Terry V. Hughes

ScholarGPS® ID: 65943079683929

Affiliation
Johnson & Johnson, New Brunswick, New Jersey, United States
Affiliation History

Field
Physical Sciences and Mathematics
Discipline
Chemistry
Top Specialties
Chemical Synthesis | Medicinal Chemistry | Protein Kinase Inhibitor
Metrics Summary
Publication Count
24
Predicted Citations
1,749
Predicted h-index
17
Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

  • Publications
  • Books
  • Patents
  • NIH/NSF
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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors (journal article)
Haffner, Curt D. | Charnley, Adam K. | Aquino, Christopher J. | Casillas, Linda | Convery, Máire A. | Cox, Julie A. | Elban, Mark A. | Goodwin, Nicole C. | Gough, Peter J. | Haile, Pamela A. | ... | Marquis, Robert W.
ACS Medicinal Chemistry Letters, volume 10, issue 11, pages 1518-1523 (2019).
10.1021/acsmedchemlett.9b00141
Cited by (17) | Cite | Source
Substituted pyrimidinyl oxime kinase inhibitors (patent)
Bignan, Gilles C. | Battista, Kathleen A. | Lee, Lily | Abad, Marta C. | Connolly, Peter J. | Kamachi, Prabha S. | Middleton, Steven A. | Wetter, Steven K. | Emanuel, Stuart L. | Hughes, Terry V. | Guozhang, Xu
Patent Number: 8367825 (2013)
Cite | Source
Substituted pyrimidinyl oxime kinase inhibitors (patent)
Xu, Guozhang | Lee, Lily | Hughes, Terry V. | Wetter, Steven K. | Connolly, Peter J. | Abad, Marta C. | Emanuel, Stuart L. | Karnachi, Prabha S. | Middleton, Steven A. | Battista, Kathleen A. | Bignan, Gilles C.
Patent Number: 8153791 (2012)
Cited by (2) | Cite | Source
Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (journal article)
Lin, Ronghui | Johnson, Sigmond G. | Connolly, Peter J. | Wetter, Steven K. | Binnun, Eva | Hughes, Terry V. | Murray, William V. | Pandey, Niranjan B. | Moreno-Mazza, Sandra J. | Adams, Mary | ... | Middleton, Steven A.
Bioorganic & Medicinal Chemistry Letters, volume 19, issue 8, pages 2333-2337 (2009).
10.1016/j.bmcl.2009.02.067
Cited by (106) | Cite | Source
Substituted pyrimidine-5-carboxamide and 5-carboxylic ester kinase inhibitors (patent)
Connolly, Peter J. | Hughes, Terry V. | Wetter, Steven K.
Patent Number: 20090111810 (2008)
Cite | Source
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: Design, synthesis, and biological activity (journal article)
Hughes, Terry V. | Xu, Guozhang | Wetter, Steven K. | Connolly, Peter J. | Emanuel, Stuart L. | Karnachi, Prabha | Pollack, Scott R. | Pandey, Niranjan | Adams, Mary | Moreno-Mazza, Sandra | ... | Greenberger, Lee M.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 17, pages 4896-4899 (2008).
10.1016/j.bmcl.2008.07.057
Cited by (23) | Cite | Source
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity (journal article)
Hughes, Terry V. | Emanuel, Stuart L. | O’Grady, Harold R. | Connolly, Peter J. | Rugg, Catherine | Fuentes-Pesquera, Angel R. | Karnachi, Prabha | Alexander, Richard | Middleton, Steven A.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 18, pages 5130-5133 (2008).
10.1016/j.bmcl.2008.07.090
Cited by (15) | Cite | Source
Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases (journal article)
Xu, Guozhang | Searle, Lily Lee | Hughes, Terry V. | Beck, Amanda K. | Connolly, Peter J. | Abad, Marta C. | Neeper, Michael P. | Struble, Geoffrey T. | Springer, Barry A. | Emanuel, Stuart L. | ... | Greenberger, Lee M.
Bioorganic & Medicinal Chemistry Letters, volume 18, issue 12, pages 3495-3499 (2008).
10.1016/j.bmcl.2008.05.024
Cited by (43) | Cite | Source
4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation (journal article)
