Jay M. Matthews

ScholarGPS® ID: 70311986994929

Affiliation

GlaxoSmithKline plc, London

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Medicinal Chemistry | Receptor Antagonist | Transient Receptor Potential Channel | Chemical Synthesis | Peptide

Metrics Summary

Publication Count

Predicted Citations

441

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Diastereoselective Copper-Mediated Conjugate Addition of Functionalized Magnesiates for the Preparation of Bisaryl Nrf2 Activators (journal article) Glogowski, Michal P. \| Matthews, Jay M. \| Lawhorn, Brian G. \| Minbiole, Kevin P. C. The Journal of Organic Chemistry, volume 86, issue 4, pages 3120-3137 (2021). 10.1021/acs.joc.0c02639 Cite \| Source
TRPV4 antagonists (patent) Brnardic, Edward J. \| Brooks, Carl A. \| Budzik, Brian W. \| Lawhorn, Brian Griffin \| Matthews, Jay M. \| McAtee, John Jeffrey \| Pero, Joseph E. \| Behm, David J. Patent Number: 10590077 (2020) Cite \| Source
TRPV4 antagonists (patent) Brnardic, Edward J. \| Brooks, Carl A. \| Lawhorn, Brian Griffin \| Ye, Guosen \| Barton, Linda S. \| Budzik, Brian W. \| Matthews, Jay M. \| McAtee, John Jeffrey \| Patterson, Jaclyn R. \| Pero, Joseph E. \| ... \| Thomas, James V. Patent Number: 10588891 (2020) Cite \| Source
Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4) (journal article) Brooks, Carl A. \| Barton, Linda S. \| Behm, David J. \| Brnardic, Edward J. \| Costell, Melissa H. \| Holt, Dennis A. \| Jolivette, Larry J. \| Matthews, Jay M. \| McAtee, John J. \| McCleland, Brent W. \| ... \| Lawhorn, Brian G. Journal of Medicinal Chemistry, volume 62, issue 20, pages 9270-9280 (2019). 10.1021/acs.jmedchem.9b01247 Cited by (18) \| Cite \| Source
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model (journal article) Pero, Joseph E. \| Matthews, Jay M. \| Behm, David J. \| Brnardic, Edward J. \| Brooks, Carl \| Budzik, Brian W. \| Costell, Melissa H. \| Donatelli, Carla A. \| Eisennagel, Stephen H. \| Erhard, Karl \| ... \| Lawhorn, Brian G. Journal of Medicinal Chemistry, volume 61, issue 24, pages 11209-11220 (2018). 10.1021/acs.jmedchem.8b01344 Cited by (22) \| Cite \| Source
Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists (journal article) Matthews, Jay M. \| McNally, James J. \| Connolly, Peter J. \| Xia, Mingde \| Zhu, Bin \| Black, Shawn \| Chen, Cailin \| Hou, Cuifen \| Liang, Yin \| Tang, Yuting \| Macielag, Mark J. Bioorganic & Medicinal Chemistry Letters, volume 26, issue 21, pages 5346-5349 (2016). 10.1016/j.bmcl.2016.09.025 Cited by (18) \| Cite \| Source
Tetrahydropyrazolo[4,3- c ]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists (journal article) Zhu, Bin \| Matthews, Jay M. \| Xia, Mingde \| Black, Shawn \| Chen, Cailin \| Hou, Cuifen \| Liang, Yin \| Tang, Yuting \| Macielag, Mark J. Bioorganic & Medicinal Chemistry Letters, volume 26, issue 22, pages 5597-5601 (2016). 10.1016/j.bmcl.2016.09.026 Cited by (5) \| Cite \| Source
Sulfonamides as TRPM8 modulators (patent) Branum, Shawn T \| Colburn, Raymond W \| Dax, Scott L \| Flores, Christopher M \| Jetter, Michele C \| Liu, Yi \| Ludovici, Donald \| Macielag, Mark J \| Matthews, Jay M \| McNally, James J \| ... \| Youngman, Mark A Patent Number: 9434711 (2016) Cite \| Source
Sulfamides as TRPM8 modulators (patent) Matthews, Jay M Patent Number: 9233947 (2016) Cite \| Source
Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators (patent) Macielag, Mark J \| Xia, Mingde \| McNally, James J \| Matthews, Jay M Patent Number: 9067935 (2015) Cite \| Source
Sulfonamides as TRPM8 modulators (patent) Branum, Shawn T. \| Colburn, Raymond W. \| Dax, Scott L. \| Flores, Christopher M. \| Jetter, Michele C. \| Liu, Yi \| Ludovici, Donald \| Macielag, Mark J. \| Matthews, Jay M. \| McNally, James J. \| ... \| Youngman, Mark A. Patent Number: 8809327 (2014) Cited by (13) \| Cite \| Source
Sulfamides as TRPM8 modulators (patent) Matthews, Jay M Patent Number: 8748478 (2014) Cite \| Source
Cold menthol receptor-1 antagonists (patent) Colburn, Raymond W. \| Dax, Scott L. \| Flores, Christopher \| Matthews, Jay \| Qin, Ning \| Reany, Laura \| Teleha, Christopher \| Youngman, Mark A. Patent Number: 8629281 (2014) Cite \| Source
Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators (patent) McNally, James J. \| Matthews, Jay M. \| Macielag, Mark J. \| Xia, Mingde Patent Number: 8618150 (2013) Cite \| Source
Cold menthol receptor-1 antagonists (patent) Flores, Christopher \| Matthews, Jay M \| Colburn, Raymond W \| Dax, Scott L Patent Number: 8558011 (2013) Cited by (3) \| Cite \| Source
Sulfamides as TRPM8 modulators (patent) Matthews, Jay M. Patent Number: 8436041 (2013) Cite \| Source
Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists (journal article) Zhu, Bin \| Xia, Mingde \| Xu, Xiaoqing \| Ludovici, Donald W. \| Tennakoon, Manomi \| Youngman, Mark A. \| Matthews, Jay M. \| Dax, Scott L. \| Colburn, Raymond W. \| Qin, Ning \| ... \| Macielag, Mark J. Bioorganic & Medicinal Chemistry Letters, volume 23, issue 7, pages 2234-2237 (2013). 10.1016/j.bmcl.2013.01.062 Cited by (24) \| Cite \| Source
Cold menthol receptor antagonists (patent) Colburn, Raymond W. \| Dax, Scott L. \| Flores, Christopher M. \| Ludovici, Donald W. \| Matthews, Jay M. \| Xia, Mingde \| Xu, Xiaoqing \| Youngman, Mark A. \| Zhu, Bin Patent Number: 8324217 (2012) Cited by (3) \| Cite \| Source
ChemInform Abstract: The Design and Synthesis of Novel, Phosphonate‐Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists. (journal article) Matthews, Jay M. \| et al., et al. ChemInform, volume 43, issue 35 (2012). 10.1002/chin.201235209 Cite \| Source
Radiolabelled TRP M8 receptor ligands (patent) Acton, Paul D. \| Hlasta, Dennis J. \| Matthews, Jay M. \| McNally, James J. Patent Number: 8216547 (2012) Cite \| Source