Clifford Quan

ScholarGPS® ID: 78733722814358

Affiliation
Genentech, Inc., South San Francisco, United States
Affiliation History

Field
Life Sciences
Discipline
Biochemistry
Top Specialties
Peptide | Growth Factor | Insulin | Insulin-like Growth Factor | Phage Display
Metrics Summary
Publication Count
42
Predicted Citations
4,468
Predicted h-index
33
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides (journal article)
Landgraf, Kyle E | Steffek, Micah | Quan, Clifford | Tom, Jeffrey | Yu, Christine | Santell, Lydia | Maun, Henry R | Eigenbrot, Charles | Lazarus, Robert A
Nature Chemical Biology, volume 10, issue 7, pages 567-573 (2014).
10.1038/nchembio.1533
Cited by (22) | Cite | Source
Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor (journal article)
Zhang, Yingnan | Eigenbrot, Charles | Zhou, Lijuan | Shia, Steven | Li, Wei | Quan, Clifford | Tom, Jeffrey | Moran, Paul | Di Lello, Paola | Skelton, Nicholas J. | ... | Kirchhofer, Daniel
Journal of Biological Chemistry, volume 289, issue 2, pages 942-955 (2014).
10.1074/jbc.M113.514067
Cited by (138) | Cite | Source | Open Access
Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity (journal article)
Okamoto, Toru | Zobel, Kerry | Fedorova, Anna | Quan, Clifford | Yang, Hong | Fairbrother, Wayne J. | Huang, David C. S. | Smith, Brian J. | Deshayes, Kurt | Czabotar, Peter E.
ACS Chemical Biology, volume 8, issue 2, pages 297-302 (2013).
10.1021/cb3005403
Cited by (123) | Cite | Source
Calcium-Independent Inhibition of PCSK9 by Affinity-Improved Variants of the LDL Receptor EGF(A) Domain (journal article)
Zhang, Yingnan | Zhou, Lijuan | Kong-Beltran, Monica | Li, Wei | Moran, Paul | Wang, Jianyong | Quan, Clifford | Tom, Jeffrey | Kolumam, Ganesh | Elliott, J. Michael | ... | Kirchhofer, Daniel
Journal of Molecular Biology, volume 422, issue 5, pages 685-696 (2012).
10.1016/j.jmb.2012.06.018
Cited by (34) | Cite | Source
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization (journal article)
Stanger, Karen | Steffek, Micah | Zhou, Lijuan | Pozniak, Christine D | Quan, Clifford | Franke, Yvonne | Tom, Jeff | Tam, Christine | Krylova, Irina | Elliott, J Michael | ... | Hannoush, Rami N
Nature Chemical Biology, volume 8, issue 7, pages 655-660 (2012).
10.1038/nchembio.967
Cited by (33) | Cite | Source
Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation (journal article)
Ma, Xiaolei | Helgason, Elizabeth | Phung, Qui T. | Quan, Clifford L. | Iyer, Rekha S. | Lee, Michelle W. | Bowman, Krista K. | Starovasnik, Melissa A. | Dueber, Erin C.
Proceedings of the National Academy of Sciences, volume 109, issue 24, pages 9378-9383 (2012).
10.1073/pnas.1121552109
Cited by (173) | Cite | Source | Open Access
Structural and Functional Analysis of HtrA1 and Its Subdomains (journal article)
Eigenbrot, Charles | Ultsch, Mark | Lipari, Michael T. | Moran, Paul | Lin, S. Jack | Ganesan, Rajkumar | Quan, Clifford | Tom, Jeffrey | Sandoval, Wendy | van Lookeren Campagne, Menno | Kirchhofer, Daniel
Structure, volume 20, issue 6, pages 1040-1050 (2012).
10.1016/j.str.2012.03.021
Cited by (84) | Cite | Source | Open Access
Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling (journal article)
Landgraf, Kyle E. | Santell, Lydia | Billeci, Karen L. | Quan, Clifford | Young, Judy C. | Maun, Henry R. | Kirchhofer, Daniel | Lazarus, Robert A.
Journal of Biological Chemistry, volume 285, issue 51, pages 40362-40372 (2010).
10.1074/jbc.M110.179721
Cited by (17) | Cite | Source | Open Access
Multiple Novel Classes of APRIL-specific Receptor-blocking Peptides Isolated by Phage Display (journal article)
Gordon, Nathaniel C. | Lien, Samantha | Johnson, Jeremy | Wallweber, Heidi J.A. | Tran, Thuy | Currell, Bridget | Mathieu, Mary | Quan, Clifford | Starovasnik, Melissa A. | Hymowitz, Sarah G. | Kelley, Robert F.
Journal of Molecular Biology, volume 396, issue 1, pages 166-177 (2010).
10.1016/j.jmb.2009.11.041
Cited by (7) | Cite | Source
