Mike Costa

ScholarGPS® ID: 65937579688616

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Medicine

Discipline

Oncology

Top Specialties

Antibody | Wnt Signaling Pathway

Metrics Summary

Publication Count

Predicted Citations

2,538

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors (journal article) Feng, Siyu \| Callow, Marinella G. \| Fortin, Jean-Philippe \| Khan, Zia \| Bray, David \| Costa, Mike \| Shi, Zhen \| Wang, Weiru \| Evangelista, Marie Proceedings of the National Academy of Sciences, volume 119, issue 18 (2022). 10.1073/pnas.2120512119 Cited by (11) \| Cite \| Source
Anti-LRP6 antibodies (patent) Bourhis, Eric \| Carano, Rick \| Cochran, Andrea \| Costa, Mike \| DeAlmeida, Venita \| Ernst, James \| Gong, Yan \| Hannoush, Rami \| Polakis, Paul \| Rubinfeld, Bonnee \| ... \| Wu, Yan Patent Number: 9556267 (2017) Cite \| Source
Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1 (journal article) Zhong, Yu \| Katavolos, Paula \| Nguyen, Trung \| Lau, Ted \| Boggs, Jason \| Sambrone, Amy \| Kan, David \| Merchant, Mark \| Harstad, Eric \| Diaz, Dolores \| ... \| Schutten, Melissa Toxicologic Pathology, volume 44, issue 2, pages 267-278 (2016). 10.1177/0192623315621192 Cited by (72) \| Cite \| Source \| Open Access
Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis (journal article) Tian, Hua \| Biehs, Brian \| Chiu, Cecilia \| Siebel, Christian W. \| Wu, Yan \| Costa, Mike \| de Sauvage, Frederic J. \| Klein, Ophir D. Cell Reports, volume 11, issue 1, pages 33-42 (2015). 10.1016/j.celrep.2015.03.007 Cited by (167) \| Cite \| Source \| Open Access
Anti-LRP6 antibodies (patent) Bourhis, Eric \| Cao, Tim \| Carano, Rick \| Cochran, Andrea \| Costa, Mike \| DeAlmeida, Venita \| Ernst, James \| Gong, Yan \| Hannoush, Rami \| Polakis, Paul \| ... \| Wu, Yan Patent Number: 8846041 (2014) Cite \| Source
Evolutionary Divergence in the Catalytic Activity of the CAM-1, ROR1 and ROR2 Kinase Domains (journal article) Bainbridge, Travis W. \| DeAlmeida, Venita I. \| Izrael-Tomasevic, Anita \| Chalouni, Cécile \| Pan, Borlan \| Goldsmith, Joshua \| Schoen, Alia P. \| Quiñones, Gabriel A. \| Kelly, Ryan \| Lill, Jennie R. \| ... \| Ernst, James A. PLoS ONE, volume 9, issue 7, pages e102695- (2014). 10.1371/journal.pone.0102695 Cited by (29) \| Cite \| Source \| Open Access
A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth (journal article) Lau, Ted \| Chan, Emily \| Callow, Marinella \| Waaler, Jo \| Boggs, Jason \| Blake, Robert A. \| Magnuson, Steven \| Sambrone, Amy \| Schutten, Melissa \| Firestein, Ron \| ... \| Costa, Mike Cancer Research, volume 73, issue 10, pages 3132-3144 (2013). 10.1158/0008-5472.CAN-12-4562 Cited by (266) \| Cite \| Source \| Open Access
Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6 (journal article) Bourhis, Eric \| Wang, Weiru \| Tam, Christine \| Hwang, Jiyoung \| Zhang, Yingnan \| Spittler, Didier \| Huang, Oscar W. \| Gong, Yan \| Estevez, Alberto \| Zilberleyb, Inna \| ... \| Cochran, Andrea G. Structure, volume 19, issue 10, pages 1433-1442 (2011). 10.1016/j.str.2011.07.005 Cited by (134) \| Cite \| Source \| Open Access
Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling (journal article) Callow, Marinella G. \| Tran, Hoanh \| Phu, Lilian \| Lau, Ted \| Lee, James \| Sandoval, Wendy N. \| Liu, Peter S. \| Bheddah, Sheila \| Tao, Janet \| Lill, Jennie R. \| ... \| Costa, Mike PLoS ONE, volume 6, issue 7, pages e22595- (2011). 10.1371/journal.pone.0022595 Cited by (170) \| Cite \| Source \| Open Access
Disheveled PDZ modulators (patent) Zhang, Yingnan \| Costa, Mike \| Sidhu, Sachdev S. Patent Number: 7977064 (2011) Cited by (3) \| Cite \| Source
Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies (journal article) Gong, Yan \| Bourhis, Eric \| Chiu, Cecilia \| Stawicki, Scott \| DeAlmeida, Venita I. \| Liu, Bob Y. \| Phamluong, Khanhky \| Cao, Tim C. \| Carano, Richard A. D. \| Ernst, James A. \| ... \| Costa, Mike PLoS ONE, volume 5, issue 9, pages e12682- (2010). 10.1371/journal.pone.0012682 Cited by (174) \| Cite \| Source \| Open Access
Disheveled PDZ modulators (patent) Zhang, Yingnan \| Costa, Mike \| Sidhu, Sachdev S. Patent Number: 7695928 (2010) Cite \| Source
Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6 (journal article) Bourhis, Eric \| Tam, Christine \| Franke, Yvonne \| Bazan, J. Fernando \| Ernst, James \| Hwang, Jiyoung \| Costa, Mike \| Cochran, Andrea G. \| Hannoush, Rami N. Journal of Biological Chemistry, volume 285, issue 12, pages 9172-9179 (2010). 10.1074/jbc.M109.092130 Cited by (197) \| Cite \| Source \| Open Access
TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling (journal article) Junge, Harald J. \| Yang, Stacey \| Burton, Jeremy B. \| Paes, Kim \| Shu, Xiao \| French, Dorothy M. \| Costa, Mike \| Rice, Dennis S. \| Ye, Weilan Cell, volume 139, issue 2, pages 299-311 (2009). 10.1016/j.cell.2009.07.048 Cited by (314) \| Cite \| Source \| Open Access
Inhibition of Wnt signaling by Dishevelled PDZ peptides (journal article) Zhang, Yingnan \| Appleton, Brent A \| Wiesmann, Christian \| Lau, Ted \| Costa, Mike \| Hannoush, Rami N \| Sidhu, Sachdev S Nature Chemical Biology, volume 5, issue 4, pages 217-219 (2009). 10.1038/nchembio.152 Cited by (140) \| Cite \| Source
Liposomal Packaging Generates Wnt Protein with In Vivo Biological Activity (journal article) Morrell, Nathan T. \| Leucht, Philipp \| Zhao, Ludan \| Kim, Jae-Beom \| ten Berge, Derk \| Ponnusamy, Karthik \| Carre, A. Lyonel \| Dudek, Henryk \| Zachlederova, Marie \| McElhaney, Michael \| ... \| Nusse, Roel PLoS ONE, volume 3, issue 8, pages e2930- (2008). 10.1371/journal.pone.0002930 Cited by (82) \| Cite \| Source \| Open Access