Fisayo A. Olotu

ScholarGPS® ID: 91961921113543

Affiliation
University of KwaZulu-Natal, Durban, Westville, Pinetown and Pietermaritzburg, South Africa
Affiliation History

Field
Pharmacy and Pharmaceutical Sciences
Discipline
Pharmaceutical Sciences
Top Specialties
Cancer | Medicinal Chemistry | Biodiversity | Alzheimer's Disease | Biotechnology | Drug Design | Molecular Modelling | Combinatorial Chemistry
Metrics Summary
Publication Count
77
Predicted Citations
943
Predicted h-index
17
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Deciphering the molecular mechanisms of selective non-covalency demonstrated differentially by 9-Allylnaphtho[1,8-ef]isoindole-7,8,10(9H)-trione (C11) against fibroblast growth factor receptors 1–4 (journal article)
Olotu, Fisayo A. | Soliman, Mahmoud E. S.
Journal of Biomolecular Structure and Dynamics, volume 41, issue 6, pages 2419-2430 (2023).
10.1080/07391102.2022.2032355
Cited by (2) | Cite | Source
Unveiling the mechanistic roles of chlorine substituted phthalazinone-based compounds containing chlorophenyl moiety towards the differential inhibition of poly (ADP-ribose) polymerase-1 in the treatment of lung cancer (journal article)
Okunlola, Felix O. | Olotu, Fisayo A. | Soliman, Mahmoud E. S.
Journal of Biomolecular Structure and Dynamics, volume 40, issue 21, pages 10878-10886 (2022).
10.1080/07391102.2021.1951354
Cited by (1) | Cite | Source
From a Computational Perspective: Elucidating the Neurotherapeutic and Inhibitory properties of LRRK2 Kinase Domain by a benzothiazole-based compound (journal article)
Subair, Temitayo I. | Soremekun, Opeyemi S. | Olotu, Fisayo A. | Soliman, Mahmoud E. S.
Current Pharmaceutical Biotechnology, volume 23 (2022).
10.2174/1389201023666220523153206
Cite | Source
Elucidating the Dynamics and Selective Mechanistic Mode of Inhibition of a Novel Poly ADP-Ribose Polymerase-1 Inhibitor (journal article)
Okunlola, Felix O. | Soremekun, Opeyemi S. | Olotu, Fisayo A. | Soliman, Mahmoud E.S.
Letters in Drug Design & Discovery, volume 19, issue 5, pages 379-386 (2022).
10.2174/1570180818666210401131531
Cite | Source
Probing Protein-protein Interactions and Druggable Site Identification: Mechanistic Binding Events Between Ubiquitin and Zinc Finger with UFM1-specific Peptidase Domain Protein (ZUFSP) (journal article)
Ajadi, Mary B. | Soremekun, Opeyemi S. | Elrashedy, Ahmed A | Olotu, Fisayo A. | Kumalo, Hezekiel M. | Soliman, Mahmoud E.S.
Combinatorial Chemistry & High Throughput Screening, volume 25, issue 5, pages 831-837 (2022).
10.2174/1386207324666210203175142
Cited by (1) | Cite | Source
Piecing the Fragments Together: Dynamical Insights into the Enhancement of BRD4-BD1 (BET Protein) Druggability in Cancer Chemotherapy Using Novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives (journal article)
Akawa, Oluwole B. | Soremekun, Opeyemi S. | Olotu, Fisayo A. | Solima, Mahmoud E.S.
Current Pharmaceutical Biotechnology, volume 23, issue 3, pages 444-456 (2022).
10.2174/1389201022666210322122056
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Atomistic insights into the selective therapeutic activity of 6-(2,4-difluorophenoxy)-5-((ethylmethyl)pyridine-3-yl)-8-methylpyrrolo[1,2-a]pyrazin-1(2H)-one towards bromodomain-containing proteins (journal article)
Akawa, Oluwole B. | Soremekun, Opeyemi S. | Olotu, Fisayo A. | Soliman, Mahmoud E.S.
Computational Biology and Chemistry, volume 95 (2021).
10.1016/j.compbiolchem.2021.107592
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Revealing the role of fluorine pharmacophore in chalcone scaffold for shifting the MAO-B selectivity: investigation of a detailed molecular dynamics and quantum chemical study (journal article)
Olotu, Fisayo A. | Joy, Monu | Abdelgawad, Mohamed A. | Narayanan, Siju E. | Soliman, Mahmoud E. | Mathew, Bijo
Journal of Biomolecular Structure and Dynamics, volume 39, issue 16, pages 6126-6139 (2021).
10.1080/07391102.2020.1796803
Cited by (4) | Cite | Source
Betulinic acid purified from Alstonia boonei inhibits folate biosynthesis in malarial Plasmodium, enhances mitochondrial pore opening and F1F0 ATPase in mice (journal article)
Olanlokun, John Oludele | Okoro, Praise Oghenegare | Lawal, Olatunde Segun | Bodede, Olusola | Olotu, Fisayo | Idowu, Thomas Oyebode | Prinsloo, Gerhard | Soliman, Mahmoud E. | Olorunsogo, Olufunso Olabode
