Alan C. Gibbs

ScholarGPS® ID: 89941414319910

Affiliation
Johnson & Johnson, New Brunswick, New Jersey, United States
Affiliation History

Field
Life Sciences
Discipline
Biology and Biological Sciences
Top Specialties
Medicinal Chemistry | Peptide | Bacteriocin | Sodium Channel
Metrics Summary
Publication Count
40
Predicted Citations
1,708
Predicted h-index
22
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav 1.7 (journal article)
Neff, Robert A. | Flinspach, Mack | Gibbs, Alan | Shih, Amy Y. | Minassian, Natali A. | Liu, Yi | Fellows, Ross | Libiger, Ondrej | Young, Stephanie | Pennington, Michael W. | ... | Wickenden, Alan D.
Journal of Biological Chemistry, volume 295, issue 5, pages 1315-1327 (2020).
10.1074/jbc.RA119.011318
Cited by (10) | Cite | Source
Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7 (journal article)
Neff, Robert A. | Flinspach, Mack | Gibbs, Alan | Shih, Amy Y. | Minassian, Natali A. | Liu, Yi | Fellows, Ross | Libiger, Ondrej | Young, Stephanie | Pennington, Michael W. | ... | Wickenden, Alan D.
Journal of Biological Chemistry, volume 295, issue 5, pages 1315-1327 (2020).
10.1016/S0021-9258(17)49888-7
Cited by (10) | Cite | Source
Huwentoxin-IV variants and methods of use (patent)
Eckert, William | Flinspach, Mack | Hunter, Michael | Liu, Yi | Neff, Robert | Wickenden, Alan | Gibbs, Alan
Patent Number: 10414808 (2019)
Cite | Source
Inhibitor Bound Dengue NS2B-NS3pro Reveals Multiple Dynamic Binding Modes (journal article)
Gibbs, Alan C. | Steele, Ruth | Liu, Gaohua | Tounge, Brett A. | Montelione, Gaetano T.
Biochemistry, volume 57, issue 10, pages 1591-1602 (2018).
10.1021/acs.biochem.7b01127
Cited by (27) | Cite | Source
Indazole compounds useful as ketohexokinase inhibitors (patent)
Zhang, Xuqing | Abad, Marta C | Gibbs, Alan C. | Kuo, Gee-Hong | Song, Fengbin | Sui, Zhihua | Kuo, Lawrence C.
Patent Number: 9771375 (2017)
Cite | Source
Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors (journal article)
Meegalla, Sanath K. | Huang, Hui | Illig, Carl R. | Parks, Daniel J. | Chen, Jinsheng | Lee, Yu-Kai | Wilson, Kenneth J. | Patel, Sharmila K. | Cheung, Wing S. | Lu, Tianbao | ... | Player, Mark R.
Bioorganic & Medicinal Chemistry Letters, volume 26, issue 17, pages 4216-4222 (2016).
10.1016/j.bmcl.2016.07.054
Cited by (12) | Cite | Source
Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokinetics (journal article)
Jacobs, Steven A. | Gibbs, Alan C. | Conk, Michelle | Yi, Fang | Maguire, Diane | Kane, Colleen | O'Neil, Karyn T.
Protein Engineering Design and Selection, volume 28, issue 10, pages 385-393 (2015).
10.1093/protein/gzv040
Cited by (54) | Cite | Source | Open Access
Elements and Modulation of Functional Dynamics (journal article)
Gibbs, Alan C.
Journal of Medicinal Chemistry, volume 57, issue 19, pages 7819-7837 (2014).
10.1021/jm500325k
Cited by (15) | Cite | Source
Indazole compounds useful as ketohexokinase inhibitors (patent)
Zhang, Xuqing | Abad, Marta C. | Gibbs, Alan C. | Kuo, Gee-Hong | Kuo, Lawrence C. | Song, Fengbin | Sui, Zhihua
Patent Number: 8822447 (2014)
Cited by (2) | Cite | Source
Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a) (journal article)
Minassian, Natali A. | Gibbs, Alan | Shih, Amy Y. | Liu, Yi | Neff, Robert A. | Sutton, Steven W. | Mirzadegan, Tara | Connor, Judith | Fellows, Ross | Husovsky, Matthew | ... | Wickenden, Alan D.
Journal of Biological Chemistry, volume 288, issue 31, pages 22707-22720 (2013).
10.1074/jbc.M113.461392
Cited by (65) | Cite | Source | Open Access
Huwentoxin-IV variants and methods of use (patent)
