David L. Akey

ScholarGPS® ID: 89108497644774

Affiliation

University of Michigan, Ann Arbor, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Structural Biology | Chemical Biology | Crystallography | Crystal Structure

Metrics Summary

Publication Count

Predicted Citations

2,440

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Structure of a modular polyketide synthase reducing region (journal article) McCullough, Tyler M. \| Dhar, Anya \| Akey, David L. \| Konwerski, Jamie R. \| Sherman, David H. \| Smith, Janet L. Structure, volume 31, issue 9, pages 1109-1120.e3 (2023). 10.1016/j.str.2023.05.019 Cited by (4) \| Cite \| Source
Structural basis for antibody inhibition of flavivirus NS1–triggered endothelial dysfunction (journal article) Biering, Scott B. \| Akey, David L. \| Wong, Marcus P. \| Brown, W. Clay \| Lo, Nicholas T. N. \| Puerta-Guardo, Henry \| Tramontini Gomes de Sousa, Francielle \| Wang, Chunling \| Konwerski, Jamie R. \| Espinosa, Diego A. \| ... \| Harris, Eva Science, volume 371, issue 6525, pages 194-200 (2021). 10.1126/science.abc0476 Cited by (77) \| Cite \| Source
Characterization of a protective antibody against dengue virus non-structural protein 1 (NS1) reveals critical domains required for NS1-triggered pathogenesis (journal article) Wong, Marcus P \| Biering, Scott B \| Akey, David L \| Lo, Nicholas TN \| Brown, W. Clay \| de Sousa, Francielle Tramontini Gomes \| Puerta-Guardo, Henry \| Wang, Chunling \| Konwerski, Jamie \| Espinosa, Diego \| ... \| Harris, Eva The Journal of Immunology, volume 204, issue 1_Supplement, pages 167.23-167.23 (2020). 10.4049/jimmunol.204.Supp.167.23 Cite \| Source
Structural Analysis of Helicobacter pylori VacA Reveals Insights into Oligomerization (journal article) Erwin, Amanda L. \| Su, Min \| Campbell, Anne M. \| Akey, David \| Lacy, D. Borden \| Cover, Timothy L. \| Ohi, Melanie D. Microscopy and Microanalysis, volume 25, issue S2, pages 1290-1291 (2019). 10.1017/S1431927619007189 Cite \| Source
Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization (journal article) Su, Min \| Erwin, Amanda L. \| Campbell, Anne M. \| Pyburn, Tasia M. \| Salay, Lauren E. \| Hanks, Jessica L. \| Lacy, D. Borden \| Akey, David L. \| Cover, Timothy L. \| Ohi, Melanie D. Journal of Molecular Biology, volume 431, issue 10, pages 1956-1965 (2019). 10.1016/j.jmb.2019.03.029 Cited by (19) \| Cite \| Source
Vaccine compositions and uses thereof (patent) Smith, Janet L. \| Akey, David L. \| Brown, W. Clay \| Kuhn, Richard J Patent Number: 10046045 (2018) Cite \| Source
Thiosulfate sulfurtransferase-like domain–containing 1 protein interacts with thioredoxin (journal article) Libiad, Marouane \| Motl, Nicole \| Akey, David L. \| Sakamoto, Naoya \| Fearon, Eric R. \| Smith, Janet L. \| Banerjee, Ruma Journal of Biological Chemistry, volume 293, issue 8, pages 2675-2686 (2018). 10.1074/jbc.RA117.000826 Cited by (47) \| Cite \| Source \| Open Access
Thiosulfate Sulfurtransferase like Domain Containing 1 Protein Interacts with Thioredoxin (journal article) Libiad, Marouane \| Motl, Nicole \| Akey, David L. \| Sakamoto, Naoya \| Fearon, Eric R. \| Smith, Janet L. \| Banerjee, Ruma Journal of Biological Chemistry, volume 293, issue 8, pages 2675-2686 (2018). 10.2210/pdb6bev/pdb Cited by (1) \| Cite \| Source
Extended surface for membrane association in Zika virus NS1 structure (journal article) Brown, W Clay \| Akey, David L \| Konwerski, Jamie R \| Tarrasch, Jeffrey T \| Skiniotis, Georgios \| Kuhn, Richard J \| Smith, Janet L Nature Structural & Molecular Biology, volume 23, issue 9, pages 865-867 (2016). 10.1038/nsmb.3268 Cited by (134) \| Cite \| Source \| Open Access
Can I solve my structure by SAD phasing? Planning an experiment, scaling data and evaluating the useful anomalous correlation and anomalous signal (journal article) Terwilliger, Thomas C. \| Bunkóczi, Gábor \| Hung, Li-Wei \| Zwart, Peter H. \| Smith, Janet L. \| Akey, David L. \| Adams, Paul D. Acta Crystallographica Section D Structural Biology, volume 72, issue 3, pages 359-374 (2016). 10.1107/S2059798315019403 Cited by (24) \| Cite \| Source \| Open Access
