Scott D. Rychnovsky

ScholarGPS® ID: 74658430176787

Affiliation
University of California, Irvine, Irvine, United States
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Chemical Synthesis | Organic Chemistry | Absolute Configuration | Mass Spectrometry | Analytical Chemistry | Cyclic Compound | Proteomics | Antibiotic | Biosynthesis | Cascade Reaction | Diels–Alder Reaction | Protein Complex | Vancomycin | Amphotericin B | Enantioselective Synthesis
Metrics Summary
Publication Count
386
Predicted Citations
15,682
Predicted h-index
67
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Formation of Chromophores from cis -Pinonaldehyde Aged in Highly Acidic Conditions (journal article)
Wong, Cynthia | Pazienza, Jessica E. | Rychnovsky, Scott D. | Nizkorodov, Sergey A.
Journal of the American Chemical Society, volume 146, issue 17, pages 11702-11710 (2024).
10.1021/jacs.3c14177
Cite | Source
Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry (journal article)
Jiao, Fenglong | Salituro, Leah J. | Yu, Clinton | Gutierrez, Craig B. | Rychnovsky, Scott D. | Huang, Lan
Analytical Chemistry, volume 95, issue 4, pages 2532-2539 (2023).
10.1021/acs.analchem.2c04986
Cited by (7) | Cite | Source
Asymmetric Total Synthesis of (2 R )-Hydroxynorneomajucin, a Norsesquiterpene from Illicium jiadifengpi (journal article)
Dooley, Charles J. | Rychnovsky, Scott D.
Organic Letters, volume 24, issue 18, pages 3411-3415 (2022).
10.1021/acs.orglett.2c01207
Cited by (4) | Cite | Source
Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis (journal article)
Jiao, Fenglong | Yu, Clinton | Wheat, Andrew | Wang, Xiaorong | Rychnovsky, Scott D. | Huang, Lan
Analytical Chemistry, volume 94, issue 10, pages 4236-4242 (2022).
10.1021/acs.analchem.1c04485
Cited by (16) | Cite | Source
Total Syntheses of Strasseriolide A and B, Antimalarial Macrolide Natural Products (journal article)
Salituro, Leah J. | Pazienza, Jessica E. | Rychnovsky, Scott D.
Organic Letters, volume 24, issue 5, pages 1190-1194 (2022).
10.1021/acs.orglett.1c04340
Cited by (10) | Cite | Source
Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry (journal article)
Wheat, Andrew | Yu, Clinton | Wang, Xiaorong | Burke, Anthony M. | Chemmama, Ilan E. | Kaake, Robyn M. | Baker, Peter | Rychnovsky, Scott D. | Yang, Jing | Huang, Lan
Proceedings of the National Academy of Sciences, volume 118, issue 32 (2021).
10.1073/pnas.2023360118
Cited by (68) | Cite | Source
Silacycle-Templated Intramolecular Diels–Alder Cyclizations for the Diastereoselective Construction of Complex Carbon Skeletons (journal article)
Carlson, Paul R. | Burns, Alexander S. | Shimizu, Emily A. | Wang, Shilin | Rychnovsky, Scott D.
Organic Letters, volume 23, issue 6, pages 2183-2188 (2021).
10.1021/acs.orglett.1c00340
Cited by (8) | Cite | Source
Enabling Photoactivated Cross-Linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-Cleavable Cross-Linkers (journal article)
Gutierrez, Craig | Salituro, Leah J. | Yu, Clinton | Wang, Xiaorong | DePeter, Sadie F. | Rychnovsky, Scott D. | Huang, Lan
Molecular & Cellular Proteomics, volume 20 (2021).
10.1016/j.mcpro.2021.100084
Cited by (16) | Cite | Source
Using the Competing Enantioselective Conversion Method to Assign the Absolute Configuration of Cyclic Amines with Bode’s Acylation Reagents (journal article)
Dooley, Charles J. | Burtea, Alexander | Mitilian, Christina | Dao, Wendy T. | Qu, Bo | Salzameda, Nicholas T. | Rychnovsky, Scott D.
The Journal of Organic Chemistry, volume 85, issue 16, pages 10750-10759 (2020).