Journal of Molecular Structure, volume 1239 (2021).
10.1016/j.molstruc.2021.130454
Cited by (5) | Cite | Source
Insight into the Therapeutic Potential of a Bicyclic Hydroxypyridone Compound 2‐[(2,4‐Dichlorophenyl)methyl]‐7‐hydroxy‐1,2,3,4‐tetrahydro‐8 H ‐pyrido[1,2‐ a ]pyrazin‐8‐one as COMT Inhibitor in the Treatment of Parkinson's Disease: A Molecular Dynamic Simu (journal article)
Subair, Temitayo I. | Akawa, Oluwole B. | Soremekun, Opeyemi S. | Olotu, Fisayo A. | Soliman, Mahmoud E. S.
Chemistry & Biodiversity, volume 18, issue 9 (2021).
10.1002/cbdv.202100204
Cited by (3) | Cite | Source
Computer-aided structural and molecular insights into the mechanisms by which Pseudouridimycin (PUM) disrupts cleft extension in bacterial RNA polymerase to block DNA entry and exit (journal article)
Rabbad, Ali H. | Olotu, Fisayo A. | Soliman, Mahmoud E.
Letters in Drug Design & Discovery, volume 18, issue 6, pages 542-550 (2021).
10.2174/1570180817999201123165144
Cited by (2) | Cite | Source
Integrative immunoinformatics paradigm for predicting potential B-cell and T-cell epitopes as viable candidates for subunit vaccine design against COVID-19 virulence (journal article)
Sarma, Vyshnavie R. | Olotu, Fisayo A. | Soliman, Mahmoud E.S.
Biomedical Journal, volume 44, issue 4, pages 447-460 (2021).
10.1016/j.bj.2021.05.001
Cited by (9) | Cite | Source
Prospecting the therapeutic edge of a novel compound (B12) over berberine in the selective targeting of Retinoid X Receptor in colon cancer (journal article)
Subair, Temitayo I. | Soremekun, Opeyemi S. | Olotu, Fisayo A. | Soliman, Mahmoud E. S.
Journal of Molecular Modeling, volume 27, issue 8 (2021).
10.1007/s00894-021-04848-4
Cited by (5) | Cite | Source
Piece of the puzzle: Remdesivir disassembles the multimeric SARS-CoV-2 RNA-dependent RNA polymerase complex (journal article)
Olotu, Fisayo A. | Omolabi, Kehinde F. | Soliman, Mahmoud E. S.
Cell Biochemistry and Biophysics, volume 79, issue 2, pages 175-187 (2021).
10.1007/s12013-021-00977-y
Cited by (5) | Cite | Source
Immunoinformatics prediction of potential B-cell and T-cell epitopes as effective vaccine candidates for eliciting immunogenic responses against Epstein–Barr virus (journal article)
Olotu, Fisayo A. | Soliman, Mahmoud E.S.
Biomedical Journal, volume 44, issue 3, pages 317-337 (2021).
10.1016/j.bj.2020.01.002
Cited by (17) | Cite | Source
‘Finding the needle in the haystack’- will natural products fit for purpose in the treatment of cryptosporidiosis? – A theoretical perspective (journal article)
Omolabi, Kehinde F. | Agoni, Clement | Olotu, Fisayo A. | Soliman, Mahmoud E.S.
Molecular Simulation, volume 47, issue 8, pages 636-649 (2021).
10.1080/08927022.2021.1895435
Cited by (2) | Cite | Source
Exploring the structural basis and atomistic binding mechanistic of the selective antagonist blockade at D3 dopamine receptor over D2 dopamine receptor (journal article)
Appiah‐Kubi, Patrick | Olotu, Fisayo Andrew | Soliman, Mahmoud E. S.
Journal of Molecular Recognition, volume 34, issue 5 (2021).
10.1002/jmr.2885
Cited by (4) | Cite | Source
East to West not North-West: Structure-Based Mechanistic Resolution of 8-Hydroxyl Replacement and Resulting Effects on the Activities of Imidazole-Based Heme Oxygenase-1 Inhibitors (journal article)
Okunlola, Felix O. | Soremekun, Opeyemi S. | Olotu, Fisayo A. | Soliman, Mahmoud E. S.
The Protein Journal, volume 40, issue 2, pages 166-174 (2021).
10.1007/s10930-021-09969-6
Cited by (1) | Cite | Source
Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties (journal article)
Jiang, Xiangyi | Huang, Boshi | Olotu, Fisayo A. | Li, Jing | Kang, Dongwei | Wang, Zhao | De Clercq, Erik | Soliman, Mahmoud E.S. | Pannecouque, Christophe | Liu, Xinyong | Zhan, Peng
European Journal of Medicinal Chemistry (2021).
10.1016/j.ejmech.2020.113051
Cited by (17) | Cite | Source
Therapeutic Path to Double Knockout: Investigating the Selective Dual-Inhibitory Mechanisms of Adenosine Receptors A1 and A2 by a Novel Methoxy-Substituted Benzofuran Derivative in the Treatment of Parkinson’s Disease (journal article)
Subair, Temitayo I. | Soremekun, Opeyemi S. | Olotu, Fisayo A. | Soliman, Mahmoud E. S.
Cell Biochemistry and Biophysics, volume 79, issue 1, pages 25-36 (2021).
10.1007/s12013-020-00957-8
Cited by (3) | Cite | Source