Scott A. Armstrong

ScholarGPS® ID: 90426106462255

Affiliation

Dana-Farber Cancer Institute, Boston, United States

Affiliation History

Field

Medicine

Discipline

Pediatrics

Top Specialties

Metrics Summary

Publication Count

229

Predicted Citations

36,166

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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A MOZ-TIF2 leukemia mouse model displays KAT6-dependent H3K23 propionylation and overexpression of a set of active developmental genes (journal article) Smolko, Anne E. \| Sullivan, Daniel W. \| Olsen, Sarah Naomi \| Kang, Hyuckjoon \| Whedon, Samuel D. \| Baell, Jonathan B. \| Cole, Philip A. \| Armstrong, Scott A. \| Kuroda, Mitzi I. Proceedings of the National Academy of Sciences, volume 121, issue 26 (2024). 10.1073/pnas.2405905121 Cite \| Source
PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway (journal article) Gu, Hao \| Chen, Chiqi \| Hou, Zhi-Shuai \| He, Xia-Di \| Xie, Shaozhen \| Ni, Jing \| Qian, Changli \| Cheng, Xin \| Jiang, Tao \| Yang, Ce \| ... \| Zhao, Jean J. Blood, volume 143, issue 19, pages 1965-1979 (2024). 10.1182/blood.2023022202 Cited by (3) \| Cite \| Source
Therapeutic Targeting of the Menin–KMT2A Interaction (journal article) Freire, Pablo R. \| Cutler, Jevon A. \| Armstrong, Scott A. Annual Review of Cancer Biology, volume 8, issue 1 (2024). 10.1146/annurev-cancerbio-062822-021934 Cite \| Source
The future of HOXA-expressing leukemias: Menin inhibitor response and resistance (journal article) Wenge, Daniela V. \| Armstrong, Scott A. Current Opinion in Hematology, volume 31, issue 2, pages 64-70 (2024). 10.1097/MOH.0000000000000796 Cited by (1) \| Cite \| Source
Functional Dissection of Cellular Programs to Uncover Novel Gene Dependencies in AML (journal article) Ellegast, Jana M \| Alexe, Gabriela \| Baniya, Subha \| Hamze, Amanda \| Taillon, Audrey \| Adane, Biniam \| Saur Conway, Amy \| Zhang, Tinghu \| Gray, Nathanael S \| Armstrong, Scott A \| Stegmaier, Kimberly Blood, volume 142, issue Supplement 1, pages 1393-1393 (2023). 10.1182/blood-2023-189304 Cite \| Source
BOD1L Facilitates Chromatin Binding of SETD1A and Promotes Leukemia Cell Growth (journal article) Hoshii, Takayuki \| Kikuchi, Sota \| Shibata, Seito \| Matsumoto, Makoto \| Rahmutulla, Bahityar \| Fukuyo, Masaki \| Armstrong, Scott A \| Kaneda, Atsushi Blood, volume 142, issue Supplement 1, pages 4114-4114 (2023). 10.1182/blood-2023-173799 Cite \| Source
Menin Inhibitor Induced Menin Protein Degradation Contributes to Menin Inhibitor Efficacy (journal article) Cutler, Jevon \| Tsai, Jonathan \| Regalado, Brandon \| Bourgeois, Wallace \| Wenge, Daniela \| Kim, Jeonghyeon \| Nowak, Radoslaw \| Ener, Elizabeth \| Donovan, Katherine \| Olsen, Sarah Naomi \| ... \| Armstrong, Scott A Blood, volume 142, issue Supplement 1, pages 2788-2788 (2023). 10.1182/blood-2023-184931 Cite \| Source
