Snahel Patel

ScholarGPS® ID: 64414863395504

Affiliation

Genentech, Inc., South San Francisco, United States

Affiliation History

Field

Physical Sciences and Mathematics

Discipline

Chemistry

Top Specialties

Medicinal Chemistry | Neurodegeneration | Protein Kinase Inhibitor

Metrics Summary

Publication Count

Predicted Citations

634

Predicted h-index

Ranking

Publications and Citation History

Publications based on Top Specialties

Types of Publication

Publications
Books
Patents
NIH/NSF

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Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors (journal article) Hu, Dennis X. \| Patel, Snahel \| Chen, Huifen \| Wang, Shumei \| Staben, Steven T. \| Dimitrova, Yoana N. \| Wallweber, Heidi Ackerly \| Lee, Joanna Y. \| Chan, Grace Ka Yan \| Sneeringer, Christopher J. \| ... \| Siu, Michael Journal of Medicinal Chemistry, volume 65, issue 17, pages 11500-11512 (2022). 10.1021/acs.jmedchem.1c01180 Cited by (13) \| Cite \| Source
Amido spirocyclic amide and sulfonamide derivatives (patent) Bair, Kenneth W. \| Baumeister, Timm R. \| Dragovich, Peter \| Liu, Xiongcai \| Patel, Snahel \| Yuen, Po-Wai \| Zak, Mark \| Zhao, Guiling \| Zhang, Yamin \| Zheng, Xiaozhang Patent Number: 10730889 (2020) Cite \| Source
RIP1 kinase activity is critical for skin inflammation but not for viral propagation (journal article) Webster, Joshua D. \| Kwon, Youngsu C. \| Park, Summer \| Zhang, Hua \| Corr, Nick \| Ljumanovic, Nina \| Adedeji, Adeyemi O. \| Varfolomeev, Eugene \| Goncharov, Tatiana \| Preston, Jessica \| ... \| Vucic, Domagoj Journal of Leukocyte Biology, volume 107, issue 6, pages 941-952 (2020). 10.1002/JLB.3MA1219-398R Cited by (33) \| Cite \| Source
Biheteroaryl compounds and uses thereof (patent) Estrada, Anthony \| Olivero, Alan G. \| Patel, Snahel \| Siu, Michael \| Lyssikatos, Joseph \| Huestis, Malcolm \| Kellar, Terry Patent Number: RE47848 (2020) Cite \| Source
Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group (journal article) Hamilton, Gregory L. \| Chen, Huifen \| Deshmukh, Gauri \| Eigenbrot, Charles \| Fong, Rina \| Johnson, Adam \| Kohli, Pawan Bir \| Lupardus, Patrick J. \| Liederer, Bianca M. \| Ramaswamy, Sreemathy \| ... \| Patel, Snahel Bioorganic & Medicinal Chemistry Letters, volume 29, issue 12, pages 1497-1501 (2019). 10.1016/j.bmcl.2019.04.014 Cited by (25) \| Cite \| Source
Tricyclic DLK inhibitors and uses thereof (patent) Estrada, Anthony \| Patel, Snahel \| Kellar, Terry \| Huestis, Malcolm \| Shore, Daniel \| Siu, Michael Patent Number: 10131675 (2018) Cite \| Source
3-substituted pyrazoles and uses thereof (patent) Estrada, Anthony \| Liu, Wen \| Patel, Snahel \| Siu, Michael Patent Number: 10028942 (2018) Cited by (1) \| Cite \| Source
Biheteroaryl compounds and uses thereof (patent) Estrada, Anthony \| Olivero, Alan G \| Patel, Snahel \| Siu, Michael \| Lyssikatos, Joseph Patent Number: 10028954 (2018) Cited by (1) \| Cite \| Source
Biheteroaryl compounds and uses thereof (patent) Estrada, Anthony \| Dong, Liting \| Chen, Kevin X. \| Gibbons, Paul \| Huestis, Malcolm \| Kellar, Terry \| Liu, Wen \| Ma, Changyou \| Lyssikatos, Joseph \| Olivero, Alan \| ... \| Siu, Michael Patent Number: 10010549 (2018) Cited by (1) \| Cite \| Source
