Richard S. Alexander

ScholarGPS® ID: 92313207010738

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

3,655

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate (journal article) Rombouts, Frederik J. R. \| Kusakabe, Ken-ichi \| Alexander, Richard \| Austin, Nigel \| Borghys, Herman \| De Cleyn, Michel \| Dhuyvetter, Deborah \| Gijsen, Harrie J. M. \| Hrupka, Brian \| Jacobs, Tom \| ... \| Moechars, Diederik Journal of Medicinal Chemistry, volume 64, issue 19, pages 14175-14191 (2021). 10.1021/acs.jmedchem.1c00935 Cited by (11) \| Cite \| Source
Identification of a new class of HBV capsid assembly modulator (journal article) Kuduk, Scott D. \| Stoops, Bart \| Alexander, Richard \| Lam, Angela M. \| Espiritu, Christine \| Vogel, Robert \| Lau, Vincent \| Klumpp, Klaus \| Flores, Osvaldo A. \| Hartman, George D. Bioorganic & Medicinal Chemistry Letters, volume 39 (2021). 10.1016/j.bmcl.2021.127848 Cited by (11) \| Cite \| Source
Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits (journal article) Sun, Weimei \| Zhang, Xuqing \| Cummings, Maxwell D. \| Albarazanji, Kamal \| Wu, Jiejun \| Wang, Mina \| Alexander, Richard \| Zhu, Bin \| Zhang, YueMei \| Leonard, James \| ... \| Lenhard, James Journal of Pharmacology and Experimental Therapeutics, volume 375, issue 3, pages 510-521 (2020). 10.1124/jpet.120.000219 Cited by (14) \| Cite \| Source
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy (journal article) Lu, Tianbao \| Schubert, Carsten \| Cummings, Maxwell D. \| Bignan, Gilles \| Connolly, Peter J. \| Smans, Karine \| Ludovici, Donald \| Parker, Michael H. \| Meyer, Christophe \| Rocaboy, Christian \| ... \| Meerpoel, Lieven Bioorganic & Medicinal Chemistry Letters, volume 28, issue 12, pages 2159-2164 (2018). 10.1016/j.bmcl.2018.05.014 Cited by (27) \| Cite \| Source
1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads (journal article) Rombouts, Frederik J. R. \| Tresadern, Gary \| Delgado, Oscar \| Martínez-Lamenca, Carolina \| Van Gool, Michiel \| García-Molina, Aránzazu \| Alonso de Diego, Sergio A. \| Oehlrich, Daniel \| Prokopcova, Hana \| Alonso, José Manuel \| ... \| Trabanco, Andrés A. Journal of Medicinal Chemistry, volume 58, issue 20, pages 8216-8235 (2015). 10.1021/acs.jmedchem.5b01101 Cited by (68) \| Cite \| Source \| Open Access
Methods of treatment using allosteric processing inhibitors for matrix metalloproteinases (patent) Leonard, Kristi A. \| Alexander, Richard Scott \| Barbay, Joseph Kent \| Bone, Roger F. \| Crysler, Carl \| Deckman, Ingrid Christa \| Jackson, Paul F. \| Kuo, Lawrence C. \| Lewandowski, Frank A. \| Maguire, Diane M. \| ... \| Wang, Aihua Patent Number: 8883473 (2014) Cited by (3) \| Cite \| Source
Methods for designing, selecting and/or optimizing allosteric processing inhibitors for matrix metalloproteinases (patent) Leonard, Kristi A. \| Alexander, Richard Scott \| Barbay, Joseph Kent \| Bone, Roger F. \| Deckman, Ingrid Christa \| Jackson, Paul F. \| Kuo, Lawrence C. \| Lewandowski, Frank A. \| Maguire, Diane M. \| Milligan, Cynthia M. \| ... \| Wang, Aihua Patent Number: 8798939 (2014) Cite \| Source
Crystal structure of the pro form of a matrix metalloproteinase and an allosteric processing inhibitor (patent) Leonard, Kristi A. \| Alexander, Richard Scott \| Barbay, Joseph Kent \| Bone, Roger F. \| Deckman, Ingrid Christa \| Jackson, Paul F. \| Kuo, Lawrence C. \| Lewandowski, Frank A. \| Maguire, Diane M. \| Milligan, Cynthia M. \| ... \| Wang, Aihua Patent Number: 8753857 (2014) Cited by (2) \| Cite \| Source
Protein engineering of monoacylglycerol lipase (MGLL) (patent) Grasberger, Bruce L. \| Schalk-Hihi, Celine \| Maguire, Diane M. \| Lewandowski, Frank A. \| Milligan, Cynthia M. \| Alexander, Richard S. Patent Number: 8257698 (2012) Cited by (2) \| Cite \| Source
