David Festus Charles Moffat

ScholarGPS® ID: 80507892053574

Affiliation

GlaxoSmithKline plc, London

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Protein Kinase Inhibitor | Protein Kinase | Chemical Synthesis | Medicinal Chemistry | Enzyme

Metrics Summary

Publication Count

Predicted Citations

1,735

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-YL]-3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof (patent) Pintat, Stéphane \| Davies, Stephen John \| Moffat, David Festus Charles Patent Number: 10370332 (2019) Cite \| Source
Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl]-L-alaninate or a salt,hydrate or solvate thereof (patent) Pintat, Stéphane \| Davies, Stephen John \| Moffat, David Festus Charles Patent Number: 9896417 (2018) Cited by (1) \| Cite \| Source
HDAC inhibitors (patent) Davidson, Alan Hornsby \| Moffat, David Festus Charles \| Day, Francesca Ann \| Donald, Alastair David Graham Patent Number: 9725407 (2017) Cite \| Source
Enzyme and receptor modulation using covalent conjugates of alpha,alpha-disubstituted glycine esters (patent) Drummond, Alan Hastings \| Davidson, Alan Hornsby \| Moffat, David Festus Charles \| Donald, Alastair David Graham \| Davies, Stephen John Patent Number: 9636409 (2017) Cite \| Source
2-aminopyrazine derivatives as CSF-1R kinase inhibitors (patent) Davies, Stephen John \| Pintat, Stephane \| North, Carl Leslie \| Moffat, David Festus Charles Patent Number: 9604940 (2017) Cite \| Source
Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof (patent) Pintat, Stéphane \| Davies, Stephen John \| Moffat, David Festus Charles Patent Number: 9388136 (2016) Cited by (2) \| Cite \| Source
TERT-BUTYL N-[2-ETHYL]-L-ALANINATE OR A SALT, HYDRATE OR SOLVATE THEREOF (patent) Pintat, Stéphane \| Davies, Stephen John \| Moffat, David Festus Charles Patent Number: 20160297760 (2016) Cite \| Source
Benzamide derivatives and their use as HSP90 inhibtors (patent) Donald, Alastair David Graham \| McDermott, Joanne \| Patel, Sanjay Ratilal \| Moffat, David Festus Charles Patent Number: 9321718 (2016) Cite \| Source
Methods of treating lymphoma and rheumatoid arthritis with cyclopentyl (2S)-cyclohexyl[({6-[3-(hydroxyamino)-3-oxopropyl]pyridin-3-yl}methyl)amino]acetate (patent) Davidson, Alan Hornsby \| Moffat, David Festus Charles \| Day, Francesca Ann \| Donald, Alastair David Graham Patent Number: 9273003 (2016) Cite \| Source
Inhibitors of P38 map kinase (patent) Moffat, David Festus Charles \| Davies, Stephen John \| Pintat, Stephane Patent Number: 8778953 (2014) Cited by (9) \| Cite \| Source
Enzyme inhibitors (patent) Davidson, Alan Hornsby \| Patel, Sanjay Ratilal \| Mazzei, Francesca Ann \| Davies, Stephen John \| Drummond, Alan Hastings \| Moffat, David Festus \| Baker, Kenneth William John \| Donald, Alistair David Graham Patent Number: 8686032 (2014) Cited by (34) \| Cite \| Source
Adenine derivative as inhibitors of HSP90 for the treatment of cancer (patent) Moffat, David Festus Charles \| Hirst, Simon Christopher \| Onions, Stuart Thomas Patent Number: 8217050 (2012) Cited by (12) \| Cite \| Source
Quinoline and quinoxaline derivatives as inhibitors of kinase enzymatic activity (patent) Davidson, Alan Hornsby \| Davies, Stephen John \| Moffat, David Festus Charles Patent Number: 8148531 (2012) Cited by (8) \| Cite \| Source
IKK-beta serine-threonine protein kinase inhibitors (patent) Moffat, David Festus Charles \| Davies, Stephen John \| Charlton, Michael Hugh \| Hirst, Simon Christopher \| Onions, Stuart Thomas \| Williams, Jonathan Gareth Patent Number: 8003695 (2011) Cited by (8) \| Cite \| Source
Hydroxamic acid derivatives as inhibitors of HDAC enzymatic activity (patent) Davidson, Alan Hornsby \| Patel, Sanjay Ratilal \| Moffat, David Festus Charles Patent Number: 7973181 (2011) Cited by (11) \| Cite \| Source
Enzyme inhibitors (patent) Davidson, Alan Hornsby \| Patel, Sanjay Ratilal \| Mazzei, Francesca Ann \| Davies, Stephen John \| Drummond, Alan Hastings \| Moffat, David Festus \| Baker, Kenneth William John \| Donald, Alistair David Graham Patent Number: 7939666 (2011) Cited by (9) \| Cite \| Source
Histone deacetylase inhibitors (patent) Moffat, David Festus Charles \| Patel, Sanjay Ratilal \| Mazzei, Francesca Ann \| Belfield, Andrew James \| Van Meurs, Sandra Patent Number: 7932246 (2011) Cited by (27) \| Cite \| Source
Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)- N -hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor (journal article) Moffat, David \| Patel, Sanjay \| Day, Francesca \| Belfield, Andrew \| Donald, Alastair \| Rowlands, Martin \| Wibawa, Judata \| Brotherton, Deborah \| Stimson, Lindsay \| Clark, Vanessa \| ... \| Aherne, Wynne Journal of Medicinal Chemistry, volume 53, issue 24, pages 8663-8678 (2010). 10.1021/jm101177s Cited by (76) \| Cite \| Source
ChemInform Abstract: Scalable Synthesis of the VEGF‐R2 Kinase Inhibitor JNJ‐17029259 Using Ultrasound‐Mediated Addition of MeLi—CeCl3 to a Nitrile. (journal article) Reuman, Michael \| Beish, Sandra \| Davis, Jeremy \| Batchelor, Mark J. \| Hutchings, Martin C. \| Moffat, David F. C. \| Connolly, Peter J. \| Russell, Ronald K. ChemInform, volume 39, issue 22 (2008). 10.1002/chin.200822161 Cite \| Source
Scalable Synthesis of the VEGF-R2 Kinase Inhibitor JNJ-17029259 Using Ultrasound-Mediated Addition of MeLi−CeCl3 to a Nitrile (journal article) Reuman, Michael \| Beish, Sandra \| Davis, Jeremy \| Batchelor, Mark J. \| Hutchings, Martin C. \| Moffat, David F. C. \| Connolly, Peter J. \| Russell, Ronald K. The Journal of Organic Chemistry, volume 73, issue 3, pages 1121-1123 (2008). 10.1021/jo7021372 Cited by (15) \| Cite \| Source