Michael T. Lipari

ScholarGPS® ID: 66629088041372

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Life Sciences

Discipline

Biochemistry

Top Specialties

Antibody | Serine Protease | Thrombosis

Metrics Summary

Publication Count

Predicted Citations

2,394

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

Add Delete
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge (journal article) Maun, Henry R. \| Vij, Rajesh \| Walters, Benjamin T. \| Morando, Ashley \| Jackman, Janet K. \| Wu, Ping \| Estevez, Alberto \| Chen, Xiaocheng \| Franke, Yvonne \| Lipari, Michael T. \| ... \| Koerber, James T. Nature Communications, volume 11, issue 1 (2020). 10.1038/s41467-020-20143-x Cited by (14) \| Cite \| Source
Anti-HtrA1 antibodies and methods of use thereof (patent) Kelley, Robert F. \| Kirchhofer, Daniel K. \| Lai, Joyce \| Lee, Chingwei V. \| Liang, Wei-Ching \| Lipari, Michael T. \| Loyet, Kelly M. \| Sai, Tao \| Van Lookeren Campagne, Menno \| Wu, Yan \| Fuh, Germaine Patent Number: 10421822 (2019) Cite \| Source
Anti-HtrA1 antibodies and methods of use thereof (patent) Kelley, Robert F. \| Kirchhofer, Daniel K. \| Lai, Joyce \| Lee, Chingwei V. \| Liang, Wei-Ching \| Lipari, Michael T. \| Loyet, Kelly M. \| Sai, Tao \| Van Lookeren Campagne, Menno \| Wu, Yan \| Fuh, Germaine Patent Number: 10421821 (2019) Cite \| Source
Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain (journal article) Ultsch, M. \| Li, W. \| Eigenbrot, C. \| Di Lello, P. \| Lipari, M.T. \| Gerhardy, S. \| AhYoung, A.P. \| Quinn, J. \| Franke, Y. \| Chen, Y. \| ... \| Kirchhofer, D. Journal of Molecular Biology, volume 431, issue 5, pages 885-903 (2019). 10.1016/j.jmb.2018.11.025 Cited by (8) \| Cite \| Source
Anti-HtrA1 antibodies and methods of use (patent) Wu, Yan \| van Lookeren-Campagne, Menno \| Kirchhofer, Daniel \| Lipari, Michael Terry \| Katschke, Jr., Kenneth J. \| Moran, Paul M. \| Stawicki, Scott \| Liang, Wei-Ching Patent Number: 9738727 (2017) Cited by (2) \| Cite \| Source
The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody (journal article) Ciferri, Claudio \| Lipari, Michael T. \| Liang, Wei-Ching \| Estevez, Alberto \| Hang, Julie \| Stawicki, Scott \| Wu, Yan \| Moran, Paul \| Elliott, Mike \| Eigenbrot, Charles \| ... \| Kirchhofer, Daniel Biochemical Journal, volume 472, issue 2, pages 169-181 (2015). 10.1042/BJ20150601 Cited by (19) \| Cite \| Source
Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels (journal article) Lipari, Michael T. \| Li, Wei \| Moran, Paul \| Kong-Beltran, Monica \| Sai, Tao \| Lai, Joyce \| Lin, S. Jack \| Kolumam, Ganesh \| Zavala-Solorio, Jose \| Izrael-Tomasevic, Anita \| ... \| Kirchhofer, Daniel Journal of Biological Chemistry, volume 287, issue 52, pages 43482-43491 (2012). 10.1074/jbc.M112.380618 Cited by (105) \| Cite \| Source \| Open Access
Structural and Functional Analysis of HtrA1 and Its Subdomains (journal article) Eigenbrot, Charles \| Ultsch, Mark \| Lipari, Michael T. \| Moran, Paul \| Lin, S. Jack \| Ganesan, Rajkumar \| Quan, Clifford \| Tom, Jeffrey \| Sandoval, Wendy \| van Lookeren Campagne, Menno \| Kirchhofer, Daniel Structure, volume 20, issue 6, pages 1040-1050 (2012). 10.1016/j.str.2012.03.021 Cited by (84) \| Cite \| Source \| Open Access
Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody (journal article) Ganesan, Rajkumar \| Eigenbrot, Charles \| Wu, Yan \| Liang, Wei-Ching \| Shia, Steven \| Lipari, Michael T. \| Kirchhofer, Daniel Structure, volume 17, issue 12, pages 1614-1624 (2009). 10.1016/j.str.2009.09.014 Cited by (58) \| Cite \| Source \| Open Access
Structural insight into distinct mechanisms of protease inhibition by antibodies (journal article) Wu, Yan \| Eigenbrot, Charles \| Liang, Wei-Ching \| Stawicki, Scott \| Shia, Steven \| Fan, Bin \| Ganesan, Rajkumar \| Lipari, Michael T. \| Kirchhofer, Daniel Proceedings of the National Academy of Sciences, volume 104, issue 50, pages 19784-19789 (2007). 10.1073/pnas.0708251104 Cited by (66) \| Cite \| Source \| Open Access
Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist (journal article) Kirchhofer, Daniel \| Lipari, Michael T. \| Santell, Lydia \| Billeci, Karen L. \| Maun, Henry R. \| Sandoval, Wendy N. \| Moran, Paul \| Ridgway, John \| Eigenbrot, Charles \| Lazarus, Robert A. Proceedings of the National Academy of Sciences, volume 104, issue 13, pages 5306-5311 (2007). 10.1073/pnas.0700184104 Cited by (43) \| Cite \| Source \| Open Access
Hepsin activates pro‐hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor‐1B (HAI‐1B) and HAI‐2 (journal article) Kirchhofer, Daniel \| Peek, Mark \| Lipari, Michael T. \| Billeci, Karen \| Fan, Bin \| Moran, Paul FEBS Letters, volume 579, issue 9, pages 1945-1950 (2005). 10.1016/j.febslet.2005.01.085 Cited by (144) \| Cite \| Source \| Open Access
Structural and Functional Basis of the Serine Protease-like Hepatocyte Growth Factor β-Chain in Met Binding and Signaling (journal article) Kirchhofer, Daniel \| Yao, Xiaoyi \| Peek, Mark \| Eigenbrot, Charles \| Lipari, Michael T. \| Billeci, Karen L. \| Maun, Henry R. \| Moran, Paul \| Santell, Lydia \| Wiesmann, Christian \| Lazarus, Robert A. Journal of Biological Chemistry, volume 279, issue 38, pages 39915-39924 (2004). 10.1074/jbc.M404795200 Cited by (79) \| Cite \| Source \| Open Access
Similar Molecular Interactions of Factor VII and Factor VIIa with the Tissue Factor Region that Allosterically Regulates Enzyme Activity (journal article) Kelley, Robert F. \| Yang, Jihong \| Eigenbrot, Charles \| Moran, Paul \| Peek, Mark \| Lipari, Michael T. \| Kirchhofer, Daniel Biochemistry, volume 43, issue 5, pages 1223-1229 (2004). 10.1021/bi035738i Cited by (14) \| Cite \| Source
Structural Insight into How An Anti-idiotypic Antibody Against D3H44 (Anti-tissue Factor Antibody) Restores Normal Coagulation (journal article) Eigenbrot, Charles \| Meng, Y.Gloria \| Krishnamurthy, Rajeswari \| Lipari, Michael T. \| Presta, Leonard \| Devaux, Brigitte \| Wong, Terence \| Moran, Paul \| Bullens, Sherron \| Kirchhofer, Daniel Journal of Molecular Biology, volume 331, issue 2, pages 433-446 (2003). 10.1016/S0022-2836(03)00735-6 Cited by (9) \| Cite \| Source
Effect of Selective or Combined Inhibition of Integrins αIIb β3 and αv β3 on Thrombosis and Neointima After Oversized Porcine Coronary Angioplasty (journal article) Chico, Timothy J. A. \| Chamberlain, Janet \| Gunn, Julian \| Arnold, Nadine \| Bullens, Sherron L. \| Gadek, Thomas R. \| Francis, Sheila E. \| Bunting, Stuart \| Horton, Michael \| Shepherd, Lynda \| ... \| Crossman, David C. Circulation, volume 103, issue 8, pages 1135-1141 (2001). 10.1161/01.CIR.103.8.1135 Cited by (26) \| Cite \| Source \| Open Access
Effect of selective or combined inhibition of integrins alpha(IIb)beta(3) and alpha(v)beta(3) on thrombosis and neointima after oversized porcine coronary angioplasty. (journal article) Chico, T J \| Chamberlain, J \| Gunn, J \| Arnold, N \| Bullens, S L \| Gadek, T R \| Francis, S E \| Bunting, S \| Horton, M \| Shepherd, L \| ... \| Crossman, D C Circulation, volume 103, issue 8 (2001). Cite
The Tissue Factor Region That Interacts with Factor Xa in the Activation of Factor VII (journal article) Kirchhofer, Daniel \| Eigenbrot, Charles \| Lipari, Michael T. \| Moran, Paul \| Peek, Mark \| Kelley, Robert F. Biochemistry, volume 40, issue 3, pages 675-682 (2001). 10.1021/bi002013v Cited by (38) \| Cite \| Source
Consequences of inhibition of plasma carboxypeptidase B on in vivo thrombolysis, thrombosis and hemostasis (journal article) Refino, C.J. \| DeGuzman, L. \| Schmitt, D. \| Smyth, R. \| Jeet, S. \| Lipari, M.T. \| Eaton, D. \| Bunting, S. Fibrinolysis and Proteolysis, volume 14, issue 5, pages 305-314 (2000). 10.1054/fipr.2000.0087 Cited by (30) \| Cite \| Source
The Tissue Factor Region That Interacts with Substrates Factor IX and Factor X (journal article) Kirchhofer, Daniel \| Lipari, Michael T. \| Moran, Paul \| Eigenbrot, Charles \| Kelley, Robert F. Biochemistry, volume 39, issue 25, pages 7380-7387 (2000). 10.1021/bi000182+ Cited by (45) \| Cite \| Source