Michael J. Orsini

ScholarGPS® ID: 88568602539598

Affiliation
Bristol-Myers Squibb Company, New York, United States
Affiliation History

Field
Life Sciences
Discipline
Biochemistry
Top Specialties
Medicinal Chemistry | HIV | Receptor-mediated Endocytosis | Adrenergic Receptor
Metrics Summary
Publication Count
36
Predicted Citations
2,224
Predicted h-index
21
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Three strikes and research is out (journal article)
Orsini, Michael J.
Science, volume 352, issue 6289, pages 1138-1138 (2016).
10.1126/science.352.6289.1138
Cite | Source | Open Access
A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety (journal article)
Ross, Tina Morgan | Battista, Kathleen | Bignan, Gilles C. | Brenneman, Doug E. | Connolly, Peter J. | Liu, Jingchun | Middleton, Steven A. | Orsini, Michael | Reitz, Allen B. | Rosenthal, Dan I. | ... | Vaidya, Anil H.
Bioorganic & Medicinal Chemistry Letters, volume 25, issue 3, pages 602-606 (2015).
10.1016/j.bmcl.2014.12.015
Cited by (14) | Cite | Source
Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders (patent)
Battista, Kathleen | Bignan, Gilles | Connolly, Peter J. | Reitz, Allen B. | Ross, Tina Morgan | Scott, Malcolm | Middleton, Steven A. | Orsini, Michael
Patent Number: 8778956 (2014)
Cited by (2) | Cite | Source
Design, Synthesis, and Structure−Activity Relationships of Novel Bicyclic Azole-amines as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (journal article)
Burdi, Douglas F. | Hunt, Rachel | Fan, Lei | Hu, Tao | Wang, Jun | Guo, Zihong | Huang, Zhiqiang | Wu, Chengde | Hardy, Larry | Detheux, Michel | ... | Spear, Kerry
Journal of Medicinal Chemistry, volume 53, issue 19, pages 7107-7118 (2010).
10.1021/jm100736h
Cited by (25) | Cite | Source
3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators (patent)
Battista, Kathleen A. | Bignan, Gilles C. | Connolly, Peter J. | Liu, Jessica J. | Middleton, Steven A. | Orsini, Michael J.
Patent Number: 7655670 (2010)
Cited by (5) | Cite | Source
Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders (patent)
Battista, Kathleen | Bignan, Gilles | Connolly, Peter J. | Reitz, Allen B. | Ross, Tina Morgan | Scott, Malcolm | Middleton, Steven A. | Orsini, Michael
Patent Number: 7582649 (2009)
Cited by (5) | Cite | Source
Identifying Nonselective Hits from a Homogeneous Calcium Assay Screen (journal article)
Cassutt, Kelly J. | Orsini, Michael J. | Abousleiman, Mojgan | Colone, Dean | Tang, Weimin
SLAS Discovery, volume 12, issue 2, pages 285-287 (2007).
10.1177/1087057106298538
Cited by (11) | Cite | Source | Open Access
Metastin (KiSS-1) Mimetics Identified from Peptide Structure−Activity Relationship-Derived Pharmacophores and Directed Small Molecule Database Screening (journal article)
Orsini, Michael J. | Klein, Mark A. | Beavers, Mary Pat | Connolly, Peter J. | Middleton, Steven A. | Mayo, Kevin H.
Journal of Medicinal Chemistry, volume 50, issue 3, pages 462-471 (2007).
10.1021/jm0609824
Cited by (69) | Cite | Source
3‐(4‐Piperidinyl)indoles and 3‐(4‐Piperidinyl)pyrrolo[2,3‐b]pyridines as Ligands for the ORL‐1 Receptor. (journal article)
Bignan, Gilles C. | Battista, Kathleen | Connolly, Peter J. | Orsini, Michael J. | Liu, Jingchun | Middleton, Steven A. | Reitz, Allen B.
ChemInform, volume 37, issue 44 (2006).
10.1002/chin.200644206
Cite | Source
Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders (patent)
Battista, Kathleen | Bignan, Gilles | Connolly, Peter J. | Reitz, Allen B. | Ross, Tina Morgan | Scott, Malcolm | Middleton, Steven A. | Orsini, Michael
Patent Number: 7081463 (2006)
