Michael Siu

ScholarGPS® ID: 72603805600665

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

Predicted Citations

1,291

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors (journal article) Hu, Dennis X. \| Patel, Snahel \| Chen, Huifen \| Wang, Shumei \| Staben, Steven T. \| Dimitrova, Yoana N. \| Wallweber, Heidi Ackerly \| Lee, Joanna Y. \| Chan, Grace Ka Yan \| Sneeringer, Christopher J. \| ... \| Siu, Michael Journal of Medicinal Chemistry, volume 65, issue 17, pages 11500-11512 (2022). 10.1021/acs.jmedchem.1c01180 Cited by (13) \| Cite \| Source
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor (journal article) Huestis, Malcolm P. \| Durk, Matthew R. \| Eigenbrot, Charles \| Gibbons, Paul \| Hunsaker, Thomas L. \| La, Hank \| Leung, Dennis H. \| Liu, Wendy \| Malek, Shiva \| Merchant, Mark \| ... \| Siu, Michael ACS Medicinal Chemistry Letters, volume 12, issue 5, pages 791-797 (2021). 10.1021/acsmedchemlett.1c00063 Cited by (3) \| Cite \| Source
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3 H )-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor (journal article) Huestis, Malcolm P. \| Dela Cruz, Darlene \| DiPasquale, Antonio G. \| Durk, Matthew R. \| Eigenbrot, Charles \| Gibbons, Paul \| Gobbi, Alberto \| Hunsaker, Thomas L. \| La, Hank \| Leung, Dennis H. \| ... \| Rudolph, Joachim Journal of Medicinal Chemistry, volume 64, issue 7, pages 3940-3955 (2021). 10.1021/acs.jmedchem.0c02085 Cited by (18) \| Cite \| Source
Fit-for-purpose synthesis of dual leucine zipper kinase (DLK) inhibitor GNE-834 (journal article) Xu, Jie \| Carrera, Diane E. \| Beaudry, Danial \| Siu, Michael \| Huestis, Malcolm P. \| Liu, Wendy \| Angelaud, Rémy \| Gosselin, Francis Tetrahedron Letters, volume 61, issue 43, pages 152430- (2020). 10.1016/j.tetlet.2020.152430 Cited by (1) \| Cite \| Source
Biheteroaryl compounds and uses thereof (patent) Estrada, Anthony \| Olivero, Alan G. \| Patel, Snahel \| Siu, Michael \| Lyssikatos, Joseph \| Huestis, Malcolm \| Kellar, Terry Patent Number: RE47848 (2020) Cite \| Source
Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability (journal article) Ladi, Ena \| Everett, Christine \| Stivala, Craig E. \| Daniels, Blake E. \| Durk, Matthew R. \| Harris, Seth F. \| Huestis, Malcolm P. \| Purkey, Hans E. \| Staben, Steven T. \| Augustin, Martin \| ... \| Siu, Michael Journal of Medicinal Chemistry, volume 62, issue 15, pages 7032-7041 (2019). 10.1021/acs.jmedchem.9b00509 Cited by (26) \| Cite \| Source
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling (journal article) Zak, Mark \| Hanan, Emily J. \| Lupardus, Patrick \| Brown, David G. \| Robinson, Colin \| Siu, Michael \| Lyssikatos, Joseph P. \| Romero, F. Anthony \| Zhao, Guiling \| Kellar, Terry \| ... \| Johnson, Adam Bioorganic & Medicinal Chemistry Letters, volume 29, issue 12, pages 1522-1531 (2019). 10.1016/j.bmcl.2019.04.008 Cited by (26) \| Cite \| Source
Tricyclic DLK inhibitors and uses thereof (patent) Estrada, Anthony \| Patel, Snahel \| Kellar, Terry \| Huestis, Malcolm \| Shore, Daniel \| Siu, Michael Patent Number: 10131675 (2018) Cite \| Source
Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration (journal article) Siu, Michael \| Sengupta Ghosh, Arundhati \| Lewcock, Joseph W. Journal of Medicinal Chemistry, volume 61, issue 18, pages 8078-8087 (2018). 10.1021/acs.jmedchem.8b00370 Cited by (36) \| Cite \| Source
