Ciara Metcalfe

ScholarGPS® ID: 81591297085396

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Cancer | Stem Cell

Metrics Summary

Publication Count

Predicted Citations

1,414

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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heredERA Breast Cancer: a phase III, randomized, open-label study evaluating the efficacy and safety of giredestrant plus the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection in patients with previously untreated HER2-positi (journal article) Kuemmel, Sherko \| Harper-Wynne, Catherine \| Park, Yeon Hee \| Franke, Fábio \| de Laurentiis, Michelino \| Schumacher-Wulf, Eva \| Eiger, Daniel \| Heeson, Sarah \| Cardona, Andrés \| Özyilkan, Özgür \| ... \| O’Shaughnessy, Joyce BMC Cancer, volume 24, issue 1 (2024). 10.1186/s12885-024-12179-9 Cite \| Source
CDK4/6i-treated HR+/HER2- breast cancer tumors show higher ESR1 mutation prevalence and more altered genomic landscape (journal article) Chaudhary, Nayan \| Chibly, Alejandro M. \| Collier, Ann \| Martinalbo, Jorge \| Perez-Moreno, Pablo \| Moore, Heather M. \| Luhn, Patricia \| Metcalfe, Ciara \| Hafner, Marc npj Breast Cancer, volume 10, issue 1 (2024). 10.1038/s41523-024-00617-7 Cited by (2) \| Cite \| Source
Therapeutic resistance to anti-oestrogen therapy in breast cancer (journal article) Will, Marie \| Liang, Jackson \| Metcalfe, Ciara \| Chandarlapaty, Sarat Nature Reviews Cancer, volume 23, issue 10, pages 673-685 (2023). 10.1038/s41568-023-00604-3 Cited by (16) \| Cite \| Source
An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor–Positive Breast Cancer (journal article) Chandarlapaty, Sarat \| Dickler, Maura N. \| Perez Fidalgo, Jose Alejandro \| Villanueva-Vázquez, Rafael \| Giltnane, Jennifer \| Gates, Mary \| Chang, Ching-Wei \| Cheeti, Sravanthi \| Fredrickson, Jill \| Wang, Xiaojing \| ... \| Bardia, Aditya Clinical Cancer Research, volume 29, issue 15, pages 2781-2790 (2023). 10.1158/1078-0432.CCR-23-0011 Cited by (3) \| Cite \| Source
Next-Generation Estrogen Receptor–Targeted Therapeutics (journal article) Fernando, Tharu M. \| Moore, Heather M. \| Wongchenko, Matthew J. \| Metcalfe, Ciara Annual Review of Cancer Biology, volume 7, issue 1, pages 313-330 (2023). 10.1146/annurev-cancerbio-061421-013525 Cited by (4) \| Cite \| Source
Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer (journal article) Liang, Jackson \| Ingalla, Ellen Rei \| Yao, Xiaosai \| Wang, Bu-Er \| Tai, Lisa \| Giltnane, Jennifer \| Liang, Yuxin \| Daemen, Anneleen \| Moore, Heather M. \| Aimi, Junko \| ... \| Metcalfe, Ciara Science Translational Medicine, volume 14, issue 663 (2022). 10.1126/scitranslmed.abo5959 Cited by (6) \| Cite \| Source
Latest generation estrogen receptor degraders for the treatment of hormone receptor-positive breast cancer (journal article) Chen, Ya-Chi \| Yu, Jiajie \| Metcalfe, Ciara \| De Bruyn, Tom \| Gelzleichter, Thomas \| Malhi, Vikram \| Perez-Moreno, Pablo D. \| Wang, Xiaojing Expert Opinion on Investigational Drugs, volume 31, issue 6, pages 515-529 (2022). 10.1080/13543784.2021.1983542 Cited by (43) \| Cite \| Source
Clinical Translation: Targeting the Estrogen Receptor (book chapter) In Nuclear Receptors in Human Health and Disease Metcalfe, Ciara \| Lauchle, Jennifer O. Springer International Publishing (2022) 10.1007/978-3-031-11836-4_17 Cited by (2) \| Cite \| Source