Combining Menin and MEK Inhibition to Target Poor Prognostic KMT2A -Rearranged RAS Pathway-Mutant Acute Leukemia (journal article) Scheidegger, Nastassja \| Alexe, Gabriela \| Khalid, Delan \| Ries, Rhonda E \| Wang, Jim \| Alonzo, Todd A. \| Perry, Jennifer \| Armstrong, Scott A \| Meshinchi, Soheil \| Pikman, Yana \| Stegmaier, Kimberly Blood, volume 142, issue Supplement 1, pages 166-166 (2023). 10.1182/blood-2023-185561 Cited by (2) \| Cite \| Source
Epitope Edited Hematopoietic Stem Cells to Enable Synergistic Immunotherapy Combinations for Acute Myeloid Leukemia (journal article) Casirati, Gabriele \| Cosentino, Andrea \| Mucci, Adele \| Mahmoud, Mohammed S \| Ugarte Zabala, Iratxe \| Zeng, Jing \| Ficarro, Scott \| Klatt, Denise \| Brendel, Christian \| Rambaldi, Alessandro \| ... \| Genovese, Pietro Blood, volume 142, issue Supplement 1, pages 7130-7130 (2023). 10.1182/blood-2023-189980 Cite \| Source
237 Epitope engineered hematopoietic stem cells to enable multi-specificity CAR-T cells for acute myeloid leukemia (conference) Casirati, Gabriele \| Cosentino, Andrea \| Mucci, Adele \| Mahmoud, Mohammed S \| Zabala, Iratxe Ugarte \| Zeng, Jing \| Klatt, Denise \| Brendel, Christian \| Ritz, Jerome \| Ficarro, Scott \| ... \| Genovese, Pietro SITC 38th Annual Meeting (SITC 2023) Abstracts (2023) 10.1136/jitc-2023-SITC2023.0237 Cite \| Source
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia (journal article) Casirati, Gabriele \| Cosentino, Andrea \| Mucci, Adele \| Salah Mahmoud, Mohammed \| Ugarte Zabala, Iratxe \| Zeng, Jing \| Ficarro, Scott B. \| Klatt, Denise \| Brendel, Christian \| Rambaldi, Alessandro \| ... \| Genovese, Pietro Nature, volume 621, issue 7978, pages 404-414 (2023). 10.1038/s41586-023-06496-5 Cited by (27) \| Cite \| Source
MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer (journal article) Zhu, Changyu \| Soto-Feliciano, Yadira M \| Morris, John P \| Huang, Chun-Hao \| Koche, Richard P \| Ho, Yu-jui \| Banito, Ana \| Chen, Chun-Wei \| Shroff, Aditya \| Tian, Sha \| ... \| Lowe, Scott W eLife, volume 12 (2023). 10.7554/eLife.80854 Cited by (5) \| Cite \| Source
Exploring the novel function of mutant NPM1 on chromatin (conference) Uckelmann, H J \| Haarer, E L \| Takeda, R \| Hatton, C \| Chen, C W \| Armstrong, S A 34. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch onkologische Forschung (2023) Wilsede 10.1055/s-0043-1768553 Cite \| Source
Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia (journal article) Uckelmann, Hannah J. \| Haarer, Elena L. \| Takeda, Reina \| Wong, Eric M. \| Hatton, Charlie \| Marinaccio, Christian \| Perner, Florian \| Rajput, Masooma \| Antonissen, Noa J.C. \| Wen, Yanhe \| ... \| Armstrong, Scott A. Cancer Discovery, volume 13, issue 3, pages 746-765 (2023). 10.1158/2159-8290.CD-22-0366 Cited by (32) \| Cite \| Source
