Gabriele Schaefer

ScholarGPS® ID: 81990926321595

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Antibody | Cancer | Epidermal Growth Factor Receptor | Epidermal Growth Factor

Metrics Summary

Publication Count

Predicted Citations

1,689

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Primary results and characterization of patients with exceptional outcomes in a phase 1b study combining PARP and MEK inhibition, with or without anti–PD‐L1, for BRCA wild‐type, platinum‐sensitive, recurrent ovarian cancer (journal article) Mutch, David \| Voulgari, Athina \| Chen, Xian (Marissa) \| Bradley, William H. \| Oaknin, Ana \| Perez Fidalgo, José Alejandro \| Montosa, Fernando Galvez \| Herraez, Antonio Casado \| Holloway, Robert W. \| Powell, Matthew A. \| ... \| Yan, Yibing Cancer, volume 130, issue 11, pages 1940-1951 (2024). 10.1002/cncr.35222 Cited by (1) \| Cite \| Source
Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action (journal article) Chan, Jocelyn \| Chan, Joyce \| Shao, Lily \| Stawicki, Scott S. \| Pham, Victoria C. \| Akita, Rob W. \| Hafner, Marc \| Crocker, Lisa \| Yu, Kebing \| Koerber, James T. \| ... \| Comps-Agrar, Laetitia Journal of Biological Chemistry, volume 299, issue 1, pages 102729- (2023). 10.1016/j.jbc.2022.102729 Cite \| Source
NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma (journal article) Hegde, Ganapati V \| de la Cruz, Cecile \| Giltnane, Jennifer M \| Crocker, Lisa \| Venkatanarayan, Avinashnarayan \| Schaefer, Gabriele \| Dunlap, Debra \| Hoeck, Joerg D \| Piskol, Robert \| Gnad, Florian \| ... \| Jackson, Erica L eLife, volume 8 (2019). 10.7554/eLife.46551 Cited by (8) \| Cite \| Source
Erratum: Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model (journal article) Kirouac, Daniel C. \| Schaefer, Gabriele \| Chan, Jocelyn \| Merchant, Mark \| Orr, Christine \| Huang, Shih-Min A. \| Moffat, John \| Liu, Lichuan \| Gadkar, Kapil \| Ramanujan, Saroja npj Systems Biology and Applications, volume 3, issue 1 (2017). 10.1038/s41540-017-0026-z Cited by (2) \| Cite \| Source \| Open Access
“Two-in-One” approach for bioassay selection for dual specificity antibodies (journal article) Lee, Ho Young \| Schaefer, Gabriele \| Lesaca, Ingrid \| Lee, Chingwei Vivian \| Wong, Pin Yee \| Jiang, Guoying Journal of Immunological Methods, volume 448 (2017). 10.1016/j.jim.2017.05.011 Cited by (8) \| Cite \| Source
Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model (journal article) Kirouac, Daniel C. \| Schaefer, Gabriele \| Chan, Jocelyn \| Merchant, Mark \| Orr, Christine \| Huang, Shih-Min A. \| Moffat, John \| Liu, Lichuan \| Gadkar, Kapil \| Ramanujan, Saroja npj Systems Biology and Applications, volume 3, issue 1 (2017). 10.1038/s41540-017-0016-1 Cited by (48) \| Cite \| Source \| Open Access
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor (journal article) Chan, Bryan K. \| Hanan, Emily J. \| Bowman, Krista K. \| Bryan, Marian C. \| Burdick, Daniel \| Chan, Emily \| Chen, Yuan \| Clausen, Saundra \| Dela Vega, Trisha \| Dotson, Jennafer \| ... \| Heffron, Timothy P. Journal of Medicinal Chemistry, volume 59, issue 19, pages 9080-9093 (2016). 10.1021/acs.jmedchem.6b00995 Cited by (20) \| Cite \| Source
High cell-surface density of HER2 deforms cell membranes (journal article) Chung, Inhee \| Reichelt, Mike \| Shao, Lily \| Akita, Robert W. \| Koeppen, Hartmut \| Rangell, Linda \| Schaefer, Gabriele \| Mellman, Ira \| Sliwkowski, Mark X. Nature Communications, volume 7, issue 1 (2016). 10.1038/ncomms12742 Cited by (57) \| Cite \| Source \| Open Access
Anti-HER antibodies (patent) Fuh, Germaine \| Haber, Lauric \| Schaefer, Gabriele \| Sliwkowski, Mark X. Patent Number: 9327035 (2016) Cited by (4) \| Cite \| Source
