Zachary Kevin Sweeney

ScholarGPS® ID: 90331693626940

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

1,311

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Hepatitis C virus inhibitors (patent) Qiu, Yao-Ling \| Cao, Hui \| Peng, Xiaowen \| Gao, Xuri \| Or, Yat Sun \| Sweeney, Zachary Kevin Patent Number: 10407445 (2019) Cite \| Source
Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2 (journal article) Shore, Daniel G.M. \| Sweeney, Zachary K. \| Beresford, Alan \| Chan, Bryan K. \| Chen, Huifen \| Drummond, Jason \| Gill, Andrew \| Kleinheinz, Tracy \| Liu, Xingrong \| Medhurst, Andrew D. \| ... \| Estrada, Anthony A. Bioorganic & Medicinal Chemistry Letters, volume 29, issue 4, pages 674-680 (2019). 10.1016/j.bmcl.2018.10.017 Cited by (7) \| Cite \| Source
A Flexible and Scalable High-Throughput Platform for Recombinant Membrane Protein Production (book chapter) In High-Throughput Protein Production and Purification Xu, Hui \| Clairfeuille, Thomas \| Jao, Christine C. \| Ho, Hoangdung \| Sweeney, Zachary \| Payandeh, Jian \| Koth, Christopher M. Springer New York (2019) 10.1007/978-1-4939-9624-7_18 Cited by (2) \| Cite \| Source
Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline (journal article) Lee, Patrick S. \| Lapointe, Guillaume \| Madera, Ann Marie \| Simmons, Robert L. \| Xu, Wenjian \| Yifru, Aregahegn \| Tjandra, Meiliana \| Karur, Subramanian \| Rico, Alice \| Thompson, Katherine \| ... \| Sweeney, Zachary K. Journal of Medicinal Chemistry, volume 61, issue 20, pages 9360-9370 (2018). 10.1021/acs.jmedchem.8b01287 Cited by (20) \| Cite \| Source
Crystalline isoxazole hydroxamic acid compounds (patent) Fu, Jiping \| Jiang, Siyi \| Kordikowski, Andreas \| Sweeney, Zachary Kevin Patent Number: 10071973 (2018) Cite \| Source
Isoxazole hydroxamic acid compounds as LpxC inhibitors (patent) Fu, Jiping \| Jin, Xianming \| Karur, Subramanian \| Lapointe, Guillaume \| Madera, Ann Marie \| Sweeney, Zachary Kevin Patent Number: 10029994 (2018) Cite \| Source
Isoxazole hydroxamic acid compounds as LpxC inhibitors (patent) Fu, Jiping \| Jin, Xianming \| Karur, Subramanian \| Lapointe, Guillaume \| Madera, Ann Marie \| Sweeney, Zachary Kevin Patent Number: 9815804 (2017) Cite \| Source
2′-ethynyl nucleoside derivatives for treatment of viral infections (patent) Anandan, Sampath-Kumar \| Aulakh, Virender Singh \| Fenaux, Martijn \| Lin, Xiaodong \| Mao, Liang \| Saunders, Oliver \| Sweeney, Zachary Kevin \| Yokokawa, Fumiaki \| Zhong, Weidong Patent Number: 9814739 (2017) Cite \| Source
Isoxazoline hydroxamic acid derivatives as LpxC inhibitors (patent) Fu, Jiping \| Jin, Xianming \| Karur, Subramanian \| LaPointe, Guillaume \| Lee, Patrick \| Sweeney, Zachary Kevin Patent Number: 9718792 (2017) Cited by (1) \| Cite \| Source
Isoxazoline hydroxamic acid derivatives as LpxC inhibitors (patent) Fu, Jiping \| Jin, Xianming \| Karur, Subramanian \| Lapointe, Guillaume \| Lee, Patrick \| Sweeney, Zachary Kevin Patent Number: 9637482 (2017) Cited by (2) \| Cite \| Source