S125: NON-GENETIC RESISTANCE TO MENIN INHIBITION IN AML IS REVERSIBLE BY PERTURBATION OF KAT6A (journal article) Perner, Florian \| Rahnamoun, Homa \| Wenge, Daniela V. \| Xiong, Yijun \| Apazidis, Athina \| Anand, Disha \| Hatton, Charlie \| Wen, Yanhe \| Gu, Shengqing \| Liu, X Shirley \| ... \| Armstrong, Scott A. HemaSphere, volume 7, issue S3, pages e6233123- (2023). 10.1097/01.HS9.0000967412.62331.23 Cited by (1) \| Cite \| Source
P410: COMBINING MENIN AND MEK INHIBITION TO TREAT CHILDREN WITH POOR PROGNOSTIC KMT2A-R RAS-MUTANT ACUTE LEUKEMIA (journal article) Scheidegger, Nastassja \| Alexe, Gabriela \| Khalid, Delan \| Perry, Jennifer \| Armstrong, Scott \| Pikman, Yana \| Stegmaier, Kimberly HemaSphere, volume 7, issue S3, pages e0491723- (2023). 10.1097/01.HS9.0000968548.04917.23 Cite \| Source
The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax (journal article) Rausch, Johanna \| Dzama, Margarita M. \| Dolgikh, Nadezda \| Stiller, Hanna \| Bohl, Stephan \| Lahrmann, Catharina \| Kunz, Kerstin \| Kessler, Linda \| Echchannaoui, Hakim \| Chen, Chun-Wei David \| ... \| Kuehn, Michael Blood, volume 140, issue Supplement 1, pages 6226-6227 (2022). 10.1182/blood-2022-167566 Cited by (1) \| Cite \| Source
Epigenetic Resistance to Menin-MLL1 Inhibition Is Driven By Loss of the Non-Canonical Polycomb Repressive Complex 1.1 in NUP98 -Rearranged AML (journal article) Heikamp, Emily B. \| Henrich, Jill A \| Rice, Hannah E \| Mahendra-Rajah, Sanisha \| Armstrong, Scott A. Blood, volume 140, issue Supplement 1, pages 95-96 (2022). 10.1182/blood-2022-170165 Cited by (1) \| Cite \| Source
Mutant NPM1 Is Recruited to MLL Target Genes Via Its Acidic Stretch and Nuclear Export Factor CRM1 and Regulates Oncogenic Transcription in Acute Myeloid Leukemia (journal article) Uckelmann, Hannah J \| Haarer, Elena L \| Takeda, Reina \| Wong, Eric \| Marinaccio, Christian \| Hatton, Charles \| Wen, Yanhe \| Perner, Florian \| Rajput, Masooma \| Antonissen, Noa J.C. \| ... \| Armstrong, Scott A. Blood, volume 140, issue Supplement 1, pages 5835-5836 (2022). 10.1182/blood-2022-166630 Cite \| Source
Epitope Engineered Hematopoietic Stem and Progenitor Cells to Enable CAR-T Cell Immunotherapy for Acute Myeloid Leukemia (journal article) Casirati, Gabriele \| Cosentino, Andrea \| Mucci, Adele \| Ugarte Zabala, Iraxte \| Mahmoud, Mohammed S. \| Brendel, Christian \| Rambaldi, Alessandro \| Ritz, Jerome \| Armstrong, Scott A. \| Genovese, Pietro Blood, volume 140, issue Supplement 1, pages 303-304 (2022). 10.1182/blood-2022-167285 Cited by (3) \| Cite \| Source