Noncompetitive Inhibition of Hepatocyte Growth Factor-dependent Met Signaling by a Phage-derived Peptide (journal article)
Tam, Eric M. | Runyon, Steven T. | Santell, Lydia | Quan, Clifford | Yao, Xiaoyi | Kirchhofer, Daniel | Skelton, Nicholas J. | Lazarus, Robert A.
Journal of Molecular Biology, volume 385, issue 1, pages 79-90 (2009).
10.1016/j.jmb.2008.09.091
Cited by (9) | Cite | Source
Fibroblast activation protein inhibitor compounds and methods (patent)
Cohen, Frederick | Fairbrother, Wayne J. | Quan, Clifford | Sutherlin, Daniel P. | Wolf, Beni B.
Patent Number: 7399869 (2008)
Cited by (11) | Cite | Source
On The Edge of Validation – Cancer Protease Fibroblast Activation Protein (journal article)
Wolf, Beni | Quan, Clifford | Tran, Thuy | Wiesmann, Christian | Sutherlin, Daniel
Mini-Reviews in Medicinal Chemistry, volume 8, issue 7, pages 719-727 (2008).
10.2174/138955708784567449
Cited by (31) | Cite | Source
A Key Claudin Extracellular Loop Domain is Critical for Epithelial Barrier Integrity (journal article)
Mrsny, Randall J. | Brown, G. Thomas | Gerner-Smidt, Kirsten | Buret, Andre G. | Meddings, Jon B. | Quan, Clifford | Koval, Michael | Nusrat, Asma
The American Journal of Pathology, volume 172, issue 4, pages 905-915 (2008).
10.2353/ajpath.2008.070698
Cited by (107) | Cite | Source | Open Access
Ala657 and Conserved Active Site Residues Promote Fibroblast Activation Protein Endopeptidase Activity via Distinct Mechanisms of Transition State Stabilization (journal article)
Meadows, Sarah A. | Edosada, Conrad Yap | Mayeda, Mark | Tran, Thuy | Quan, Clifford | Raab, Helga | Wiesmann, Christian | Wolf, Beni B.
Biochemistry, volume 46, issue 15, pages 4598-4605 (2007).
10.1021/bi062227y
Cited by (27) | Cite | Source
Synthesis and structure–activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP (journal article)
Tran, Thuy | Quan, Clifford | Edosada, Conrad Yap | Mayeda, Mark | Wiesmann, Christian | Sutherlin, Dan | Wolf, Beni B.
Bioorganic & Medicinal Chemistry Letters, volume 17, issue 5, pages 1438-1442 (2007).
10.1016/j.bmcl.2006.11.072
Cited by (46) | Cite | Source
Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly2 ‐Pro1 ‐cleaving specificity (journal article)
Edosada, Conrad Yap | Quan, Clifford | Tran, Thuy | Pham, Victoria | Wiesmann, Christian | Fairbrother, Wayne | Wolf, Beni B.
FEBS Letters, volume 580, issue 6, pages 1581-1586 (2006).
10.1016/j.febslet.2006.01.087
Cited by (87) | Cite | Source | Open Access
Selective Inhibition of Fibroblast Activation Protein Protease Based on Dipeptide Substrate Specificity (journal article)
Edosada, Conrad Yap | Quan, Clifford | Wiesmann, Christian | Tran, Thuy | Sutherlin, Dan | Reynolds, Mark | Elliott, J. Michael | Raab, Helga | Fairbrother, Wayne | Wolf, Beni B.
Journal of Biological Chemistry, volume 281, issue 11, pages 7437-7444 (2006).
10.1074/jbc.M511112200
Cited by (118) | Cite | Source | Open Access
Multiple Protein Interactions Involving Proposed Extracellular Loop Domains of the Tight Junction Protein Occludin (journal article)
Nusrat, Asma | Brown, G. Thomas | Tom, Jeffrey | Drake, Alex | Bui, Tam T.T. | Quan, Cliff | Mrsny, Randall J.
Molecular Biology of the Cell, volume 16, issue 4, pages 1725-1734 (2005).
10.1091/mbc.e04-06-0465
Cited by (65) | Cite | Source | Open Access
Achaete-Scute Like-2 Polypeptides and Encoding Nucleic Acids and Methods for the Diagnosis and Treatment of Tumor (patent)
Baldwin, Daryl T. | Clark, Hilary | Jubb, Adrian M. | Koeppen, Hartmut | Quan, Clifford | Wu, Thomas D. | Zhang, Zemin
Patent Number: 20070117124 (2005)
Cite | Source
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease (journal article)
Zolotarevsky, Yevgeny | Hecht, Gail | Koutsouris, Athanasia | Gonzalez, Deborah E. | Quan, Cliff | Tom, Jeffrey | Mrsny, Randall J. | Turner, Jerrold R.
Gastroenterology, volume 123, issue 1, pages 163-172 (2002).
10.1053/gast.2002.34235
Cited by (325) | Cite | Source