Yin Liang

ScholarGPS® ID: 81723846951499

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Medicine

Discipline

Cardiology

Top Specialties

Medicinal Chemistry | Diabetes | Insulin | Chemical Synthesis

Metrics Summary

Publication Count

Predicted Citations

1,884

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists (journal article) Patch, Raymond J. \| Zhang, Rui \| Edavettal, Suzanne \| Macielag, Mark J. \| Eckardt, Annette J. \| Li, Jiali \| Rives, Marie-Laure \| Edwards, Wilson \| Hinke, Simon A. \| Qiu, Xi \| ... \| Hornby, Pamela European Journal of Medicinal Chemistry, volume 236 (2022). 10.1016/j.ejmech.2022.114330 Cited by (2) \| Cite \| Source
5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors (journal article) Xu, Guozhang \| Du, Fuyong \| Kuo, Gee-Hong \| Xu, June Zhi \| Liang, Yin \| Demarest, Keith \| Gaul, Michael D. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 17, pages 127387- (2020). 10.1016/j.bmcl.2020.127387 Cited by (8) \| Cite \| Source
Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes (journal article) Xu, Guozhang \| Gaul, Michael D. \| Song, Fengbin \| Du, Fuyong \| Liang, Yin \| DesJarlais, Renee L. \| DiLoreto, Karen \| Shook, Brian \| Rentzeperis, Dennis \| Santulli, Rosie \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 29, issue 20, pages 126668- (2019). 10.1016/j.bmcl.2019.126668 Cited by (3) \| Cite \| Source
Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors (journal article) Xu, Guozhang \| Gaul, Michael D. \| Kuo, Gee-Hong \| Du, Fuyong \| Xu, June Zhi \| Wallace, Nathaniel \| Hinke, Simon \| Kirchner, Thomas \| Silva, Jose \| Huebert, Norman D. \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 28, issue 21, pages 3446-3453 (2018). 10.1016/j.bmcl.2018.09.025 Cited by (9) \| Cite \| Source
Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors (journal article) Kuo, Gee-Hong \| Gaul, Micheal D. \| Liang, Yin \| Xu, June Z. \| Du, Fuyong \| Hornby, Pamela \| Xu, Guozhang \| Qi, Jenson \| Wallace, Nathaniel \| Lee, Seunghun \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 28, issue 7, pages 1182-1187 (2018). 10.1016/j.bmcl.2018.02.057 Cited by (29) \| Cite \| Source
Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody (journal article) Hinke, Simon A. \| Cieniewicz, Anne M. \| Kirchner, Thomas \| D'Aquino, Katharine \| Nanjunda, Rupesh \| Aligo, Jason \| Perkinson, Robert \| Cooper, Philip \| Boayke, Ken \| Chiu, Mark L. \| ... \| Kihm, Anthony J. Molecular Metabolism, volume 10 (2018). 10.1016/j.molmet.2018.01.014 Cited by (14) \| Cite \| Source \| Open Access
Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes (journal article) Zhang, Xuqing \| Wall, Mark \| Sui, Zhihua \| Kauffman, Jack \| Hou, Cuifen \| Chen, Cailin \| Du, Fuyong \| Kirchner, Thomas \| Liang, Yin \| Johnson, Dana L. \| ... \| Demarest, Keith ACS Medicinal Chemistry Letters, volume 8, issue 5, pages 560-565 (2017). 10.1021/acsmedchemlett.7b00116 Cited by (8) \| Cite \| Source \| Open Access
Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo (journal article) Qi, Jenson \| Lang, Wensheng \| Connelly, Margery A. \| Du, Fuyong \| Liang, Yin \| Caldwell, Gary W. \| Martin, Tonya \| Hansen, Michael K. \| Kuo, Gee-Hong \| Gaul, Michael D. \| ... \| Lee, Seunghun Analytical Biochemistry, volume 524 (2017). 10.1016/j.ab.2016.09.017 Cited by (2) \| Cite \| Source
Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists (journal article) Zhang, Xuqing \| Sui, Zhihua \| Kauffman, Jack \| Hou, Cuifen \| Chen, Cailin \| Du, Fuyong \| Kirchner, Thomas \| Liang, Yin \| Johnson, Dana \| Murray, William V. \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 27, issue 8, pages 1760-1764 (2017). 10.1016/j.bmcl.2017.02.069 Cited by (15) \| Cite \| Source
Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance (journal article) Cieniewicz, Anne M. \| Kirchner, Thomas \| Hinke, Simon A. \| Nanjunda, Rupesh \| D’Aquino, Katharine \| Boayke, Ken \| Cooper, Philip R. \| Perkinson, Robert \| Chiu, Mark L. \| Jarantow, Stephen \| ... \| Kihm, Anthony J. Diabetes, volume 66, issue 1, pages 206-217 (2017). 10.2337/db16-0633 Cited by (10) \| Cite \| Source
