Michael A. Brehm

ScholarGPS® ID: 88686812226660

Affiliation

University of Massachusetts Medical School, Worcester, United States

Affiliation History

Field

Life Sciences

Discipline

Molecular and Cell Biology

Top Specialties

Metrics Summary

Publication Count

220

Predicted Citations

20,296

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance (journal article) O’Connor, Kevin W. \| Kishimoto, Kensei \| Kuzma, Irena O. \| Wagner, Kelsey P. \| Selway, Jonathan S. \| Roderick, Justine E. \| Karna, Keshab K. \| Gallagher, Kayleigh M. \| Hu, Kai \| Liu, Haibo \| ... \| Kelliher, Michelle A. Leukemia, volume 38, issue 5, pages 951-962 (2024). 10.1038/s41375-024-02232-8 Cited by (1) \| Cite \| Source
Nuclear factor kappa B-dependent persistence of Salmonella Typhi and Paratyphi in human macrophages (journal article) Stepien, Taylor A. \| Singletary, Larissa A. \| Guerra, Fermin E. \| Karlinsey, Joyce E. \| Libby, Stephen J. \| Jaslow, Sarah L. \| Gaggioli, Margaret R. \| Gibbs, Kyle D. \| Ko, Dennis C. \| Brehm, Michael A. \| ... \| Fang, Ferric C. mBio, volume 15, issue 4 (2024). 10.1128/mbio.00454-24 Cited by (1) \| Cite \| Source
CDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis (journal article) Nayyar, Naema \| de Sauvage, Magali A. \| Chuprin, Jane \| Sullivan, Emily M. \| Singh, Mohini \| Torrini, Consuelo \| Zhang, Britney S. \| Bandyopadhyay, Sushobhana \| Daniels, Keith A. \| Alvarez-Breckenridge, Christopher \| ... \| Brastianos, Priscilla K. Clinical Cancer Research, volume 30, issue 2, pages 420-435 (2024). 10.1158/1078-0432.CCR-23-0433 Cited by (4) \| Cite \| Source
PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages (journal article) Kauffman, Kevin \| Manfra, Denise \| Nowakowska, Dominika \| Zafari, Mohammad \| Nguyen, Phuong A. \| Phennicie, Ryan \| Vollmann, Elisabeth H. \| O'Nuallain, Brian \| Basinski, Sara \| Komoroski, Veronica \| ... \| Novobrantseva, Tatiana I. Cancer Research Communications, volume 3, issue 10, pages 2182-2194 (2023). 10.1158/2767-9764.CRC-22-0513 Cited by (3) \| Cite \| Source
Generation and molecular characterization of human pluripotent stem cell-derived pharyngeal foregut endoderm (journal article) Kearns, Nicola A. \| Lobo, Macrina \| Genga, Ryan M.J. \| Abramowitz, Ryan G. \| Parsi, Krishna M. \| Min, Jiang \| Kernfeld, Eric M. \| Huey, Jack D. \| Kady, Jamie \| Hennessy, Erica \| ... \| Maehr, René Developmental Cell, volume 58, issue 18, pages 1801-1818.e15 (2023). 10.1016/j.devcel.2023.08.024 Cited by (1) \| Cite \| Source
Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV ‐1 pathogenesis (journal article) Wang, Yetao \| Lifshitz, Lawrence \| Silverstein, Noah J \| Mintzer, Esther \| Luk, Kevin \| StLouis, Pamela \| Brehm, Michael A \| Wolfe, Scot A \| Deeks, Steven G \| Luban, Jeremy The EMBO Journal, volume 42, issue 16 (2023). 10.15252/embj.2023114153 Cited by (4) \| Cite \| Source
Generation of the NeoThy mouse model for human immune system studies (journal article) Del Rio, Natalia M. \| Huang, Liupei \| Murphy, Lydia \| Babu, Jayalaxmi Suresh \| Daffada, Cross Matthew \| Haynes, William John \| Keck, James G. \| Brehm, Michael. A. \| Shultz, Leonard D. \| Brown, Matthew E. Lab Animal, volume 52, issue 7, pages 149-168 (2023). 10.1038/s41684-023-01196-z Cite \| Source
Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response (journal article) Doloff, Joshua C. \| Ma, Minglin \| Sadraei, Atieh \| Tam, Hok Hei \| Farah, Shady \| Hollister-Lock, Jennifer \| Vegas, Arturo J. \| Veiseh, Omid \| Quiroz, Victor M. \| Rakoski, Amanda \| ... \| Anderson, Daniel G. Science Advances, volume 9, issue 24 (2023). 10.1126/sciadv.ade9488 Cited by (8) \| Cite \| Source
Simultaneous evaluation of treatment efficacy and toxicity for bispecific T‐cell engager therapeutics in a humanized mouse model (journal article) Yang, Jiwon \| Jiao, Jing \| Draheim, Kyle M. \| Yang, Guoxiang \| Yang, Hongyuan \| Yao, Li‐Chin \| Shultz, Leonard D. \| Greiner, Dale L. \| Rajagopal, Deepa \| Vessillier, Sandrine \| ... \| Keck, James G. The FASEB Journal, volume 37, issue 6 (2023). 10.1096/fj.202300040R Cited by (2) \| Cite \| Source
Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer (journal article) Wang, Mengdie \| Wisniewski, Christi A. \| Xiong, Choua \| Chhoy, Peter \| Goel, Hira Lal \| Kumar, Ayush \| Zhu, Lihua Julie \| Li, Rui \| St. Louis, Pamela A. \| Ferreira, Lindsay M. \| ... \| Mercurio, Arthur M. Science Translational Medicine, volume 15, issue 694 (2023). 10.1126/scitranslmed.ade5855 Cited by (12) \| Cite \| Source
NOD- scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity (journal article) Aryee, Ken-Edwin \| Shultz, Leonard D \| Burzenski, Lisa M \| Greiner, Dale L \| Brehm, Michael A Journal of Leukocyte Biology, volume 113, issue 5, pages 418-433 (2023). 10.1093/jleuko/qiac020 Cited by (1) \| Cite \| Source
I-Ag7 β56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes (journal article) Stadinski, Brian D. \| Cleveland, Sarah B. \| Brehm, Michael A. \| Greiner, Dale L. \| Huseby, Priya G. \| Huseby, Eric S. Nature Immunology, volume 24, issue 4, pages 652-663 (2023). 10.1038/s41590-023-01441-0 Cited by (3) \| Cite \| Source
Humanized mouse models for immuno-oncology research (journal article) Chuprin, Jane \| Buettner, Hannah \| Seedhom, Mina O. \| Greiner, Dale L. \| Keck, James G. \| Ishikawa, Fumihiko \| Shultz, Leonard D. \| Brehm, Michael A. Nature Reviews Clinical Oncology, volume 20, issue 3, pages 192-206 (2023). 10.1038/s41571-022-00721-2 Cited by (84) \| Cite \| Source
202.1: Pancreatic islets from genetically altered porcine donors are metabolically competent and cure diabetes in mice post xenotransplantation (journal article) Kalekar, Lucky \| Perrat, Paola N \| Grosh, David M \| Lougee Rodriguez, William F \| Pearce, Owen J \| Policastro, Robert A \| Waltzer, Leo \| Akkad, Adam \| Pandelakis, Matthew \| Esch, Nicholas M \| ... \| Youd, Michele E Transplantation, volume 107, issue 10S2, pages 39-39 (2023). 10.1097/01.tp.0000993944.30236.5d Cite \| Source
DR-01, a Non-Fucosylated Anti-CD94 Antibody, Depletes Leukemic Cells in Ex Vivo and In Vivo Models of Large Granular Lymphocyte Leukemia (journal article) Shi, Kelly \| Tan, Cindy \| Bai, Lu \| Richardson, Jennifer \| Deng, Andy \| Will, Matthias \| Brehm, Michael \| Greiner, Dale \| Shultz, Leonard \| Teramo, Antonella \| ... \| Tomasevic, Nenad Blood, volume 140, issue Supplement 1, pages 2259-2260 (2022). 10.1182/blood-2022-159242 Cited by (1) \| Cite \| Source
Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells (journal article) Schanin, Julia \| Korver, Wouter \| Brock, Emily C. \| Leung, John \| Benet, Zachary \| Luu, Thuy \| Chang, Katherine \| Xu, Alan \| De Freitas, Naomi \| Luehrsen, Kenneth \| ... \| Youngblood, Bradford A. Communications Biology, volume 5, issue 1 (2022). 10.1038/s42003-022-04207-w Cited by (8) \| Cite \| Source
Enhanced development of functional human NK cells in NOD‐ mice expressing human IL15 (journal article) Aryee, Ken‐Edwin \| Burzenski, Lisa M. \| Yao, Li‐Chin \| Keck, James G. \| Greiner, Dale L. \| Shultz, Leonard D. \| Brehm, Michael A. The FASEB Journal, volume 36, issue 9 (2022). 10.1096/fj.202200045R Cited by (22) \| Cite \| Source
Analysis of Salmonella Typhi Pathogenesis in a Humanized Mouse Model (book chapter) In Bacterial Virulence Stepien, Taylor A. \| Libby, Stephen J. \| Karlinsey, Joyce E. \| Brehm, Michael A. \| Greiner, Dale L. \| Shultz, Leonard D. \| Brabb, Thea \| Fang, Ferric C. Springer US (2022) 10.1007/978-1-0716-1971-1_18 Cited by (1) \| Cite \| Source
877 PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth (conference) Nguyen, Phuong \| Ritter, Jessica \| Zafari, Mohammad \| Manfra, Denise \| Komoroski, Veronica \| O’Nuallain, Brian \| Phennicie, Ryan \| Kauffman, Kevin \| Nowakowska, Dominika \| Wahle, Joe \| ... \| Novobrantseva, Tatiana SITC 36th Anniversary Annual Meeting (SITC 2021) Abstracts (2021) 10.1136/jitc-2021-SITC2021.877 Cited by (1) \| Cite \| Source
Noninvasive Determination of CMV Serostatus From Dried Buccal Swab Samples: Assay Development, Validation, and Application to 1.2 Million Samples (journal article) Behrens, Geoffrey A \| Brehm, Michael \| Groß, Rita \| Heider, Jana \| Sauter, Jürgen \| Baier, Daniel M \| Wehde, Tatjana \| Castriciano, Santina \| Schmidt, Alexander H \| Lange, Vinzenz The Journal of Infectious Diseases, volume 224, issue 7, pages 1152-1159 (2021). 10.1093/infdis/jiaa067 Cited by (5) \| Cite \| Source

