Xun Li

ScholarGPS® ID: 68192709530703

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Receptor Modulator | Carboxylic Acid | Medicinal Chemistry

Metrics Summary

Publication Count

Predicted Citations

513

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Synthesis of Mavatrep: A Potent Antagonist of Transient Receptor Potential Vanilloid-1 (journal article) Wells, Kenneth M. \| Mehrman, Steven J. \| Abdel-Magid, Ahmed F. \| Ferraro, Caterina \| Scott, Lorraine \| Zhong, Hua Marlon \| Teleha, Christopher A. \| Ballentine, Scott \| Li, Xun \| Russell, Ronald K. \| ... \| Beauchamp, Derek A. Organic Process Research & Development, volume 19, issue 11, pages 1774-1783 (2015). 10.1021/acs.oprd.5b00271 Cited by (6) \| Cite \| Source
Process Development for Scale-Up of a Novel 3,5-Substituted Thiazolidine-2,4-dione Compound as a Potent Inhibitor for Estrogen-Related Receptor 1 (journal article) Li, Xun \| Russell, Ronald K. \| Spink, Jan \| Ballentine, Scott \| Teleha, Christopher \| Branum, Shawn \| Wells, Kenneth \| Beauchamp, Derek \| Patch, Raymond \| Huang, Hui \| ... \| Murray, William Organic Process Research & Development, volume 18, issue 2, pages 321-330 (2014). 10.1021/op400325r Cited by (14) \| Cite \| Source
Crystallization of a Cephalosporin and an ERR-1: Assembly of an Inexpensive Crystallization Platform (journal article) Wells, Kenneth M. \| Beauchamp, Derek A. \| Fermier, Adam \| Wu, Wenju \| Mehrman, Steven \| Youells, Scott \| Hu, Zhiyong \| Li, Xun \| Macielag, Mark J. \| Bignan, Gilles \| ... \| Russell, Ronald K. Crystal Growth & Design, volume 13, issue 11, pages 4635-4641 (2013). 10.1021/cg401147b Cited by (1) \| Cite \| Source
An Efficient Synthesis of 3-Substituted N -Glycoside Indoles Useful as Sodium-Dependent Glucose Transporter Inhibitors (journal article) Li, Xun \| Wells, Kenneth M. \| Branum, Shawn \| Damon, Sandra \| Youells, Scott \| Beauchamp, Derek A. \| Palmer, David \| Stefanick, Stephen \| Russell, Ronald K. \| Murray, William Organic Process Research & Development, volume 16, issue 11, pages 1727-1732 (2012). 10.1021/op3001355 Cited by (9) \| Cite \| Source
Crystal Structure of (1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-(oxo-\κO)-3-quinolinecarboxylato-κO3) difluoro-boron (journal article) Beauchamp, Derek A. \| Li, Xun \| Russell, Ronald K. Journal of Chemical Crystallography, volume 41, issue 6, pages 895-897 (2011). 10.1007/s10870-011-0058-y Cite \| Source
ChemInform Abstract: An Improved Non‐chromatographic Scale‐up Synthesis of a New 1,6,7,8‐Substituted‐4‐oxo‐1,4‐dihydroquinoline‐3‐carboxylic Acid (V) as a Potent Bacterial Topoisomerase Inhibitor. (journal article) Li, Xun \| Youells, Scott \| Russell, Ronald K. \| Roessler, Armin \| Schmid, Tobias \| Faessler, Roger \| Weidner‐Wells, Michele A. \| Grant, Eugene B. \| Macielag, Mark J. ChemInform, volume 41, issue 38 (2010). 10.1002/chin.201038157 Cite \| Source
An Improved Non-chromatographic Scale-up Synthesis of a New 1,6,7,8-Substituted-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid as a Potent Bacterial Topoisomerase Inhibitor (journal article) Li, Xun \| Youells, Scott \| Russell, Ronald K. \| Roessler, Armin \| Schmid, Tobias \| Faessler, Roger \| Weidner-Wells, Michele A. \| Grant, Eugene B. \| Macielag, Mark J. Organic Preparations and Procedures International, volume 42, issue 2, pages 151-160 (2010). 10.1080/00304941003680731 Cited by (3) \| Cite \| Source
Regio- and diastereoselective ring-opening of (S)-(−)-2-(trifluoromethyl)oxirane with chiral 2,5-disubstituted tetrahydroquinolines in hexafluoro-2-propanol (journal article) Li, Xun \| Russell, Ronald K. \| Chen, Hongfeng \| Zhang, Yongzheng \| Ballentine, Scott \| Spink, Jan \| Branum, Shawn \| Liu, Fuqiang \| Chen, Yanping \| Rammeloo, Thomas \| ... \| Murray, William V. Green Chemistry, volume 12, issue 9, pages 1548- (2010). 10.1039/c004726k Cited by (3) \| Cite \| Source
Identification and Structure−Activity Relationships of Chromene-Derived Selective Estrogen Receptor Modulators for Treatment of Postmenopausal Symptoms (journal article) Jain, Nareshkumar \| Xu, Jiayi \| Kanojia, Ramesh M. \| Du, Fuyong \| Jian-Zhong, Guo \| Pacia, Emmanuel \| Lai, Muh-Tsann \| Musto, Amy \| Allan, George \| Reuman, Michael \| ... \| Sui, Zhihua Journal of Medicinal Chemistry, volume 52, issue 23, pages 7544-7569 (2009). 10.1021/jm900146e Cited by (87) \| Cite \| Source
