Isidro E. Zarraga

ScholarGPS® ID: 73648937102407

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Pharmacy and Pharmaceutical Sciences

Discipline

Pharmacy

Top Specialties

Antibody | Monoclonal Antibody | Biophysics | Physical Chemistry | Rheology

Metrics Summary

Publication Count

Predicted Citations

2,554

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Adsorption of non-ionic surfactant and monoclonal antibody on siliconized surface studied by neutron reflectometry (journal article) Zhang, Zhenhuan \| Marie Woys, Ann \| Hong, Kunlun \| Grapentin, Christoph \| Khan, Tarik A. \| Zarraga, Isidro E. \| Wagner, Norman J. \| Liu, Yun Journal of Colloid and Interface Science, volume 584 (2021). 10.1016/j.jcis.2020.09.110 Cited by (23) \| Cite \| Source
Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform (journal article) Bailey-Hytholt, Christina M. \| Ghosh, Paroma \| Dugas, Julia \| Zarraga, Isidro E. \| Bandekar, Amey Journal of Visualized Experiments (2021). 10.3791/62226 Cited by (3) \| Cite \| Source
Characterization of Polysorbate Ester Fractions and Implications in Protein Drug Product Stability (journal article) Tomlinson, Anthony \| Zarraga, Isidro E. \| Demeule, Barthélemy Molecular Pharmaceutics, volume 17, issue 7, pages 2345-2353 (2020). 10.1021/acs.molpharmaceut.0c00093 Cited by (35) \| Cite \| Source
Micellar Morphology of Polysorbate 20 and 80 and Their Ester Fractions in Solution via Small-Angle Neutron Scattering (journal article) Nayem, Jannatun \| Zhang, Zhenhuan \| Tomlinson, Anthony \| Zarraga, Isidro E. \| Wagner, Norman J. \| Liu, Yun Journal of Pharmaceutical Sciences, volume 109, issue 4, pages 1498-1508 (2020). 10.1016/j.xphs.2019.12.016 Cited by (37) \| Cite \| Source
Optimizing the Formulation and Lyophilization Process for a Fragment Antigen Binding (Fab) Protein Using Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry (ssHDX-MS) (journal article) Kumar, Lokesh \| Chandrababu, Karthik Balakrishna \| Balakrishnan, Shenbaga Moorthy \| Allmendinger, Andrea \| Walters, Benjamin \| Zarraga, Isidro E. \| Chang, Debby P. \| Nayak, Purnendu \| Topp, Elizabeth M. Molecular Pharmaceutics, volume 16, issue 11, pages 4485-4495 (2019). 10.1021/acs.molpharmaceut.9b00614 Cited by (8) \| Cite \| Source
Data-Driven Development of Predictive Models for Sustained Drug Release (journal article) Koshari, Stijn H.S. \| Chang, Debby P. \| Wang, Nathan B. \| Zarraga, Isidro E. \| Rajagopal, Karthikan \| Lenhoff, Abraham M. \| Wagner, Norman J. Journal of Pharmaceutical Sciences, volume 108, issue 11, pages 3582-3591 (2019). 10.1016/j.xphs.2019.06.027 Cited by (4) \| Cite \| Source
In Situ Characterization of the Microstructural Evolution of Biopharmaceutical Solid-State Formulations with Implications for Protein Stability (journal article) Koshari, Stijn H. S. \| Nayak, Purnendu K. \| Burra, Shalini \| Zarraga, Isidro E. \| Rajagopal, Karthikan \| Liu, Yun \| Wagner, Norman J. \| Lenhoff, Abraham M. Molecular Pharmaceutics, volume 16, issue 1, pages 173-183 (2019). 10.1021/acs.molpharmaceut.8b00935 Cited by (8) \| Cite \| Source
Adsorption of polysorbate 20 and proteins on hydrophobic polystyrene surfaces studied by neutron reflectometry (journal article) Zhang, Zhenhuan \| Orski, Sara \| Woys, Ann Marie \| Yuan, Guangcui \| Zarraga, Isidro E. \| Wagner, Norman J. \| Liu, Yun Colloids and Surfaces B: Biointerfaces, volume 168 (2018). 10.1016/j.colsurfb.2018.04.036 Cited by (22) \| Cite \| Source
Antibody formulations (patent) Gokarn, Yatin \| Zarraga, Isidro E. \| Zarzar, Jonathan \| Patapoff, Thomas Patent Number: 10010611 (2018) Cite \| Source
