Prabha Karnachi

ScholarGPS® ID: 65926877339370

Affiliation

Merck & Co., Inc., United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Medicinal Chemistry | Chemical Synthesis | Matrix Metallopeptidase

Metrics Summary

Publication Count

Predicted Citations

492

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Prediction Accuracy of Production ADMET Models as a Function of Version: Activity Cliffs Rule (journal article) Sheridan, Robert P. \| Culberson, J. Chris \| Joshi, Elizabeth \| Tudor, Matthew \| Karnachi, Prabha Journal of Chemical Information and Modeling, volume 62, issue 14, pages 3275-3280 (2022). 10.1021/acs.jcim.2c00699 Cited by (10) \| Cite \| Source
Experimental Error, Kurtosis, Activity Cliffs, and Methodology: What Limits the Predictivity of Quantitative Structure–Activity Relationship Models? (journal article) Sheridan, Robert P. \| Karnachi, Prabha \| Tudor, Matthew \| Xu, Yuting \| Liaw, Andy \| Shah, Falgun \| Cheng, Alan C. \| Joshi, Elizabeth \| Glick, Meir \| Alvarez, Juan Journal of Chemical Information and Modeling, volume 60, issue 4, pages 1969-1982 (2020). 10.1021/acs.jcim.9b01067 Cited by (35) \| Cite \| Source
3-amino-pyridines as GPBAR1 agonists (patent) Bissantz, Caterina \| Dehmlow, Henrietta \| Erickson, Shawn David \| Karnachi, Prabha Saba \| Kim, Kyungjin \| Martin, Rainer E. \| Mattei, Patrizio \| Sander, Ulrike Obst \| Pietranico-Cole, Sherrie Lynn \| Richter, Hans \| Ullmer, Christoph Patent Number: 10385022 (2019) Cite \| Source
Augmenting decision making in early discovery – Efforts to derisk bsep inhibition potential utilizing in silico modeling (journal article) Joshi, Elizabeth \| Hafey, Michael \| Houle, Robert \| Karnachi, Prabha Drug Metabolism and Pharmacokinetics, volume 33, issue 1, pages S64-S65 (2018). 10.1016/j.dmpk.2017.11.216 Cite \| Source
3-amino-pyridines as GPBAR1 agonists (patent) Bissantz, Caterina \| Dehmlow, Henrietta \| Erickson, Shawn David \| Karnachi, Prabha Saba \| Kim, Kyungjin \| Martin, Rainer E. \| Mattei, Patrizio \| Sander, Ulrike Obst \| Pietranico-Cole, Sherrie Lynn \| Richter, Hans \| Ullmer, Christoph Patent Number: 8987307 (2015) Cite \| Source
Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development (journal article) Zhang, Zhuming \| Chu, Xin-Jie \| Liu, Jin-Jun \| Ding, Qingjie \| Zhang, Jing \| Bartkovitz, David \| Jiang, Nan \| Karnachi, Prabha \| So, Sung-Sau \| Tovar, Christian \| ... \| Graves, Bradford ACS Medicinal Chemistry Letters, volume 5, issue 2, pages 124-127 (2014). 10.1021/ml400359z Cited by (76) \| Cite \| Source \| Open Access
GPR119 receptor agonists (patent) Erickson, Shawn David \| Gillespie, Paul \| Guertin, Kevin Richard \| Karnachi, Prabha Saba \| Kim, Kyungjin \| Ma, Chun \| McComas, Warren William \| Pietranico-Cole, Sherrie Lynn \| Qi, Lida \| Tilley, Jefferson Wright \| Zhang, Qiang Patent Number: 8188098 (2012) Cited by (10) \| Cite \| Source
Substituted pyrimidinyl oxime kinase inhibitors (patent) Xu, Guozhang \| Lee, Lily \| Hughes, Terry V. \| Wetter, Steven K. \| Connolly, Peter J. \| Abad, Marta C. \| Emanuel, Stuart L. \| Karnachi, Prabha S. \| Middleton, Steven A. \| Battista, Kathleen A. \| Bignan, Gilles C. Patent Number: 8153791 (2012) Cited by (2) \| Cite \| Source
ChemInform Abstract: Discovery of Novel Cobactin‐T Based Matrix Metalloproteinase Inhibitors via a Ring Closing Metathesis Strategy. (journal article) Wilson, Lawrence J. \| Wang, Bingbing \| Yang, Shyh‐Ming \| Scannevin, Robert H. \| Burke, Sharon L. \| Karnachi, Prabha \| Rhodes, Kenneth J. \| Murray, William V. ChemInform, volume 43, issue 10 (2012). 10.1002/chin.201210212 Cite \| Source
Discovery of novel Cobactin-T based matrix metalloproteinase inhibitors via a ring closing metathesis strategy (journal article) Wilson, Lawrence J. \| Wang, Bingbing \| Yang, Shyh-Ming \| Scannevin, Robert H. \| Burke, Sharon L. \| Karnachi, Prabha \| Rhodes, Kenneth J. \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 21, issue 21, pages 6485-6490 (2011). 10.1016/j.bmcl.2011.08.068 Cited by (10) \| Cite \| Source
Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists (patent) Bartkovitz, David Joseph \| Chu, Xin-Jie \| Ding, Qingjie \| Karnachi, Prabha Saba \| Liu, Jin-Jun \| So, Sung-Sau \| Zhang, Jing \| Zhang, Zhuming Patent Number: 20120046306 (2011) Cite \| Source
Heterocyclic derived metalloprotease inhibitors (patent) Zhang, Yue-Mei \| Xiang, Bangping \| Yang, Shyh-Ming \| Rhodes, Kenneth \| Scannevin, Robert \| Jackson, Paul \| Chakravarty, Davraj \| Fan, Xiaodong \| Wilson, Lawrence J. \| Karnachi, Prabha Patent Number: 7803793 (2010) Cited by (3) \| Cite \| Source
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity (journal article) Hughes, Terry V. \| Emanuel, Stuart L. \| O’Grady, Harold R. \| Connolly, Peter J. \| Rugg, Catherine \| Fuentes-Pesquera, Angel R. \| Karnachi, Prabha \| Alexander, Richard \| Middleton, Steven A. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 18, pages 5130-5133 (2008). 10.1016/j.bmcl.2008.07.090 Cited by (15) \| Cite \| Source
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: Design, synthesis, and biological activity (journal article) Hughes, Terry V. \| Xu, Guozhang \| Wetter, Steven K. \| Connolly, Peter J. \| Emanuel, Stuart L. \| Karnachi, Prabha \| Pollack, Scott R. \| Pandey, Niranjan \| Adams, Mary \| Moreno-Mazza, Sandra \| ... \| Greenberger, Lee M. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 17, pages 4896-4899 (2008). 10.1016/j.bmcl.2008.07.057 Cited by (23) \| Cite \| Source
β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 2. Optimization of α-amino substituents (journal article) Yang, Shyh-Ming \| Scannevin, Robert H. \| Wang, Bingbing \| Burke, Sharon L. \| Huang, Zhihong \| Karnachi, Prabha \| Wilson, Lawrence J. \| Rhodes, Kenneth J. \| Lagu, Bharat \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 3, pages 1140-1145 (2008). 10.1016/j.bmcl.2007.11.129 Cited by (18) \| Cite \| Source
β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 1. Design, synthesis, and lead identification (journal article) Yang, Shyh-Ming \| Scannevin, Robert H. \| Wang, Bingbing \| Burke, Sharon L. \| Wilson, Lawrence J. \| Karnachi, Prabha \| Rhodes, Kenneth J. \| Lagu, Bharat \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 3, pages 1135-1139 (2008). 10.1016/j.bmcl.2007.11.119 Cited by (27) \| Cite \| Source
1-Hydroxy-2-pyridinone-based MMP inhibitors: Synthesis and biological evaluation for the treatment of ischemic stroke (journal article) Zhang, Yue-Mei \| Fan, Xiaodong \| Chakaravarty, Devraj \| Xiang, Bangping \| Scannevin, Robert H. \| Huang, Zhihong \| Ma, Jianya \| Burke, Sharon L. \| Karnachi, Prabha \| Rhodes, Kenneth J. \| Jackson, Paul F. Bioorganic & Medicinal Chemistry Letters, volume 18, issue 1, pages 409-413 (2008). 10.1016/j.bmcl.2007.10.045 Cited by (34) \| Cite \| Source
4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation (journal article) Hughes, Terry V. \| Emanuel, Stuart L. \| Beck, Amanda K. \| Wetter, Steven K. \| Connolly, Peter J. \| Karnachi, Prabha \| Reuman, Michael \| Seraj, Jabed \| Fuentes-Pesquera, Angel R. \| Gruninger, Robert H. \| ... \| Moffat, David F.C. Bioorganic & Medicinal Chemistry Letters, volume 17, issue 12, pages 3266-3270 (2007). 10.1016/j.bmcl.2007.04.021 Cited by (42) \| Cite \| Source
Synthesis and SAR of α‐Sulfonylcarboxylic Acids as Potent Matrix Metalloproteinase Inhibitors. (journal article) Zhang, Yue‐Mei \| Fan, Xiaodong \| Xiang, Bangping \| Chakravarty, Devraj \| Scannevin, Robert \| Burke, Sharon \| Karnachi, Prabha \| Rhodes, Kenneth \| Jackson, Paul ChemInform, volume 37, issue 37 (2006). 10.1002/chin.200637084 Cite \| Source
Application of Pharmacophore Fingerprints to Structure‐Based Design and Data Mining (book chapter) In Pharmacophores and Pharmacophore Searches Karnachi, Prabha \| Kulkarni, Amit Wiley (2006) 10.1002/3527609164.ch9 Cited by (11) \| Cite \| Source