine I. \| Tarhonskaya, Hanna \| Chowdhury, Rasheduzzaman \| Loenarz, Christoph \| Schofield, Christopher J. Hypoxia, volume Volume 6 (2018). 10.2147/HP.S174655 Cited by (10) \| Cite \| Source
Method for assaying OGFOD1 activity (patent) Schofield, Christopher Joseph \| Wolf, Alexander \| Ge, Wei \| Thalhammer, Armin \| Loenarz, Christoph \| Ratcliffe, Peter John \| Cockman, Matthew Edward Patent Number: 9228224 (2016) Cite \| Source
Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase (journal article) Longbotham, James E. \| Levy, Colin \| Johannissen, Linus O. \| Tarhonskaya, Hanna \| Jiang, Shuo \| Loenarz, Christoph \| Flashman, Emily \| Hay, Sam \| Schofield, Christopher J. \| Scrutton, Nigel S. Biochemistry, volume 54, issue 39, pages 6093-6105 (2015). 10.1021/acs.biochem.5b00789 Cited by (19) \| Cite \| Source \| Open Access
Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases (journal article) Horita, Shoichiro \| Scotti, John S. \| Thinnes, Cyrille \| Mottaghi-Taromsari, Yousef S. \| Thalhammer, Armin \| Ge, Wei \| Aik, WeiShen \| Loenarz, Christoph \| Schofield, Christopher J. \| McDonough, Michael A. Structure, volume 23, issue 4, pages 639-652 (2015). 10.1016/j.str.2015.01.014 Cited by (33) \| Cite \| Source \| Open Access
Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2) (journal article) Davydova, Erna \| Ho, Angela Y.Y. \| Malecki, Jedrzej \| Moen, Anders \| Enserink, Jorrit M. \| Jakobsson, Magnus E. \| Loenarz, Christoph \| Falnes, Pål Ø. Journal of Biological Chemistry, volume 289, issue 44, pages 30499-30510 (2014). 10.1074/jbc.M114.601658 Cited by (42) \| Cite \| Source \| Open Access
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth (journal article) Katz, Maximiliano J. \| Acevedo, Julieta M. \| Loenarz, Christoph \| Galagovsky, Diego \| Liu-Yi, Phebee \| Pérez-Pepe, Marcelo \| Thalhammer, Armin \| Sekirnik, Rok \| Ge, Wei \| Melani, Mariana \| ... \| Wappner, Pablo Proceedings of the National Academy of Sciences, volume 111, issue 11, pages 4025-4030 (2014). 10.1073/pnas.1314485111 Cited by (46) \| Cite \| Source \| Open Access
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation (journal article) Singleton, Rachelle S. \| Liu-Yi, Phebee \| Formenti, Fabio \| Ge, Wei \| Sekirnik, Rok \| Fischer, Roman \| Adam, Julie \| Pollard, Patrick J. \| Wolf, Alexander \| Thalhammer, Armin \| ... \| Cockman, Matthew E. Proceedings of the National Academy of Sciences, volume 111, issue 11, pages 4031-4036 (2014). 10.1073/pnas.1314482111 Cited by (100) \| Cite \| Source \| Open Access
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy (journal article) Loenarz, Christoph \| Sekirnik, Rok \| Thalhammer, Armin \| Ge, Wei \| Spivakovsky, Ekaterina \| Mackeen, Mukram M. \| McDonough, Michael A. \| Cockman, Matthew E. \| Kessler, Benedikt M. \| Ratcliffe, Peter J. \| ... \| Schofield, Christopher J. Proceedings of the National Academy of Sciences, volume 111, issue 11, pages 4019-4024 (2014). 10.1073/pnas.1311750111 Cited by (106) \| Cite \| Source \| Open Access
A mechanism for induction of a hypoxic response by vaccinia virus (journal article) Mazzon, Michela \| Peters, Nicholas E. \| Loenarz, Christoph \| Krysztofinska, Ewelina M. \| Ember, Stuart W. J. \| Ferguson, Brian J. \| Smith, Geoffrey L. Proceedings of the National Academy of Sciences, volume 110, issue 30, pages 12444-12449 (2013). 10.1073/pnas.1302140110 Cited by (65) \| Cite \| Source \| Open Access
Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family (journal article) Hillringhaus, Lars \| Yue, Wyatt W. \| Rose, Nathan R. \| Ng, Stanley S. \| Gileadi, Carina \| Loenarz, Christoph \| Bello, Simon H. \| Bray, James E. \| Schofield, Christopher J. \| Oppermann, Udo Journal of Biological Chemistry, volume 286, issue 48, pages 41616-41625 (2011). 10.1074/jbc.M111.283689 Cited by (134) \| Cite \| Source \| Open Access