Triazolopyridazine compounds (patent) Lu, Tianbao \| Alexander, Richard \| Connors, Richard W. \| Cummings, Maxwell D. \| Galemmo, Robert A. \| Hufnagel, Heather Rae \| Johnson, Dana L. \| Khalil, Ehab \| Leonard, Kristi A. \| Markotan, Thomas P. \| ... \| Tuman, Robert W. Patent Number: 8173654 (2012) Cite \| Source
Structural Biology in Early Phase Drug Discovery (book chapter) In Frontiers in Drug Design & Discovery (Volume 1) Alexander, Richard \| Spurlino, John BENTHAM SCIENCE PUBLISHERS (2012) 10.2174/978160805199110501010287 Cite \| Source
Crystal structure of monoacylglycerol lipase (MGLL) (patent) Schubert, Carsten \| Grasberger, Bruce L. \| Schalk-Hihi, Celine \| Maguire, Diane M. \| Lewandowski, Frank A. \| Milligan, Cynthia M. \| Alexander, Richard S. Patent Number: 8080400 (2011) Cited by (6) \| Cite \| Source
Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors (journal article) Tresadern, Gary \| Delgado, Francisca \| Delgado, Oscar \| Gijsen, Harrie \| Macdonald, Gregor J. \| Moechars, Dieder \| Rombouts, Frederik \| Alexander, Richard \| Spurlino, John \| Gool, Michiel Van \| ... \| Trabanco, Andrés A. Bioorganic & Medicinal Chemistry Letters, volume 21, issue 24, pages 7255-7260 (2011). 10.1016/j.bmcl.2011.10.050 Cited by (47) \| Cite \| Source
Alternative crystal form of monoacylglycerol lipase (MGLL) (patent) Schubert, Carsten \| Grasberger, Bruce L. \| Schalk-Hihi, Celine \| Maguire, Diane M. \| Lewandowski, Frank A. \| Milligan, Cynthia M. \| Alexander, Richard S. Patent Number: 8067220 (2011) Cite \| Source
Triazolopyridazines as kinase modulators (patent) Lu, Tianbao \| Alexander, Richard \| Connors, Richard W. \| Cummings, Maxwell D. \| Galemmo, Robert A. \| Hufnagel, Heather Rae \| Johnson, Dana L. \| Khalil, Ehab \| Leonard, Kristi A. \| Markotan, Thomas P. \| ... \| Tuman, Robert W. Patent Number: 8030305 (2011) Cited by (8) \| Cite \| Source
Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads (journal article) Huang, Yifang \| Strobel, Eric D. \| Ho, Chih Y. \| Reynolds, Charles H. \| Conway, Kelly A. \| Piesvaux, Jennifer A. \| Brenneman, Douglas E. \| Yohrling, George J. \| Moore Arnold, H. \| Rosenthal, Daniel \| ... \| Baxter, Ellen W. Bioorganic & Medicinal Chemistry Letters, volume 20, issue 10, pages 3158-3160 (2010). 10.1016/j.bmcl.2010.03.097 Cited by (26) \| Cite \| Source
Acylhydrazones as kinase modulators (patent) Leonard, Kristi \| Lu, Tianbao \| Tuman, Robert W. \| Johnson, Dana L. \| Maroney, Anna C. \| Sechler, Jan L. \| Connors, Richard W. \| Alexander, Richard S. \| Cummings, Maxwell D. \| Galemmo, Robert A. \| Markotan, Thomas P. Patent Number: 7662824 (2010) Cited by (2) \| Cite \| Source
Phenyltriazolinones as potent factor Xa inhibitors (journal article) Quan, Mimi L. \| Pinto, Donald J.P. \| Rossi, Karen A. \| Sheriff, Steven \| Alexander, Richard S. \| Amparo, Eugene \| Kish, Kevin \| Knabb, Robert M. \| Luettgen, Joseph M. \| Morin, Paul \| ... \| Wexler, Ruth R. Bioorganic & Medicinal Chemistry Letters, volume 20, issue 4, pages 1373-1377 (2010). 10.1016/j.bmcl.2010.01.011 Cited by (11) \| Cite \| Source
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity (journal article) Hughes, Terry V. \| Emanuel, Stuart L. \| O’Grady, Harold R. \| Connolly, Peter J. \| Rugg, Catherine \| Fuentes-Pesquera, Angel R. \| Karnachi, Prabha \| Alexander, Richard \| Middleton, Steven A. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 18, pages 5130-5133 (2008). 10.1016/j.bmcl.2008.07.090 Cited by (15) \| Cite \| Source
Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: Discovery of novel, highly potent inhibitors of Factor Xa (journal article) Qiao, Jennifer X. \| Cheney, Daniel L. \| Alexander, Richard S. \| Smallwood, Angela M. \| King, Sarah R. \| He, Kan \| Rendina, Alan R. \| Luettgen, Joseph M. \| Knabb, Robert M. \| Wexler, Ruth R. \| Lam, Patrick Y.S. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 14, pages 4118-4123 (2008). 10.1016/j.bmcl.2008.05.095 Cited by (50) \| Cite \| Source