Hughes, Terry V. | Emanuel, Stuart L. | Beck, Amanda K. | Wetter, Steven K. | Connolly, Peter J. | Karnachi, Prabha | Reuman, Michael | Seraj, Jabed | Fuentes-Pesquera, Angel R. | Gruninger, Robert H. | ... | Moffat, David F.C.
Bioorganic & Medicinal Chemistry Letters, volume 17, issue 12, pages 3266-3270 (2007).
10.1016/j.bmcl.2007.04.021
Cited by (42) | Cite | Source
Substituted dihydro-isoindolones useful in treating kinase disorders (patent)
Connolly, Peter J. | Emanuel, Stuart | Hughes, Terry V. | Rugg, Catherine A.
Patent Number: 20070161648 (2006)
Cite | Source
Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives (journal article)
Parrish, Jay P. | Trzupek, John D. | Hughes, Terry V. | Hwang, Inkyu | Boger, Dale L.
Bioorganic & Medicinal Chemistry, volume 12, issue 22, pages 5845-5856 (2004).
10.1016/j.bmc.2004.08.032
Cited by (27) | Cite | Source
Establishing the Parabolic Relationship between Reactivity and Activity for Derivatives and Analogues of the Duocarmycin and CC-1065 Alkylation Subunits (journal article)
Parrish, Jay P. | Hughes, Terry V. | Hwang, Inkyu | Boger, Dale L.
Journal of the American Chemical Society, volume 126, issue 1, pages 80-81 (2004).
10.1021/ja038162t
Cited by (35) | Cite | Source
ChemInform Abstract: Synthesis, Chemical Properties, and Biological Evaluation of CC‐1065 and Duocarmycin Analogues Incorporating the 5‐Methoxycarbonyl‐1,2,9,9a‐tetrahydrocyclopropa[c]benz[e]indol‐4‐one Alkylation Subunit. (journal article)
Boger, Dale L. | Hughes, Terry V. | Hedrick, Michael P.
ChemInform, volume 32, issue 33 (2001).
10.1002/chin.200133254
Cite | Source
Synthesis, Chemical Properties, and Biological Evaluation of CC-1065 and Duocarmycin Analogues Incorporating the 5-Methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa[ c ]benz[ e ]indol-4-one Alkylation Subunit (journal article)
Boger, Dale L. | Hughes, Terry V. | Hedrick, Michael P.
The Journal of Organic Chemistry, volume 66, issue 7, pages 2207-2216 (2001).
10.1021/jo001772g
Cited by (47) | Cite | Source
Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa. (journal article)
Boger, D L | Hughes, T V | Hedrick, M P
The Journal of organic chemistry, volume 66, issue 7 (2001).
Cite
Synthesis and Langmuir−Blodgett Film Formation of Amphiphilic Zwitterions Based on Benzothiazolium Tricyanoquinodimethanide (journal article)
Hughes, Terry V. | Mokijewski, Brenda | Chen, Bo | Lakshmikantham, M. V. | Cava, Michael P. | Metzger, Robert M.
Langmuir, volume 15, issue 20, pages 6925-6930 (1999).
10.1021/la9817260
Cited by (9) | Cite | Source
ChemInform Abstract: Electrophilic Cyanations Using 1‐Cyanobenzotriazole: sp2 and sp Carbanions. (journal article)
Hughes, Terry V. | Cava, Michael P.
ChemInform, volume 30, issue 28 (1999).
10.1002/chin.199928040
Cite | Source
Spectroscopic Studies of Hexadecylquinolinium Tricyanoquinodimethanide (journal article)
Baldwin, Jeffrey W. | Chen, Bo | Street, Shane C. | Konovalov, Valery V. | Sakurai, Hiromi | Hughes, Terry V. | Simpson, Camino S. | Lakshmikantham, M. V. | Cava, Michael P. | Kispert, Lowell D. | Metzger, Robert M.
The Journal of Physical Chemistry B, volume 103, issue 21, pages 4269-4277 (1999).
10.1021/jp983759u
Cited by (51) | Cite | Source
Electrophilic Cyanations Using 1-Cyanobenzotriazole:  sp2 and sp Carbanions (journal article)
Hughes, Terry V.
The Journal of Organic Chemistry, volume 64, issue 7, pages 2599-2599 (1999).
10.1021/jo994001p
Cited by (4) | Cite | Source
ChemInform Abstract: Total Synthesis of Didemnimide A and B. (journal article)
Hughes, Terry V. | Cava, Michael P.
ChemInform, volume 30, issue 12 (1999).
10.1002/chin.199912228
Cite | Source