Impact of polymer geometry on the interactions of protein-PEG conjugates (journal article) Zarzar, Jonathan \| Shatz, Whitney \| Peer, Nikhil \| Taing, Rosalynn \| McGarry, Brian \| Liu, Yun \| Greene, Daniel G. \| Zarraga, Isidro E. Biophysical Chemistry, volume 236 (2018). 10.1016/j.bpc.2017.10.003 Cited by (14) \| Cite \| Source
Structure and Relaxation in Solutions of Monoclonal Antibodies (journal article) Wang, Gang \| Varga, Zsigmond \| Hofmann, Jennifer \| Zarraga, Isidro E. \| Swan, James W. The Journal of Physical Chemistry B, volume 122, issue 11, pages 2867-2880 (2018). 10.1021/acs.jpcb.7b11053 Cited by (35) \| Cite \| Source
Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations (journal article) Moorthy, Balakrishnan S. \| Zarraga, Isidro E. \| Kumar, Lokesh \| Walters, Benjamin T. \| Goldbach, Pierre \| Topp, Elizabeth M. \| Allmendinger, Andrea Molecular Pharmaceutics, volume 15, issue 1, pages 1-11 (2018). 10.1021/acs.molpharmaceut.7b00504 Cited by (38) \| Cite \| Source
Antibody formulations (patent) Gokarn, Yatin \| Zarraga, Isidro E. \| Zarzar, Jonathan \| Patapoff, Thomas \| Wurth, Christine Patent Number: 9821065 (2017) Cite \| Source
Methods and compositions for enhancing immune response (patent) Miller, Richard L. \| Tomai, Mark A. \| Kedl, Ross M. \| Zarraga, Isidro Angelo Eleazar \| Ortiz, Ronnie \| Stoesz, James D. \| Wightman, Paul D. Patent Number: 9801947 (2017) Cited by (4) \| Cite \| Source
Characterization of Protein–Excipient Microheterogeneity in Biopharmaceutical Solid-State Formulations by Confocal Fluorescence Microscopy (journal article) Koshari, Stijn H. S. \| Ross, Jean L. \| Nayak, Purnendu K. \| Zarraga, Isidro E. \| Rajagopal, Karthikan \| Wagner, Norman J. \| Lenhoff, Abraham M. Molecular Pharmaceutics, volume 14, issue 2, pages 546-553 (2017). 10.1021/acs.molpharmaceut.6b00940 Cited by (12) \| Cite \| Source
Impact of mono- and poly-ester fractions on polysorbate quantitation using mixed-mode HPLC-CAD/ELSD and the fluorescence micelle assay (journal article) Lippold, Steffen \| Koshari, Stijn H.S. \| Kopf, Robert \| Schuller, Rudolf \| Buckel, Thomas \| Zarraga, Isidro E. \| Koehn, Henning Journal of Pharmaceutical and Biomedical Analysis, volume 132 (2017). 10.1016/j.jpba.2016.09.033 Cited by (45) \| Cite \| Source
Molecular simulations of micellar aggregation of polysorbate 20 ester fractions and their interaction with N-phenyl-1-naphthylamine dye (journal article) Lapelosa, Mauro \| Patapoff, Thomas W. \| Zarraga, Isidro E. Biophysical Chemistry, volume 213 (2016). 10.1016/j.bpc.2016.03.003 Cited by (19) \| Cite \| Source
Effect of Hierarchical Cluster Formation on the Viscosity of Concentrated Monoclonal Antibody Formulations Studied by Neutron Scattering (journal article) Godfrin, P. Douglas \| Zarraga, Isidro E. \| Zarzar, Jonathan \| Porcar, Lionel \| Falus, Peter \| Wagner, Norman J. \| Liu, Yun The Journal of Physical Chemistry B, volume 120, issue 2, pages 278-291 (2016). 10.1021/acs.jpcb.5b07260 Cited by (93) \| Cite \| Source
Modeling of protein–anion exchange resin interaction for the human growth hormone charge variants (journal article) Lapelosa, Mauro \| Patapoff, Thomas W. \| Zarraga, Isidro E. Biophysical Chemistry, volume 207 (2015). 10.1016/j.bpc.2015.07.004 Cited by (4) \| Cite \| Source
Interactions Between Peptide and Preservatives: Effects on Peptide Self-Interactions and Antimicrobial Efficiency In Aqueous Multi-Dose Formulations (journal article) Heljo, P. \| Ross, A. \| Zarraga, I. E. \| Pappenberger, A. \| Mahler, H-C. Pharmaceutical Research, volume 32, issue 10, pages 3201-3212 (2015). 10.1007/s11095-015-1697-z Cited by (21) \| Cite \| Source