Thomas A. Rano

ScholarGPS® ID: 93278002790175

Affiliation

Janssen Pharmaceutica

Affiliation History

Field

Medicine

Discipline

Cardiology

Top Specialties

Medicinal Chemistry | Chemical Synthesis | Cholesteryl Ester | HIV

Metrics Summary

Publication Count

Predicted Citations

3,865

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Substituted piperidinyl-carboxamide derivatives useful as SCD 1 inhibitors (patent) Yang, Shyh-Ming \| Kuo, Gee-Hong \| Gaul, Micheal D. \| Rano, Thomas A. Patent Number: 9238658 (2016) Cite \| Source
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: Part 2. Pyridazine-based analogs (journal article) Yang, Shyh-Ming \| Tang, Yuting \| Rano, Thomas \| Lu, Huajun \| Kuo, Gee-Hong \| Gaul, Michael D. \| Li, Yaxin \| Ho, George \| Lang, Wensheng \| Conway, James G. \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 24, issue 5, pages 1437-1441 (2014). 10.1016/j.bmcl.2013.12.075 Cited by (5) \| Cite \| Source
SUBSTITUTED PIPERIDINYL-PYRIDAZINYL DERIVATIVES USEFUL AS SCD 1 INHIBITORS (patent) Yang, Shyh-Ming \| Kuo, Gee-Hong \| Gaul, Micheal D. \| Rano, Thomas Patent Number: 9102669 (2012) Cite \| Source
3,4-dihydro-2H-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors (patent) Kuo, Gee-Hong \| Rano, Thomas \| Wang, Aihua \| Prouty, Catherine \| Demarest, Keith T. \| Pelton, Patricia Patent Number: 8012963 (2011) Cite \| Source
1,2,3,4-tetrahydro-quinoline derivatives as CETP inhibitors (patent) Rano, Thomas \| Kuo, Gee-Hong \| Sieber-McMaster, Ellen \| Demarest, Keith T. \| Pelton, Patricia \| Wang, Aihua Patent Number: 7928238 (2011) Cited by (10) \| Cite \| Source
3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors (patent) Kuo, Gee-Hong \| Wang, Aihua \| Rano, Thomas \| Prouty, Catherine \| Demarest, Keith T. \| Pelton, Patricia Patent Number: 7749995 (2010) Cite \| Source
Improved Asymmetric Synthesis of 3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)phenyl]-α-(trifluoromethyl)-1(2 H )-quinolineethanol, a Potent Cholesteryl Ester Transfer Protein Inhibitor (journal article) Rano, Thomas A. \| Kuo, Gee-Hong Organic Letters, volume 11, issue 13, pages 2812-2815 (2009). 10.1021/ol900639j Cited by (25) \| Cite \| Source
Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform (journal article) Rano, Thomas A. \| Sieber-McMaster, Ellen \| Pelton, Patricia D. \| Yang, Maria \| Demarest, Keith T. \| Kuo, Gee-Hong Bioorganic & Medicinal Chemistry Letters, volume 19, issue 9, pages 2456-2460 (2009). 10.1016/j.bmcl.2009.03.051 Cited by (73) \| Cite \| Source
Design, Synthesis, and Biological Evaluation of (2 R ,α S )-3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-α-(trifluoromethyl)-1(2 H )-quinolineethanol as Potent and Orally Active Cholesteryl Ester Transfer Protein Inh (journal article) Kuo, Gee-Hong \| Rano, Thomas \| Pelton, Patricia \| Demarest, Keith T. \| Gibbs, Alan C. \| Murray, William V. \| Damiano, Bruce P. \| Connelly, Margery A. Journal of Medicinal Chemistry, volume 52, issue 6, pages 1768-1772 (2009). 10.1021/jm801319d Cited by (37) \| Cite \| Source
3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as cetp inhibitors (patent) Kuo, Gee-Hong \| Wang, Aihua \| Rano, Thomas \| Prouty, Catherine \| Demarest, Keith T. \| Pelton, Patricia Patent Number: 20100227857 (2007) Cited by (1) \| Cite \| Source
Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides and uses thereof (patent) Tata, James R. \| Chapman, Kevin T. \| Duffy, Joseph Leslie \| Kevin, Nancy J. \| Cheng, Yuan \| Rano, Thomas A. \| Zhang, Fengqi \| Huening, Tracy \| Kirk, Brian Anthony \| Lu, Zhijian \| ... \| Petrillo, Daniel E. Patent Number: 6642237 (2003) Cited by (6) \| Cite \| Source
HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent (journal article) Duffy, Joseph L. \| Rano, Thomas A. \| Kevin, Nancy J. \| Chapman, Kevin T. \| Schleif, William A. \| Olsen, David B. \| Stahlhut, Mark \| Rutkowski, Carrie A. \| Kuo, Lawrence C. \| Jin, Lixia \| ... \| Tata, James R. Bioorganic & Medicinal Chemistry Letters, volume 13, issue 15, pages 2569-2572 (2003). 10.1016/S0960-894X(03)00475-X Cited by (16) \| Cite \| Source
Alpha-hydroxy-gamma-[[(carbocyclic-or heterocyclic-substituted)amino]carbonyl]alkanamide derivatives and uses thereof (patent) Tata, James R \| Lu, Zhijian \| Raghavan, Subharekha \| Huening, Tracy T. \| Rano, Thomas A. \| Charest, Mark G. Patent Number: 6589962 (2003) Cite \| Source
Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-Resistant viral strains (journal article) Cheng, Yuan \| Zhang, Fengqi \| Rano, Thomas A \| Lu, Zhijian \| Schleif, William A \| Gabryelski, Lori \| Olsen, David B \| Stahlhut, Mark \| Rutkowski, Carrie A \| Lin, Jiunn H \| ... \| Tata, James R Bioorganic & Medicinal Chemistry Letters, volume 12, issue 17, pages 2419-2422 (2002). 10.1016/S0960-894X(02)00424-9 Cited by (30) \| Cite \| Source
A Combinatorial Library of Indinavir Analogues and Its In Vitro and In Vivo Studies (journal article) Cheng, Yuan \| Rano, Thomas A \| Huening, Tracy T \| Zhang, Fengqi \| Lu, Zhijian \| Schleif, William A \| Gabryelski, Lori \| Olsen, David B \| Stahlhut, Mark \| Kuo, Lawrence C \| ... \| Tata, James R Bioorganic & Medicinal Chemistry Letters, volume 12, issue 4, pages 529-532 (2002). 10.1016/S0960-894X(01)00824-1 Cited by (11) \| Cite \| Source
Combinatorial diversification of indinavir: in vivo mixture dosing of an HIV protease inhibitor library (journal article) Rano, Thomas A \| Cheng, Yuan \| Huening, Tracy T \| Zhang, Fengqi \| Schleif, William A \| Gabryelski, Lori \| Olsen, David B \| Kuo, Lawrence C \| Lin, Jiunn H \| Xu, Xin \| ... \| Tata, James R Bioorganic & Medicinal Chemistry Letters, volume 10, issue 14, pages 1527-1530 (2000). 10.1016/S0960-894X(00)00276-6 Cited by (17) \| Cite \| Source
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B (journal article) Thornberry, Nancy A. \| Rano, Thomas A. \| Peterson, Erin P. \| Rasper, Dita M. \| Timkey, Tracy \| Garcia-Calvo, Margarita \| Houtzager, Vicky M. \| Nordstrom, Penny A. \| Roy, Sophie \| Vaillancourt, John P. \| ... \| Nicholson, Donald W. Journal of Biological Chemistry, volume 272, issue 29, pages 17907-17911 (1997). 10.1074/jbc.272.29.17907 Cited by (1,841) \| Cite \| Source \| Open Access
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). (journal article) Rano, T A \| Timkey, T \| Peterson, E P \| Rotonda, J \| Nicholson, D W \| Becker, J W \| Chapman, K T \| Thornberry, N A Chemistry & biology, volume 4, issue 2 (1997). Cited by (2) \| Cite
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. (journal article) Thornberry, N A \| Rano, T A \| Peterson, E P \| Rasper, D M \| Timkey, T \| Garcia-Calvo, M \| Houtzager, V M \| Nordstrom, P A \| Roy, S \| Vaillancourt, J P \| ... \| Nicholson, D W The Journal of biological chemistry, volume 272, issue 29 (1997). Cited by (12) \| Cite
A combinatorial approach for determining protease specificities: application to interleukin-1β converting enzyme (ICE) (journal article) Rano, Thomas A. \| Timkey, Tracy \| Peterson, Erin P. \| Rotonda, Jennifer \| Nicholson, Donald W. \| Becker, Joseph W. \| Chapman, Kevin T. \| Thornberry, Nancy A. Chemistry & Biology, volume 4, issue 2, pages 149-155 (1997). 10.1016/S1074-5521(97)90258-1 Cited by (233) \| Cite \| Source \| Open Access