Gemma Fabriàs

ScholarGPS® ID: 65122623420320

Affiliation

Spanish National Research Council, Madrid, Spain

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Metrics Summary

Publication Count

141

Predicted Citations

5,770

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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S-Adenosyl-l-methionine restores brain mitochondrial membrane fluidity and GSH content improving Niemann-Pick type C disease (journal article) Goicoechea, Leire \| Torres, Sandra \| Fàbrega, Laura \| Barrios, Mónica \| Núñez, Susana \| Casas, Josefina \| Fabrias, Gemma \| García-Ruiz, Carmen \| Fernández-Checa, José C. Redox Biology, volume 72 (2024). 10.1016/j.redox.2024.103150 Cited by (1) \| Cite \| Source
Targeting dihydroceramide desaturase 1 (Des1): Syntheses of ceramide analogues with a rigid scaffold, inhibitory assays, and AlphaFold2-assisted structural insights reveal cyclopropenone PR280 as a potent inhibitor (journal article) Rivero, Pablo \| Ivanova, Varbina \| Barril, Xavier \| Casampere, Mireia \| Casas, Josefina \| Fabriàs, Gemma \| Díaz, Yolanda \| Matheu, M. Isabel Bioorganic Chemistry, volume 145 (2024). 10.1016/j.bioorg.2024.107233 Cite \| Source
A fluorogenic substrate for the detection of lipid amidases in intact cells (journal article) Casasampere, Mireia \| Ung, Johnson \| Iñáñez, Alejandro \| Dufau, Carine \| Tsuboi, Kazuhito \| Casas, Josefina \| Tan, Su-Fern \| Feith, David J. \| Andrieu-Abadie, Nathalie \| Segui, Bruno \| ... \| Fabrias, Gemma Journal of Lipid Research, volume 65, issue 3, pages 100520- (2024). 10.1016/j.jlr.2024.100520 Cited by (1) \| Cite \| Source
High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase (journal article) Aseeri, Mazen \| Abad, José Luis \| Delgado, Antonio \| Fabriàs, Gemma \| Triola, Gemma \| Casas, Josefina Journal of Enzyme Inhibition and Medicinal Chemistry, volume 38, issue 1, pages 343-348 (2023). 10.1080/14756366.2022.2150183 Cite \| Source
Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia (journal article) Fisher-Wellman, Kelsey H. \| Kassai, Miki \| Hagen, James T. \| Neufer, P. Darrell \| Kester, Mark \| Loughran, Thomas P. \| Chalfant, Charles E. \| Feith, David J. \| Tan, Su-Fern \| Fox, Todd E. \| ... \| Cabot, Myles C. Cancers, volume 15, issue 6, pages 1883- (2023). 10.3390/cancers15061883 Cited by (2) \| Cite \| Source
Fluorescently Labeled Ceramides and 1-Deoxyceramides: Synthesis, Characterization, and Cellular Distribution Studies (journal article) Izquierdo, Eduardo \| López-Corrales, Marta \| Abad-Montero, Diego \| Rovira, Anna \| Fabriàs, Gemma \| Bosch, Manel \| Abad, José Luís \| Marchán, Vicente The Journal of Organic Chemistry, volume 87, issue 24, pages 16351-16367 (2022). 10.1021/acs.joc.2c02019 Cited by (4) \| Cite \| Source
Methuosis Contributes to Jaspine-B-Induced Cell Death (journal article) Bielsa, Núria \| Casasampere, Mireia \| Abad, Jose Luis \| Enrich, Carlos \| Delgado, Antonio \| Fabriàs, Gemma \| Lizcano, Jose M. \| Casas, Josefina International Journal of Molecular Sciences, volume 23, issue 13, pages 7257- (2022). 10.3390/ijms23137257 Cited by (3) \| Cite \| Source
Diets with Higher ω-6/ω-3 Ratios Show Differences in Ceramides and Fatty Acid Levels Accompanied by Increased Amyloid-Beta in the Brains of Male APP/PS1 Transgenic Mice (journal article) Ordóñez-Gutiérrez, Lara \| Fábrias, Gemma \| Casas, Josefina \| Wandosell, Francisco International Journal of Molecular Sciences, volume 22, issue 20, pages 10907- (2021). 10.3390/ijms222010907 Cited by (7) \| Cite \| Source
Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation (journal article) Torres, Sandra \| Solsona-Vilarrasa, Estel \| Nuñez, Susana \| Matías, Nuria \| Insausti-Urkia, Naroa \| Castro, Fernanda \| Casasempere, Mireia \| Fabriás, Gemma \| Casas, Josefina \| Enrich, Carlos \| ... \| Garcia-Ruiz, Carmen Redox Biology, volume 45 (2021). 10.1016/j.redox.2021.102052 Cited by (22) \| Cite \| Source
Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells (journal article) Bielsa, Núria \| Casasampere, Mireia \| Aseeri, Mazen \| Casas, Josefina \| Delgado, Antonio \| Abad, José Luis \| Fabriàs, Gemma European Journal of Medicinal Chemistry, volume 216 (2021). 10.1016/j.ejmech.2021.113296 Cited by (8) \| Cite \| Source
