Wen-Ning Zhao

ScholarGPS® ID: 75643499894067

Affiliation

Massachusetts General Hospital, Boston, United States

Affiliation History

Field

Life Sciences

Discipline

Neurosciences

Top Specialties

Medicinal Chemistry | Histone | Histone Deacetylase

Metrics Summary

Publication Count

Predicted Citations

2,739

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration (journal article) Patnaik, Debasis \| Pao, Ping-Chieh \| Zhao, Wen-Ning \| Silva, M. Catarina \| Hylton, Norma K. \| Chindavong, Peter S. \| Pan, Ling \| Tsai, Li-Huei \| Haggarty, Stephen J. ACS Chemical Neuroscience, volume 12, issue 2, pages 271-284 (2021). 10.1021/acschemneuro.0c00308 Cited by (13) \| Cite \| Source
Induced pluripotent stem cells as tools to investigate the neurobiology of bipolar disorder and advance novel therapeutic discovery (book chapter) In Neurobiology of Bipolar Disorder Zhao, Wen-Ning \| Garza, Jacob C. \| Perlis, Roy H. \| Haggarty, Stephen J. Elsevier (2021) 10.1016/B978-0-12-819182-8.00014-4 Cite \| Source
Deep Learning Benchmarks on L1000 Gene Expression Data (journal article) McDermott, Matthew B.A. \| Wang, Jennifer \| Zhao, Wen-Ning \| Sheridan, Steven D. \| Szolovits, Peter \| Kohane, Isaac \| Haggarty, Stephen J. \| Perlis, Roy H. IEEE/ACM Transactions on Computational Biology and Bioinformatics, volume 17, issue 6, pages 1846-1857 (2020). 10.1109/TCBB.2019.2910061 Cited by (7) \| Cite \| Source
Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate (journal article) Zaldivar-Diez, Josefa \| Li, Lingling \| Garcia, Ana M. \| Zhao, Wen-Ning \| Medina-Menendez, Cristina \| Haggarty, Stephen. J. \| Gil, Carmen \| Morales, Aixa V. \| Martinez, Ana Journal of Medicinal Chemistry, volume 63, issue 5, pages 2638-2655 (2020). 10.1021/acs.jmedchem.9b01752 Cited by (13) \| Cite \| Source
Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion (journal article) Zhao, Wen-Ning \| Tobe, Brian T. D. \| Udeshi, Namrata D. \| Xuan, Lucius L. \| Pernia, Cameron D. \| Zolg, Daniel P. \| Roberts, Amanda J. \| Mani, Deepak \| Blumenthal, Sarah R. \| Kurtser, Iren \| ... \| Haggarty, Stephen J. Translational Psychiatry, volume 10, issue 1 (2020). 10.1038/s41398-020-0753-6 Cited by (11) \| Cite \| Source
An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration (journal article) Petcherski, Anton \| Chandrachud, Uma \| Butz, Elisabeth \| Klein, Madeleine \| Zhao, Wen-Ning \| Reis, Surya \| Haggarty, Stephen \| Ruonala, Mika \| Cotman, Susan Cells, volume 8, issue 12, pages 1531- (2019). 10.3390/cells8121531 Cited by (10) \| Cite \| Source
Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery (journal article) Bernard-Gauthier, Vadim \| Mossine, Andrew V. \| Knight, Ashley \| Patnaik, Debasis \| Zhao, Wen-Ning \| Cheng, Chialin \| Krishnan, Hema S. \| Xuan, Lucius L. \| Chindavong, Peter S. \| Reis, Surya A. \| ... \| Vasdev, Neil Journal of Medicinal Chemistry, volume 62, issue 21, pages 9600-9617 (2019). 10.1021/acs.jmedchem.9b01030 Cited by (30) \| Cite \| Source
Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA) (journal article) Zhao, Wen-Ning \| Hylton, Norma K. \| Wang, Jennifer \| Chindavong, Peter S. \| Alural, Begum \| Kurtser, Iren \| Subramanian, Aravind \| Mazitschek, Ralph \| Perlis, Roy H. \| Haggarty, Stephen J. Molecular and Cellular Neuroscience, volume 99 (2019). 10.1016/j.mcn.2019.06.006 Cited by (19) \| Cite \| Source
High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology (journal article) Lin, Xudong \| Duan, Xin \| Jacobs, Claire \| Ullmann, Jeremy \| Chan, Chung-Yuen \| Chen, Siya \| Cheng, Shuk-Han \| Zhao, Wen-Ning \| Poduri, Annapurna \| Wang, Xin \| ... \| Shi, Peng Nature Communications, volume 9, issue 1 (2018). 10.1038/s41467-018-07289-5 Cited by (34) \| Cite \| Source
Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory (journal article) Zhao, Wen-Ning \| Ghosh, Balaram \| Tyler, Marshall \| Lalonde, Jasmin \| Joseph, Nadine F. \| Kosaric, Nina \| Fass, Daniel M. \| Tsai, Li-Huei \| Mazitschek, Ralph \| Haggarty, Stephen J. ACS Chemical Neuroscience, volume 9, issue 9, pages 2262-2273 (2018). 10.1021/acschemneuro.8b00116 Cited by (23) \| Cite \| Source
Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling (journal article) Garza, Jacob C. \| Qi, Xiaoli \| Gjeluci, Klaudio \| Leussis, Melanie P. \| Basu, Himanish \| Reis, Surya A. \| Zhao, Wen Ning \| Piguel, Nicolas H. \| Penzes, Peter \| Haggarty, Stephen J. \| ... \| Petryshen, Tracey L. Translational Psychiatry, volume 8, issue 1 (2018). 10.1038/s41398-018-0182-y Cited by (26) \| Cite \| Source \| Open Access
Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability (journal article) Lalonde, Jasmin \| Reis, Surya A. \| Sivakumaran, Sudhir \| Holland, Carl S. \| Wesseling, Hendrik \| Sauld, John F. \| Alural, Begum \| Zhao, Wen-Ning \| Steen, Judith A. \| Haggarty, Stephen J. Nature Communications, volume 8, issue 1 (2017). 10.1038/s41467-017-01750-7 Cited by (16) \| Cite \| Source \| Open Access
HDAC6 Brain Mapping with [18 F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination (journal article) Strebl, Martin G. \| Campbell, Arthur J. \| Zhao, Wen-Ning \| Schroeder, Frederick A. \| Riley, Misha M. \| Chindavong, Peter S. \| Morin, Thomas M. \| Haggarty, Stephen J. \| Wagner, Florence F. \| Ritter, Tobias \| Hooker, Jacob M. ACS Central Science, volume 3, issue 9, pages 1006-1014 (2017). 10.1021/acscentsci.7b00274 Cited by (59) \| Cite \| Source \| Open Access
Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia (journal article) She, Angela \| Kurtser, Iren \| Reis, Surya A. \| Hennig, Krista \| Lai, Jenny \| Lang, Audrey \| Zhao, Wen-Ning \| Mazitschek, Ralph \| Dickerson, Bradford C. \| Herz, Joachim \| Haggarty, Stephen J. Cell Chemical Biology, volume 24, issue 7, pages 892-906.e5 (2017). 10.1016/j.chembiol.2017.06.010 Cited by (38) \| Cite \| Source
WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4 (journal article) Hennig, Krista M. \| Fass, Daniel M. \| Zhao, Wen-Ning \| Sheridan, Steven D. \| Fu, Ting \| Erdin, Serkan \| Stortchevoi, Alexei \| Lucente, Diane \| Cody, Jannine D. \| Sweetser, David \| ... \| Haggarty, Stephen J. Complex Psychiatry, volume 3, issue 1, pages 53-71 (2017). 10.1159/000475666 Cited by (21) \| Cite \| Source
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors (journal article) Wagner, Florence F. \| Weïwer, Michel \| Steinbacher, Stefan \| Schomburg, Adrian \| Reinemer, Peter \| Gale, Jennifer P. \| Campbell, Arthur J. \| Fisher, Stewart L. \| Zhao, Wen-Ning \| Reis, Surya A. \| ... \| Holson, Edward B. Bioorganic & Medicinal Chemistry, volume 24, issue 18, pages 4008-4015 (2016). 10.1016/j.bmc.2016.06.040 Cited by (50) \| Cite \| Source
Dissecting structure–activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation (journal article) Ghosh, Balaram \| Zhao, Wen-Ning \| Reis, Surya A. \| Patnaik, Debasis \| Fass, Daniel M. \| Tsai, Li-Huei \| Mazitschek, Ralph \| Haggarty, Stephen J. Bioorganic & Medicinal Chemistry Letters, volume 26, issue 4, pages 1265-1271 (2016). 10.1016/j.bmcl.2016.01.022 Cited by (23) \| Cite \| Source \| Open Access
A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas (journal article) Beauchamp, Roberta L. \| James, Marianne F. \| DeSouza, Patrick A. \| Wagh, Vilas \| Zhao, Wen-Ning \| Jordan, Justin T. \| Stemmer-Rachamimov, Anat \| Plotkin, Scott R. \| Gusella, James F. \| Haggarty, Stephen J. \| Ramesh, Vijaya Oncotarget, volume 6, issue 19 (2015). 10.18632/oncotarget.4858 Cited by (44) \| Cite \| Source \| Open Access
Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function (journal article) Chandrachud, Uma \| Walker, Mathew W. \| Simas, Alexandra M. \| Heetveld, Sasja \| Petcherski, Anton \| Klein, Madeleine \| Oh, Hyejin \| Wolf, Pavlina \| Zhao, Wen-Ning \| Norton, Stephanie \| ... \| Cotman, Susan L. Journal of Biological Chemistry, volume 290, issue 23, pages 14361-14380 (2015). 10.1074/jbc.M114.621706 Cited by (70) \| Cite \| Source \| Open Access
A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests (journal article) Schroeder, Frederick A. \| Lewis, Michael C. \| Fass, Daniel M. \| Wagner, Florence F. \| Zhang, Yan-Ling \| Hennig, Krista M. \| Gale, Jennifer \| Zhao, Wen-Ning \| Reis, Surya \| Barker, Douglas D. \| ... \| Petryshen, Tracey L. PLoS ONE, volume 8, issue 8, pages e71323- (2013). 10.1371/journal.pone.0071323 Cited by (114) \| Cite \| Source \| Open Access