James N. Leonard

ScholarGPS® ID: 85114851030521

Affiliation

Janssen Pharmaceutica

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmacology and Toxicology

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

1,383

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists (journal article) Patch, Raymond J. \| Zhang, Rui \| Edavettal, Suzanne \| Macielag, Mark J. \| Eckardt, Annette J. \| Li, Jiali \| Rives, Marie-Laure \| Edwards, Wilson \| Hinke, Simon A. \| Qiu, Xi \| ... \| Hornby, Pamela European Journal of Medicinal Chemistry, volume 236 (2022). 10.1016/j.ejmech.2022.114330 Cited by (2) \| Cite \| Source
Discovery of a novel series of guanidinebenzoates as gut-restricted enteropeptidase and trypsin dual inhibitors for the treatment of metabolic syndrome (journal article) Zhang, Xuqing \| Zhu, Bin \| Sun, Weimei \| Wang, Mina \| Albarazanji, Kamal \| Ghosh, Brahma \| Cummings, Maxwell \| Lenhard, James \| Leonard, James \| Macielag, Mark \| Lanter, James Bioorganic & Medicinal Chemistry Letters, volume 40 (2021). 10.1016/j.bmcl.2021.127939 Cited by (2) \| Cite \| Source
Renal GPNMB Is Highly Upregulated in Rodent Models of AKI and Is Further Elevated with Pharmacological AMPK Activation (journal article) Qi, Jenson \| Frikke-Schmidt, Henriette \| Muench, German Aleman \| Ma, Li-Jun \| Albarazanji, Kamal \| Skrypnyk, Nataliya \| Devine, Zheng Huang \| Guo, Lili \| Pocai, Alessandro \| Leonard, James Journal of the American Society of Nephrology, volume 32, issue 10S, pages 176-177 (2021). 10.1681/ASN.20213210S1176d Cite \| Source
Immunoglobulins and uses thereof (patent) Macielag, Mark \| Patch, Raymond J. \| Zhang, Rui \| Case, Martin A. \| Wall, Mark J. \| Zhang, Yue-Mei \| Rangwala, Shamina M. \| Leonard, James N. \| Camacho, Raul C. \| Hunter, Michael J. \| ... \| Chi, Ellen Patent Number: 10858413 (2020) Cite \| Source
Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits (journal article) Sun, Weimei \| Zhang, Xuqing \| Cummings, Maxwell D. \| Albarazanji, Kamal \| Wu, Jiejun \| Wang, Mina \| Alexander, Richard \| Zhu, Bin \| Zhang, YueMei \| Leonard, James \| ... \| Lenhard, James Journal of Pharmacology and Experimental Therapeutics, volume 375, issue 3, pages 510-521 (2020). 10.1124/jpet.120.000219 Cited by (14) \| Cite \| Source
Immunoglobulins and uses thereof (patent) Macielag, Mark \| Patch, Raymond J. \| Zhang, Rui \| Case, Martin A. \| Rangwala, Shamina M. \| Leonard, James N. \| Camacho, Raul C. \| Hunter, Michael J. \| D'Aquino, Katharine E. \| Edwards, Wilson \| ... \| Chi, Ellen Patent Number: 10787495 (2020) Cite \| Source
Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide Y receptors (patent) Macielag, Mark \| Patch, Raymond J \| Zhang, Rui \| Case, Martin A \| Rangwala, Shamina M \| Leonard, James N \| Camacho, Raul C \| Hunter, Michael J \| D'Aquino, Katharine E. \| Edwards, Wilson \| ... \| Chi, Ellen Patent Number: 10640544 (2020) Cite \| Source
Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity (journal article) Camacho, Raul C. \| You, Seohee \| D’Aquino, Katharine E. \| Li, Wenyu \| Wang, Yuanping \| Gunnet, Joseph \| Littrell, James \| Qi, Jian Shen \| Kang, Lijuan \| Jian, Wenying \| ... \| Case, Martin A. mAbs, volume 12, issue 1 (2020). 10.1080/19420862.2020.1794687 Cited by (7) \| Cite \| Source
Immunoglobulins and uses thereof (patent) Macielag, Mark \| Patch, Raymond J \| Zhang, Rui \| Case, Martin A \| Rangwala, Shamina M \| Leonard, James N \| Camacho, Raul C \| Hunter, Michael J \| D'Aquino, Katharine E. \| Edwards, Wilson \| ... \| Chi, Ellen Patent Number: 10428134 (2019) Cited by (2) \| Cite \| Source