3-substituted pyrazoles and uses thereof (patent) Estrada, Anthony \| Liu, Wen \| Patel, Snahel \| Siu, Michael Patent Number: 10028942 (2018) Cited by (1) \| Cite \| Source
Biheteroaryl compounds and uses thereof (patent) Estrada, Anthony \| Olivero, Alan G \| Patel, Snahel \| Siu, Michael \| Lyssikatos, Joseph Patent Number: 10028954 (2018) Cited by (1) \| Cite \| Source
Biheteroaryl compounds and uses thereof (patent) Estrada, Anthony \| Dong, Liting \| Chen, Kevin X. \| Gibbons, Paul \| Huestis, Malcolm \| Kellar, Terry \| Liu, Wen \| Ma, Changyou \| Lyssikatos, Joseph \| Olivero, Alan \| ... \| Siu, Michael Patent Number: 10010549 (2018) Cited by (1) \| Cite \| Source
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease (journal article) Patel, Snahel \| Meilandt, William J. \| Erickson, Rebecca I. \| Chen, Jinhua \| Deshmukh, Gauri \| Estrada, Anthony A. \| Fuji, Reina N. \| Gibbons, Paul \| Gustafson, Amy \| Harris, Seth F. \| ... \| Siu, Michael Journal of Medicinal Chemistry, volume 60, issue 19, pages 8083-8102 (2017). 10.1021/acs.jmedchem.7b00843 Cited by (43) \| Cite \| Source
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease (journal article) Le Pichon, Claire E. \| Meilandt, William J. \| Dominguez, Sara \| Solanoy, Hilda \| Lin, Han \| Ngu, Hai \| Gogineni, Alvin \| Sengupta Ghosh, Arundhati \| Jiang, Zhiyu \| Lee, Seung-Hye \| ... \| Lewcock, Joseph W. Science Translational Medicine, volume 9, issue 403 (2017). 10.1126/scitranslmed.aag0394 Cited by (96) \| Cite \| Source \| Open Access
Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450 (journal article) Takahashi, Ryan H. \| Halladay, Jason S. \| Siu, Michael \| Chen, Yuan \| Hop, Cornelis E. C. A. \| Khojasteh, S. Cyrus \| Ma, Shuguang Drug Metabolism and Disposition, volume 45, issue 5, pages 430-440 (2017). 10.1124/dmd.116.074336 Cited by (9) \| Cite \| Source
Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult (journal article) Larhammar, Martin \| Huntwork-Rodriguez, Sarah \| Jiang, Zhiyu \| Solanoy, Hilda \| Sengupta Ghosh, Arundhati \| Wang, Bei \| Kaminker, Joshua S \| Huang, Kevin \| Eastham-Anderson, Jeffrey \| Siu, Michael \| ... \| Watkins, Trent A eLife, volume 6 (2017). 10.7554/eLife.20725 Cited by (44) \| Cite \| Source \| Open Access
3-substituted pyrazoles and use as DLK inhibitors (patent) Estrada, Anthony \| Liu, Wen \| Patel, Snahel \| Siu, Michael Patent Number: 9550777 (2017) Cite \| Source
Triazolopyridine JAK inhibitor compounds and methods (patent) Zhu, Bing-Yan \| Siu, Michael \| Magnuson, Steven R. \| Pastor, Richard \| Haiying, He \| Yisong, Xiao \| Jifu, Zheng \| Xing, Xu \| Junping, Zhao \| Hurley, Christopher \| ... \| Lyssikatos, Joseph P. Patent Number: 9434732 (2016) Cite \| Source
Substituted dipyridylamines and uses thereof (patent) Cohen, Frederick \| Huestis, Malcolm \| Ly, Cuong \| Patel, Snahel \| Siu, Michael \| Zhao, Xianrui Patent Number: 9399636 (2016) Cite \| Source
Preparation of 2-Azabicyclo[2.1.1]hexane Hydrochloride (journal article) Liao, Haili \| Li, Aimin \| Chen, Xingsong \| Liang, Kun \| Shen, Yang \| Liang, Qingfeng \| Xu, Kewei \| Shore, Daniel \| Villemure, Elisia \| Siu, Michael \| Huestis, Malcolm Synlett, volume 27, issue 15, pages 2251-2253 (2016). 10.1055/s-0035-1562380 Cited by (7) \| Cite \| Source