Triazolopyridine compounds, compositions and methods of use thereof (patent) Ray, Nicholas C. \| Cheng, Yun-Xing \| Edwards, Christine \| Goodacre, Simon C. \| Li, Wei \| Patel, Snahel \| Cartwright, Matthew W. \| Sajad, Mohammed \| Yuen, Po-wai \| Zak, Mark E. Patent Number: 9873709 (2018) Cited by (1) \| Cite \| Source
C-linked heterocycloaklyl substituted pyrimidines and their uses (patent) Cohen, Frederick \| Patel, Snahel Patent Number: 9868720 (2018) Cite \| Source
Amido spirocyclic amide and sulfonamide derivatives (patent) Bair, Kenneth W \| Baumeister, Timm R \| Dragovich, Peter \| Liu, Xiongcai \| Patel, Snahel \| Yuen, Po-Wai \| Zak, Mark \| Zhao, Guiling \| Zhang, Yamin \| Zheng, Xiaozhang Patent Number: 9822129 (2017) Cited by (10) \| Cite \| Source
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease (journal article) Patel, Snahel \| Meilandt, William J. \| Erickson, Rebecca I. \| Chen, Jinhua \| Deshmukh, Gauri \| Estrada, Anthony A. \| Fuji, Reina N. \| Gibbons, Paul \| Gustafson, Amy \| Harris, Seth F. \| ... \| Siu, Michael Journal of Medicinal Chemistry, volume 60, issue 19, pages 8083-8102 (2017). 10.1021/acs.jmedchem.7b00843 Cited by (43) \| Cite \| Source
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease (journal article) Le Pichon, Claire E. \| Meilandt, William J. \| Dominguez, Sara \| Solanoy, Hilda \| Lin, Han \| Ngu, Hai \| Gogineni, Alvin \| Sengupta Ghosh, Arundhati \| Jiang, Zhiyu \| Lee, Seung-Hye \| ... \| Lewcock, Joseph W. Science Translational Medicine, volume 9, issue 403 (2017). 10.1126/scitranslmed.aag0394 Cited by (96) \| Cite \| Source \| Open Access
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors (journal article) Liang, Jun \| Labadie, Sharada \| Zhang, Birong \| Ortwine, Daniel F. \| Patel, Snahel \| Vinogradova, Maia \| Kiefer, James R. \| Mauer, Till \| Gehling, Victor S. \| Harmange, Jean-Christophe \| ... \| Murray, Lesley Bioorganic & Medicinal Chemistry Letters, volume 27, issue 13, pages 2974-2981 (2017). 10.1016/j.bmcl.2017.05.016 Cited by (43) \| Cite \| Source
3-substituted pyrazoles and use as DLK inhibitors (patent) Estrada, Anthony \| Liu, Wen \| Patel, Snahel \| Siu, Michael Patent Number: 9550777 (2017) Cite \| Source
Substituted dipyridylamines and uses thereof (patent) Cohen, Frederick \| Huestis, Malcolm \| Ly, Cuong \| Patel, Snahel \| Siu, Michael \| Zhao, Xianrui Patent Number: 9399636 (2016) Cite \| Source
Substituted pyrazoles and uses thereof (patent) Siu, Michael \| Estrada, Anthony \| Liu, Wen \| Lyssikatos, Joseph P. \| Patel, Snahel \| Liang, Guibai \| Chen, Kevin Patent Number: 9365583 (2016) Cited by (2) \| Cite \| Source
Biheteroaryl compounds and uses thereof (patent) Estrada, Anthony \| Olivero, Alan G. \| Patel, Snahel \| Siu, Michael Patent Number: 9266862 (2016) Cited by (4) \| Cite \| Source
Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N -(1 H -Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) (journal article) Patel, Snahel \| Harris, Seth F. \| Gibbons, Paul \| Deshmukh, Gauri \| Gustafson, Amy \| Kellar, Terry \| Lin, Han \| Liu, Xingrong \| Liu, Yanzhou \| Liu, Yichin \| ... \| Lewcock, Joseph W. Journal of Medicinal Chemistry, volume 58, issue 20, pages 8182-8199 (2015). 10.1021/acs.jmedchem.5b01072 Cited by (49) \| Cite \| Source