Title	Investigators	Year	Cost	Agency
Targeting DOT1L for Degradation in MLL-rearranged Leukemia	Armstrong, Scott A \| QI, JUN	2020	$404,076	NATIONAL CANCER INSTITUTE
Research Training in Pediatric Oncology	Armstrong, Scott A	2020	$378,385	NATIONAL CANCER INSTITUTE
Biology and therapeutic targeting of zinc finger transcription factors in AML	Armstrong, Scott A	2020	$405,564	NATIONAL CANCER INSTITUTE
Targeting DOT1L for Degradation in MLL-rearranged Leukemia	Armstrong, Scott A \| QI, JUN	2019	$239,963	NATIONAL CANCER INSTITUTE
Targeting DOT1L for Degradation in MLL-rearranged Leukemia	Armstrong, Scott A \| QI, JUN	2019	$391,951	NATIONAL CANCER INSTITUTE
Research Training in Pediatric Oncology	Armstrong, Scott A	2018	$491,462	NATIONAL CANCER INSTITUTE
Targeting DOT1L for Degradation in MLL-rearranged Leukemia	Armstrong, Scott A \| QI, JUN	2018	$404,076	NATIONAL CANCER INSTITUTE
The Center for Therapeutic Targeting of EWS-oncoproteins	Armstrong, Scott A \| Stegmaier, Kimberly	2018	$12,500,000	NATIONAL CANCER INSTITUTE
Targeting MLL/Menin in AML	Armstrong, Scott A	2018	$88,243	NATIONAL CANCER INSTITUTE
Research Training in Pediatric Oncology	Armstrong, Scott A	2017	$538,819	NATIONAL CANCER INSTITUTE
Targeting to Epigenetic Modications in ALL	Armstrong, Scott A	2016	$402,250	NATIONAL CANCER INSTITUTE
Targeting to Epigenetic Modications in ALL	Armstrong, Scott A	2015	$402,250	NATIONAL CANCER INSTITUTE
Targeting to Epigenetic Modications in ALL	Armstrong, Scott A	2014	$390,183	NATIONAL CANCER INSTITUTE
Molecular pathogenesis of MLL-AF4 leukemias	Armstrong, Scott A	2014	$345,179	NATIONAL CANCER INSTITUTE
Targeting to Epigenetic Modications in ALL	Armstrong, Scott A	2013	$378,115	NATIONAL CANCER INSTITUTE
Molecular pathogenesis of MLL-AF4 leukemias	Armstrong, Scott A	2013	$334,504	NATIONAL CANCER INSTITUTE
MLL FUSION GENES IN MYELOID AND LYMPHOID LEUKEMIAS	Armstrong, Scott A	2012	$477,230	NATIONAL CANCER INSTITUTE
Targeting to Epigenetic Modications in ALL	Armstrong, Scott A	2012	$402,250	NATIONAL CANCER INSTITUTE
MLL FUSION GENES IN MYELOID AND LYMPHOID LEUKEMIAS	Armstrong, Scott A	2011	$470,757	NATIONAL CANCER INSTITUTE
The Core Apoptotic Pathway Controlling Glucocorticoid-induced Apoptosis in ALL	Armstrong, Scott A	2010	$371,859	NATIONAL CANCER INSTITUTE
MLL FUSION GENES IN MYELOID AND LYMPHOID LEUKEMIAS	Armstrong, Scott A	2010	$536,418	NATIONAL CANCER INSTITUTE
Comprehensive Phenotypic Comparison of Normal and Cancer Stem Cells	Shivdasani, RAMESH A (contact) \| Armstrong, Scott A	2010	$1,702,016	NATIONAL CANCER INSTITUTE
The Core Apoptotic Pathway Controlling Glucocorticoid-induced Apoptosis in ALL	Armstrong, Scott A	2009	$364,604	NATIONAL CANCER INSTITUTE
MLL FUSION GENES IN MYELOID AND LYMPHOID LEUKEMIAS	Armstrong, Scott A	2009	$526,079	NATIONAL CANCER INSTITUTE
Comprehensive Phenotypic Comparison of Normal and Cancer Stem Cells	Shivdasani, RAMESH A (contact) \| Armstrong, Scott A	2009	$1,723,218	NATIONAL CANCER INSTITUTE
The Core Apoptotic Pathway Controlling Glucocorticoid-induced Apoptosis in ALL	Armstrong, Scott A	2008	$354,060	NATIONAL CANCER INSTITUTE
MLL FUSION GENES IN MYELOID AND LYMPHOID LEUKEMIAS	Armstrong, Scott A	2008	$510,801	NATIONAL CANCER INSTITUTE
The Core Apoptotic Pathway Controlling Glucocorticoid-induced Apoptosis in ALL	Armstrong, Scott A	2007	$350,594	NATIONAL CANCER INSTITUTE
The Core Apoptotic Pathway Controlling Glucocorticoid-induced Apoptosis in ALL	Armstrong, Scott A	2006	$257,099	NATIONAL CANCER INSTITUTE
MLL Gene Regulation in Hematopoiesis and Leukemia	Armstrong, Scott A	2006	$66,379	NATIONAL CANCER INSTITUTE
MLL Gene Regulation in Hematopoiesis and Leukemia	Armstrong, Scott A	2005	$132,759	NATIONAL CANCER INSTITUTE
MLL Gene Regulation in Hematopoiesis and Leukemia	Armstrong, Scott A	2004	$132,759	NATIONAL CANCER INSTITUTE
MLL Gene Regulation in Hematopoiesis and Leukemia	Armstrong, Scott A	2003	$132,759	NATIONAL CANCER INSTITUTE
MLL Gene Regulation in Hematopoiesis and Leukemia	Armstrong, Scott A	2002	$66,380	NATIONAL CANCER INSTITUTE
MLL Gene Regulation in Hematopoiesis and Leukemia	Armstrong, Scott A	2001	$132,759	NATIONAL CANCER INSTITUTE