4-Aminoindazolyl-dihydrofuro[3,4- d ]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase (journal article) Hanan, Emily J. \| Baumgardner, Matt \| Bryan, Marian C. \| Chen, Yuan \| Eigenbrot, Charles \| Fan, Peter \| Gu, Xiao-Hui \| La, Hank \| Malek, Shiva \| Purkey, Hans E. \| ... \| Heffron, Timothy P. Bioorganic & Medicinal Chemistry Letters, volume 26, issue 2, pages 534-539 (2016). 10.1016/j.bmcl.2015.11.078 Cited by (41) \| Cite \| Source
Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation (journal article) Hanan, Emily J. \| Eigenbrot, Charles \| Bryan, Marian C. \| Burdick, Daniel J. \| Chan, Bryan K. \| Chen, Yuan \| Dotson, Jennafer \| Heald, Robert A. \| Jackson, Philip S. \| La, Hank \| ... \| Heffron, Timothy P. Journal of Medicinal Chemistry, volume 57, issue 23, pages 10176-10191 (2014). 10.1021/jm501578n Cited by (54) \| Cite \| Source \| Open Access
Dual Targeting of HER2-Positive Cancer with Trastuzumab Emtansine and Pertuzumab: Critical Role for Neuregulin Blockade in Antitumor Response to Combination Therapy (journal article) Phillips, Gail D. Lewis \| Fields, Carter T. \| Li, Guangmin \| Dowbenko, Donald \| Schaefer, Gabriele \| Miller, Kathy \| Andre, Fabrice \| Burris, Howard A. \| Albain, Kathy S. \| Harbeck, Nadia \| ... \| Sliwkowski, Mark X. Clinical Cancer Research, volume 20, issue 2, pages 456-468 (2014). 10.1158/1078-0432.CCR-13-0358 Cited by (153) \| Cite \| Source \| Open Access
Multispecific anti-HER antibodies (patent) Schaefer, Gabriele \| Fuh, Germaine \| Haber, Lauric \| Sliwkowski, Mark X. Patent Number: 8597652 (2013) Cited by (4) \| Cite \| Source
Anti-her antibodies (patent) Fuh, Germaine \| Haber, Lauric \| Schaefer, Gabriele \| Sliwkowski, Mark X. Patent Number: 20100255010 (2013) Cite \| Source
Noncovalent Wild-type–Sparing Inhibitors of EGFR T790M (journal article) Lee, Ho-June \| Schaefer, Gabriele \| Heffron, Timothy P. \| Shao, Lily \| Ye, Xiaofen \| Sideris, Steve \| Malek, Shiva \| Chan, Emily \| Merchant, Mark \| La, Hank \| ... \| Settleman, Jeff Cancer Discovery, volume 3, issue 2, pages 168-181 (2013). 10.1158/2159-8290.CD-12-0357 Cited by (79) \| Cite \| Source \| Open Access
Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators (journal article) Scheer, Justin M. \| Sandoval, Wendy \| Elliott, J. Michael \| Shao, Lily \| Luis, Elizabeth \| Lewin-Koh, Sock-Cheng \| Schaefer, Gabriele \| Vandlen, Richard PLoS ONE, volume 7, issue 12, pages e51817- (2012). 10.1371/journal.pone.0051817 Cited by (37) \| Cite \| Source \| Open Access
LUZ-Y, a Novel Platform for the Mammalian Cell Production of Full-length IgG-bispecific Antibodies (journal article) Wranik, Bernd J. \| Christensen, Erin L. \| Schaefer, Gabriele \| Jackman, Janet K. \| Vendel, Andrew C. \| Eaton, Dan Journal of Biological Chemistry, volume 287, issue 52, pages 43331-43339 (2012). 10.1074/jbc.M112.397869 Cited by (45) \| Cite \| Source \| Open Access
Hepatitis C Virus Induces Epidermal Growth Factor Receptor Activation via CD81 Binding for Viral Internalization and Entry (journal article) Diao, Jingyu \| Pantua, Homer \| Ngu, Hai \| Komuves, Laszlo \| Diehl, Lauri \| Schaefer, Gabriele \| Kapadia, Sharookh B. Journal of Virology, volume 86, issue 20, pages 10935-10949 (2012). 10.1128/JVI.00750-12 Cited by (115) \| Cite \| Source \| Open Access
NEUREGULIN ANTIBODIES AND USES THEREOF (patent) Jackson, Erica \| Schaefer, Gabriele \| Wu, Yan Patent Number: 20140363438 (2012) Cite \| Source
Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose (journal article) Kamath, Amrita V. \| Lu, Dan \| Gupta, Priyanka \| Jin, Denise \| Xiang, Hong \| Wong, Anne \| Leddy, Cecilia \| Crocker, Lisa \| Schaefer, Gabriele \| Sliwkowski, Mark X. \| Damico-Beyer, Lisa A. Cancer Chemotherapy and Pharmacology, volume 69, issue 4, pages 1063-1069 (2012). 10.1007/s00280-011-1806-6 Cited by (38) \| Cite \| Source