Cited by (5) | Cite | Source
3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor (journal article)
Bignan, Gilles C. | Battista, Kathleen | Connolly, Peter J. | Orsini, Michael J. | Liu, Jingchun | Middleton, Steven A. | Reitz, Allen B.
Bioorganic & Medicinal Chemistry Letters, volume 16, issue 13, pages 3524-3528 (2006).
10.1016/j.bmcl.2006.03.094
Cited by (16) | Cite | Source
Preparation of 3‐Spirocyclic Indolin‐2‐ones as Ligands for the ORL‐1 Receptor. (journal article)
Bignan, Gilles C. | Battista, Kathleen | Connolly, Peter J. | Orsini, Michael J. | Liu, Jingchun | Middleton, Steven A. | Reitz, Allen B.
ChemInform, volume 37, issue 8 (2006).
10.1002/chin.200608218
Cite | Source
8-(Heteroaryl)phenalkyl-1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-ones as Opioid Receptor Modulators (journal article)
Jordan, A. | Orsini, M. | Middleton, S. | Connolly, P. | Brenneman, D. | Pan, K. | Reitz, A.
Medicinal Chemistry, volume 1, issue 6, pages 601-610 (2005).
10.2174/157340605774598207
Cited by (5) | Cite | Source
Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor (journal article)
Bignan, Gilles C. | Battista, Kathleen | Connolly, Peter J. | Orsini, Michael J. | Liu, Jingchun | Middleton, Steven A. | Reitz, Allen B.
Bioorganic & Medicinal Chemistry Letters, volume 15, issue 22, pages 5022-5026 (2005).
10.1016/j.bmcl.2005.08.009
Cited by (78) | Cite | Source
Pharmacophores for nociceptin, methods of obtaining and using in screening for nociceptin mimics (patent)
Mayo, Kevin H. | Beavers, Mary Pat | Orsini, Michael J. | Middleton, Steven A. | Connolly, Peter J.
Patent Number: 20050266575 (2005)
Cite | Source
The Nociceptin Pharmacophore Site for Opioid Receptor Binding Derived from the NMR Structure and Bioactivity Relationships (journal article)
Orsini, Michael J. | Nesmelova, Irina | Young, Helen C. | Hargittai, Balazs | Beavers, Mary Pat | Liu, Jingchun | Connolly, Peter J. | Middleton, Steven A. | Mayo, Kevin H.
Journal of Biological Chemistry, volume 280, issue 9, pages 8134-8142 (2005).
10.1074/jbc.M406405200
Cited by (27) | Cite | Source | Open Access
Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial κ-opioid agonist effect (journal article)
Creighton, Christopher J | Ramabadran, Kris | Ciccone, Patrick E | Liu, Jingchun | Orsini, Michael J | Reitz, Allen B
Bioorganic & Medicinal Chemistry Letters, volume 14, issue 15, pages 4083-4085 (2004).
10.1016/j.bmcl.2004.05.018
Cited by (20) | Cite | Source
Mechanisms of Proliferation Synergy by Receptor Tyrosine Kinase and G Protein–Coupled Receptor Activation in Human Airway Smooth Muscle (journal article)
Krymskaya, Vera P. | Orsini, Michael J. | Eszterhas, Andrew J. | Brodbeck, Kristin C. | Benovic, Jeffrey L. | Panettieri, Reynold A. | Penn, Raymond B.
American Journal of Respiratory Cell and Molecular Biology, volume 23, issue 4, pages 546-554 (2000).
10.1165/ajrcmb.23.4.4115
Cited by (119) | Cite | Source
Trafficking of the HIV coreceptor CXCR4: Role of arrestins and identification of residues in the C-terminal tail that mediate receptor internalization. (journal article)
Orsini, Michael J. | Parent, Jean-Luc | Mundell, Stuart J. | Marchese, Adriano | Benovic, Jeffrey L.
Journal of Biological Chemistry, volume 275, issue 33, pages 25876- (2000).
10.1016/S0021-9258(19)62160-5
Cited by (15) | Cite | Source
Trafficking of the HIV Coreceptor CXCR4 (journal article)
Orsini, Michael J. | Parent, Jean-Luc | Mundell, Stuart J. | Benovic, Jeffrey L.
Journal of Biological Chemistry, volume 274, issue 43, pages 31076-31086 (1999).
10.1074/jbc.274.43.31076
Cited by (229) | Cite | Source | Open Access