Tetrahydropyrazolo[4,3- c ]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists (journal article) Zhu, Bin \| Matthews, Jay M. \| Xia, Mingde \| Black, Shawn \| Chen, Cailin \| Hou, Cuifen \| Liang, Yin \| Tang, Yuting \| Macielag, Mark J. Bioorganic & Medicinal Chemistry Letters, volume 26, issue 22, pages 5597-5601 (2016). 10.1016/j.bmcl.2016.09.026 Cited by (5) \| Cite \| Source
Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists (journal article) Matthews, Jay M. \| McNally, James J. \| Connolly, Peter J. \| Xia, Mingde \| Zhu, Bin \| Black, Shawn \| Chen, Cailin \| Hou, Cuifen \| Liang, Yin \| Tang, Yuting \| Macielag, Mark J. Bioorganic & Medicinal Chemistry Letters, volume 26, issue 21, pages 5346-5349 (2016). 10.1016/j.bmcl.2016.09.025 Cited by (18) \| Cite \| Source
SGLT2 inhibitors act from the extracellular surface of the cell membrane (journal article) Ghezzi, Chiara \| Hirayama, Bruce A. \| Gorraitz, Edurne \| Loo, Donald D. F. \| Liang, Yin \| Wright, Ernest M. Physiological Reports, volume 2, issue 6, pages e12058- (2014). 10.14814/phy2.12058 Cited by (45) \| Cite \| Source \| Open Access
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: Part 2. Pyridazine-based analogs (journal article) Yang, Shyh-Ming \| Tang, Yuting \| Rano, Thomas \| Lu, Huajun \| Kuo, Gee-Hong \| Gaul, Michael D. \| Li, Yaxin \| Ho, George \| Lang, Wensheng \| Conway, James G. \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 24, issue 5, pages 1437-1441 (2014). 10.1016/j.bmcl.2013.12.075 Cited by (5) \| Cite \| Source
Thioredoxin-mimetic peptide CB3 lowers MAPKinase activity in the Zucker rat brain (journal article) Cohen-Kutner, Moshe \| Khomsky, Lena \| Trus, Michael \| Ben-Yehuda, Hila \| Lenhard, James M. \| Liang, Yin \| Martin, Tonya \| Atlas, Daphne Redox Biology, volume 2 (2014). 10.1016/j.redox.2013.12.018 Cited by (17) \| Cite \| Source \| Open Access
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs (journal article) Yang, Shyh-Ming \| Tang, Yuting \| Zhang, Rui \| Lu, Huajun \| Kuo, Gee-Hong \| Gaul, Michael D. \| Li, Yaxin \| Ho, George \| Conway, James G. \| Liang, Yin \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 23, issue 24, pages 6773-6776 (2013). 10.1016/j.bmcl.2013.09.096 Cited by (5) \| Cite \| Source
Beneficial Metabolic Effects of CB1R Anti-Sense Oligonucleotide Treatment in Diet-Induced Obese AKR/J Mice (journal article) Tang, Yuting \| Ho, George \| Li, Yaxin \| Hall, Meghan A. \| Hills, Robert L. \| Black, Shawn C. \| Liang, Yin \| Demarest, Keith T. PLoS ONE, volume 7, issue 8, pages e42134- (2012). 10.1371/journal.pone.0042134 Cited by (16) \| Cite \| Source \| Open Access
Effect of Canagliflozin on Renal Threshold for Glucose, Glycemia, and Body Weight in Normal and Diabetic Animal Models (journal article) Liang, Yin \| Arakawa, Kenji \| Ueta, Kiichiro \| Matsushita, Yasuaki \| Kuriyama, Chiaki \| Martin, Tonya \| Du, Fuyong \| Liu, Yi \| Xu, June \| Conway, Bruce \| ... \| Demarest, Keith PLoS ONE, volume 7, issue 2, pages e30555- (2012). 10.1371/journal.pone.0030555 Cited by (201) \| Cite \| Source \| Open Access
Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile (journal article) Semple, Graeme \| Lehmann, Juerg \| Wong, Amy \| Ren, Albert \| Bruce, Marc \| Shin, Young-Jun \| Sage, Carleton R. \| Morgan, Michael \| Chen, Wei-Chao \| Sebring, Kristen \| ... \| Jones, Robert M. Bioorganic & Medicinal Chemistry Letters, volume 22, issue 4, pages 1750-1755 (2012). 10.1016/j.bmcl.2011.12.092 Cited by (42) \| Cite \| Source
Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control (journal article) Semple, Graeme \| Ren, Albert \| Fioravanti, Beatriz \| Pereira, Guillherme \| Calderon, Imelda \| Choi, Karoline \| Xiong, Yifeng \| Shin, Young-Jun \| Gharbaoui, Tawfik \| Sage, Carleton R. \| ... \| Jones, Robert M. Bioorganic & Medicinal Chemistry Letters, volume 21, issue 10, pages 3134-3141 (2011). 10.1016/j.bmcl.2011.03.007 Cited by (57) \| Cite \| Source