Mark J. Macielag

ScholarGPS® ID: 71837580292485

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

174

Predicted Citations

4,728

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists (journal article) Patch, Raymond J. \| Zhang, Rui \| Edavettal, Suzanne \| Macielag, Mark J. \| Eckardt, Annette J. \| Li, Jiali \| Rives, Marie-Laure \| Edwards, Wilson \| Hinke, Simon A. \| Qiu, Xi \| ... \| Hornby, Pamela European Journal of Medicinal Chemistry, volume 236 (2022). 10.1016/j.ejmech.2022.114330 Cited by (2) \| Cite \| Source
Discovery and Optimization of 7-Alkylidenyltetrahydroindazole-Based Acylsulfonamide EP3 Antagonists (journal article) Zhu, Bin \| Zhang, Xuqing \| Guo, Lili \| Rankin, Matthew \| Bakaj, Ivona \| Ho, George \| Lee, Seunghun P. \| Norquay, Lisa \| Macielag, Mark ACS Medicinal Chemistry Letters, volume 13, issue 1, pages 111-117 (2022). 10.1021/acsmedchemlett.1c00594 Cited by (1) \| Cite \| Source
Erratum to “Optimization of physicochemical properties of pyridone-based EP3 receptor antagonists” [Bioorg. Med. Chem. Lett. 47 (2021) 128172] (journal article) Zhang, Xuqing \| Zhu, Bin \| Guo, Lili \| Bakaj, Ivona \| Rankin, Matthew \| Ho, George \| Kauffman, Jack \| Lee, Seunghun P. \| Norquay, Lisa \| Macielag, Mark Bioorganic & Medicinal Chemistry Letters, volume 47 (2021). 10.1016/j.bmcl.2021.128232 Cite \| Source
Optimization of physicochemical properties of pyridone-based EP3 receptor antagonists (journal article) Zhang, Xuqing \| Zhu, Bin \| Guo, Lili \| Bakaj, Ivona \| Rankin, Matthew \| Ho, George \| Kauffman, Jack \| Lee, Seunghun P. \| Norquay, Lisa \| Macielag, Mark Bioorganic & Medicinal Chemistry Letters, volume 47 (2021). 10.1016/j.bmcl.2021.128172 Cited by (3) \| Cite \| Source
Discovery of a novel series of guanidinebenzoates as gut-restricted enteropeptidase and trypsin dual inhibitors for the treatment of metabolic syndrome (journal article) Zhang, Xuqing \| Zhu, Bin \| Sun, Weimei \| Wang, Mina \| Albarazanji, Kamal \| Ghosh, Brahma \| Cummings, Maxwell \| Lenhard, James \| Leonard, James \| Macielag, Mark \| Lanter, James Bioorganic & Medicinal Chemistry Letters, volume 40 (2021). 10.1016/j.bmcl.2021.127939 Cited by (2) \| Cite \| Source
Discovery of a Novel Series of Pyridone-Based EP3 Antagonists for the Treatment of Type 2 Diabetes (journal article) Zhang, Xuqing \| Zhu, Bin \| Guo, Lili \| Bakaj, Ivona \| Rankin, Matthew \| Ho, George \| Kauffman, Jack \| Lee, Seunghun P. \| Norquay, Lisa \| Macielag, Mark J. ACS Medicinal Chemistry Letters, volume 12, issue 3, pages 451-458 (2021). 10.1021/acsmedchemlett.0c00667 Cited by (3) \| Cite \| Source
Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CB1 R Inverse Agonists (journal article) Zhang, Yue-Mei \| Greco, Michael \| Le Blanc, Tonya \| Lang, Wensheng \| Kauffman, Jack \| Masucci, John \| Murray, William V. \| Demarest, Keith \| Macielag, Mark Joseph ACS Medicinal Chemistry Letters, volume 11, issue 12, pages 2504-2509 (2020). 10.1021/acsmedchemlett.0c00495 Cite \| Source
Immunoglobulins and uses thereof (patent) Macielag, Mark \| Patch, Raymond J. \| Zhang, Rui \| Case, Martin A. \| Wall, Mark J. \| Zhang, Yue-Mei \| Rangwala, Shamina M. \| Leonard, James N. \| Camacho, Raul C. \| Hunter, Michael J. \| ... \| Chi, Ellen Patent Number: 10858413 (2020) Cite \| Source
GPR120 agonists for the treatment of diabetes: a patent review (2014 present) (journal article) Zhang, Xuqing \| Macielag, Mark J. Expert Opinion on Therapeutic Patents, volume 30, issue 10, pages 729-742 (2020). 10.1080/13543776.2020.1811852 Cited by (17) \| Cite \| Source
Immunoglobulins and uses thereof (patent) Macielag, Mark \| Patch, Raymond J. \| Zhang, Rui \| Case, Martin A. \| Rangwala, Shamina M. \| Leonard, James N. \| Camacho, Raul C. \| Hunter, Michael J. \| D'Aquino, Katharine E. \| Edwards, Wilson \| ... \| Chi, Ellen Patent Number: 10787495 (2020) Cite \| Source
The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors (journal article) Zhu, Bin \| Connolly, Peter J. \| Zhang, Yue-Mei \| McDonnell, Mark E. \| Bian, Haiyan \| Lin, Shu-Chen \| Liu, Li \| Zhang, Sui-Po \| Chevalier, Kristen M. \| Brandt, Michael R. \| ... \| Macielag, Mark J. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 14, pages 127243- (2020). 10.1016/j.bmcl.2020.127243 Cited by (12) \| Cite \| Source
The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL) (journal article) Zhu, Bin \| Connolly, Peter J. \| Zhang, Sui-Po \| Chevalier, Kristen M. \| Milligan, Cynthia M. \| Flores, Christopher M. \| Macielag, Mark J. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 12, pages 127198- (2020). 10.1016/j.bmcl.2020.127198 Cited by (7) \| Cite \| Source
Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide Y receptors (patent) Macielag, Mark \| Patch, Raymond J \| Zhang, Rui \| Case, Martin A \| Rangwala, Shamina M \| Leonard, James N \| Camacho, Raul C \| Hunter, Michael J \| D'Aquino, Katharine E. \| Edwards, Wilson \| ... \| Chi, Ellen Patent Number: 10640544 (2020) Cite \| Source
Pyridin-2-one derivatives of formula (I) useful as EP3 receptor antagonists (patent) Zhang, Xuqing \| Macielag, Mark J. Patent Number: 10590083 (2020) Cite \| Source
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor (journal article) Wyatt, Ryan M. \| Fraser, Ian \| Welty, Natalie \| Lord, Brian \| Wennerholm, Michelle \| Sutton, Steven \| Ameriks, Michael K. \| Dugovic, Christine \| Yun, Sujin \| White, Allison \| ... \| Bonaventure, Pascal Journal of Pharmacology and Experimental Therapeutics, volume 372, issue 3, pages 339-353 (2020). 10.1124/jpet.119.262139 Cited by (15) \| Cite \| Source
Immunoglobulins and uses thereof (patent) Macielag, Mark \| Patch, Raymond J \| Zhang, Rui \| Case, Martin A \| Rangwala, Shamina M \| Leonard, James N \| Camacho, Raul C \| Hunter, Michael J \| D'Aquino, Katharine E. \| Edwards, Wilson \| ... \| Chi, Ellen Patent Number: 10428134 (2019) Cited by (2) \| Cite \| Source
Pyridin-2-one derivatives of formula (III) useful as EP3 receptor antagonists (patent) Zhang, Xuqing \| Macielag, Mark J. Patent Number: 10399944 (2019) Cite \| Source
Pyridin-2-one derivatives of formula (II) useful as EP3 receptor antagonists (patent) Zhang, Xuqing \| Macielag, Mark J. Patent Number: 10336701 (2019) Cite \| Source
A Long-Acting PYY3–36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates (journal article) Rangwala, Shamina M. \| D’Aquino, Katharine \| Zhang, Yue-Mei \| Bader, Lindsay \| Edwards, Wilson \| Zheng, Songmao \| Eckardt, Annette \| Lacombe, Ann \| Pick, Rebecca \| Moreno, Veronica \| ... \| Leonard, James N. Cell Metabolism, volume 29, issue 4, pages 837-843.e5 (2019). 10.1016/j.cmet.2019.01.017 Cited by (49) \| Cite \| Source
Injectable Diabetes Treatments Targeting Glucose Regulation and Satiety Pathways (book chapter) In 2018 Medicinal Chemistry Reviews Lanter, James C. \| Zhang, Yue-Mai \| Macielag, Mark J. Medicinal Chemistry Division of the American Chemical Society (2018) 10.29200/acsmedchemrev-v53.ch7 Cite \| Source