Title	Investigators	Year	Cost	Agency
Humanized mice for investigating human stem cell-derived microglia in Alzheimers Disease	Brehm, Michael Allen \| Greiner, Dale Leslie \| Shultz, Leonard	2020	$420,750	OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
Humanized Mouse Avatars for T1D	Brehm, Michael Allen \| Daley, George Q \| Greiner, Dale Leslie \| Kent, Sally Choate \| Maehr, Rene \| Melton, Douglas A \| Shultz, Leonard	2020	$1,011,466	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Immunogenicity of Human Stem Cell-Derived Beta Cells and Muscle Cells in Humanized Mice	Brehm, Michael Allen \| Emerson, Charles P. \| Greiner, Dale Leslie \| Luban, Jeremy \| Shultz, Leonard	2020	$823,750	OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
Novel humanized mouse model developed from cord blood CD34 positive HSC and autologous iPS cell derived thymus	Brehm, Michael Allen \| Maehr, Rene \| Shultz, Leonard	2020	$782,684	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Humanized Mouse Avatars for T1D	Brehm, Michael Allen \| Daley, George Q \| Greiner, Dale Leslie \| Kent, Sally Choate \| Maehr, Rene \| Melton, Douglas A \| Shultz, Leonard	2019	$1,064,644	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Immunogenicity of Human Stem Cell-Derived Beta Cells and Muscle Cells in Humanized Mice	Brehm, Michael Allen \| Emerson, Charles P. \| Greiner, Dale Leslie \| Luban, Jeremy \| Shultz, Leonard	2019	$840,625	OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
Novel humanized mouse model developed from cord blood CD34 positive HSC and autologous iPS cell derived thymus	Brehm, Michael Allen \| Maehr, Rene \| Shultz, Leonard	2019	$1,212,059	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Novel humanized mouse model developed from cord blood CD34 positive HSC and autologous iPS cell derived thymus	Brehm, Michael Allen \| Maehr, Rene \| Shultz, Leonard	2018	$782,684	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Novel humanized mouse model developed from cord blood CD34 positive HSC and autologous iPS cell derived thymus	Brehm, Michael Allen \| Maehr, Rene \| Shultz, Leonard	2017	$799,559	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Development and Validation of Novel NSG Mouse Models for Human Stem Cell Therapy	Brehm, Michael Allen \| Greiner, Dale Leslie \| Mueller, Christian	2017	$725,922	OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
Development and Validation of Novel NSG Mouse Models for Human Stem Cell Therapy	Mueller, Christian \| Greiner, DALE LESLIE (contact) \| Brehm, Michael Allen	2016	$764,128	OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
Development and Validation of Novel NSG Mouse Models for Human Stem Cell Therapy	Mueller, Christian \| Greiner, DALE LESLIE (contact) \| Brehm, Michael Allen	2015	$748,845	OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
Retrogenic humanized mice for the study of T1D	Greiner, DALE LESLIE (contact) \| Shultz, Leonard \| Brehm, Michael Allen	2015	$213,125	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Humanized Mouse Avatars for T1D	Greiner, DALE LESLIE (contact) \| Rossi, Derrick J. \| Melton, Douglas A \| Shultz, Leonard \| Brehm, Michael Allen	2014	$4,109,951	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Retrogenic humanized mice for the study of T1D	Greiner, DALE LESLIE (contact) \| Shultz, Leonard \| Brehm, Michael Allen	2014	$271,354	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Development and Validation of Novel NSG Mouse Models for Human Stem Cell Therapy	Mueller, Christian \| Greiner, DALE LESLIE (contact) \| Brehm, Michael Allen	2014	$780,422	OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
Virology and Technology Core	Brehm, Michael Allen	2014	$137,760	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Virology and Technology Core	Brehm, Michael Allen	2013	$103,295	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Virology and Technology Core	Brehm, Michael Allen	2012	$114,574	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Virology and Technology Core	Brehm, Michael Allen	2011	$181,251	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Virology and Technology Core	Brehm, Michael Allen	2010	$183,393	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Regulation of Virus-Specific T cell Responses by TNF	Brehm, Michael Allen	2010	$205,573	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Regulation of Virus-Specific T cell Responses by TNF	Brehm, Michael Allen	2009	$245,938	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES