Michael D. Gaul

ScholarGPS® ID: 64734090943820

Affiliation

Johnson & Johnson, New Brunswick, New Jersey, United States

Affiliation History

Field

Medicine

Discipline

Cardiology

Top Specialties

Medicinal Chemistry | Receptor Modulator | Chemical Synthesis | Cross-coupling Reaction | Diels–Alder Reaction

Metrics Summary

Publication Count

Predicted Citations

321

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor (journal article) Xu, Guozhang \| Gaul, Michael D. \| Liu, Zhijie \| DesJarlais, Renee L. \| Qi, Jenson \| Wang, Weixue \| Krosky, Daniel \| Petrounia, Ioanna \| Milligan, Cynthia M. \| Hermans, An \| ... \| Spurlino, John C. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 23, pages 127602- (2020). 10.1016/j.bmcl.2020.127602 Cited by (4) \| Cite \| Source
5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors (journal article) Xu, Guozhang \| Du, Fuyong \| Kuo, Gee-Hong \| Xu, June Zhi \| Liang, Yin \| Demarest, Keith \| Gaul, Michael D. Bioorganic & Medicinal Chemistry Letters, volume 30, issue 17, pages 127387- (2020). 10.1016/j.bmcl.2020.127387 Cited by (8) \| Cite \| Source
Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes (journal article) Xu, Guozhang \| Gaul, Michael D. \| Song, Fengbin \| Du, Fuyong \| Liang, Yin \| DesJarlais, Renee L. \| DiLoreto, Karen \| Shook, Brian \| Rentzeperis, Dennis \| Santulli, Rosie \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 29, issue 20, pages 126668- (2019). 10.1016/j.bmcl.2019.126668 Cited by (3) \| Cite \| Source
Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists (journal article) Song, Fengbin \| Xu, Guozhang \| Gaul, Michael D. \| Zhao, Baoping \| Lu, Tianbao \| Zhang, Rui \| DesJarlais, Renee L. \| DiLoreto, Karen \| Huebert, Norman \| Shook, Brian \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 29, issue 15, pages 1974-1980 (2019). 10.1016/j.bmcl.2019.05.036 Cited by (15) \| Cite \| Source
Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors (journal article) Xu, Guozhang \| Gaul, Michael D. \| Kuo, Gee-Hong \| Du, Fuyong \| Xu, June Zhi \| Wallace, Nathaniel \| Hinke, Simon \| Kirchner, Thomas \| Silva, Jose \| Huebert, Norman D. \| ... \| Demarest, Keith Bioorganic & Medicinal Chemistry Letters, volume 28, issue 21, pages 3446-3453 (2018). 10.1016/j.bmcl.2018.09.025 Cited by (9) \| Cite \| Source
Photocatalytic CO2 reduction by Cr-substituted Ba2(In2-Cr )O5·(H2O) (0.04 ≤ x ≤ 0.60) (journal article) Yoon, Songhak \| Gaul, Michael \| Sharma, Sitansh \| Son, Kwanghyo \| Hagemann, Hans \| Ziegenbalg, Dirk \| Schwingenschlogl, Udo \| Widenmeyer, Marc \| Weidenkaff, Anke Solid State Sciences, volume 78 (2018). 10.1016/j.solidstatesciences.2018.02.005 Cited by (5) \| Cite \| Source \| Open Access
Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo (journal article) Qi, Jenson \| Lang, Wensheng \| Connelly, Margery A. \| Du, Fuyong \| Liang, Yin \| Caldwell, Gary W. \| Martin, Tonya \| Hansen, Michael K. \| Kuo, Gee-Hong \| Gaul, Michael D. \| ... \| Lee, Seunghun Analytical Biochemistry, volume 524 (2017). 10.1016/j.ab.2016.09.017 Cited by (2) \| Cite \| Source
Novel LC/MS/MS and High-Throughput Mass Spectrometric Assays for Monoacylglycerol Acyltransferase Inhibitors (journal article) Qi, Jenson \| Masucci, John A. \| Lang, Wensheng \| Connelly, Margery A. \| Caldwell, Gary W. \| Petrounia, Ioanna \| Kirkpatrick, Jennifer \| Barnakov, Alexander N. \| Struble, Geoffrey \| Miller, Robyn \| ... \| Lee, Seunghun SLAS Discovery, volume 22, issue 4, pages 433-439 (2017). 10.1177/2472555217690101 Cited by (2) \| Cite \| Source