Cyclic peptides and use as medicines (patent) Fu, Jiping \| Karur, Subramanian \| Li, Xiaolin \| Lu, Peichao \| Mergo, Wosenu \| Rivkin, Alexey \| Sweeney, Zachary Kevin \| Tjandra, Meiliana \| Weiss, Andrew \| Yifru, Aregahegn Patent Number: 9566312 (2017) Cite \| Source
2′-Ethynyl nucleoside derivatives for treatment of viral infections (patent) Anandan, Sampath-Kumar \| Aulakh, Virender Singh \| Fenaux, Martijn \| Lin, Xiaodong \| Mao, Liang \| Saunders, Oliver \| Sweeney, Zachary Kevin \| Yokokawa, Fumiaki \| Zhong, Weidong Patent Number: 9556216 (2017) Cited by (1) \| Cite \| Source
Isoxazole hydroxamic acid compounds as LpxC inhibitors (patent) Fu, Jiping \| Jin, Xianming \| Karur, Subramanian \| Lapointe, Guillaume \| Madera, Ann Marie \| Sweeney, Zachary Kevin Patent Number: 9549916 (2017) Cited by (1) \| Cite \| Source
Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors (journal article) Estrada, Anthony A. \| Sweeney, Zachary K. Journal of Medicinal Chemistry, volume 58, issue 17, pages 6733-6746 (2015). 10.1021/acs.jmedchem.5b00261 Cited by (38) \| Cite \| Source
Promiscuity and the Conformational Rearrangement of Drug‐Like Molecules: Insight from the Protein Data Bank (journal article) He, Michael W. \| Lee, Patrick S. \| Sweeney, Zachary K. ChemMedChem, volume 10, issue 2, pages 238-244 (2015). 10.1002/cmdc.201402389 Cited by (8) \| Cite \| Source
Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis (journal article) Lou, Yan \| Han, Xiaochun \| Kuglstatter, Andreas \| Kondru, Rama K. \| Sweeney, Zachary K. \| Soth, Michael \| McIntosh, Joel \| Litman, Renee \| Suh, Judy \| Kocer, Buelent \| ... \| Owens, Timothy D. Journal of Medicinal Chemistry, volume 58, issue 1, pages 512-516 (2015). 10.1021/jm500305p Cited by (90) \| Cite \| Source
Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton’s Tyrosine Kinase (BTK) inhibitor scaffold (journal article) Lou, Yan \| Sweeney, Zachary K. \| Kuglstatter, Andreas \| Davis, Dana \| Goldstein, David M. \| Han, Xiaochun \| Hong, Junbae \| Kocer, Buelent \| Kondru, Rama K. \| Litman, Renee \| ... \| Owens, Timothy D. Bioorganic & Medicinal Chemistry Letters, volume 25, issue 2, pages 367-371 (2015). 10.1016/j.bmcl.2014.11.030 Cited by (30) \| Cite \| Source
From Chemical Tools to Clinical Medicines: Nonimmunosuppressive Cyclophilin Inhibitors Derived from the Cyclosporin and Sanglifehrin Scaffolds (journal article) Sweeney, Zachary K. \| Fu, Jiping \| Wiedmann, Brigitte Journal of Medicinal Chemistry, volume 57, issue 17, pages 7145-7159 (2014). 10.1021/jm500223x Cited by (54) \| Cite \| Source
Pyrazole aminopyrimidine derivatives as LRRK2 modulators (patent) Baker-Glenn, Charles \| Burdick, Daniel Jon \| Chambers, Mark \| Chan, Bryan K. \| Chen, Huifen \| Estrada, Anthony \| Sweeney, Zachary Kevin Patent Number: 8815882 (2014) Cited by (7) \| Cite \| Source
Aminopyrimidine derivatives as LRRK2 modulators (patent) Baker-Glenn, Charles \| Burdick, Daniel Jon \| Chambers, Mark \| Chan, Bryan K. \| Chen, Huifen \| Estrada, Anthony \| Gunzner-Toste, Janet L. \| Shore, Daniel \| Sweeney, Zachary Kevin \| Wang, Shumei \| Zhao, Guiling Patent Number: 8809331 (2014) Cited by (3) \| Cite \| Source