An Efficient Synthetic Process for Scale-Up Production of 4,5-Diamino-2-(trifluoromethyl)benzonitrile and 5-Bromo-3-(trifluoromethyl)benzene-1,2-diamine (journal article) Li, Xun \| Ng, Raymond A. \| Zhang, Yongzheng \| Russell, Ronald K. \| Sui, Zhihua Organic Process Research & Development, volume 13, issue 3, pages 652-655 (2009). 10.1021/op9000498 Cited by (1) \| Cite \| Source
Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARδ agonists (journal article) Zhang, Rui \| DeAngelis, Alan \| Wang, Aihua \| Sieber-McMaster, Ellen \| Li, Xun \| Russell, Ronald \| Pelton, Patricia \| Xu, Jun \| Zhu, Peifang \| Zhou, Lubing \| ... \| Kuo, Gee-Hong Bioorganic & Medicinal Chemistry Letters, volume 19, issue 4, pages 1101-1104 (2009). 10.1016/j.bmcl.2008.12.113 Cited by (11) \| Cite \| Source
Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 3. Development of an Acid-Catalyzed Racemization Process for ( S )-2,8-(Dimethoxy)-5-{4-[2-(1-piperidinyl)ethoxy]phenyl}−11,12-dihydro- 5H -6,13-dioxabenzo[3,4]cycloh (journal article) Li, Xun \| Russell, Ronald K. \| Horváth, András \| Jain, Nareshkumar \| Depré, Dominique \| Ormerod, Dominic \| Aelterman, Wim \| Sui, Zhihua Organic Process Research & Development, volume 13, issue 1, pages 102-105 (2009). 10.1021/op800237y Cited by (2) \| Cite \| Source
Using Potassium Carbonate to Scavenge Hydrogen Fluoride: A Scale-Up Process for Quantitative Production of (1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinolinecarboxylato-κO3)difluoro−Boron (journal article) Li, Xun \| Russell, Ronald K. Organic Process Research & Development, volume 12, issue 3, pages 464-466 (2008). 10.1021/op8000228 Cited by (9) \| Cite \| Source
Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 2. Process Improvement for Scale-Up of 2,5,8-Substituted 11,12-Dihydro-5 H -6,13-dioxabenzo[3,4]cyclohepta-[1,2- a ]naphthalene Derivatives (journal article) Li, Xun \| Reuman, Michael \| Russell, Ronald K. \| Youells, Scott \| Beish, Sandra \| Hu, Zhiyong \| Branum, Shawn \| Jain, Nareshkumar \| Sui, Zhihua Organic Process Research & Development, volume 12, issue 1, pages 125-125 (2008). 10.1021/op700254f Cited by (3) \| Cite \| Source \| Open Access
Synthesis of a 5-((Aryloxy)methyl)-3-(4-(trifluoromethyl)phenyl)[1,2,4]thiadiazole Derivative: A Promising PPARα,δ Agonist (journal article) Reuman, Michael \| Hu, Zhiyong \| Kuo, Gee-Hong \| Li, Xun \| Russell, Ronald K. \| Shen, Lan \| Youells, Scott \| Zhang, Yongzheng Organic Process Research & Development, volume 11, issue 6, pages 1010-1014 (2007). 10.1021/op700141u Cited by (6) \| Cite \| Source
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents (journal article) Lin, Ronghui \| Connolly, Peter J. \| Lu, Yanhua \| Chiu, George \| Li, Shengjian \| Yu, Yang \| Huang, Shenlin \| Li, Xun \| Emanuel, Stuart L. \| Middleton, Steven A. \| ... \| Greenberger, Lee M. Bioorganic & Medicinal Chemistry Letters, volume 17, issue 15, pages 4297-4302 (2007). 10.1016/j.bmcl.2007.05.029 Cited by (133) \| Cite \| Source
Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 2. Process Improvement for Scale-Up Of 2,5,8-Substituted 11,12-Dihydro-5 H -6,13-dioxabenzo[3,4]cyclohepta-[1,2- a ]naphthalene Derivatives (journal article) Li, Xun \| Reuman, Michael \| Russell, Ronald K. \| Youells, Scott \| Beish, Sandra \| Hu, Zhiyong \| Branum, Shawn \| Jain, Nareshkumar \| Sui, Zhihua Organic Process Research & Development, volume 11, issue 4, pages 731-738 (2007). 10.1021/op700061x Cited by (8) \| Cite \| Source
Direct Conversion of Substituted Pyrrole‐2‐carboxylic Acid Methyl Esters to Their 2‐Carbonitrile Analogues (journal article) Li, Xun \| Reuman, Michael \| Russell, Ronald K. ChemInform, volume 38, issue 22 (2007). 10.1002/chin.200722096 Cite \| Source
Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 1. Process Development for Scale-up of 2,5,8-Substituted 5,11-Dihydrochromeno[4,3- c ]chromene Derivatives (journal article) Li, Xun \| Reuman, Michael \| Russell, Ronald K. \| Adams, Richard \| Ma, Robert \| Branum, Shawn \| Youells, Scott \| Roberts, Jerry \| Jain, Nareshkumar \| Kanojia, Ramesh \| Sui, Zhihua Organic Process Research & Development, volume 11, issue 3, pages 414-421 (2007). 10.1021/op700020f Cited by (11) \| Cite \| Source
Synthesis of Novel Tetracyclic Chromenes Through Carbanion Chemistry of 4‐Methyl Coumarins. (journal article) Chen, Ningyi \| Jain, Nareshkumar \| Xu, Jiayi \| Reuman, Michael \| Li, Xun \| Russell, Ronald K. \| Sui, Zhihua ChemInform, volume 37, issue 47 (2006). 10.1002/chin.200647150 Cite \| Source