Barry A. Springer

ScholarGPS® ID: 92651461646892

Affiliation
Janssen Pharmaceutica
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Fibroblast Growth Factor | Growth Factor | Basic Fibroblast Growth Factor | Directed Mutagenesis | Mutagenesis
Metrics Summary
Publication Count
48
Predicted Citations
6,784
Predicted h-index
31
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Chemically modified quinoline and quinolone derivatives useful as CB-1 inverse agonists (patent)
Macielag, Mark J. | Zhang, Yue-Mei | Greco, Michael N. | Springer, Barry A. | Murray, William V.
Patent Number: 9815790 (2017)
Cite | Source
Methods of treatment using allosteric processing inhibitors for matrix metalloproteinases (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Crysler, Carl | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | ... | Wang, Aihua
Patent Number: 8883473 (2014)
Cited by (3) | Cite | Source
Methods for designing, selecting and/or optimizing allosteric processing inhibitors for matrix metalloproteinases (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | Milligan, Cynthia M. | ... | Wang, Aihua
Patent Number: 8798939 (2014)
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Crystal structure of the pro form of a matrix metalloproteinase and an allosteric processing inhibitor (patent)
Leonard, Kristi A. | Alexander, Richard Scott | Barbay, Joseph Kent | Bone, Roger F. | Deckman, Ingrid Christa | Jackson, Paul F. | Kuo, Lawrence C. | Lewandowski, Frank A. | Maguire, Diane M. | Milligan, Cynthia M. | ... | Wang, Aihua
Patent Number: 8753857 (2014)
Cited by (2) | Cite | Source
METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION (patent)
Jackson, Paul Francis | Manthey, Carl | Rhodes, Kenneth | Scannevin, Robert | Leonard, Kristi Anne | Barbay, Joseph Kent | Todd, Matthew | Springer, Barry A.
Patent Number: 20120302573 (2012)
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4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors (journal article)
Xu, Guozhang | Abad, Marta C. | Connolly, Peter J. | Neeper, Michael P. | Struble, Geoffrey T. | Springer, Barry A. | Emanuel, Stuart L. | Pandey, Niranjan | Gruninger, Robert H. | Adams, Mary | ... | Middleton, Steven A.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 16, pages 4615-4619 (2008).
10.1016/j.bmcl.2008.07.020
Cited by (63) | Cite | Source
Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases (journal article)
Xu, Guozhang | Searle, Lily Lee | Hughes, Terry V. | Beck, Amanda K. | Connolly, Peter J. | Abad, Marta C. | Neeper, Michael P. | Struble, Geoffrey T. | Springer, Barry A. | Emanuel, Stuart L. | ... | Greenberger, Lee M.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 12, pages 3495-3499 (2008).
10.1016/j.bmcl.2008.05.024
Cited by (44) | Cite | Source
Structural determination of estrogen-related receptor γ in the presence of phenol derivative compounds (journal article)
Abad, Marta C. | Askari, Hossein | O’Neill, John | Klinger, Alexandra L. | Milligan, Cynthia | Lewandowski, Frank | Springer, Barry | Spurlino, John | Rentzeperis, Dionisios
The Journal of Steroid Biochemistry and Molecular Biology, volume 108, issue 1-2, pages 44-54 (2008).
10.1016/j.jsbmb.2007.06.006
Cited by (54) | Cite | Source
Enhancing Recombinant Protein Quality and Yield by Protein Stability Profiling (journal article)
Mezzasalma, Tara M. | Kranz, James K. | Chan, Winnie | Struble, Geoffrey T. | Schalk-Hihi, Céline | Deckman, Ingrid C. | Springer, Barry A. | Todd, Matthew J.
SLAS Discovery, volume 12, issue 3, pages 418-428 (2007).
10.1177/1087057106297984
Cited by (87) | Cite | Source | Open Access
Crystal Structure of the Tyrosine Kinase Domain of Colony-stimulating Factor-1 Receptor (cFMS) in Complex with Two Inhibitors (journal article)
Schubert, Carsten | Schalk-Hihi, Céline | Struble, Geoffrey T. | Ma, Hong-Chang | Petrounia, Ioanna P. | Brandt, Benjamin | Deckman, Ingrid C. | Patch, Raymond J. | Player, Mark R. | Spurlino, John C. | Springer, Barry A.
Journal of Biological Chemistry, volume 282, issue 6, pages 4094-4101 (2007).
