Todd E. Fox

ScholarGPS® ID: 77749279183335

Affiliation

University of Virginia, Charlottesville, United States

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmacology and Toxicology

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

4,026

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Pronecroptotic Therapy Using Ceramide Nanoliposomes Is Effective for Triple-Negative Breast Cancer Cells (journal article) Ohya, Yuki \| Ogiso, Yuri \| Matsuda, Masaya \| Sakae, Harumi \| Nishida, Kentaro \| Miki, Yasuhiro \| Fox, Todd E. \| Kester, Mark \| Sakamoto, Wataru \| Nabe, Takeshi \| Kitatani, Kazuyuki Cells, volume 13, issue 5, pages 405- (2024). 10.3390/cells13050405 Cite \| Source
A phase I study of the ceramide nanoliposome in patients with advanced solid tumors (journal article) Ciner, Aaron \| Gourdin, Theodore \| Davidson, Jeff \| Parette, Mylisa \| Walker, Susan J. \| Fox, Todd E. \| Jiang, Yixing Cancer Chemotherapy and Pharmacology, volume 93, issue 1, pages 23-29 (2024). 10.1007/s00280-023-04588-7 Cited by (4) \| Cite \| Source
Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia (journal article) Ung, Johnson \| Tan, Su-Fern \| Fox, Todd E. \| Shaw, Jeremy J. P. \| Taori, Maansi \| Horton, Bethany J. \| Golla, Upendarrao \| Sharma, Arati \| Szulc, Zdzislaw M. \| Wang, Hong-Gang \| ... \| Feith, David J. Cancers, volume 15, issue 24, pages 5866- (2023). 10.3390/cancers15245866 Cite \| Source
Solid tumor treatment via augmentation of bioactive C6 ceramide levels with thermally ablative focused ultrasound (journal article) Thim, E. Andrew \| Fox, Todd \| Deering, Tye \| Vass, Luke R. \| Sheybani, Natasha D. \| Kester, Mark \| Price, Richard J. Drug Delivery and Translational Research, volume 13, issue 12, pages 3145-3153 (2023). 10.1007/s13346-023-01377-w Cite \| Source
Synthesis and Preclinical Development of a Promising Novel Romidepsin Nanoparticle for the Treatment of Peripheral T‐Cell Lymphoma (PTCL) (journal article) O'Connor, O. A. \| Illendula, A. \| Jayappa, K. D. \| Fox, T. E. \| Loughran, T. P. \| Feith, D. J. \| Marchi, E. \| Pal, I. Hematological Oncology, volume 41, issue S2, pages 548-548 (2023). 10.1002/hon.3164_409 Cite \| Source
Identifying the mechanistic differences between hypomethylating agents for the treatment of peripheral T cell lymphoma (journal article) Pal, I. \| Scotto, L. \| Sabzevari, A. \| Kinahan, C. \| Fox, T. E. \| Feith, D. J. \| Marchi, E. \| Loughran, T. P. \| O'Connor, O. A. Hematological Oncology, volume 41, issue S2, pages 313-314 (2023). 10.1002/hon.3164_220 Cite \| Source
Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia (journal article) Fisher-Wellman, Kelsey H. \| Kassai, Miki \| Hagen, James T. \| Neufer, P. Darrell \| Kester, Mark \| Loughran, Thomas P. \| Chalfant, Charles E. \| Feith, David J. \| Tan, Su-Fern \| Fox, Todd E. \| ... \| Cabot, Myles C. Cancers, volume 15, issue 6, pages 1883- (2023). 10.3390/cancers15061883 Cited by (2) \| Cite \| Source
Ceramide Nanoliposomes as Potential Therapeutic Reagents for Asthma (journal article) Sakae, Harumi \| Ogiso, Yuri \| Matsuda, Masaya \| Shimora, Hayato \| Deering, Tye \| Fox, Todd E. \| Kester, Mark \| Nabe, Takeshi \| Kitatani, Kazuyuki Cells, volume 12, issue 4, pages 591- (2023). 10.3390/cells12040591 Cited by (3) \| Cite \| Source
Nanoliposomal C6-Ceramide Exhibits Synergistic Anti-Cancer Activity with a Small Molecule Agonist of PP2A in Chronic Lymphocytic Leukemia (journal article) Jayappa, Kallesh D. \| Vass, Luke R. \| Farrington, Caroline \| Illendula, Anuradha \| Walker, Susan \| Williams, Michael E. \| Portell, Craig A. \| Fox, Todd \| Narla, Goutham \| Kester, Mark Blood, volume 140, issue Supplement 1, pages 7816-7817 (2022). 10.1182/blood-2022-168086 Cited by (1) \| Cite \| Source
Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia (journal article) Khokhlatchev, Andrei V. \| Sharma, Arati \| Deering, Tye G. \| Shaw, Jeremy J. P. \| Costa‐Pinheiro, Pedro \| Golla, Upendarrao \| Annageldiyev, Charyguly \| Cabot, Myles C. \| Conaway, Mark R. \| Tan, Su‐Fern \| ... \| Kester, Mark The FASEB Journal, volume 36, issue 10 (2022). 10.1096/fj.202200765R Cited by (7) \| Cite \| Source
Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia (journal article) Ung, Johnson \| Tan, Su-Fern \| Fox, Todd E. \| Shaw, Jeremy J.P. \| Vass, Luke R. \| Costa-Pinheiro, Pedro \| Garrett-Bakelman, Francine E. \| Keng, Michael K. \| Sharma, Arati \| Claxton, David F. \| ... \| Loughran, Thomas P. Blood Reviews, volume 55 (2022). 10.1016/j.blre.2022.100950 Cited by (8) \| Cite \| Source
Combined epigenetic and immunotherapy for blastic and classical mantle cell lymphoma (journal article) LeBlanc, Francis R. \| Hasanali, Zainul S. \| Stuart, August \| Shimko, Sara \| Sharma, Kamal \| Leshchenko, Violetta V. \| Parekh, Samir \| Fu, Haiqing \| Zhang, Ya \| Martin, Melvenia M. \| ... \| Epner, Elliot M. Oncotarget, volume 13, issue 1, pages 986-1002 (2022). 10.18632/oncotarget.28258 Cite \| Source
Influence of ceramide on lipid domain stability studied with small-angle neutron scattering: The role of acyl chain length and unsaturation (journal article) DiPasquale, Mitchell \| Deering, Tye G. \| Desai, Dhimant \| Sharma, Arun K. \| Amin, Shantu \| Fox, Todd E. \| Kester, Mark \| Katsaras, John \| Marquardt, Drew \| Heberle, Frederick A. Chemistry and Physics of Lipids, volume 245 (2022). 10.1016/j.chemphyslip.2022.105205 Cited by (9) \| Cite \| Source
Nanoliposome C6‐Ceramide in combination with anti‐CTLA4 antibody improves anti‐tumor immunity in hepatocellular cancer (journal article) Qi, Xiaoqiang \| Wu, Feng \| Kim, Sung Hoon \| Kaifi, Jussuf T. \| Kimchi, Eric T. \| Snyder, Helena \| Illendula, Anuradha \| Fox, Todd \| Kester, Mark \| Staveley‐O'Carroll, Kevin F. \| Li, Guangfu The FASEB Journal, volume 36, issue 4 (2022). 10.1096/fj.202101707R Cited by (8) \| Cite \| Source
A nano-enhanced vaccine for metastatic melanoma immunotherapy (journal article) Salotto, Katelyn E. \| Olson, Walter C. \| Pollack, Karlyn E. \| Illendula, Anuradha \| Michel, Elishama \| Henriques, Sydney \| Fox, Todd \| Walker, Susan \| Dunlap-Brown, Marya \| Slingluff, Craig L. \| ... \| Snyder, Helena W. Cancer Drug Resistance, volume 5, issue 3, pages 829-45 (2022). 10.20517/cdr.2021.132 Cited by (1) \| Cite \| Source
Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia (journal article) Fisher‐Wellman, Kelsey H. \| Hagen, James T. \| Kassai, Miki \| Kao, Li‐Pin \| Nelson, Margaret A. M. \| McLaughlin, Kelsey L. \| Coalson, Hannah S. \| Fox, Todd E. \| Tan, Su‐Fern \| Feith, David J. \| ... \| Cabot, Myles C. The FASEB Journal, volume 36, issue 1 (2022). 10.1096/fj.202101194RRR Cited by (5) \| Cite \| Source
Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma (journal article) Shaw, Jeremy J.P. \| Boyer, Timothy L. \| Venner, Emily \| Beck, Patrick J. \| Slamowitz, Tristen \| Caste, Tara \| Hickman, Alexandra \| Raymond, Michael H. \| Costa-Pinheiro, Pedro \| Jameson, Mark J. \| ... \| Kester, Mark Molecular Cancer Therapeutics, volume 19, issue 12, pages 2621-2633 (2020). 10.1158/1535-7163.MCT-20-0182 Cited by (9) \| Cite \| Source
Glucosylceramide production maintains colon integrity in response to Bacteroides fragilis toxin‐induced colon epithelial cell signaling (journal article) Patterson, Logan \| Allen, Jawara \| Posey, Isabella \| Shaw, Jeremy Joseph Porter \| Costa‐Pinheiro, Pedro \| Walker, Susan J. \| Gademsey, Alexis \| Wu, Xinqun \| Wu, Shaoguang \| Zachos, Nicholas C. \| ... \| Kester, Mark The FASEB Journal, volume 34, issue 12, pages 15922-15945 (2020). 10.1096/fj.202001669R Cited by (25) \| Cite \| Source
Role of SPTSSB-Regulated de Novo Sphingolipid Synthesis in Prostate Cancer Depends on Androgen Receptor Signaling (journal article) Costa-Pinheiro, Pedro \| Heher, Abigail \| Raymond, Michael H. \| Jividen, Kasey \| Shaw, Jeremy JP. \| Paschal, Bryce M. \| Walker, Susan J. \| Fox, Todd E. \| Kester, Mark iScience, volume 23, issue 12, pages 101855- (2020). 10.1016/j.isci.2020.101855 Cited by (7) \| Cite \| Source
Nervonic acid limits weight gain in a mouse model of diet‐induced obesity (journal article) Keppley, Laura J. W. \| Walker, Susan J. \| Gademsey, Alexis N. \| Smith, Jason P. \| Keller, Susanna R. \| Kester, Mark \| Fox, Todd E. The FASEB Journal, volume 34, issue 11, pages 15314-15326 (2020). 10.1096/fj.202000525R Cited by (26) \| Cite \| Source

Title	Investigators	Year	Cost	Agency
Targeted Sphingomics Core	FOX, Todd E	2020	$157,587	NATIONAL CANCER INSTITUTE
Targeted Sphing''omics'' Core	FOX, Todd E \| Kester, Mark	2017	$136,170	NATIONAL CANCER INSTITUTE