6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1 ) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity (journal article) Zhang, Yue-Mei \| Greco, Michael N. \| Macielag, Mark J. \| Teleha, Christopher A. \| DesJarlais, Renee L. \| Tang, Yuting \| Ho, George \| Hou, Cuifen \| Chen, Cailin \| Zhao, Shuyuan \| ... \| Leonard, James Journal of Medicinal Chemistry, volume 61, issue 22, pages 10276-10298 (2018). 10.1021/acs.jmedchem.8b01467 Cited by (13) \| Cite \| Source
Erratum to “Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes” Bioorg. Med. Chem. Lett. 28 (2018) [841–846] (journal article) Winters, Michael P. \| Sui, Zhihua \| Wall, Mark \| Wang, Yuanping \| Gunnet, Joseph \| Leonard, James \| Hua, Hong \| Yan, Wen \| Suckow, Arthur \| Bell, Austin \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 28, issue 9, pages 1676-1678 (2018). 10.1016/j.bmcl.2018.03.053 Cite \| Source
Discovery of N -arylpyrroles as agonists of GPR120 for the treatment of type II diabetes (journal article) Winters, Michael P. \| Sui, Zhihua \| Wall, Mark \| Wang, Yuanping \| Gunnet, Joseph \| Leonard, James \| Hua, Hong \| Yan, Wen \| Suckow, Arthur \| Bell, Austin \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 28, issue 5, pages 841-846 (2018). 10.1016/j.bmcl.2018.02.013 Cited by (16) \| Cite \| Source
Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes (journal article) Zhang, Xuqing \| Cai, Chaozhong \| Sui, Zhihua \| Macielag, Mark \| Wang, Yuanping \| Yan, Wen \| Suckow, Arthur \| Hua, Hong \| Bell, Austin \| Haug, Peter \| ... \| Murray, William V. ACS Medicinal Chemistry Letters, volume 8, issue 9, pages 947-952 (2017). 10.1021/acsmedchemlett.7b00233 Cited by (18) \| Cite \| Source
Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists (journal article) Zhang, Xuqing \| Cai, Chaozhong \| Winters, Michael \| Wells, Michele \| Wall, Mark \| Lanter, James \| Sui, Zhihua \| Ma, Jingyuan \| Novack, Aaron \| Nashashibi, Imad \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 27, issue 15, pages 3272-3278 (2017). 10.1016/j.bmcl.2017.06.028 Cited by (19) \| Cite \| Source
Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series (journal article) Han, Sangdon \| Narayanan, Sanju \| Kim, Sun Hee \| Calderon, Imelda \| Zhu, Xiuwen \| Kawasaki, Andrew \| Yue, Dawei \| Lehmann, Juerg \| Wong, Amy \| Buzard, Daniel J. \| ... \| Jones, Robert M. Bioorganic & Medicinal Chemistry Letters, volume 25, issue 15, pages 3034-3038 (2015). 10.1016/j.bmcl.2015.04.102 Cited by (8) \| Cite \| Source
Method of screening for compounds useful in the treatment of insulin resistance, impaired glucose tolerance or diabetes (patent) Leonard, James N. \| Hakak, Yaron Patent Number: 9017949 (2015) Cite \| Source
Pharmaceutical compositions comprising GPR119 agonists which act as peptide YY (PYY) secretagogues (patent) Chu, Zhi-Liang \| Leonard, James N. \| Jones, Robert M. Patent Number: 8883714 (2014) Cite \| Source
Alteration of the Glucagon Axis in GPR120 (FFAR4) Knockout Mice (journal article) Suckow, Arthur T. \| Polidori, David \| Yan, Wen \| Chon, Suhyoun \| Ma, Jing Ying \| Leonard, James \| Briscoe, Celia P. Journal of Biological Chemistry, volume 289, issue 22, pages 15751-15763 (2014). 10.1074/jbc.M114.568683 Cited by (79) \| Cite \| Source \| Open Access
Methods of using GPR119 receptor to identify compounds which stimulate glucose-dependent insulinotropic peptide secretion (patent) Leonard, James N. \| Chu, Zhi-Liang Patent Number: 8580526 (2013) Cited by (1) \| Cite \| Source
Methods of using a G protein-coupled receptor to identify peptide YY (PYY) secretagogues (patent) Leonard, James N. \| Jones, Robert M. \| Chu, Zhi-Liang Patent Number: 8486646 (2013) Cited by (1) \| Cite \| Source