Synthesis and characterization of bichromophoric 1-deoxyceramides as FRET probes (journal article) Izquierdo, Eduardo \| Casasampere, Mireia \| Fabriàs, Gemma \| Abad, José Luís \| Casas, Josefina \| Delgado, Antonio Organic & Biomolecular Chemistry, volume 19, issue 11, pages 2456-2467 (2021). 10.1039/D1OB00113B Cited by (5) \| Cite \| Source
Cholesterol in the Viral Membrane is a Molecular Switch Governing HIV‐1 Env Clustering (journal article) Nieto‐Garai, Jon Ander \| Arboleya, Aroa \| Otaegi, Sara \| Chojnacki, Jakub \| Casas, Josefina \| Fabriàs, Gemma \| Contreras, F‐Xabier \| Kräusslich, Hans‐Georg \| Lorizate, Maier Advanced Science, volume 8, issue 3 (2021). 10.1002/advs.202003468 Cited by (14) \| Cite \| Source
Click and count: specific detection of acid ceramidase activity in live cells (journal article) Casasampere, Mireia \| Izquierdo, Eduardo \| Casas, Josefina \| Abad, José Luís \| Liu, Xiao \| Xu, Ruijuan \| Mao, Cungui \| Chang, Young-Tae \| Delgado, Antonio \| Fabrias, Gemma Chemical Science, volume 11, issue 48, pages 13044-13051 (2020). 10.1039/D0SC03166F Cited by (9) \| Cite \| Source
β-Galactosylceramidase Promotes Melanoma Growth via Modulation of Ceramide Metabolism (journal article) Belleri, Mirella \| Paganini, Giuseppe \| Coltrini, Daniela \| Ronca, Roberto \| Zizioli, Daniela \| Corsini, Michela \| Barbieri, Andrea \| Grillo, Elisabetta \| Calza, Stefano \| Bresciani, Roberto \| ... \| Presta, Marco Cancer Research, volume 80, issue 22, pages 5011-5023 (2020). 10.1158/0008-5472.CAN-19-3382 Cited by (14) \| Cite \| Source
CCR 5 deficiency impairs CD 4+ T‐cell memory responses and antigenic sensitivity through increased ceramide synthesis (journal article) Martín‐Leal, Ana \| Blanco, Raquel \| Casas, Josefina \| Sáez, María E \| Rodríguez‐Bovolenta, Elena \| de Rojas, Itziar \| Drechsler, Carina \| Real, Luis Miguel \| Fabrias, Gemma \| Ruíz, Agustín \| ... \| Mañes, Santos The EMBO Journal, volume 39, issue 15 (2020). 10.15252/embj.2020104749 Cited by (14) \| Cite \| Source
Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia (journal article) Pearson, Jennifer M. \| Tan, Su-Fern \| Sharma, Arati \| Annageldiyev, Charyguly \| Fox, Todd E. \| Abad, Jose Luis \| Fabrias, Gemma \| Desai, Dhimant \| Amin, Shantu \| Wang, Hong-Gang \| ... \| Loughran, Thomas P. Molecular Cancer Research, volume 18, issue 3, pages 352-363 (2020). 10.1158/1541-7786.MCR-19-0619 Cited by (22) \| Cite \| Source
A Mechanism-Based Sphingosine-1-phosphate Lyase Inhibitor (journal article) Pons, Guillem \| Riba, Daniel \| Casasampere, Mireia \| Izquierdo, Eduardo \| Abad, José-Luís \| Fabriàs, Gemma \| Rodríguez Ortega, Pilar G. \| López-González, Juan J. \| Montejo, Manuel \| Casas, Josefina \| Delgado, Antonio The Journal of Organic Chemistry, volume 85, issue 2, pages 419-429 (2020). 10.1021/acs.joc.9b02420 Cited by (6) \| Cite \| Source
Ovarian Hormone-Dependent Effects of Dietary Lipids on APP/PS1 Mouse Brain (journal article) Herrera, Jose Luis \| Ordoñez-Gutierrez, Lara \| Fabrias, Gemma \| Casas, Josefina \| Morales, Araceli \| Hernandez, Guadalberto \| Acosta, Nieves G. \| Rodriguez, Covadonga \| Prieto-Valiente, Luis \| Garcia-Segura, Luis M. \| ... \| Alonso, Rafael Frontiers in Aging Neuroscience, volume 11 (2019). 10.3389/fnagi.2019.00346 Cited by (3) \| Cite \| Source
Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells (journal article) Kao, Li-Pin \| Morad, Samy A.F. \| Davis, Traci S. \| MacDougall, Matthew R. \| Kassai, Miki \| Abdelmageed, Noha \| Fox, Todd E. \| Kester, Mark \| Loughran, Thomas P. \| Abad, Jose' L. \| ... \| Cabot, Myles C. Journal of Lipid Research, volume 60, issue 9, pages 1590-1602 (2019). 10.1194/jlr.RA119000251 Cited by (19) \| Cite \| Source
New fluorogenic probes for neutral and alkaline ceramidases (journal article) Casasampere, Mireia \| Bielsa, Núria \| Riba, Daniel \| Bassas, Laura \| Xu, Ruijuan \| Mao, Cungui \| Fabriàs, Gemma \| Abad, José-Luis \| Delgado, Antonio \| Casas, Josefina Journal of Lipid Research, volume 60, issue 6, pages 1174-1181 (2019). 10.1194/jlr.D092759 Cited by (5) \| Cite \| Source