Evaluation of pharmacodynamic (PD) and biologic activity in a preoperative window-of-opportunity (WOO) study of giredestrant (GDC-9545) in postmenopausal patients (pts) with estrogen receptor-positive, HER2-negative (ER+/HER2–) operable breast cancer (BC) (journal article) Moore, Heather M. \| Boni, Valentina \| Bellet, Meritxell \| Bermejo De Las Heras, Begoña \| Gión Cortés, Maria \| Oakman, Catherine \| Schmid, Peter \| Trinh, Xuan Bich \| Wheatley, Duncan \| Jhaveri, Komal L. \| ... \| Bardia, Aditya Journal of Clinical Oncology, volume 39, issue 15_suppl, pages 577-577 (2021). 10.1200/JCO.2021.39.15_suppl.577 Cited by (16) \| Cite \| Source
Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models (journal article) Moore, Heather M. \| Savage, Heidi M. \| O'Brien, Carol \| Zhou, Wei \| Sokol, Ethan S. \| Goldberg, Michael E. \| Metcalfe, Ciara \| Friedman, Lori S. \| Lackner, Mark R. \| Wilson, Timothy R. Molecular Cancer Therapeutics, volume 19, issue 1, pages 292-303 (2020). 10.1158/1535-7163.MCT-19-0284 Cited by (9) \| Cite \| Source
Hormone-Targeted Therapy and Resistance (journal article) Metcalfe, Ciara \| Friedman, Lori S. \| Hager, Jeffrey H. Annual Review of Cancer Biology, volume 2, issue 1, pages 291-312 (2018). 10.1146/annurev-cancerbio-030617-050512 Cited by (12) \| Cite \| Source
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function (journal article) Storm, Elaine E. \| Durinck, Steffen \| de Sousa e Melo, Felipe \| Tremayne, Jarrod \| Kljavin, Noelyn \| Tan, Christine \| Ye, Xiaofen \| Chiu, Cecilia \| Pham, Thinh \| Hongo, Jo-Anne \| ... \| de Sauvage, Frederic J. Nature, volume 529, issue 7584, pages 97-100 (2016). 10.1038/nature16466 Cited by (195) \| Cite \| Source
The Hedgehog Hold on Homeostasis (journal article) Metcalfe, Ciara \| Siebel, Christian W. Cell Stem Cell, volume 17, issue 5, pages 505-506 (2015). 10.1016/j.stem.2015.10.010 Cited by (1) \| Cite \| Source \| Open Access
Stromal Indian Hedgehog Signaling Is Required for Intestinal Adenoma Formation in Mice (journal article) Büller, Nikè V.J.A. \| Rosekrans, Sanne L. \| Metcalfe, Ciara \| Heijmans, Jarom \| van Dop, Willemijn A. \| Fessler, Evelyn \| Jansen, Marnix \| Ahn, Christina \| Vermeulen, Jacqueline L.M. \| Westendorp, B. Florien \| ... \| van den Brink, Gijs R. Gastroenterology, volume 148, issue 1, pages 170-180.e6 (2015). 10.1053/j.gastro.2014.10.006 Cited by (33) \| Cite \| Source
Modeling Targeted Inhibition of MEK and PI3 Kinase in Human Pancreatic Cancer (journal article) Junttila, Melissa R. \| Devasthali, Vidusha \| Cheng, Jason H. \| Castillo, Joseph \| Metcalfe, Ciara \| Clermont, Anne C. \| Otter, Douglas Den \| Chan, Emily \| Bou-Reslan, Hani \| Cao, Tim \| ... \| Singh, Mallika Molecular Cancer Therapeutics, volume 14, issue 1, pages 40-47 (2015). 10.1158/1535-7163.MCT-14-0030 Cited by (42) \| Cite \| Source \| Open Access
Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration (journal article) Metcalfe, Ciara \| Kljavin, Noelyn M. \| Ybarra, Ryan \| de Sauvage, Frederic J. Cell Stem Cell, volume 14, issue 2, pages 149-159 (2014). 10.1016/j.stem.2013.11.008 Cited by (426) \| Cite \| Source \| Open Access
PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition (journal article) Metcalfe, Ciara \| Alicke, Bruno \| Crow, Ailey \| Lamoureux, Marlea \| Dijkgraaf, Gerrit J.P. \| Peale, Franklin \| Gould, Stephen E. \| de Sauvage, Frederic J. Cancer Research, volume 73, issue 23, pages 7034-7042 (2013). 10.1158/0008-5472.CAN-13-1222 Cited by (49) \| Cite \| Source \| Open Access
A tumor-specific stem cell (journal article) Metcalfe, Ciara \| de Sauvage, Frederic J Nature Genetics, volume 45, issue 1, pages 7-9 (2013). 10.1038/ng.2502 Cited by (9) \| Cite \| Source
Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists (journal article) Metcalfe, Ciara \| de Sauvage, Frederic J. Cancer Research, volume 71, issue 15, pages 5057-5061 (2011). 10.1158/0008-5472.CAN-11-0923 Cited by (165) \| Cite \| Source \| Open Access