Leighton Coates | Scholar Profiles and Rankings

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Visualizing the Active Site Oxyanion Loop Transition Upon Ensitrelvir Binding and Transient Dimerization of SARS-CoV-2 Main Protease (journal article) Kovalevsky, Andrey \| Aniana, Annie \| Coates, Leighton \| Ghirlando, Rodolfo \| Nashed, Nashaat T. \| Louis, John M. Journal of Molecular Biology, volume 436, issue 13, pages 168616- (2024). 10.1016/j.jmb.2024.168616 Cite \| Source
New Opportunities for Neutrons in Environmental and Biological Sciences (journal article) Johs, Alexander \| Qian, Shuo \| Coates, Leighton \| Davison, Brian H. \| Elkins, James G. \| Gu, Xin \| Morrell-Falvey, Jennifer \| O’Neill, Hugh \| Warren, Jeffrey M. \| Pierce, Eric M. \| Herwig, Kenneth Frontiers of Environmental Science & Engineering, volume 18, issue 7 (2024). 10.1007/s11783-024-1852-z Cite \| Source
Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors (journal article) Aniana, Annie \| Nashed, Nashaat T. \| Ghirlando, Rodolfo \| Coates, Leighton \| Kneller, Daniel W. \| Kovalevsky, Andrey \| Louis, John M. Communications Biology, volume 6, issue 1 (2023). 10.1038/s42003-023-05469-8 Cited by (3) \| Cite \| Source
Visualization of the human manganese superoxide dismutase product inhibition mechanism and protonation states (journal article) Azadmanesh, Jahaun \| Slobodnik, Katelyn \| Lutz, William E. \| Coates, Leighton \| Weiss, Kevin L. \| Myles, Dean A. A. \| Kroll, Thomas \| Borgstahl, Gloria E. O. Acta Crystallographica Section A Foundations and Advances, volume 79, issue a1, pages a56-a56 (2023). 10.1107/S2053273323099436 Cite \| Source
Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors (journal article) Kovalevsky, Andrey \| Aniana, Annie \| Coates, Leighton \| Bonnesen, Peter V. \| Nashed, Nashaat T. \| Louis, John M. Journal of Biological Chemistry, volume 299, issue 7, pages 104886- (2023). 10.1016/j.jbc.2023.104886 Cited by (8) \| Cite \| Source
Perfect Crystals: microgravity capillary counterdiffusion crystallization of human manganese superoxide dismutase for neutron crystallography (journal article) Lutz, William E. \| Azadmanesh, Jahaun \| Lovelace, Jeffrey J. \| Kolar, Carol \| Coates, Leighton \| Weiss, Kevin L. \| Borgstahl, Gloria E. O. npj Microgravity, volume 9, issue 1 (2023). 10.1038/s41526-023-00288-x Cited by (2) \| Cite \| Source
Special Topic on “Initial instruments at the Second Target Station of the Spallation Neutron Source” (journal article) Coates, Leighton Review of Scientific Instruments, volume 94, issue 4 (2023). 10.1063/5.0141985 Cite \| Source
A realistic guide misalignment model for the Second Target Station instruments at the Spallation Neutron Source (journal article) Lin, Jiao Y.Y. \| Huegle, Thomas \| Coates, Leighton \| Stoica, Alexandru Dan Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, volume 1047 (2023). 10.1016/j.nima.2022.167881 Cited by (1) \| Cite \| Source
Unmasking the Conformational Stability and Inhibitor Binding to SARS-CoV-2 Main Protease Active Site Mutants and Miniprecursor (journal article) Kovalevsky, Andrey \| Coates, Leighton \| Kneller, Daniel W. \| Ghirlando, Rodolfo \| Aniana, Annie \| Nashed, Nashaat T. \| Louis, John M. Journal of Molecular Biology, volume 434, issue 24, pages 167876- (2022). 10.1016/j.jmb.2022.167876 Cited by (6) \| Cite \| Source
Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain (journal article) Nashed, Nashaat T. \| Kneller, Daniel W. \| Coates, Leighton \| Ghirlando, Rodolfo \| Aniana, Annie \| Kovalevsky, Andrey \| Louis, John M. Communications Biology, volume 5, issue 1 (2022). 10.1038/s42003-022-03910-y Cited by (13) \| Cite \| Source
