Paolo A. Centrella

ScholarGPS® ID: 86082034353166

Affiliation
GlaxoSmithKline plc, London
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
DNA | Medicinal Chemistry | Mycobacterium Tuberculosis
Metrics Summary
Publication Count
26
Predicted Citations
1,263
Predicted h-index
17
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry (journal article)
Guilinger, John P. | Archna, Archna | Augustin, Martin | Bergmann, Andreas | Centrella, Paolo A. | Clark, Matthew A. | Cuozzo, John W. | Däther, Maike | Guié, Marie-Aude | Habeshian, Sevan | ... | Keefe, Anthony D.
Bioorganic & Medicinal Chemistry, volume 42 (2021).
10.1016/j.bmc.2021.116223
Cited by (21) | Cite | Source
Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT) (journal article)
Ding, Yun | Belyanskaya, Svetlana | DeLorey, Jennifer L. | Messer, Jeffrey A. | Joseph Franklin, G. | Centrella, Paolo A. | Morgan, Barry A. | Clark, Matthew A. | Skinner, Steven R. | Dodson, Jason W. | ... | Israel, David I.
Bioorganic & Medicinal Chemistry, volume 41 (2021).
10.1016/j.bmc.2021.116216
Cited by (19) | Cite | Source
Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening (journal article)
Lee, Esther C. Y. | McRiner, Andrew J. | Georgiadis, Katy E. | Liu, Julie | Wang, Zooey | Ferguson, Andrew D. | Levin, Benjamin | von Rechenberg, Moritz | Hupp, Christopher D. | Monteiro, Michael I. | ... | Kohlmann, Anna
Journal of Medicinal Chemistry, volume 64, issue 10, pages 6730-6744 (2021).
10.1021/acs.jmedchem.0c02271
Cited by (12) | Cite | Source
Methods for tagging DNA-encoded libraries (patent)
Keefe, Anthony D. | Wagner, Richard W. | Litovchick, Alexander | Clark, Matthew | Cuozzo, John W. | Zhang, Ying | Centrella, Paolo A. | Hupp, Christopher D.
Patent Number: 10865409 (2020)
Cite | Source
Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry (journal article)
Litovchick, Alexander | Tian, Xia | Monteiro, Michael I. | Kennedy, Kaitlyn M. | Guié, Marie-Aude | Centrella, Paolo | Zhang, Ying | Clark, Matthew A. | Keefe, Anthony D.
Molecules, volume 24, issue 10, pages 2026- (2019).
10.3390/molecules24102026
Cited by (26) | Cite | Source
Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target (journal article)
Brown, Dean G. | Brown, Giles A. | Centrella, Paolo | Certel, Kaan | Cooke, Robert M. | Cuozzo, John W. | Dekker, Niek | Dumelin, Christoph E. | Ferguson, Andrew | Fiez-Vandal, Cédric | ... | Clark, Matthew A.
SLAS Discovery, volume 23, issue 5, pages 429-436 (2018).
10.1177/2472555217749847
Cited by (39) | Cite | Source
Development and Synthesis of DNA-Encoded Benzimidazole Library (journal article)
Ding, Yun | Chai, Jing | Centrella, Paolo A. | Gondo, Chenaimwoyo | DeLorey, Jennifer L. | Clark, Matthew A.
ACS Combinatorial Science, volume 20, issue 5, pages 251-255 (2018).
10.1021/acscombsci.8b00009
Cited by (41) | Cite | Source
Inside Cover: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library (ChemBioChem 9/2017) (journal article)
Cuozzo, John W. | Centrella, Paolo A. | Gikunju, Diana | Habeshian, Sevan | Hupp, Christopher D. | Keefe, Anthony D. | Sigel, Eric A. | Soutter, Holly H. | Thomson, Heather A. | Zhang, Ying | Clark, Matthew A.
ChemBioChem, volume 18, issue 9, pages 826-826 (2017).
10.1002/cbic.201700180
Cite | Source | Open Access
Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library (journal article)
Cuozzo, John W. | Centrella, Paolo A. | Gikunju, Diana | Habeshian, Sevan | Hupp, Christopher D. | Keefe, Anthony D. | Sigel, Eric A. | Soutter, Holly H. | Thomson, Heather A. | Zhang, Ying | Clark, Matthew A.
ChemBioChem, volume 18, issue 9, pages 864-871 (2017).
10.1002/cbic.201600573
Cited by (63) | Cite | Source
Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology (journal article)
Soutter, Holly H. | Centrella, Paolo | Clark, Matthew A. | Cuozzo, John W. | Dumelin, Christoph E. | Guie, Marie-Aude | Habeshian, Sevan | Keefe, Anthony D. | Kennedy, Kaitlyn M. | Sigel, Eric A. | ... | Read, Jon A.
Proceedings of the National Academy of Sciences, volume 113, issue 49 (2016).