Can I solve my structure by SAD phasing? Anomalous signal in SAD phasing (journal article) Terwilliger, Thomas C. \| Bunkóczi, Gábor \| Hung, Li-Wei \| Zwart, Peter H. \| Smith, Janet L. \| Akey, David L. \| Adams, Paul D. Acta Crystallographica Section D Structural Biology, volume 72, issue 3, pages 346-358 (2016). 10.1107/S2059798315019269 Cited by (31) \| Cite \| Source \| Open Access
Efficient merging of data from multiple samples for determination of anomalous substructure (journal article) Akey, David L. \| Terwilliger, Thomas C. \| Smith, Janet L. Acta Crystallographica Section D Structural Biology, volume 72, issue 3, pages 296-302 (2016). 10.1107/S2059798315021920 Cited by (12) \| Cite \| Source \| Open Access
Context-Dependent Cleavage of the Capsid Protein by the West Nile Virus Protease Modulates the Efficiency of Virus Assembly (journal article) VanBlargan, Laura A. \| Davis, Kaitlin A. \| Dowd, Kimberly A. \| Akey, David L. \| Smith, Janet L. \| Pierson, Theodore C. Journal of Virology, volume 89, issue 16, pages 8632-8642 (2015). 10.1128/JVI.01253-15 Cited by (16) \| Cite \| Source \| Open Access
Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O -Methyltransferases. (journal article) Bernard, Steffen M. \| Akey, David L. \| Tripathi, Ashootosh \| Park, Sung Ryeol \| Konwerski, Jamie R. \| Anzai, Yojiro \| Li, Shengying \| Kato, Fumio \| Sherman, David H. \| Smith, Janet L. ACS Chemical Biology, volume 10, issue 5, pages 1340-1351 (2015). 10.1021/cb5009348 Cited by (9) \| Cite \| Source \| Open Access
Structure‐guided insights on the role of NS1 in flavivirus infection (journal article) Akey, David L. \| Brown, W.Clay \| Jose, Joyce \| Kuhn, Richard J. \| Smith, Janet L. BioEssays, volume 37, issue 5, pages 489-494 (2015). 10.1002/bies.201400182 Cited by (56) \| Cite \| Source \| Open Access
Use of massively multiple merged data for low-resolution S-SAD phasing and refinement of flavivirus NS1 (journal article) Akey, David L. \| Brown, W. Clay \| Konwerski, Jamie R. \| Ogata, Craig M. \| Smith, Janet L. Acta Crystallographica Section D Biological Crystallography, volume 70, issue 10, pages 2719-2729 (2014). 10.1107/S1399004714017556 Cited by (29) \| Cite \| Source \| Open Access
Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System (journal article) Akey, David L. \| Brown, W. Clay \| Dutta, Somnath \| Konwerski, Jamie \| Jose, Joyce \| Jurkiw, Thomas J. \| DelProposto, James \| Ogata, Craig M. \| Skiniotis, Georgios \| Kuhn, Richard J. \| Smith, Janet L. Science, volume 343, issue 6173, pages 881-885 (2014). 10.1126/science.1247749 Cited by (311) \| Cite \| Source \| Open Access
Biochemical and Structural Characterization of Germicidin Synthase: Analysis of a Type III Polyketide Synthase That Employs Acyl-ACP as a Starter Unit Donor (journal article) Chemler, Joseph A. \| Buchholz, Tonia J. \| Geders, Todd W. \| Akey, David L. \| Rath, Christopher M. \| Chlipala, George E. \| Smith, Janet L. \| Sherman, David H. Journal of the American Chemical Society, volume 134, issue 17, pages 7359-7366 (2012). 10.1021/ja2112228 Cited by (49) \| Cite \| Source \| Open Access
Insights from the sea: Structural biology of marine polyketide synthases (journal article) Akey, David L. \| Gehret, Jennifer J. \| Khare, Dheeraj \| Smith, Janet L. Natural Product Reports, volume 29, issue 10, pages 1038- (2012). 10.1039/c2np20016c Cited by (21) \| Cite \| Source \| Open Access
A New Structural Form in the SAM/Metal-Dependent O-Methyltransferase Family: MycE from the Mycinamicin Biosynthetic Pathway (journal article) Akey, David L. \| Li, Shengying \| Konwerski, Jamie R. \| Confer, Laura A. \| Bernard, Steffen M. \| Anzai, Yojiro \| Kato, Fumio \| Sherman, David H. \| Smith, Janet L. Journal of Molecular Biology, volume 413, issue 2, pages 438-450 (2011). 10.1016/j.jmb.2011.08.040 Cited by (23) \| Cite \| Source \| Open Access