Flinspach, Mack | Hunter, Michael | Liu, Yi | Neff, Robert | Wickenden, Alan D. | Gibbs, Alan C.
Patent Number: 9102751 (2013)
Cited by (3) | Cite | Source
Pyrimidinopyrimidine inhibitors of ketohexokinase: Exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket (journal article)
Maryanoff, Bruce E. | O’Neill, John C. | McComsey, David F. | Yabut, Stephen C. | Luci, Diane K. | Gibbs, Alan C. | Connelly, Margery A.
Bioorganic & Medicinal Chemistry Letters, volume 22, issue 16, pages 5326-5329 (2012).
10.1016/j.bmcl.2012.06.008
Cited by (15) | Cite | Source
Optimization of a pyrazole hit from FBDD into a novel series of indazoles as ketohexokinase inhibitors (journal article)
Zhang, Xuqing | Song, Fengbing | Kuo, Gee-Hong | Xiang, Amy | Gibbs, Alan C. | Abad, Marta C. | Sun, Weimei | Kuo, Lawrence C. | Sui, Zhihua
Bioorganic & Medicinal Chemistry Letters, volume 21, issue 16, pages 4762-4767 (2011).
10.1016/j.bmcl.2011.06.067
Cited by (22) | Cite | Source
Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site (journal article)
Maryanoff, Bruce E. | O'Neill, John C. | McComsey, David F. | Yabut, Stephen C. | Luci, Diane K. | Jordan, Alfonzo D. | Masucci, John A. | Jones, William J. | Abad, Marta C. | Gibbs, Alan C. | Petrounia, Ioanna
ACS Medicinal Chemistry Letters, volume 2, issue 7, pages 538-543 (2011).
10.1021/ml200070g
Cited by (32) | Cite | Source | Open Access
Electron Density Guided Fragment-Based Drug Design—A Lead Generation Example (book chapter)
In Fragment-Based Drug Design - Tools, Practical Approaches, and Examples
Abad, Marta C. | Gibbs, Alan C. | Zhang, Xuqing
Elsevier (2011)
10.1016/B978-0-12-381274-2.00019-4
Cited by (7) | Cite | Source
Electron Density Guided Fragment-Based Lead Discovery of Ketohexokinase Inhibitors (journal article)
Gibbs, Alan C. | Abad, Marta C. | Zhang, Xuqing | Tounge, Brett A. | Lewandowski, Francis A. | Struble, Geoffrey T. | Sun, Weimei | Sui, Zhihua | Kuo, Lawrence C.
Journal of Medicinal Chemistry, volume 53, issue 22, pages 7979-7991 (2010).
10.1021/jm100677s
Cited by (35) | Cite | Source
Quantum Mechanical Pairwise Decomposition Analysis of Protein Kinase B Inhibitors: Validating a New Tool for Guiding Drug Design (journal article)
Zhang, Xiaohua | Gibbs, Alan C. | Reynolds, Charles H. | Peters, Martin B. | Westerhoff, Lance M.
Journal of Chemical Information and Modeling, volume 50, issue 4, pages 651-661 (2010).
10.1021/ci9003333
Cited by (18) | Cite | Source | Open Access
Design, Synthesis, and Biological Evaluation of (2 R ,α S )-3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-α-(trifluoromethyl)-1(2 H )-quinolineethanol as Potent and Orally Active Cholesteryl Ester Transfer Protein Inh (journal article)
Kuo, Gee-Hong | Rano, Thomas | Pelton, Patricia | Demarest, Keith T. | Gibbs, Alan C. | Murray, William V. | Damiano, Bruce P. | Connelly, Margery A.
Journal of Medicinal Chemistry, volume 52, issue 6, pages 1768-1772 (2009).
10.1021/jm801319d
Cited by (37) | Cite | Source
CRYSTAL STRUCTURE OF THE CARBOXYL TRANSFERASE DOMAIN OF HUMAN ACETYL-COA CARBOXYLASE 2 PROTEIN (ACC2 CT) AND USES THEREOF (patent)
Grasberger, Bruce L. | Milligan, Cynthia M. | Spurlino, John | Steele, Ruth A. | Singleton, Kenneth R. | Gibbs, Alan C. | Lewandowski, Francis A.
Patent Number: 20090155815 (2008)
Cite | Source
ChemInform Abstract: Cycloaddition Reactions of Thiazolium Azomethine Ylides: Application to Pyrrolo[2,1‐b]thiazoles. (journal article)
Berry, Craig R. | Zificsak, Craig A. | Gibbs, Alan C. | Hlasta, Dennis J.
ChemInform, volume 39, issue 14 (2008).
10.1002/chin.200814146
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