10.1074/jbc.M608183200
Cited by (57) | Cite | Source | Open Access
Protein Engineering of the Colony-stimulating Factor-1 Receptor Kinase Domain for Structural Studies (journal article)
Schalk-Hihi, Céline | Ma, Hong-Chang | Struble, Geoffrey T. | Bayoumy, Shariff | Williams, Robyn | Devine, Eric | Petrounia, Ioanna P. | Mezzasalma, Tara | Zeng, Lee | Schubert, Carsten | ... | Deckman, Ingrid C.
Journal of Biological Chemistry, volume 282, issue 6, pages 4085-4093 (2007).
10.1074/jbc.M608182200
Cited by (11) | Cite | Source | Open Access
Methods of using analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamate 89, asparate 101 or leucine 137 (patent)
Springer, Barry A. | Pantoliano, Michael W. | Sharp, Celia M.
Patent Number: 7138374 (2006)
Cite | Source
Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity (journal article)
Kervinen, Jukka | Ma, Hongchang | Bayoumy, Shariff | Schubert, Carsten | Milligan, Cynthia | Lewandowski, Frank | Moriarty, Kevin | DesJarlais, Renee L. | Ramachandren, Kannan | Wang, Haiyun | ... | Deckman, Ingrid
Archives of Biochemistry and Biophysics, volume 449, issue 1-2, pages 47-56 (2006).
10.1016/j.abb.2006.03.018
Cited by (16) | Cite | Source
Functional reconstitution of β2 -adrenergic receptors utilizing self-assembling Nanodisc technology (journal article)
Leitz, Andrew J. | Bayburt, Timothy H. | Barnakov, Alexander N. | Springer, Barry A. | Sligar, Stephen G.
BioTechniques, volume 40, issue 5, pages 601-612 (2006).
10.2144/000112169
Cited by (179) | Cite | Source
Functional reconstitution of Beta2-adrenergic receptors utilizing self-assembling Nanodisc technology. (journal article)
Leitz, Andrew J | Bayburt, Timothy H | Barnakov, Alexander N | Springer, Barry A | Sligar, Stephen G
BioTechniques, volume 40, issue 5 (2006).
Cited by (6) | Cite
Crystal structure of the c-fms kinase domain: applications and use of heterologous substitutions of kinase insert domains for crystallization (patent)
Schubert, Carsten | Springer, Barry A. | Deckman, Ingrid C. | Patch, Raymond J. | Struble, Geoffrey T. | Ma, Hongchang | Schalk-Hihi, Celine | Brandt, Benjamin M. | Petrounia, Ioanna
Patent Number: 20060094081 (2005)
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2-Hydroxy-4,6-diamino-[1,3,5]triazines: A Novel Class of VEGF-R2 (KDR) Tyrosine Kinase Inhibitors (journal article)
Baindur, Nand | Chadha, Naresh | Brandt, Benjamin M. | Asgari, Davoud | Patch, Raymond J. | Schalk-HiHi, Celine | Carver, Theodore E. | Petrounia, Ioanna P. | Baumann, Christian A. | Ott, Heidi | ... | Player, Mark R.
Journal of Medicinal Chemistry, volume 48, issue 6, pages 1717-1720 (2005).
10.1021/jm049372z
Cited by (52) | Cite | Source
Decrypting the Biochemical Function of an Essential Gene from Streptococcus pneumoniae Using ThermoFluor® Technology (journal article)
Carver, Theodore E. | Bordeau, Brian | Cummings, Maxwell D. | Petrella, Eugene C. | Pucci, Michael J. | Zawadzke, Laura E. | Dougherty, Brian A. | Tredup, Jeffrey A. | Bryson, James W. | Yanchunas, Joseph | ... | Todd, Matthew J.
Journal of Biological Chemistry, volume 280, issue 12, pages 11704-11712 (2005).
10.1074/jbc.M413278200
Cited by (51) | Cite | Source | Open Access
Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamate 89, Aspartate 101 or Leucine 137 (patent)
Springer, Barry A. | Pantoliano, Michael W. | Sharp, Celia M.
Patent Number: 6767722 (2004)
Cite | Source
Methods of using analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamate 89, aspartate 101 or leucine 137 (patent)
Springer, Barry A. | Pantoliano, Michael W. | Sharp, Celia M.
Patent Number: 6737404 (2004)
Cite | Source