10.1021/acs.joc.0c01275
Cited by (5) | Cite | Source
Mass spectrometry-cleavable cross-linker (patent)
Huang, Lan | Rychnovsky, Scott D. | Yu, Clinton | Novitsky, Eric James | Gutierrez, Craig Bryant
Patent Number: 10697977 (2020)
Cite | Source
Exploring Spacer Arm Structures for Designs of Asymmetric Sulfoxide-Containing MS-Cleavable Cross-Linkers (journal article)
Yu, Clinton | Novitsky, Eric J. | Cheng, Nicholas W. | Rychnovsky, Scott D. | Huang, Lan
Analytical Chemistry, volume 92, issue 8, pages 6026-6033 (2020).
10.1021/acs.analchem.0c00298
Cited by (5) | Cite | Source
Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling (journal article)
Gutierrez, Craig | Chemmama, Ilan E. | Mao, Haibin | Yu, Clinton | Echeverria, Ignacia | Block, Sarah A. | Rychnovsky, Scott D. | Zheng, Ning | Sali, Andrej | Huang, Lan
Proceedings of the National Academy of Sciences, volume 117, issue 8, pages 4088-4098 (2020).
10.1073/pnas.1915542117
Cited by (49) | Cite | Source
Relative and Absolute Structure Assignments of Alkenes Using Crystalline Osmate Derivatives for X-ray Analysis (journal article)
Burns, Alexander S. | Dooley, Charles | Carlson, Paul R. | Ziller, Joseph W. | Rychnovsky, Scott D.
Organic Letters, volume 21, issue 24, pages 10125-10129 (2019).
10.1021/acs.orglett.9b04133
Cited by (6) | Cite | Source
Total Synthesis of (−)‐Himeradine A (journal article)
Burtea, Alexander | DeForest, Jacob | Li, Xinting | Rychnovsky, Scott D.
Angewandte Chemie International Edition, volume 58, issue 45, pages 16193-16197 (2019).
10.1002/anie.201910129
Cited by (15) | Cite | Source
Total Synthesis of (−)‐Himeradine A (journal article)
Burtea, Alexander | DeForest, Jacob | Li, Xinting | Rychnovsky, Scott D.
Angewandte Chemie, volume 131, issue 45, pages 16339-16343 (2019).
10.1002/ange.201910129
Cited by (4) | Cite | Source
Total Synthesis and Structure Revision of (−)-Illisimonin A, a Neuroprotective Sesquiterpenoid from the Fruits of Illicium simonsii (journal article)
Burns, Alexander S. | Rychnovsky, Scott D.
Journal of the American Chemical Society, volume 141, issue 34, pages 13295-13300 (2019).
10.1021/jacs.9b05065
Cited by (54) | Cite | Source
Mass spectrometry-cleavable cross-linking agents (patent)
Rychnovsky, Scott D. | Huang, Lan
Patent Number: 10393752 (2019)
Cited by (1) | Cite | Source
Probing H2O2-mediated Structural Dynamics of the Human 26S Proteasome Using Quantitative Cross-linking Mass Spectrometry (QXL-MS) (journal article)
Yu, Clinton | Wang, Xiaorong | Huszagh, Alexander Scott | Viner, Rosa | Novitsky, Eric | Rychnovsky, Scott D. | Huang, Lan
Molecular & Cellular Proteomics, volume 18, issue 5, pages 954a-967 (2019).
10.1074/mcp.TIR119.001323
Cited by (12) | Cite | Source
Biosynthesis-Inspired Approach to Kujounin A2 Using a Stereoselective Tsuji–Trost Alkylation (journal article)
Burtea, Alexander | Rychnovsky, Scott D.
Organic Letters, volume 20, issue 18, pages 5849-5852 (2018).
10.1021/acs.orglett.8b02530
Cited by (8) | Cite | Source
Second-Generation Synthesis of (+)-Fastigiatine Inspired by Conformational Studies (journal article)
DeForest, Jacob C. | Samame, Renzo A. | Suryn, Gregory | Burtea, Alexander | Rychnovsky, Scott D.
The Journal of Organic Chemistry, volume 83, issue 16, pages 8914-8925 (2018).
10.1021/acs.joc.8b01144
Cited by (15) | Cite | Source