Cryo neutron crystallography demonstrates influence of RNA 2′-OH orientation on conformation, sugar pucker and water structure (journal article) Harp, Joel M \| Lybrand, Terry P \| Pallan, Pradeep S \| Coates, Leighton \| Sullivan, Brendan \| Egli, Martin Nucleic Acids Research, volume 50, issue 13, pages 7721-7738 (2022). 10.1093/nar/gkac577 Cited by (4) \| Cite \| Source
EWALD: A macromolecular diffractometer for the second target station (journal article) Borgstahl, Gloria E. O. \| O’Dell, William B. \| Egli, Martin \| Kern, Jan F. \| Kovalevsky, Andrey \| Lin, Jiao Y. Y. \| Myles, Dean \| Wilson, Mark A. \| Zhang, Wen \| Zwart, Petrus \| Coates, Leighton Review of Scientific Instruments, volume 93, issue 6 (2022). 10.1063/5.0090810 Cited by (4) \| Cite \| Source
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature (journal article) Correy, Galen J. \| Kneller, Daniel W. \| Phillips, Gwyndalyn \| Pant, Swati \| Russi, Silvia \| Cohen, Aina E. \| Meigs, George \| Holton, James M. \| Gahbauer, Stefan \| Thompson, Michael C. \| ... \| Fraser, James S. Science Advances, volume 8, issue 21 (2022). 10.1126/sciadv.abo5083 Cited by (18) \| Cite \| Source
Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease (journal article) Kneller, Daniel W. \| Li, Hui \| Phillips, Gwyndalyn \| Weiss, Kevin L. \| Zhang, Qiu \| Arnould, Mark A. \| Jonsson, Colleen B. \| Surendranathan, Surekha \| Parvathareddy, Jyothi \| Blakeley, Matthew P. \| ... \| Kovalevsky, Andrey Nature Communications, volume 13, issue 1 (2022). 10.1038/s41467-022-29915-z Cited by (70) \| Cite \| Source
Hit Expansion of a Noncovalent SARS-CoV-2 Main Protease Inhibitor (journal article) Glaser, Jens \| Sedova, Ada \| Galanie, Stephanie \| Kneller, Daniel W. \| Davidson, Russell B. \| Maradzike, Elvis \| Del Galdo, Sara \| Labbé, Audrey \| Hsu, Darren J. \| Agarwal, Rupesh \| ... \| Smith, Jeremy C. ACS Pharmacology & Translational Science, volume 5, issue 4, pages 255-265 (2022). 10.1021/acsptsci.2c00026 Cited by (17) \| Cite \| Source
Cryotrapping peroxide in the active site of human mitochondrial manganese superoxide dismutase crystals for neutron diffraction (journal article) Azadmanesh, Jahaun \| Lutz, William E. \| Coates, Leighton \| Weiss, Kevin L. \| Borgstahl, Gloria E. O. Acta Crystallographica Section F Structural Biology Communications, volume 78, issue 1, pages 8-16 (2022). 10.1107/S2053230X21012413 Cited by (4) \| Cite \| Source
Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease (journal article) Kneller, Daniel W. \| Li, Hui \| Galanie, Stephanie \| Phillips, Gwyndalyn \| Labbé, Audrey \| Weiss, Kevin L. \| Zhang, Qiu \| Arnould, Mark A. \| Clyde, Austin \| Ma, Heng \| ... \| Kovalevsky, Andrey Journal of Medicinal Chemistry, volume 64, issue 23, pages 17366-17383 (2021). 10.1021/acs.jmedchem.1c01475 Cited by (32) \| Cite \| Source
Michaelis-like complex of SARS-CoV-2 main protease visualized by room-temperature X-ray crystallography (journal article) Kneller, Daniel W. \| Zhang, Qiu \| Coates, Leighton \| Louis, John M. \| Kovalevsky, Andrey IUCrJ, volume 8, issue 6, pages 973-979 (2021). 10.1107/S2052252521010113 Cited by (20) \| Cite \| Source
Toho-1 β-lactamase: backbone chemical shift assignments and changes in dynamics upon binding with avibactam (journal article) Sakhrani, Varun V. \| Ghosh, Rittik K. \| Hilario, Eduardo \| Weiss, Kevin L. \| Coates, Leighton \| Mueller, Leonard J. Journal of Biomolecular NMR, volume 75, issue 8-9, pages 303-318 (2021). 10.1007/s10858-021-00375-9 Cited by (2) \| Cite \| Source
Neutron crystallography for drug design targeting SARS-CoV-2 viral proteins (journal article) Kovalevsky, Andrey \| Kneller, Daniel \| Coates, Leighton Acta Crystallographica Section A Foundations and Advances, volume 77, issue a2, pages C613-C613 (2021). 10.1107/S0108767321090814 Cite \| Source