10.1073/pnas.1610978113
Cited by (49) | Cite | Source | Open Access
Design and Synthesis of Biaryl DNA-Encoded Libraries (journal article)
Ding, Yun | Franklin, G. Joseph | DeLorey, Jennifer L. | Centrella, Paolo A. | Mataruse, Sibongile | Clark, Matthew A. | Skinner, Steven R. | Belyanskaya, Svetlana
ACS Combinatorial Science, volume 18, issue 10, pages 625-629 (2016).
10.1021/acscombsci.6b00078
Cited by (53) | Cite | Source
Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor (journal article)
Wu, Zining | Graybill, Todd L. | Zeng, Xin | Platchek, Michael | Zhang, Jean | Bodmer, Vera Q. | Wisnoski, David D. | Deng, Jianghe | Coppo, Frank T. | Yao, Gang | ... | Israel, David I.
ACS Combinatorial Science, volume 17, issue 12, pages 722-731 (2015).
10.1021/acscombsci.5b00124
Cited by (106) | Cite | Source
Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library (journal article)
Litovchick, Alexander | Dumelin, Christoph E. | Habeshian, Sevan | Gikunju, Diana | Guié, Marie-Aude | Centrella, Paolo | Zhang, Ying | Sigel, Eric A. | Cuozzo, John W. | Keefe, Anthony D. | Clark, Matthew A.
Scientific Reports, volume 5, issue 1 (2015).
10.1038/srep10916
Cited by (94) | Cite | Source | Open Access
Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT) (journal article)
Yang, Hongfang | Medeiros, Patricia F. | Raha, Kaushik | Elkins, Patricia | Lind, Kenneth E. | Lehr, Ruth | Adams, Nicholas D. | Burgess, Joelle L. | Schmidt, Stanley J. | Knight, Steven D. | ... | Evindar, Ghotas
ACS Medicinal Chemistry Letters, volume 6, issue 5, pages 531-536 (2015).
10.1021/acsmedchemlett.5b00025
Cited by (61) | Cite | Source | Open Access
Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA (journal article)
Encinas, Lourdes | O’Keefe, Heather | Neu, Margarete | Remuiñán, Modesto J. | Patel, Amish M. | Guardia, Ana | Davie, Christopher P. | Pérez-Macías, Natalia | Yang, Hongfang | Convery, Maire A. | ... | Evindar, Ghotas
Journal of Medicinal Chemistry, volume 57, issue 4, pages 1276-1288 (2014).
10.1021/jm401326j
Cited by (103) | Cite | Source | Open Access
Methods for synthesis of encoded libraries (patent)
Morgan, Barry | Arico-Muendel, Christopher C. | Israel, David I. | Benjamin, Dennis | Franklin, George J. | Kavarana, Malcolm J. | Gefter, Malcolm L. | Clark, Matthew | Hansen, Nils Jakob Vest | Centrella, Paolo A. | ... | Hale, Stephen
Patent Number: 8598089 (2013)
Cite | Source
Orally Active Fumagillin Analogues: Transformations of a Reactive Warhead in the Gastric Environment (journal article)
Arico-Muendel, Christopher C. | Blanchette, Heather | Benjamin, Dennis R. | Caiazzo, Teresa M. | Centrella, Paolo A. | DeLorey, Jennifer | Doyle, Elisabeth G. | Johnson, Steven R. | Labenski, Matthew T. | Morgan, Barry A. | ... | White, Kerry F.
ACS Medicinal Chemistry Letters, volume 4, issue 4, pages 381-386 (2013).
10.1021/ml3003633
Cited by (8) | Cite | Source | Open Access
Methods for synthesis of encoded libraries (patent)
Morgan, Barry | Arico-Muendel, Christopher C. | Israel, David I. | Benjamin, Dennis | Franklin, George J. | Kavarana, Malcolm J. | Gefter, Malcolm L. | Clark, Matthew | Hansen, Nils Jakob Vest | Centrella, Paolo A. | ... | Hale, Stephen
Patent Number: 8410028 (2013)
Cite | Source
Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity (journal article)
Arico-Muendel, Christopher C. | Belanger, Bruce | Benjamin, Dennis | Blanchette, Heather S. | Caiazzo, Teresa M. | Centrella, Paolo A. | DeLorey, Jennifer | Doyle, Elisabeth G. | Gradhand, Ulrike | Griffin, Sarah T. | ... | White, Kerry F.
Drug Metabolism and Disposition, volume 41, issue 4, pages 814-826 (2013).
10.1124/dmd.112.048355
Cited by (10) | Cite | Source | Open Access
Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT) (journal article)
Deng, Hongfeng | O’Keefe, Heather | Davie, Christopher P. | Lind, Kenneth E. | Acharya, Raksha A. | Franklin, G. Joseph | Larkin, Jonathan | Matico, Rosalie | Neeb, Michael | Thompson, Monique M. | ... | Morgan, Barry A.
Journal of Medicinal Chemistry, volume 55, issue 16, pages 7061-7079 (2012).
10.1021/jm300449x
Cited by (129) | Cite | Source