John E. Macor | Scholar Profiles and Rankings

Publications and Citation History

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Design, Structure–Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2- b ]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors (journal article) Hartz, Richard A. \| Ahuja, Vijay T. \| Sivaprakasam, Prasanna \| Xiao, Hong \| Krause, Carol M. \| Clarke, Wendy J. \| Kish, Kevin \| Lewis, Hal \| Szapiel, Nicolas \| Ravirala, Ramu \| ... \| Dubowchik, Gene M. Journal of Medicinal Chemistry, volume 66, issue 6, pages 4231-4252 (2023). 10.1021/acs.jmedchem.3c00133 Cited by (8) \| Cite \| Source
Site-Selective C–H Functionalization of N -Aryl and N -Heteroaryl Piperidines, Morpholines, and Piperazines Controlled by a Chiral Dirhodium Tetracarboxylate Catalyst (journal article) Korvorapun, Korkit \| Boni, Yannick T. \| Maier, Thomas C. \| Bauer, Armin \| Licher, Thomas \| Macor, John E. \| Derdau, Volker \| Davies, Huw M. L. ACS Catalysis, volume 13, issue 4, pages 2359-2366 (2023). 10.1021/acscatal.2c05283 Cited by (8) \| Cite \| Source
Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors (journal article) Luo, Guanglin \| Chen, Ling \| Jacutin-Porte, Swanee \| Han, Ying \| Burton, Catherine R. \| Xiao, Hong \| Krause, Carol M. \| Cao, Yang \| Liu, Nengyin \| Kish, Kevin \| ... \| Dubowchik, Gene M. Bioorganic & Medicinal Chemistry Letters, volume 81 (2023). 10.1016/j.bmcl.2023.129143 Cited by (6) \| Cite \| Source
Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8) (journal article) Sreekantha, Ratna Kumar \| Mussari, Christopher P. \| Dodd, Dharmpal S. \| Pasunoori, Laxman \| Hegde, Subramanya \| Posy, Shana L. \| Critton, David \| Ruepp, Stefan \| Subramanian, Murali \| Salter-Cid, Luisa M. \| ... \| Dyckman, Alaric J. ACS Medicinal Chemistry Letters, volume 13, issue 5, pages 812-818 (2022). 10.1021/acsmedchemlett.2c00049 Cited by (5) \| Cite \| Source
Development of a Rapid Scale-Up Synthesis of ( S )- N -(8-((2-Amino-2,4-dimethylpentyl)oxy)-5 H -chromeno[3,4- c ]pyridin-2-yl)acetamide, a Potent Adaptor-Associated Kinase 1 Inhibitor (journal article) Li, Jianqing \| Smith, Daniel \| Pawluczyk, Joseph \| Krishnananthan, Subramaniam \| Wang, Bei \| Hou, Xiaoping \| Zhao, Rulin \| Kempson, James \| Sun, Dawn \| Yip, Shiuhang \| ... \| Mathur, Arvind Organic Process Research & Development, volume 26, issue 2, pages 437-446 (2022). 10.1021/acs.oprd.1c00452 Cited by (4) \| Cite \| Source
What I Did on My Summer Vacation and Molecules That Broke My Heart: Insights from a 35-Year Adventure In Drug Discovery (book chapter) In 2021 Medicinal Chemistry Reviews Macor, John E. Medicinal Chemistry Division of the American Chemical Society (2021) 10.29200/acsmedchemrev-v56.ch1 Cite \| Source
Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain (journal article) Hartz, Richard A \| Ahuja, Vijay T. \| Nara, Susheel J. \| Kumar, C.M. Vijaya \| Brown, Jeffrey M. \| Bristow, Linda J. \| Rajamani, Ramkumar \| Muckelbauer, Jodi K. \| Camac, Daniel \| Kiefer, Susan E. \| ... \| Dzierba, Carolyn D. Journal of Medicinal Chemistry, volume 64, issue 15, pages 11090-11128 (2021). 10.1021/acs.jmedchem.1c00472 Cited by (12) \| Cite \| Source
Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead (journal article) Luo, Guanglin \| Jiang, Xiang-Jun \| Chen, Ling \| Conway, Charles M. \| Gulianello, Michael \| Kostich, Walter \| Keavy, Deborah \| Signor, Laura J. \| Chen, Ping \| Davis, Carl \| ... \| Dubowchik, Gene M. Bioorganic & Medicinal Chemistry Letters, volume 43 (2021). 10.1016/j.bmcl.2021.128077 Cited by (4) \| Cite \| Source
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2 (journal article) Liu, Chunjian \| Lin, James \| Langevine, Charles \| Smith, Daniel \| Li, Jianqing \| Tokarski, John S. \| Khan, Javed \| Ruzanov, Max \| Strnad, Joann \| Zupa-Fernandez, Adriana \| ... \| Weinstein, David S. Journal of Medicinal Chemistry, volume 64, issue 1, pages 677-694 (2021). 10.1021/acs.jmedchem.0c01698 Cited by (44) \| Cite \| Source
Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists (journal article) Mercer, Stephen E. \| Chaturvedula, Prasad V. \| Conway, Charles M. \| Cook, Deborah A. \| Davis, Carl D. \| Pin, Sokhom S. \| Macci, Robert \| Schartman, Richard \| Signor, Laura J. \| Widmann, Kimberly A. \| ... \| Dubowchik, Gene M. Bioorganic & Medicinal Chemistry Letters, volume 31 (2021). 10.1016/j.bmcl.2020.127624 Cited by (11) \| Cite \| Source
Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach (journal article) Liu, Qingjie \| Batt, Douglas G. \| Weigelt, Carolyn A. \| Yip, Shiuhang \| Wu, Dauh-Rurng \| Ruzanov, Max \| Sack, John S. \| Wang, Jinhong \| Yarde, Melissa \| Li, Sha \| ... \| Dhar, T. G. Murali ACS Medicinal Chemistry Letters, volume 11, issue 12, pages 2510-2518 (2020). 10.1021/acsmedchemlett.0c00496 Cited by (12) \| Cite \| Source
Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches (journal article) Xiao, Hai-Yun \| Li, Ning \| Duan, James J.-W. \| Jiang, Bin \| Lu, Zhonghui \| Ngu, Khehyong \| Tino, Joseph \| Kopcho, Lisa M. \| Lu, Hao \| Chen, Jing \| ... \| Dhar, T. G. Murali Journal of Medicinal Chemistry, volume 63, issue 23, pages 15050-15071 (2020). 10.1021/acs.jmedchem.0c01732 Cited by (21) \| Cite \| Source
Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite (journal article) Zhang, Yunhui \| Boy, Kenneth M. \| Wu, Yong-Jin \| Ramirez, Antonio \| Toyn, Jeremy H. \| Ahlijanian, Michael K. \| Albright, Charles F. \| Zhuo, Xiaoliang \| Johnson, Benjamin M. \| Denton, R. Rex \| ... \| Macor, John E. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 22, pages 127530- (2020). 10.1016/j.bmcl.2020.127530 Cited by (3) \| Cite \| Source
Brain Penetrable Inhibitors of Ceramide Galactosyltransferase for the Treatment of Lysosomal Storage Disorders (journal article) Thurairatnam, Sukanthini \| Lim, Sungtaek \| Barker, Robert H. \| Choi-Sledeski, Yong Mi \| Hirth, Bradford H. \| Jiang, John \| Macor, John E. \| Makino, Elina \| Maniar, Sachin \| Musick, Kwon \| ... \| Munson, Mark ACS Medicinal Chemistry Letters, volume 11, issue 10, pages 2010-2016 (2020). 10.1021/acsmedchemlett.0c00120 Cited by (13) \| Cite \| Source
GSK-3 inhibitors (patent) Hartz, Richard A. \| Ahuja, Vijay T. \| Sivaprakasam, Prasanna \| Dubowchik, Gene M. \| Macor, John E. Patent Number: 10774086 (2020) Cite \| Source
GSK-3 inhibitors (patent) Hartz, Richard A. \| Ahuja, Vijay T. \| Luo, Guanglin \| Chen, Ling \| Sivaprakasam, Prasanna \| Dubowchik, Gene M. \| Jacutin-Porte, Swanee E. \| Macor, John E. Patent Number: 10752609 (2020) Cite \| Source
Biaryl kinase inhibitors (patent) Luo, Guanglin \| Dzierba, Carolyn Diane \| Macor, John E. Patent Number: 10723734 (2020) Cite \| Source
Carbazole derivatives (patent) Ahmad, Saleem \| Batt, Douglas G. \| Liu, Qingjie \| Macor, John E. \| Tino, Joseph A. \| Watterson, Scott Hunter \| Nair, Satheesh Kesavan \| Maishal, Tarun Kumar Patent Number: 10676434 (2020) Cite \| Source
Pyridyl substituted indole compounds (patent) Dyckman, Alaric J. \| Dodd, Dharmpal S. \| Haque, Tasir Shamsul \| Lombardo, Louis J. \| Macor, John E. \| Mussari, Christopher P. \| Pasunoori, Laxman \| Poss, Michael A. \| Kumar, Sreekantha Ratna \| Posy, Shoshana L. \| ... \| Ramachandra Reddy, Anupama Kandhi Patent Number: 10660877 (2020) Cite \| Source
Heteroaryl substituted aminopyridine compounds (patent) Duncia, John V. \| Gardner, Daniel S. \| Hynes, John \| Macor, John E. \| Murugesan, Natesan \| Santella, Joseph B. \| Wu, Hong \| Kantheti, Durgarao \| Nair, Satheesh Kesavan \| Paidi, Venkatram Reddy \| ... \| Polimera, Subba Rao Patent Number: 10618903 (2020) Cite \| Source