ChemInform Abstract: Synthesis of β‐Substituted Cyclic Enones via Phosphonium Salt‐Activated, Palladium‐Catalyzed Cross‐Coupling of Cyclic 1,3‐Diones. (journal article) Yang, Shyh‐Ming \| Kuo, Gee‐Hong \| Gaul, Michael D. \| Murray, William V. ChemInform, volume 47, issue 34 (2016). 10.1002/chin.201634053 Cite \| Source
Synthesis of β-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones (journal article) Yang, Shyh-Ming \| Kuo, Gee-Hong \| Gaul, Michael D. \| Murray, William V. The Journal of Organic Chemistry, volume 81, issue 8, pages 3464-3469 (2016). 10.1021/acs.joc.6b00317 Cited by (5) \| Cite \| Source
A facile synthesis of 2-(3-alkynyl-2,3-dihydrobenzofuran-3-yl)acetate (journal article) Song, Fengbin \| Gaul, Michael D. \| Murray, William V. Tetrahedron Letters, volume 56, issue 40, pages 5413-5415 (2015). 10.1016/j.tetlet.2015.08.007 Cited by (1) \| Cite \| Source
Substituted phenoxy N-alkylated thiazolidinediones as estrogen related receptor-α modulators (patent) Gaul, Michael \| Searle, Lily Lee \| Rentzeperis, Dionisios Patent Number: 9034852 (2015) Cite \| Source
Diaminopyrimidines, diaminopyridines and diaminopyridazines as histamine H4 receptor modulators (journal article) Savall, Brad M. \| Meduna, Steven P. \| Tays, Kevin \| Cai, Hui \| Thurmond, Robin L. \| McGovern, Patricia \| Gaul, Michael \| Zhao, Bao-Ping \| Edwards, James P. Bioorganic & Medicinal Chemistry Letters, volume 25, issue 4, pages 956-959 (2015). 10.1016/j.bmcl.2014.12.027 Cited by (3) \| Cite \| Source
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: Part 2. Pyridazine-based analogs (journal article) Yang, Shyh-Ming \| Tang, Yuting \| Rano, Thomas \| Lu, Huajun \| Kuo, Gee-Hong \| Gaul, Michael D. \| Li, Yaxin \| Ho, George \| Lang, Wensheng \| Conway, James G. \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 24, issue 5, pages 1437-1441 (2014). 10.1016/j.bmcl.2013.12.075 Cited by (5) \| Cite \| Source
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs (journal article) Yang, Shyh-Ming \| Tang, Yuting \| Zhang, Rui \| Lu, Huajun \| Kuo, Gee-Hong \| Gaul, Michael D. \| Li, Yaxin \| Ho, George \| Conway, James G. \| Liang, Yin \| ... \| Murray, William V. Bioorganic & Medicinal Chemistry Letters, volume 23, issue 24, pages 6773-6776 (2013). 10.1016/j.bmcl.2013.09.096 Cited by (5) \| Cite \| Source
Substituted phenoxy aminothiazolones as estrogen related receptor-α modulators (patent) Kim, Alexander \| Rentzeperis, Dionisios \| Bignan, Gilles C. \| Searle, Lily Lee \| Gaul, Michael Patent Number: 8580832 (2013) Cite \| Source
Synergistic modulation of FLT3 kinase using a FLT3 inhibitor and a farnesyl transferase inhibitor (patent) Baumann, Christian Andrew \| Johnson, Dana L. \| Gaul, Michael David \| Tuman, Robert W. Patent Number: 8557847 (2013) Cite \| Source
Substituted phenoxy thiazolidinediones as estrogen related receptor-á modulators (patent) Gaul, Michael \| Kim, Alexander \| Searle, Lily Lee \| Patch, Raymond \| Rentzeperis, Dionisois \| Xu, Guozhang \| Zhu, Xizhen Patent Number: 8344009 (2013) Cite \| Source
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s (journal article) Subasinghe, Nalin L. \| Khalil, Ehab \| Travins, Jeremy M. \| Ali, Farah \| Ballentine, Shelley K. \| Hufnagel, Heather R. \| Pan, Wenxi \| Leonard, Kristi \| Bone, Roger F. \| Soll, Richard M. \| ... \| Gaul, Michael D. Bioorganic & Medicinal Chemistry Letters, volume 22, issue 16, pages 5303-5307 (2012). 10.1016/j.bmcl.2012.06.030 Cited by (12) \| Cite \| Source
Substituted phenoxy N-alkylated thiazolidinediones as estrogen related receptor-α modulators (patent) Gaul, Michael \| Searle, Lily Lee \| Rentzeperis, Dionisios Patent Number: 8119669 (2012) Cite \| Source